The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives

Molecules

Volumn 16, Issue 12, 2011, Pages 10619-10630

  Dong, Hang ^a   Bai, Li Ping ^a,b   Wong, Vincent Kam Wai ^a,b   Zhou, Hua ^a,b   Wang, Jing Rong ^a,b   Liu, Yan ^a   Jiang, Zhi Hong ^a,b   Liu, Liang ^a,b  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Anti cancer; Cytotoxicity; Ginsenosides; Protopanaxadiol; Structure related activity

Indexed keywords

ANTINEOPLASTIC AGENT; GINSENOSIDE; PLANT EXTRACT; PROTOPANAXADIOL; PROTOPANAXATRIOL; SAPOGENIN;

ARTICLE; CELL DEATH; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; STRUCTURE ACTIVITY RELATION; TIME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; GINSENOSIDES; HUMANS; HYDROLYSIS; PLANT EXTRACTS; SAPOGENINS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 84555188034     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules161210619     Document Type: Article

References (17)

1. Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN. Int. J. Cancer 2008, 127, 2893-2917.
2. Hernandez, B.Y.; Green, M.D.; Cassel, K.D.; Pobutsky, A.M.; Vu, V.; Wilkens, L.R. Preview of Hawaii Cancer Facts and Figures. Hawaii Med. J. 2010, 69, 223-224.
3. Du, G.J.; Dai, Q.; Williams, S.; Wang, C.Z.; Yuan, C.S. Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities. Anticancer Drugs 2011, 22, 35-45.
4. Wang, W.; Wang, H.; Rayburn, E.R.; Zhao, Y.; Hill, D.L.; Zhang, R. 20(S)-25-methoxyldammarane- 3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: Activity in vitro and in vivo and mechanisms of action. Br. J. Cancer 2008, 98, 792-802. (Pubitemid 351272613)
5. Attele, A.S.; Wu, J.A.; Yuan, C.S. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 1999, 58, 1685-1693. (Pubitemid 29505408)
6. Tawab, M.A.; Bahr, U.; Karas, M.; Wurglics, M.; Schubert-Zsilavecz, M. Degradation of ginsenosides in humans after oral administration. Drug Metab. Dispos. 2003, 31, 1065-1071. (Pubitemid 36975678)
7. Pietta, P.; Mauri, P.; Rava, A. Hydrolysis of ginsenosides in artificial gastric fluid monitored by high-performance liquid chromatography. J. Chromatogr. 1986, 362, 291-297. (Pubitemid 16077732)
8. Zhang, X.; Song, F.; Cui, M.; Liu, Z.; Liu, S. Investigation of the hydrolysis of ginsenosides by high performance liquid chromatography- electrospray ionization mass spectrometry. Planta Med. 2007, 73, 1225-1229. (Pubitemid 47572363)
9. Han, B.H.; Park, M.H.; Han, Y.N.; Woo, L.K.; Sankawa, U.; Yahara, S.; Tanaka, O. Degradation of ginseng saponins under mild acidic conditions. Planta Med. 1982, 44, 146-149. (Pubitemid 12101117)
10. Bae, E.A.; Han, M.J.; Kim, E.J.; Kim, D.H. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch. Pharm. Res. 2004, 27, 61-67.
11. Usami, Y.; Liu, Y.N.; Lin, A.S.; Shibano, M.; Akiyama, T.; Itokawa, H.; Morris-Natschke, S.L.; Bastow, K.; Kasai, R.; Lee, K.H. Antitumor agents. 261. 20(S)-protopanaxadiol and 20(S)- protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra. J. Nat. Prod. 2008, 71, 478-481. (Pubitemid 351549379)
12. Tanaka, N.; Tanaka, O.; Shibata, S. Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chem. Pharm. Bull. 1972, 20, 1212-1216.
13. Park, M.H.; Park, T.Y. Treatment and Prevention of Cancer with New Ginsenoside Derivatives. WIPO Patent WO/2005/116042, 7 April 2005.
14. Chen, J.; Peng, H.; Ou-Yang, X.; He, X. Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells. Melanoma Res. 2008, 18, 322-329.
15. Keum, Y.S.; Han, S.S.; Chun, K.S.; Park, K.K.; Park, J.H.; Lee, S.K.; Surh, Y.J. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat. Res. 2003, 523-524, 75-85. (Pubitemid 36293234)
16. Yue, P.Y.; Wong, D.Y.; Wu, P.K.; Leung, P.Y.; Mak, N.K.; Yeung, H.W.; Liu, L.; Cai, Z.; Jiang, Z.H.; Fan, T.P.; Wong, R.N. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem. Pharmacol. 2006, 72, 437-445. (Pubitemid 44061747)
17. Wong, V.K.; Cheung, S.S.; Li, T.; Jiang, Z.H.; Wang, J.R.; Dong, H.; Yi, X.Q.; Zhou, H.; Liu, L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling. J. Cell Biochem. 2010, 111, 899-910.