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Volumn , Issue , 2010, Pages 75-105

Impact of nuclear receptors CAR, PXR, FXR, and VDR, and their ligands on enzymes and transporters

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EID: 84878404330     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0840-7_4     Document Type: Chapter
Times cited : (2)

References (256)
  • 1
    • 0017944237 scopus 로고
    • Clinical pharmacokinetics of rifampicin
    • Acocella G (1978) Clinical pharmacokinetics of rifampicin. Clin Pharmacokinet 3:108-127.
    • (1978) Clin Pharmacokinet , vol.3 , pp. 108-127
    • Acocella, G.1
  • 3
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ and Suchy FJ (2001) Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 276:28857-28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 7
    • 0028210426 scopus 로고
    • A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
    • Baes M, Gulick T, Choi HS, Martinoli MG, Simha D and Moore DD (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14:1544-1551.
    • (1994) Mol Cell Biol , vol.14 , pp. 1544-1551
    • Baes, M.1    Gulick, T.2    Choi, H.S.3    Martinoli, M.G.4    Simha, D.5    Moore, D.D.6
  • 10
    • 4944230477 scopus 로고    scopus 로고
    • Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
    • Bauer B, Hartz AM, Fricker G and Miller DS (2004) Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol 66:413-419.
    • (2004) Mol Pharmacol , vol.66 , pp. 413-419
    • Bauer, B.1    Hartz, A.M.2    Fricker, G.3    Miller, D.S.4
  • 11
    • 44349163325 scopus 로고    scopus 로고
    • Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier
    • Bauer B, Hartz AM, Lucking JR, Yang X, Pollack GM and Miller DS (2008) Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. J Cereb Blood Flow Metab 28:1222-1234.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1222-1234
    • Bauer, B.1    Hartz, A.M.2    Lucking, J.R.3    Yang, X.4    Pollack, G.M.5    Miller, D.S.6
  • 12
    • 33748950454 scopus 로고    scopus 로고
    • In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    • Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM and Miller DS (2006) In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol Pharmacol 70:1212-1219.
    • (2006) Mol Pharmacol , vol.70 , pp. 1212-1219
    • Bauer, B.1    Yang, X.2    Hartz, A.M.3    Olson, E.R.4    Zhao, R.5    Kalvass, J.C.6    Pollack, G.M.7    Miller, D.S.8
  • 14
    • 0033821932 scopus 로고    scopus 로고
    • Enzyme induction and inhibition by new antiepileptic drugs: A review of human studies
    • Benedetti MS (2000) Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies. Fundam Clin Pharmacol 14:301-319.
    • (2000) Fundam Clin Pharmacol , vol.14 , pp. 301-319
    • Benedetti, M.S.1
  • 15
    • 0034811083 scopus 로고    scopus 로고
    • Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7
    • Bertilsson G, Berkenstam A and Blomquist P (2001) Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7. Biochem Biophys Res Commun 280:139-144.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 139-144
    • Bertilsson, G.1    Berkenstam, A.2    Blomquist, P.3
  • 17
    • 0018838326 scopus 로고
    • Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique
    • Bertilsson L, Hojer B, Tybring G, Osterloh J and Rane A (1980) Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique. Clin Pharmacol Ther 27:83-88.
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 83-88
    • Bertilsson, L.1    Hojer, B.2    Tybring, G.3    Osterloh, J.4    Rane, A.5
  • 21
    • 0026725943 scopus 로고
    • Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
    • Burbach KM, Poland A and Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89:8185-8189.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8185-8189
    • Burbach, K.M.1    Poland, A.2    Bradfield, C.A.3
  • 22
    • 21744451835 scopus 로고    scopus 로고
    • Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor
    • Burk O, Arnold KA, Nussler AK, Schaeffeler E, Efimova E, Avery BA, Avery MA, Fromm MF and Eichelbaum M (2005) Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 67:1954-1965.
    • (2005) Mol Pharmacol , vol.67 , pp. 1954-1965
    • Burk, O.1    Arnold, K.A.2    Nussler, A.K.3    Schaeffeler, E.4    Efimova, E.5    Avery, B.A.6    Avery, M.A.7    Fromm, M.F.8    Eichelbaum, M.9
  • 25
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A, Repa JJ, Evans RM and Mangelsdorf DJ (2001) Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 26
    • 0042844649 scopus 로고    scopus 로고
    • Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter
    • Chen Y, Ferguson SS, Negishi M and Goldstein JA (2003) Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol 64:316-324.
    • (2003) Mol Pharmacol , vol.64 , pp. 316-324
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 27
    • 1642498178 scopus 로고    scopus 로고
    • Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
    • Chen Y, Ferguson SS, Negishi M and Goldstein JA (2004) Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 308:495-501.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 495-501
    • Chen, Y.1    Ferguson, S.S.2    Negishi, M.3    Goldstein, J.A.4
  • 28
    • 0002753650 scopus 로고
    • Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs
    • Conney AH, Davison C, Gastel R and Burns JJ (1960) Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs. J Pharmacol Exp Ther 130:1-8.
    • (1960) J Pharmacol Exp Ther , vol.130 , pp. 1-8
    • Conney, A.H.1    Davison, C.2    Gastel, R.3    Burns, J.J.4
  • 29
    • 0013781880 scopus 로고
    • Induction of liver microsomal cortisol 6beta-hydroxylase by diphenylhydantoin or phenobarbital: An explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugs
    • Conney AH, Jacobson M, Schneidman K and Kuntzman R (1965) Induction of liver microsomal cortisol 6beta-hydroxylase by diphenylhydantoin or phenobarbital: an explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugs. Life Sci 4:1091-1098.
    • (1965) Life Sci , vol.4 , pp. 1091-1098
    • Conney, A.H.1    Jacobson, M.2    Schneidman, K.3    Kuntzman, R.4
  • 30
    • 12644267853 scopus 로고
    • Stimulatory effect of phenobarbital on the metabolism of diphenylhydantoin
    • Cucinell SA, Koster R, Conney AH and Burns JJ (1963) Stimulatory Effect Of Phenobarbital On The Metabolism Of Diphenylhydantoin. J Pharmacol Exp Ther 141:157-160.
    • (1963) J Pharmacol Exp Ther , vol.141 , pp. 157-160
    • Cucinell, S.A.1    Koster, R.2    Conney, A.H.3    Burns, J.J.4
  • 31
    • 0025863054 scopus 로고
    • The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland
    • Curran PG and De Groot LJ (1991) The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Endocr Rev 12:135-150.
    • (1991) Endocr Rev , vol.12 , pp. 135-150
    • Curran, P.G.1    De Groot, L.J.2
  • 33
    • 64249112729 scopus 로고    scopus 로고
    • Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant, CAR2
    • Dekeyser JG, Stagliano MC, Auerbach SS, Prabu KS, Jones AD and Omiecinski CJ (2009) Di (2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant, CAR2. Mol Pharmacol 75:1003-1013.
    • (2009) Mol Pharmacol , vol.75 , pp. 1003-1013
    • Dekeyser, J.G.1    Stagliano, M.C.2    Auerbach, S.S.3    Prabu, K.S.4    Jones, A.D.5    Omiecinski, C.J.6
  • 35
    • 3242690866 scopus 로고    scopus 로고
    • Pharmacokinetics, drug interactions, and tolerability of valproate
    • De Vane CL (2003) Pharmacokinetics, drug interactions, and tolerability of valproate. Psychopharmacol Bull 37 Suppl 2:25-42.
    • (2003) Psychopharmacol Bull , vol.37 , Issue.SUPPL. 2 , pp. 25-42
    • De Vane, C.L.1
  • 36
    • 33744782612 scopus 로고    scopus 로고
    • The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor
    • Ding X, Lichti K and Staudinger JL (2006) The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor. Toxicol Sci 91:448-455.
    • (2006) Toxicol Sci , vol.91 , pp. 448-455
    • Ding, X.1    Lichti, K.2    Staudinger, J.L.3
  • 37
    • 13244291443 scopus 로고    scopus 로고
    • Induction of drug metabolism by forskolin: The role of the pregnane X receptor and the protein kinase a signal transduction pathway
    • Ding X and Staudinger JL (2005a) Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 312:849-856.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 849-856
    • Ding, X.1    Staudinger, J.L.2
  • 38
    • 13844253850 scopus 로고    scopus 로고
    • Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C
    • Ding X and Staudinger JL (2005b) Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. Biochem Pharmacol 69:867-873.
    • (2005) Biochem Pharmacol , vol.69 , pp. 867-873
    • Ding, X.1    Staudinger, J.L.2
  • 39
    • 0042950000 scopus 로고    scopus 로고
    • Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects
    • Dresser GK, Schwarz UI, Wilkinson GR and Kim RB (2003) Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects. Clin Pharmacol Ther 73:41-50.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 41-50
    • Dresser, G.K.1    Schwarz, U.I.2    Wilkinson, G.R.3    Kim, R.B.4
  • 41
    • 0037067665 scopus 로고    scopus 로고
    • Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes
    • Drocourt L, Ourlin JC, Pascussi JM, Maurel P and Vilarem MJ (2002) Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 277:25125-25132.
    • (2002) J Biol Chem , vol.277 , pp. 25125-25132
    • Drocourt, L.1    Ourlin, J.C.2    Pascussi, J.M.3    Maurel, P.4    Vilarem, M.J.5
  • 42
    • 0034827301 scopus 로고    scopus 로고
    • Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes
    • Drocourt L, Pascussi JM, Assenat E, Fabre JM, Maurel P and Vilarem MJ (2001) Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes. Drug Metab Dispos 29:1325-1331.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1325-1331
    • Drocourt, L.1    Pascussi, J.M.2    Assenat, E.3    Fabre, J.M.4    Maurel, P.5    Vilarem, M.J.6
  • 46
    • 34548301080 scopus 로고    scopus 로고
    • The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4 in the regulation of human steroid-/bile acid-sulfotransferase
    • Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ and Chatterjee B (2007) The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4 in the regulation of human steroid-/bile acid-sulfotransferase. Mol Endocrinol 21:2099-2111.
    • (2007) Mol Endocrinol , vol.21 , pp. 2099-2111
    • Echchgadda, I.1    Song, C.S.2    Oh, T.3    Ahmed, M.4    De La Cruz, I.J.5    Chatterjee, B.6
  • 47
    • 1342265781 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor
    • Echchgadda I, Song CS, Roy AK and Chatterjee B (2004) Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol 65:720-729.
    • (2004) Mol Pharmacol , vol.65 , pp. 720-729
    • Echchgadda, I.1    Song, C.S.2    Roy, A.K.3    Chatterjee, B.4
  • 50
    • 35548997887 scopus 로고    scopus 로고
    • Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) gene transcription by rifampicin: Roles of hepatocyte nuclear factor 4? and pregnane X receptor
    • Fang HL, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA and Runge-Morris M (2007) Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4? and Pregnane X Receptor. J Pharmacol Exp Ther 323:586-590.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 586-590
    • Fang, H.L.1    Strom, S.C.2    Ellis, E.3    Duanmu, Z.4    Fu, J.5    Duniec-Dmuchowski, Z.6    Falany, C.N.7    Falany, J.L.8    Kocarek, T.A.9    Runge-Morris, M.10
  • 51
    • 0036765751 scopus 로고    scopus 로고
    • Regulation of human CYP2C9 by the constitutive androstane receptor: Discovery of a new distal binding site
    • Ferguson SS, Le Cluyse EL, Negishi M and Goldstein JA (2002) Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. Mol Pharmacol 62:737-746.
    • (2002) Mol Pharmacol , vol.62 , pp. 737-746
    • Ferguson, S.S.1    Le Cluyse, E.L.2    Negishi, M.3    Goldstein, J.A.4
  • 54
    • 33751573877 scopus 로고    scopus 로고
    • ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics
    • Finkelstein D, Lamba V, Assem M, Rengelshausen J, Yasuda K, Strom S and Schuetz E (2006) ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics. Xenobiotica 36:989-1012.
    • (2006) Xenobiotica , vol.36 , pp. 989-1012
    • Finkelstein, D.1    Lamba, V.2    Assem, M.3    Rengelshausen, J.4    Yasuda, K.5    Strom, S.6    Schuetz, E.7
  • 55
    • 58249089410 scopus 로고    scopus 로고
    • Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway
    • Finn RD, Henderson CJ, Scott CL and Wolf CR (2009) Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417:43-54.
    • (2009) Biochem J , vol.417 , pp. 43-54
    • Finn, R.D.1    Henderson, C.J.2    Scott, C.L.3    Wolf, C.R.4
  • 63
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick A, Eichelbaum M and Burk O (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587.
    • (2001) J Biol Chem , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 64
    • 0037016761 scopus 로고    scopus 로고
    • Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
    • Gerbal-Chaloin S, Daujat M, Pascussi JM, Pichard-Garcia L, Vilarem MJ and Maurel P (2002) Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. J Biol Chem 277:209-217.
    • (2002) J Biol Chem , vol.277 , pp. 209-217
    • Gerbal-Chaloin, S.1    Daujat, M.2    Pascussi, J.M.3    Pichard-Garcia, L.4    Vilarem, M.J.5    Maurel, P.6
  • 67
    • 6944234902 scopus 로고    scopus 로고
    • Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene
    • Gnerre C, Blattler S, Kaufmann MR, Looser R and Meyer UA (2004) Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 14:635-645.
    • (2004) Pharmacogenetics , vol.14 , pp. 635-645
    • Gnerre, C.1    Blattler, S.2    Kaufmann, M.R.3    Looser, R.4    Meyer, U.A.5
  • 68
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • Goodwin B, Hodgson E and Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339.
    • (1999) Mol Pharmacol , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 72
    • 44149104931 scopus 로고    scopus 로고
    • Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction
    • Hariparsad N, Carr BA, Evers R and Chu X (2008) Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. Drug Metab Dispos 36:1046-1055.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1046-1055
    • Hariparsad, N.1    Carr, B.A.2    Evers, R.3    Chu, X.4
  • 73
    • 67650566600 scopus 로고    scopus 로고
    • Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/-mice
    • Jan, Epub ahead of print
    • Hartman HB, Gardell SJ, Petucci CJ, Wang S, Krueger JA and Evans MJ (2009) Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/-mice. J Lipid Res Jan 27. [Epub ahead of print].
    • (2009) J Lipid Res , pp. 27
    • Hartman, H.B.1    Gardell, S.J.2    Petucci, C.J.3    Wang, S.4    Krueger, J.A.5    Evans, M.J.6
  • 74
    • 0141534255 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts
    • Hayashi A, Suzuki H, Itoh K, Yamamoto M and Sugiyama Y (2003) Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem Biophys Res Commun 310:824-829.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 824-829
    • Hayashi, A.1    Suzuki, H.2    Itoh, K.3    Yamamoto, M.4    Sugiyama, Y.5
  • 75
    • 40849083767 scopus 로고    scopus 로고
    • A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
    • Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG and Kim RB (2008) A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor. Drug Metab Dispos 36:500-507.
    • (2008) Drug Metab Dispos , vol.36 , pp. 500-507
    • Healan-Greenberg, C.1    Waring, J.F.2    Kempf, D.J.3    Blomme, E.A.4    Tirona, R.G.5    Kim, R.B.6
  • 77
    • 62649157432 scopus 로고    scopus 로고
    • Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice
    • Hoekstra M, Lammers B, Out R, Li Z, Van Eck M and Van Berkel TJ (2009) Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice. Mol Pharm 6:182-189.
    • (2009) Mol Pharm , vol.6 , pp. 182-189
    • Hoekstra, M.1    Lammers, B.2    Out, R.3    Li, Z.4    Van Eck, M.5    Van Berkel, T.J.6
  • 80
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski P, Zelko I, Sueyoshi T and Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital- responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658.
    • (1998) Mol Cell Biol , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 81
    • 34948849836 scopus 로고    scopus 로고
    • Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver
    • Hosseinpour F, Timsit Y, Koike C, Matsui K, Yamamoto Y, Moore R and Negishi M (2007) Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. FEBS Lett 581:4937-4942.
    • (2007) FEBS Lett , vol.581 , pp. 4937-4942
    • Hosseinpour, F.1    Timsit, Y.2    Koike, C.3    Matsui, K.4    Yamamoto, Y.5    Moore, R.6    Negishi, M.7
  • 84
    • 1542781600 scopus 로고    scopus 로고
    • A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
    • Huang W, Zhang J and Moore DD (2004) A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 113:137-143.
    • (2004) J Clin Invest , vol.113 , pp. 137-143
    • Huang, W.1    Zhang, J.2    Moore, D.D.3
  • 86
    • 33644879162 scopus 로고    scopus 로고
    • Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin
    • Huwyler J, Wright MB, Gutmann H and Drewe J (2006) Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin. Curr Drug Metab 7:119-126.
    • (2006) Curr Drug Metab , vol.7 , pp. 119-126
    • Huwyler, J.1    Wright, M.B.2    Gutmann, H.3    Drewe, J.4
  • 87
    • 44849100002 scopus 로고    scopus 로고
    • Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene
    • Inoue K and Negishi M (2008) Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene. J Biol Chem 283:10425-10432.
    • (2008) J Biol Chem , vol.283 , pp. 10425-10432
    • Inoue, K.1    Negishi, M.2
  • 88
    • 33751170721 scopus 로고    scopus 로고
    • Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha
    • Itoh M, Nakajima M, Higashi E, Yoshida R, Nagata K, Yamazoe Y and Yokoi T (2006) Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. J Pharmacol Exp Ther 319:693-702.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 693-702
    • Itoh, M.1    Nakajima, M.2    Higashi, E.3    Yoshida, R.4    Nagata, K.5    Yamazoe, Y.6    Yokoi, T.7
  • 89
    • 0000006828 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
    • Johne A, Brockmoller J, Bauer S, Maurer A, Langheinrich M and Roots I (1999) Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin Pharmacol Ther 66:338-345.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 338-345
    • Johne, A.1    Brockmoller, J.2    Bauer, S.3    Maurer, A.4    Langheinrich, M.5    Roots, I.6
  • 90
    • 33846419835 scopus 로고    scopus 로고
    • Analysis of bile acid-induced regulation of FXR target genes in human liver slices
    • Jung D, Elferink MG, Stellaard F and Groothuis GM (2007) Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int 27:137-144.
    • (2007) Liver Int , vol.27 , pp. 137-144
    • Jung, D.1    Elferink, M.G.2    Stellaard, F.3    Groothuis, G.M.4
  • 91
    • 33745830106 scopus 로고    scopus 로고
    • Pregnane X receptor is a target of farnesoid X receptor
    • Jung D, Mangelsdorf DJ and Meyer UA (2006) Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 281:19081-19091.
    • (2006) J Biol Chem , vol.281 , pp. 19081-19091
    • Jung, D.1    Mangelsdorf, D.J.2    Meyer, U.A.3
  • 92
    • 0036080163 scopus 로고    scopus 로고
    • Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Jung D, Podvinec M, Meyer UA, Mangelsdorf DJ, Fried M, Meier PJ and Kullak-Ublick GA (2002) Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 122:1954-1966.
    • (2002) Gastroenterology , vol.122 , pp. 1954-1966
    • Jung, D.1    Podvinec, M.2    Meyer, U.A.3    Mangelsdorf, D.J.4    Fried, M.5    Meier, P.J.6    Kullak-Ublick, G.A.7
  • 93
    • 0037238536 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers
    • Justesen US, Klitgaard NA, Brosen K and Pedersen C (2003) Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers. Br J Clin Pharmacol 55:100-106.
    • (2003) Br J Clin Pharmacol , vol.55 , pp. 100-106
    • Justesen, U.S.1    Klitgaard, N.A.2    Brosen, K.3    Pedersen, C.4
  • 95
    • 37549004782 scopus 로고    scopus 로고
    • HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans
    • Kanebratt KP and Andersson TB (2008) HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Drug Metab Dispos 36:137-145.
    • (2008) Drug Metab Dispos , vol.36 , pp. 137-145
    • Kanebratt, K.P.1    Andersson, T.B.2
  • 96
    • 1242274394 scopus 로고    scopus 로고
    • Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
    • Kang MI, Kobayashi A, Wakabayashi N, Kim SG and Yamamoto M (2004) Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci USA 101:2046-2051.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2046-2051
    • Kang, M.I.1    Kobayashi, A.2    Wakabayashi, N.3    Kim, S.G.4    Yamamoto, M.5
  • 97
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM and Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277:2908-2915.
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6    Tontonoz, P.7    Kliewer, S.8    Willson, T.M.9    Edwards, P.A.10
  • 99
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbitalresponsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K and Negishi M (1999) Phenobarbitalresponsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19:6318-6322.
    • (1999) Mol Cell Biol , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 100
    • 56749149546 scopus 로고    scopus 로고
    • Patient disclosure about herb and supplement use among adults in the US
    • Kennedy J, Wang CC and Wu CH (2008) Patient disclosure about herb and supplement use among adults in the US. Evid Based Complement Alternat Med 5:451-456.
    • (2008) Evid Based Complement Alternat Med , vol.5 , pp. 451-456
    • Kennedy, J.1    Wang, C.C.2    Wu, C.H.3
  • 102
    • 36649000115 scopus 로고    scopus 로고
    • Rifampin-induced hypothyroidism without underlying thyroid disease
    • Kim DL, Song KH, Lee JH, Lee KY and Kim SK (2007) Rifampin-induced hypothyroidism without underlying thyroid disease. Thyroid 17:793-795.
    • (2007) Thyroid , vol.17 , pp. 793-795
    • Kim, D.L.1    Song, K.H.2    Lee, J.H.3    Lee, K.Y.4    Kim, S.K.5
  • 103
    • 33745603209 scopus 로고    scopus 로고
    • Tipranavir: A novel nonpeptidic protease inhibitor of HIV
    • King JR and Acosta EP (2006) Tipranavir: a novel nonpeptidic protease inhibitor of HIV. Clin Pharmacokinet 45:665-682.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 665-682
    • King, J.R.1    Acosta, E.P.2
  • 105
    • 22344439421 scopus 로고    scopus 로고
    • Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor
    • Kobayashi K, Yamanaka Y, Iwazaki N, Nakajo I, Hosokawa M, Negishi M and Chiba K (2005) Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos 33:924-929.
    • (2005) Drug Metab Dispos , vol.33 , pp. 924-929
    • Kobayashi, K.1    Yamanaka, Y.2    Iwazaki, N.3    Nakajo, I.4    Hosokawa, M.5    Negishi, M.6    Chiba, K.7
  • 106
    • 0028918996 scopus 로고
    • Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes
    • Kocarek TA, Schuetz EG, Strom SC, Fisher RA and Guzelian PS (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 23:415-421.
    • (1995) Drug Metab Dispos , vol.23 , pp. 415-421
    • Kocarek, T.A.1    Schuetz, E.G.2    Strom, S.C.3    Fisher, R.A.4    Guzelian, P.S.5
  • 108
    • 0033755482 scopus 로고    scopus 로고
    • Drug-drug interactions in medical patients: Effects of in-hospital treatment and relation to multiple drug use
    • Kohler GI, Bode-Boger SM, Busse R, Hoopmann M, Welte T and Boger RH (2000) Drug-drug interactions in medical patients: effects of in-hospital treatment and relation to multiple drug use. Int J Clin Pharmacol Ther 38:504-513.
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 504-513
    • Kohler, G.I.1    Bode-Boger, S.M.2    Busse, R.3    Hoopmann, M.4    Welte, T.5    Boger, R.H.6
  • 109
    • 59149106502 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    • Kong B, Luyendyk JP, Tawfik O and Guo GL (2009) Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther 328:116-122.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 116-122
    • Kong, B.1    Luyendyk, J.P.2    Tawfik, O.3    Guo, G.L.4
  • 112
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M and Kensler TW (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278:8135-8145.
    • (2003) J Biol Chem , vol.278 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 113
    • 37549010733 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    • Lamba J, Lamba V, Strom S, Venkataramanan R and Schuetz E (2008) Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression. Drug Metab Dispos 36:169-181.
    • (2008) Drug Metab Dispos , vol.36 , pp. 169-181
    • Lamba, J.1    Lamba, V.2    Strom, S.3    Venkataramanan, R.4    Schuetz, E.5
  • 114
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • Lamba JK, Lin YS, Schuetz EG and Thummel KE (2002) Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev 54:1271-1294.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 115
    • 4444264038 scopus 로고    scopus 로고
    • PXR (NR1I2): Splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    • Lamba V, Yasuda K, Lamba JK, Assem M, Davila J, Strom S and Schuetz EG (2004) PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol Appl Pharmacol 199:251-265.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 251-265
    • Lamba, V.1    Yasuda, K.2    Lamba, J.K.3    Assem, M.4    Davila, J.5    Strom, S.6    Schuetz, E.G.7
  • 116
    • 58949088436 scopus 로고    scopus 로고
    • Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
    • Lambert CB, Spire C, Claude N and Guillouzo A (2009a) Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol 234:345-360.
    • (2009) Toxicol Appl Pharmacol , vol.234 , pp. 345-360
    • Lambert, C.B.1    Spire, C.2    Claude, N.3    Guillouzo, A.4
  • 117
    • 60849106634 scopus 로고    scopus 로고
    • Reproducible chemicalinduced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions
    • Lambert CB, Spire C, Renaud MP, Claude N and Guillouzo A (2009b) Reproducible chemicalinduced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro 23:466-475.
    • (2009) Toxicol in Vitro , vol.23 , pp. 466-475
    • Lambert, C.B.1    Spire, C.2    Renaud, M.P.3    Claude, N.4    Guillouzo, A.5
  • 121
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
    • Lazarou J, Pomeranz BH and Corey PN (1998) Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. J Am Med Assoc 279:1200-1205.
    • (1998) J Am Med Assoc , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 122
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 123
    • 47949111469 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl- methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor
    • Li L, Chen T, Stanton JD, Sueyoshi T, Negishi M and Wang H (2008) The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3- isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol Pharmacol 74:443-453.
    • (2008) Mol Pharmacol , vol.74 , pp. 443-453
    • Li, L.1    Chen, T.2    Stanton, J.D.3    Sueyoshi, T.4    Negishi, M.5    Wang, H.6
  • 124
    • 65349184457 scopus 로고    scopus 로고
    • Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner
    • Li Y, Ross-Viola JS, Shay NF, Moore DD and Ricketts ML (2009b) Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr 139:898-904.
    • (2009) J Nutr , vol.139 , pp. 898-904
    • Li, Y.1    Ross-Viola, J.S.2    Shay, N.F.3    Moore, D.D.4    Ricketts, M.L.5
  • 125
    • 61449220882 scopus 로고    scopus 로고
    • Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways
    • Li L, Stanton JD, Tolson AH, Luo Y and Wang H (2009a) Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res 26:872-882.
    • (2009) Pharm Res , vol.26 , pp. 872-882
    • Li, L.1    Stanton, J.D.2    Tolson, A.H.3    Luo, Y.4    Wang, H.5
  • 127
    • 18744407581 scopus 로고    scopus 로고
    • Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects
    • Lim YP, Liu CH, Shyu LJ and Huang JD (2005) Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects. Pharmacogenet Genomics 15:337-341.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 337-341
    • Lim, Y.P.1    Liu, C.H.2    Shyu, L.J.3    Huang, J.D.4
  • 128
    • 0028258322 scopus 로고
    • Clinical pharmacology and pharmacokinetics of oxcarbazepine
    • Lloyd P, Flesch G and Dieterle W (1994) Clinical pharmacology and pharmacokinetics of oxcarbazepine. Epilepsia 35 Suppl 3:S10-S13.
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 3
    • Lloyd, P.1    Flesch, G.2    Dieterle, W.3
  • 130
  • 132
    • 64249083389 scopus 로고    scopus 로고
    • The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress
    • Maglich JM, Lobe DC and Moore JT (2009) The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. J Lipid Res 50:439-445.
    • (2009) J Lipid Res , vol.50 , pp. 439-445
    • Maglich, J.M.1    Lobe, D.C.2    Moore, J.T.3
  • 134
    • 0036765785 scopus 로고    scopus 로고
    • Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
    • Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT and Kliewer SA (2002) Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 62:638-646.
    • (2002) Mol Pharmacol , vol.62 , pp. 638-646
    • Maglich, J.M.1    Stoltz, C.M.2    Goodwin, B.3    Hawkins-Brown, D.4    Moore, J.T.5    Kliewer, S.A.6
  • 135
    • 0037383772 scopus 로고    scopus 로고
    • Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients
    • Mai I, Stormer E, Bauer S, Kruger H, Budde K and Roots I (2003) Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients. Nephrol Dial Transplant 18:819-822.
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 819-822
    • Mai, I.1    Stormer, E.2    Bauer, S.3    Kruger, H.4    Budde, K.5    Roots, I.6
  • 138
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf DJ and Evans RM (1995) The RXR heterodimers and orphan receptors. Cell 83:841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 139
    • 24344454303 scopus 로고    scopus 로고
    • Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubulestabilizing agents
    • Mani S, Huang H, Sundarababu S, Liu W, Kalpana G, Smith AB and Horwitz SB (2005) Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubulestabilizing agents. Clin Cancer Res 11:6359-6369.
    • (2005) Clin Cancer Res , vol.11 , pp. 6359-6369
    • Mani, S.1    Huang, H.2    Sundarababu, S.3    Liu, W.4    Kalpana, G.5    Smith, A.B.6    Horwitz, S.B.7
  • 144
    • 0041440254 scopus 로고    scopus 로고
    • The protease inhibitor lopinavirritonavir may produce opiate withdrawal in methadone-maintained patients
    • McCance-Katz EF, Rainey PM, Friedland G and Jatlow P (2003) The protease inhibitor lopinavirritonavir may produce opiate withdrawal in methadone-maintained patients. Clin Infect Dis 37:476-482.
    • (2003) Clin Infect Dis , vol.37 , pp. 476-482
    • McCance-Katz, E.F.1    Rainey, P.M.2    Friedland, G.3    Jatlow, P.4
  • 145
    • 20744446883 scopus 로고    scopus 로고
    • Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids
    • McCarthy TC, Li X and Sinal CJ (2005) Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids. J Biol Chem 280:23232-23242.
    • (2005) J Biol Chem , vol.280 , pp. 23232-23242
    • McCarthy, T.C.1    Li, X.2    Sinal, C.J.3
  • 146
    • 66649089506 scopus 로고    scopus 로고
    • Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: Human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells
    • Mar, Epub ahead of print
    • McGinnity DF, Zhang G, Kenny J, Hamilton G, Otmani S, Stams K, Haney S, Brassil P, Stresser DM and Riley RJ (2009) Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, PXR reporter gene, Fa2N-4 and HepaRG cells. Drug Metab Dispos Mar. 23. [Epub ahead of print].
    • (2009) Drug Metab Dispos , pp. 23
    • McGinnity, D.F.1    Zhang, G.2    Kenny, J.3    Hamilton, G.4    Otmani, S.5    Stams, K.6    Haney, S.7    Brassil, P.8    Stresser, D.M.9    Riley, R.J.10
  • 149
    • 56449083452 scopus 로고    scopus 로고
    • Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer
    • Meyer Zu Schwabedissen HE, Tirona RG, Yip CS, Ho RH and Kim RB (2008) Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res 68:9338-9347.
    • (2008) Cancer Res , vol.68 , pp. 9338-9347
    • Meyer Zu Schwabedissen, H.E.1    Tirona, R.G.2    Yip, C.S.3    Ho, R.H.4    Kim, R.B.5
  • 150
    • 31644436285 scopus 로고    scopus 로고
    • Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
    • Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B and Sasano H (2006) Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res 66:535-542.
    • (2006) Cancer Res , vol.66 , pp. 535-542
    • Miki, Y.1    Suzuki, T.2    Kitada, K.3    Yabuki, N.4    Shibuya, R.5    Moriya, T.6    Ishida, T.7    Ohuchi, N.8    Blumberg, B.9    Sasano, H.10
  • 151
    • 1642273510 scopus 로고    scopus 로고
    • Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    • Mills JB, Rose KA, Sadagopan N, Sahi J and De Morais SM (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 303-309
    • Mills, J.B.1    Rose, K.A.2    Sadagopan, N.3    Sahi, J.4    De Morais, S.M.5
  • 155
    • 34147103413 scopus 로고    scopus 로고
    • Liver triglyceride content in HIV-1-infected patients on combination antiretroviral therapy studied with 1H-MR spectroscopy
    • Moreno-Torres A, Domingo P, Pujol J, Blanco-Vaca F, Arroyo JA and Sambeat MA (2007) Liver triglyceride content in HIV-1-infected patients on combination antiretroviral therapy studied with 1H-MR spectroscopy. Antivir Ther 12:195-203.
    • (2007) Antivir Ther , vol.12 , pp. 195-203
    • Moreno-Torres, A.1    Domingo, P.2    Pujol, J.3    Blanco-Vaca, F.4    Arroyo, J.A.5    Sambeat, M.A.6
  • 156
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • Moschetta A, Bookout AL and Mangelsdorf DJ (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 10:1352-1358.
    • (2004) Nat Med , vol.10 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 158
    • 0033046403 scopus 로고    scopus 로고
    • Antiviral effect and pharmacokinetic interaction between nevirapine and indinavir in persons infected with human immunodeficiency virus type 1
    • Murphy RL, Sommadossi JP, Lamson M, Hall DB, Myers M and Dusek A (1999) Antiviral effect and pharmacokinetic interaction between nevirapine and indinavir in persons infected with human immunodeficiency virus type 1. J Infect Dis 179:1116-1123.
    • (1999) J Infect Dis , vol.179 , pp. 1116-1123
    • Murphy, R.L.1    Sommadossi, J.P.2    Lamson, M.3    Hall, D.B.4    Myers, M.5    Dusek, A.6
  • 159
    • 55949099344 scopus 로고    scopus 로고
    • Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier
    • Narang VS, Fraga C, Kumar N, Shen J, Throm S, Stewart CF and Waters CM (2008) Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol 295:C440-C450.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Narang, V.S.1    Fraga, C.2    Kumar, N.3    Shen, J.4    Throm, S.5    Stewart, C.F.6    Waters, C.M.7
  • 160
    • 0032914931 scopus 로고    scopus 로고
    • Potential metabolic interaction between St. John's wort and theophylline
    • Nebel A, Schneider BJ, Baker RK and Kroll DJ (1999) Potential metabolic interaction between St. John's wort and theophylline. Ann Pharmacother 33:502.
    • (1999) Ann Pharmacother , vol.33 , pp. 502
    • Nebel, A.1    Schneider, B.J.2    Baker, R.K.3    Kroll, D.J.4
  • 161
    • 0034685897 scopus 로고    scopus 로고
    • Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
    • Nguyen T, Huang HC and Pickett CB (2000) Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem 275:15466-15473.
    • (2000) J Biol Chem , vol.275 , pp. 15466-15473
    • Nguyen, T.1    Huang, H.C.2    Pickett, C.B.3
  • 164
    • 0035659943 scopus 로고    scopus 로고
    • Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor
    • Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P and Vilarem MJ (2001) Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 268:6346-6358.
    • (2001) Eur J Biochem , vol.268 , pp. 6346-6358
    • Pascussi, J.M.1    Drocourt, L.2    Gerbal-Chaloin, S.3    Fabre, J.M.4    Maurel, P.5    Vilarem, M.J.6
  • 167
    • 1642330468 scopus 로고    scopus 로고
    • Incidence and severity of potential drug-dietary supplement interactions in primary care patients: An exploratory study of 2 outpatient practices
    • Peng CC, Glassman PA, Trilli LE, Hayes-Hunter J and Good CB (2004) Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices. Arch Intern Med 164:630-636.
    • (2004) Arch Intern Med , vol.164 , pp. 630-636
    • Peng, C.C.1    Glassman, P.A.2    Trilli, L.E.3    Hayes-Hunter, J.4    Good, C.B.5
  • 168
    • 34948900399 scopus 로고    scopus 로고
    • The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers
    • Pentikis HS, Connolly M, Trapnell CB, Forbes WP and Bettenhausen DK (2007) The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers. Pharmacotherapy 27:1361-1369.
    • (2007) Pharmacotherapy , vol.27 , pp. 1361-1369
    • Pentikis, H.S.1    Connolly, M.2    Trapnell, C.B.3    Forbes, W.P.4    Bettenhausen, D.K.5
  • 170
    • 61849153597 scopus 로고    scopus 로고
    • The Nrf2-ARE signaling pathway and its activation by oxidative stress
    • Jan, Epub ahead of print
    • Pickett CBPD, Nguyen T and Nioi P (2009) The Nrf2-ARE signaling pathway and its activation by oxidative stress. J Biol Chem Jan 30. [Epub ahead of print].
    • (2009) J Biol Chem , pp. 30
    • Pickett, C.B.P.D.1    Nguyen, T.2    Nioi, P.3
  • 173
    • 0036186337 scopus 로고    scopus 로고
    • Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
    • Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL and Muller M (2002) Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 35:589-596.
    • (2002) Hepatology , vol.35 , pp. 589-596
    • Plass, J.R.1    Mol, O.2    Heegsma, J.3    Geuken, M.4    Faber, K.N.5    Jansen, P.L.6    Muller, M.7
  • 174
    • 0017145975 scopus 로고
    • Stereospecific, high affinity binding of 2, 3, 7, 8-tetrachlorodibenzo-p- dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
    • Poland A, Glover E and Kende AS (1976) Stereospecific, high affinity binding of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251:4936-4946.
    • (1976) J Biol Chem , vol.251 , pp. 4936-4946
    • Poland, A.1    Glover, E.2    Kende, A.S.3
  • 175
    • 63849272898 scopus 로고    scopus 로고
    • A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor
    • Pondugula SR, Brimer-Cline C, Wu J, Schuetz EG, Tyagi RK and Chen T (2009) A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metab Dispos 37:719-730.
    • (2009) Drug Metab Dispos , vol.37 , pp. 719-730
    • Pondugula, S.R.1    Brimer-Cline, C.2    Wu, J.3    Schuetz, E.G.4    Tyagi, R.K.5    Chen, T.6
  • 176
    • 33748671122 scopus 로고    scopus 로고
    • Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: An open-label, pharmacokinetic interaction clinical trial
    • Portoles A, Terleira A, Calvo A, Martinez I and Resplandy G (2006) Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial. J Clin Pharmacol 46:1188-1194.
    • (2006) J Clin Pharmacol , vol.46 , pp. 1188-1194
    • Portoles, A.1    Terleira, A.2    Calvo, A.3    Martinez, I.4    Resplandy, G.5
  • 177
    • 14244270349 scopus 로고    scopus 로고
    • Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism
    • Qatanani M, Zhang J and Moore DD (2005) Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology 146:995-1002.
    • (2005) Endocrinology , vol.146 , pp. 995-1002
    • Qatanani, M.1    Zhang, J.2    Moore, D.D.3
  • 179
    • 0036784511 scopus 로고    scopus 로고
    • A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system
    • Raucy J, Warfe L, Yueh MF and Allen SW (2002) A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. J Pharmacol Exp Ther 303:412-423.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 412-423
    • Raucy, J.1    Warfe, L.2    Yueh, M.F.3    Allen, S.W.4
  • 180
    • 0015551909 scopus 로고
    • Induction of the unspecific microsomal hydroxylase in the human liver
    • Remmer H, Schoene B and Fleischmann RA (1973) Induction of the unspecific microsomal hydroxylase in the human liver. Drug Metab Dispos 1:224-230.
    • (1973) Drug Metab Dispos , vol.1 , pp. 224-230
    • Remmer, H.1    Schoene, B.2    Fleischmann, R.A.3
  • 182
    • 0035813195 scopus 로고    scopus 로고
    • HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus
    • Riddle TM, Kuhel DG, Woollett LA, Fichtenbaum CJ and Hui DY (2001) HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus. J Biol Chem 276:37514-37519.
    • (2001) J Biol Chem , vol.276 , pp. 37514-37519
    • Riddle, T.M.1    Kuhel, D.G.2    Woollett, L.A.3    Fichtenbaum, C.J.4    Hui, D.Y.5
  • 183
    • 33748905486 scopus 로고    scopus 로고
    • Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    • Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS and De Morais SM (2006) Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos 34:1742-1748.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1742-1748
    • Ripp, S.L.1    Mills, J.B.2    Fahmi, O.A.3    Trevena, K.A.4    Liras, J.L.5    Maurer, T.S.6    De Morais, S.M.7
  • 184
    • 23044444663 scopus 로고    scopus 로고
    • The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes
    • Rizzo G, Renga B, Antonelli E, Passeri D, Pellicciari R and Fiorucci S (2005) The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol 68:551-558.
    • (2005) Mol Pharmacol , vol.68 , pp. 551-558
    • Rizzo, G.1    Renga, B.2    Antonelli, E.3    Passeri, D.4    Pellicciari, R.5    Fiorucci, S.6
  • 185
    • 39749122043 scopus 로고    scopus 로고
    • Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects
    • Robertson SM, Davey RT, Voell J, Formentini E, Alfaro RM and Penzak SR (2008) Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. Curr Med Res Opin 24:591-599.
    • (2008) Curr Med Res Opin , vol.24 , pp. 591-599
    • Robertson, S.M.1    Davey, R.T.2    Voell, J.3    Formentini, E.4    Alfaro, R.M.5    Penzak, S.R.6
  • 186
  • 187
    • 48149113288 scopus 로고    scopus 로고
    • Identification of the functional vitamin D response elements in the human MDR1 gene
    • Saeki M, Kurose K, Tohkin M and Hasegawa R (2008) Identification of the functional vitamin D response elements in the human MDR1 gene. Biochem Pharmacol 76:531-542.
    • (2008) Biochem Pharmacol , vol.76 , pp. 531-542
    • Saeki, M.1    Kurose, K.2    Tohkin, M.3    Hasegawa, R.4
  • 188
    • 58149265463 scopus 로고    scopus 로고
    • PXR pharmacogenetics: Association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients
    • Sandanaraj E, Lal S, Selvarajan V, Ooi LL, Wong ZW, Wong NS, Ang PC, Lee EJ and Chowbay B (2008) PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients. Clin Cancer Res 14:7116-7126.
    • (2008) Clin Cancer Res , vol.14 , pp. 7116-7126
    • Sandanaraj, E.1    Lal, S.2    Selvarajan, V.3    Ooi, L.L.4    Wong, Z.W.5    Wong, N.S.6    Ang, P.C.7    Lee, E.J.8    Chowbay, B.9
  • 189
    • 51349112400 scopus 로고    scopus 로고
    • A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
    • Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N and Wolf CR (2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest 118:3228-3239.
    • (2008) J Clin Invest , vol.118 , pp. 3228-3239
    • Scheer, N.1    Ross, J.2    Rode, A.3    Zevnik, B.4    Niehaves, S.5    Faust, N.6    Wolf, C.R.7
  • 192
    • 0036765746 scopus 로고    scopus 로고
    • Development of a real-time in vivo transcription assay: Application reveals pregnane X receptormediated induction of CYP3A4 by cancer chemotherapeutic agents
    • Schuetz E, Lan L, Yasuda K, Kim R, Kocarek TA, Schuetz J and Strom S (2002) development of a real-time in vivo transcription assay: application reveals pregnane X receptormediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol Pharmacol 62:439-445.
    • (2002) Mol Pharmacol , vol.62 , pp. 439-445
    • Schuetz, E.1    Lan, L.2    Yasuda, K.3    Kim, R.4    Kocarek, T.A.5    Schuetz, J.6    Strom, S.7
  • 193
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
    • Schuetz EG, Schinkel AH, Relling MV and Schuetz JD (1996) P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci USA 93:4001-4005.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 195
    • 0037241016 scopus 로고    scopus 로고
    • Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception
    • Schwarz UI, Buschel B and Kirch W (2003) Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Br J Clin Pharmacol 55:112-113.
    • (2003) Br J Clin Pharmacol , vol.55 , pp. 112-113
    • Schwarz, U.I.1    Buschel, B.2    Kirch, W.3
  • 197
    • 34147170945 scopus 로고    scopus 로고
    • Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression
    • Shah YM, Ma X, Morimura K, Kim I and Gonzalez FJ (2007) Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am J Physiol 292:G1114-G1122.
    • (2007) Am J Physiol , vol.292
    • Shah, Y.M.1    Ma, X.2    Morimura, K.3    Kim, I.4    Gonzalez, F.J.5
  • 199
    • 1642304065 scopus 로고    scopus 로고
    • Structural determinants of allosteric ligand activation in RXR heterodimers
    • Shulman AI, Larson C, Mangelsdorf DJ and Ranganathan R (2004) Structural determinants of allosteric ligand activation in RXR heterodimers. Cell 116:417-429.
    • (2004) Cell , vol.116 , pp. 417-429
    • Shulman, A.I.1    Larson, C.2    Mangelsdorf, D.J.3    Ranganathan, R.4
  • 202
    • 18844425192 scopus 로고    scopus 로고
    • Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I
    • Sporstol M, Tapia G, Malerod L, Mousavi SA and Berg T (2005) Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun 331:1533-1541.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 1533-1541
    • Sporstol, M.1    Tapia, G.2    Malerod, L.3    Mousavi, S.A.4    Berg, T.5
  • 203
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P and Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046.
    • (1999) J Biol Chem , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 204
    • 41149143719 scopus 로고    scopus 로고
    • PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor
    • Sueyoshi T, Moore R, Sugatani J, Matsumura Y and Negishi M (2008) PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor. Mol Pharmacol 73:1113-1121.
    • (2008) Mol Pharmacol , vol.73 , pp. 1113-1121
    • Sueyoshi, T.1    Moore, R.2    Sugatani, J.3    Matsumura, Y.4    Negishi, M.5
  • 205
    • 0035029401 scopus 로고    scopus 로고
    • The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
    • Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M and Sueyoshi T (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232-1238.
    • (2001) Hepatology , vol.33 , pp. 1232-1238
    • Sugatani, J.1    Kojima, H.2    Ueda, A.3    Kakizaki, S.4    Yoshinari, K.5    Gong, Q.H.6    Owens, I.S.7    Negishi, M.8    Sueyoshi, T.9
  • 206
  • 207
    • 10944250224 scopus 로고    scopus 로고
    • The nuclear xenobiotic receptor CAR: Structural determinants of constitutive activation and heterodimerization
    • Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA and Xu HE (2004) The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell 16:893-905.
    • (2004) Mol Cell , vol.16 , pp. 893-905
    • Suino, K.1    Peng, L.2    Reynolds, R.3    Li, Y.4    Cha, J.Y.5    Repa, J.J.6    Kliewer, S.A.7    Xu, H.E.8
  • 208
    • 17444409275 scopus 로고    scopus 로고
    • Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virus
    • Sulkowski MS, Mehta SH, Torbenson M, Afdhal NH, Mirel L, Moore RD and Thomas DL (2005) Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virus. Aids 19:585-592.
    • (2005) Aids , vol.19 , pp. 585-592
    • Sulkowski, M.S.1    Mehta, S.H.2    Torbenson, M.3    Afdhal, N.H.4    Mirel, L.5    Moore, R.D.6    Thomas, D.L.7
  • 209
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold TW, Dussault I and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
    • (2001) Nat Med , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 210
    • 44349182094 scopus 로고    scopus 로고
    • Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4
    • Takagi S, Nakajima M, Mohri T and Yokoi T (2008) Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 283:9674-9680.
    • (2008) J Biol Chem , vol.283 , pp. 9674-9680
    • Takagi, S.1    Nakajima, M.2    Mohri, T.3    Yokoi, T.4
  • 211
    • 57349137333 scopus 로고    scopus 로고
    • Structural basis of human pregnane X receptor activation by the hops constituent colupulone
    • Teotico DG, Bischof JJ, Peng L, Kliewer SA and Redinbo MR (2008) Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Mol Pharmacol 74:1512-1520.
    • (2008) Mol Pharmacol , vol.74 , pp. 1512-1520
    • Teotico, D.G.1    Bischof, J.J.2    Peng, L.3    Kliewer, S.A.4    Redinbo, M.R.5
  • 214
    • 84890751175 scopus 로고    scopus 로고
    • Nuclear receptors and drug-drug interactions with prescription and herbal medicines
    • Xie W ed, Wiley, Hoboken, NJ
    • Tirona RG and Kim RB (2009) Nuclear receptors and drug-drug interactions with prescription and herbal medicines, in Nuclear Receptors in Drug Metabolism (Xie W ed) pp. 211-239, Wiley, Hoboken, NJ.
    • (2009) Nuclear Receptors in Drug Metabolism , pp. 211-239
    • Tirona, R.G.1    Kim, R.B.2
  • 215
    • 1642454581 scopus 로고    scopus 로고
    • Identification of amino acids in rat pregnane X receptor that determine species-specific activation
    • Tirona RG, Leake BF, Podust LM and Kim RB (2004) Identification of amino acids in rat pregnane X receptor that determine species-specific activation. Mol Pharmacol 65:36-44.
    • (2004) Mol Pharmacol , vol.65 , pp. 36-44
    • Tirona, R.G.1    Leake, B.F.2    Podust, L.M.3    Kim, R.B.4
  • 216
    • 0037216648 scopus 로고    scopus 로고
    • Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation
    • Tirona RG, Leake BF, Wolkoff AW and Kim RB (2003) Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther 304:223-228.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 223-228
    • Tirona, R.G.1    Leake, B.F.2    Wolkoff, A.W.3    Kim, R.B.4
  • 217
    • 0032801792 scopus 로고    scopus 로고
    • Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: Intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction
    • Tran JQ, Kovacs SJ, McIntosh TS, Davis HM and Martin DE (1999) Morning spot and 24-hour urinary 6 beta-hydroxycortisol to cortisol ratios: intraindividual variability and correlation under basal conditions and conditions of CYP 3A4 induction. J Clin Pharmacol 39:487-494.
    • (1999) J Clin Pharmacol , vol.39 , pp. 487-494
    • Tran, J.Q.1    Kovacs, S.J.2    McIntosh, T.S.3    Davis, H.M.4    Martin, D.E.5
  • 218
    • 33847342947 scopus 로고    scopus 로고
    • Absence of effect of oral rifaximin on the pharmacokinetics of ethinyl estradiol/norgestimate in healthy females
    • Trapnell CB, Connolly M, Pentikis H, Forbes WP and Bettenhausen DK (2007) Absence of effect of oral rifaximin on the pharmacokinetics of ethinyl estradiol/norgestimate in healthy females. Ann Pharmacother 41:222-228.
    • (2007) Ann Pharmacother , vol.41 , pp. 222-228
    • Trapnell, C.B.1    Connolly, M.2    Pentikis, H.3    Forbes, W.P.4    Bettenhausen, D.K.5
  • 219
    • 27644553953 scopus 로고    scopus 로고
    • A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line
    • Trubetskoy O, Marks B, Zielinski T, Yueh MF and Raucy J (2005) A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. Aaps J 7:E6-E13.
    • (2005) Aaps J , vol.7
    • Trubetskoy, O.1    Marks, B.2    Zielinski, T.3    Yueh, M.F.4    Raucy, J.5
  • 221
    • 0037162704 scopus 로고    scopus 로고
    • Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor
    • Van Giersbergen PL, Gnerre C, Treiber A, Dingemanse J and Meyer UA (2002) Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. Eur J Pharmacol 450:115-121.
    • (2002) Eur J Pharmacol , vol.450 , pp. 115-121
    • Van Giersbergen, P.L.1    Gnerre, C.2    Treiber, A.3    Dingemanse, J.4    Meyer, U.A.5
  • 223
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD (P) H: Quinone oxidoreductase1 gene
    • Venugopal R and Jaiswal AK (1996) Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD (P) H: quinone oxidoreductase1 gene. Proc Natl Acad Sci U S A 93:14960-14965.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 225
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC and Forman BM (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3:543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 226
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • Wang YD, Chen WD, Wang M, Yu D, Forman BM and Huang W (2008b) Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48:1632-1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 227
    • 3142764845 scopus 로고    scopus 로고
    • Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin
    • Wang H, Faucette SR, Moore R, Sueyoshi T, Negishi M and Le Cluyse EL (2004a) Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem 279:29295-29301.
    • (2004) J Biol Chem , vol.279 , pp. 29295-29301
    • Wang, H.1    Faucette, S.R.2    Moore, R.3    Sueyoshi, T.4    Negishi, M.5    Le Cluyse, E.L.6
  • 228
    • 0037515661 scopus 로고    scopus 로고
    • A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression
    • Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M and Le Cluyse EL (2003) A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem 278:14146-14152.
    • (2003) J Biol Chem , vol.278 , pp. 14146-14152
    • Wang, H.1    Faucette, S.2    Sueyoshi, T.3    Moore, R.4    Ferguson, S.5    Negishi, M.6    Le Cluyse, E.L.7
  • 233
    • 0043168030 scopus 로고    scopus 로고
    • Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
    • Watkins RE, Davis-Searles PR, Lambert MH and Redinbo MR (2003a) Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 331:815-828.
    • (2003) J Mol Biol , vol.331 , pp. 815-828
    • Watkins, R.E.1    Davis-Searles, P.R.2    Lambert, M.H.3    Redinbo, M.R.4
  • 238
    • 66149142211 scopus 로고    scopus 로고
    • Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1
    • Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT and Tian Y (2009) Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem 284:9199-9205.
    • (2009) J Biol Chem , vol.284 , pp. 9199-9205
    • Xie, Y.1    Ke, S.2    Ouyang, N.3    He, J.4    Xie, W.5    Bedford, M.T.6    Tian, Y.7
  • 240
    • 34147212096 scopus 로고    scopus 로고
    • The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of nonalcoholic steatohepatitis
    • Yamazaki Y, Kakizaki S, Horiguchi N, Sohara N, Sato K, Takagi H, Mori M and Negishi M (2007) The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of nonalcoholic steatohepatitis. Gut 56:565-574.
    • (2007) Gut , vol.56 , pp. 565-574
    • Yamazaki, Y.1    Kakizaki, S.2    Horiguchi, N.3    Sohara, N.4    Sato, K.5    Takagi, H.6    Mori, M.7    Negishi, M.8
  • 241
    • 67349083616 scopus 로고    scopus 로고
    • Pyrethroid insecticides: Isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor
    • Feb, Epub ahead of print
    • Yang D, Wang X, Chen YT, Deng R and Yan B (2009) Pyrethroid insecticides: Isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol Feb. 26. [Epub ahead of print].
    • (2009) Toxicol Appl Pharmacol , pp. 26
    • Yang, D.1    Wang, X.2    Chen, Y.T.3    Deng, R.4    Yan, B.5
  • 242
    • 33845626633 scopus 로고    scopus 로고
    • Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: Evidence on an involvement of the pregnane X receptor
    • Yang J and Yan B (2007) Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci 95:13-22.
    • (2007) Toxicol Sci , vol.95 , pp. 13-22
    • Yang, J.1    Yan, B.2
  • 243
    • 47949085749 scopus 로고    scopus 로고
    • A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
    • Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E and Bachmann K (2008) A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine. Drug Metab Dispos 36:1689-1697.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1689-1697
    • Yasuda, K.1    Ranade, A.2    Venkataramanan, R.3    Strom, S.4    Chupka, J.5    Ekins, S.6    Schuetz, E.7    Bachmann, K.8
  • 244
    • 54349103738 scopus 로고    scopus 로고
    • Identification of Ginkgo biloba as a novel activator of pregnane X receptor
    • Yeung EY, Sueyoshi T, Negishi M and Chang TK (2008) Identification of Ginkgo biloba as a novel activator of pregnane X receptor. Drug Metab Dispos 36:2270-2276.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2270-2276
    • Yeung, E.Y.1    Sueyoshi, T.2    Negishi, M.3    Chang, T.K.4
  • 245
    • 11144232127 scopus 로고    scopus 로고
    • Pharmacogenetics and herb-drug interactions: Experience with Ginkgo biloba and omeprazole
    • Yin OQ, Tomlinson B, Waye MM, Chow AH and Chow MS (2004) Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics 14:841-850.
    • (2004) Pharmacogenetics , vol.14 , pp. 841-850
    • Yin, O.Q.1    Tomlinson, B.2    Waye, M.M.3    Chow, A.H.4    Chow, M.S.5
  • 246
    • 3042737049 scopus 로고    scopus 로고
    • Brief communication: American ginseng reduces warfarin's effect in healthy patients: A randomized, controlled trial
    • Yuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, Ang-Lee M and Moss J (2004) Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 141:23-27.
    • (2004) Ann Intern Med , vol.141 , pp. 23-27
    • Yuan, C.S.1    Wei, G.2    Dey, L.3    Karrison, T.4    Nahlik, L.5    Maleckar, S.6    Kasza, K.7    Ang-Lee, M.8    Moss, J.9
  • 247
    • 0034639580 scopus 로고    scopus 로고
    • Safety of St John's wort (Hypericum perforatum)
    • Yue QY, Bergquist C and Gerden B (2000) Safety of St John's wort (Hypericum perforatum). Lancet 355:576-577.
    • (2000) Lancet , vol.355 , pp. 576-577
    • Yue, Q.Y.1    Bergquist, C.2    Gerden, B.3
  • 249
    • 33845970888 scopus 로고    scopus 로고
    • Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis
    • Zhai Y, Pai HV, Zhou J, Amico JA, Vollmer RR and Xie W (2007) Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. Mol Endocrinol 21:138-147.
    • (2007) Mol Endocrinol , vol.21 , pp. 138-147
    • Zhai, Y.1    Pai, H.V.2    Zhou, J.3    Amico, J.A.4    Vollmer, R.R.5    Xie, W.6
  • 251
    • 58149511929 scopus 로고    scopus 로고
    • Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
    • Zhang S, Liu Q, Wang J and Harnish DC (2009) Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists. Biochem Biophys Res Commun 379:476-479.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 476-479
    • Zhang, S.1    Liu, Q.2    Wang, J.3    Harnish, D.C.4
  • 252
    • 33745217611 scopus 로고    scopus 로고
    • Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia
    • Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG and Thummel KE (2006a) Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 116:1703-1712.
    • (2006) J Clin Invest , vol.116 , pp. 1703-1712
    • Zhou, C.1    Assem, M.2    Tay, J.C.3    Watkins, P.B.4    Blumberg, B.5    Schuetz, E.G.6    Thummel, K.E.7
  • 254
    • 41649111966 scopus 로고    scopus 로고
    • The antiapoptotic role of pregnane X receptor in human colon cancer cells
    • Zhou J, Liu M, Zhai Y and Xie W (2008b) The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol Endocrinol 22:868-880.
    • (2008) Mol Endocrinol , vol.22 , pp. 868-880
    • Zhou, J.1    Liu, M.2    Zhai, Y.3    Xie, W.4
  • 255
    • 33845904129 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
    • Zhou C, Poulton EJ, Grun F, Bammler TK, Blumberg B, Thummel KE and Eaton DL (2007) The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 71:220-229.
    • (2007) Mol Pharmacol , vol.71 , pp. 220-229
    • Zhou, C.1    Poulton, E.J.2    Grun, F.3    Bammler, T.K.4    Blumberg, B.5    Thummel, K.E.6    Eaton, D.L.7


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