Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 7, 2000, Pages 3473-3478

  Hoffmeyer, S ^a   Burk, O ^b   Von Richter, O ^b   Arnold, H P ^a   Brockmoller J ^c   Johne, A ^c   Cascorbi, I ^c   Gerloff, T ^c   Roots, I ^c   Eichelbaum, M ^b   Brinkmann, U ^a  

^a Epidauros Biotechnologie AG   (Germany)

^b DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cancer therapy; Drug resistance; Molecular transport; Pharmacogenetics

Indexed keywords

ANTINEOPLASTIC AGENT; DIGOXIN; GLYCOPROTEIN P;

ALLELE; ARTICLE; CANCER THERAPY; DNA POLYMORPHISM; DRUG BLOOD LEVEL; EXON; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOBLOTTING; IN VIVO STUDY; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS;

EUKARYOTA;

EID: 0034724324     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.7.3473     Document Type: Article

References (35)

1. Gottesman, M. M., Pastan, I. & Ambudkar, V. (1996) Curr. Opin. Genet. Dev. 6, 610-617.
2. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. & Gottesman, M. M. (1999) Annu. Rev. Pharmacol. Toxicol. 39, 361-398.
3. Ueda, K., Clark, D. P., Chen, C. J., Roninson, I. B., Gottesman, M. M. & Pastan, I. (1987) J. Biol. Chem. 262, 505-508.
4. Chen, C. J., Clark, D., Ueda, K., Pastan, I., Gottesman, M. M. & Roninson, I. B. (1990) J. Biol. Chem. 265, 506-514.
5. Schinkel, A. H. (1998) Int. J. Clin. Pharmacol. Ther. 36, 9-13.
6. Schinkel, A. H., Mayer, U., Wagenaar, E., Mol, C. A., van Deemter, L., Smit, J. J., van der Valk, M. A., Voordouw, A. C., Spits, H., van Tellingen, O., et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4028-4033.
7. Cordon-Cardo, C., O'Brien, J. P., Boccia, J., Casals, D., Bertino, J. R. & Melamed, M. R. (1990) J. Histochem. Cytochem. 38, 1277-1287.
8. Schuetz, E. G., Schinkel, A. H., Relling, M. V. & Schuetz, J. D. (1996) Proc. Natl. Acad. Sci. USA 93, 4001-4005.
9. Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J. & Kroemer, H. K. (1999) J. Clin. Invest. 104, 147-153.
10. Schumacher, U. & Mollgard, K. (1997) Histochem. Cell Biol. 108, 179-182.
11. Rao, V. V., Dahlheimer, J. L., Bardgett, M. E., Snyder, A. Z., Finch, R. A., Sartorelli, A. C. & Piwnica-Worms, D. (1999) Proc. Natl. Acad. Sci. USA 96, 3900-3905.
12. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I. & Willingham, M. C. (1989) J. Histochem. Cytochem. 37, 159-164.
13. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I. & Willingham, M. C. (1987) Proc. Natl. Acad. Sci. USA 84, 7735-7738.
14. Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M. & Roninson, I. B. (1986) Cell 47, 381-389.
15. Schoenlein, P. V., Shen, D. W., Barrett, J. T., Pastan, I. & Gottesman, M. M. (1992) Mol. Biol. Cell 3, 507-520.
16. Knutsen, T., Mickley, L. A., Ried, T., Green, E. D., du Manoir, S., Schrock, E., Macville, M., Ning, Y., Robey, R., Polymeropoulos, M., Torres, R., et al. (1998) Genes Chromosomes Cancer 23, 44-54.
17. Yoshimoto, K., Iwahana, H., Yokogoshi, Y., Saito, S., Shiraishi, M., Sekiya, T., Gottesman, M. M. & Pastan, I. (1988) Nucleic Acids Res. 16, 11850.
18. Chin, K. V., Chauhan, S. S., Pastan, I. & Gottesman, M. M. (1990) Cell Growth Differ. 1, 361-365.
19. Chaudhary, P. M. & Roninson, I. B. (1993) J. Natl. Cancer Inst. 85, 632-639.
20. Germann, U. A., Schoenlein, P. V., Zimonjic, D. B., Popescu, N. C., Pastan, I. & Gottesman, M. M. (1994) Genes Chromosomes Cancer 10, 267-274.
21. Long, A. D. & Langley, C. H. (1999) Genome Res. 9, 720-731.
22. Mickley, L. A., Lee, J. S., Weng, Z., Zhan, Z., Alvarez, M., Wilson, W., Bates, S. E. & Fojo, T. (1998) Blood 91, 1749-1756.
23. Ramachandra, M., Amhudkar, S. V., Gottesman, M. M., Pastan, I. & Hrycyna, C. A. (1996) Mol. Biol. Cell 7, 1485-1498.
24. Muller, M., Bakos, E., Welker, E., Varadi, A., Germann, U. A., Gottesman, M. M., Morse, B. S., Roninson, I. B. & Sarkadi, B. (1996) J. Biol. Chem. 271, 1877-1883.
25. Germann, U. A., Chambers, T. C., Ambudkar, S. V., Licht, T., Cardarelli, C. O., Pastan, I. & Gottesman, M. M. (1996) J. Biol. Chem. 271, 1708-1716.
26. Loo, T. W. & Clarke, D. M. (1997) J. Biol. Chem. 272, 31945-31948.
27. Loo, T. W. & Clarke, D. M. (1995) J. Biol. Chem. 270, 22957-22961.
28. Loo, T. W. & Clarke, D. M. (1998) Methods Enzymol. 292, 480-492.
29. Gros, P., Dhir, R., Croop, J. & Talbot, F. (1991) Proc. Natl. Acad. Sci. USA 88, 7289-7293.
30. Dey, S., Hafkemeyer, P., Pastan, I. & Gottesman, M. M. (1999) Biochemistry 38, 6630-6639.
31. Hafkemeyer, P., Dey, S., Ambudkar, S. V., Hrycyna, C. A., Pastan, I. & Gottesman, M. M. (1998) Biochemistry 37, 16400-16409.
32. Hrycyna, C. A., Airan, L. E., Germann, U. A., Ambudkar, S. V., Pastan, I. & Gottesman, M. M. (1998) Biochemistry 37, 13660-13673.
33. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M. & Ambudkar, S. V. (1998) Methods Enzymol. 292, 318-328.
34. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M. & Ambudkar, S. V. (1997) Proc. Natl. Acad. Sci. USA 94, 10594-10599.
35. Johne, A., Brockmöller, J., Bauer, S., Maurer, A., Langheinrich, M. & Roots, I. (1999) Clin. Pharmacol. Ther. 66, 338-345.