Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 657-669

  Lv, Linlin ^a   Zheng, Lingli ^a   Dong, Deshi ^a   Xu, Lina ^a   Yin, Lianhong ^a   Xu, Youwei ^a   Qi, Yan ^a   Han, Xu ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; C6 glioma cells; Dioscin; DNA damage; Mitochondrial pathways; ROS

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 9; CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; DIOSCIN; DNA TOPOISOMERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; MALONALDEHYDE; NAVELBINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; GLIOBLASTOMA; GLIOMA CELL; INTRACELLULAR SIGNALING; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; TREATMENT RESPONSE; TUMOR VOLUME;

2-(6-AMINO-3-IMINO-3H-XANTHEN-9-YL) BENZOIC ACID METHYL ESTER; 3-(4,5-DIMETHYL-2-THIAZOLYL)-2,5-DIPHENYL TETRAZOLIUM BROMIDE; 4′6′-DIAMIDINO-2-PHENYL-INDOLE; ACRIDINE ORANGE/ETHIDIUM BROMIDE; AO/EB; APOPTOSIS; C6 GLIOMA CELLS; CDK2; CYCLIN-DEPENDENT KINASE 2; DAPI; DIOSCIN; DNA DAMAGE; DNA TOPO I; DNA TOPOISMERASE I; ECL; ENHANCED CHEMILUMINESCENCE; FBS; FETAL BOVINE SERUM; GLUTATHIONE; GLUTATHIONE DISULFIDE; GSH; GSSG; HE; HEMATOXYLIN AND EOSIN; MAGNETIC RESONANCE IMAGING; MALONDIALDEHYDE; MDA; MITOCHONDRIA MEMBRANE POTENTIAL; MITOCHONDRIAL PATHWAYS; MITOCHONDRIAL PERMEABILITY TRANSITION; MITOTRACKER GREEN-FM; MPT; MRI; MTG; MTT; NITRIC OXIDE; NO; P-NITROANILINE; PARP; PDCD5; PHENYLMETHANESULFONYL FLUORIDE; PMSF; PNA; POLY (ADP-RIBOSE) POLYMERASE; PROGRAMMED CELL DEATH-5; REACTIVE OXYGEN SPECIES; RH123; ROS; SDS-PAGE; SODIUM DODECYL SULFATE POLYACRYLAMIDE GEL ELECTROPHORESIS; TDT-MEDIATED DUTP NICK-END LABELING; TEM; TRANSMISSION ELECTRON MICROSCOPE; TUNEL; ΔΨM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM SIGNALING; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSGENIN; DNA DAMAGE; GLIOBLASTOMA; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SAPONINS; SURVIVAL ANALYSIS; TUMOR BURDEN;

EID: 84881237192     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.07.012     Document Type: Article

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