Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance

Toxicology

Volumn 322, Issue , 2014, Pages 23-33

  Kim, Young Joo ^a   Choi, Won Il ^b   Jeon, Bu Nam ^b   Choi, Kyung Chul ^c   Kim, Kunhong ^b   Kim, Tae Jin ^d   Ham, Jungyeob ^a   Jang, Hyuk Jai ^f   Kang, Ki Sung ^e   Ko, Hyeonseok ^d  

^a Korea Institute of Science and Technology   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Kwandong University College of Medicine   (South Korea)

^e Gachon University College of Medicine   (South Korea)

^f University of Ulsan   (South Korea)

Author keywords

Epithelial mesenchymal transition (EMT); Ginsenoside 20(R) Rg3; Lung cancer; Metastasis; Transforming growth factor beta 1 (TGF 1)

Indexed keywords

DIMETHYL SULFOXIDE; GELATINASE A; GINSENOSIDE 20 RG 3; GINSENOSIDE RG 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANOIKIS; ANOIKIS RESISTANCE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LUNG CANCER; LUNG CANCER CELL LINE; METASTASIS; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOSPECIFICITY; TUMOR INVASION; UPREGULATION;

EPITHELIAL-MESENCHYMAL TRANSITION (EMT); GINSENOSIDE 20(R)-RG3; LUNG CANCER; METASTASIS; TRANSFORMING GROWTH FACTOR-BETA 1 (TGF-Β1);

ANOIKIS; BLOTTING, WESTERN; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; GINSENOSIDES; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SMAD2 PROTEIN; STEREOISOMERISM; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN; WOUND HEALING;

EID: 84901228851     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.04.002     Document Type: Article

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