Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

Drug Metabolism and Disposition

Volumn 36, Issue 1, 2008, Pages 169-181

  Lamba, Jatinder ^a   Lamba, Vishal ^a   Strom, Stephen ^b   Venkataramanan, Raman ^c   Schuetz, Erin ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DNA; HEPATOCYTE NUCLEAR FACTOR 3BETA; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; RIFAMPICIN;

ALGORITHM; ALLELE; ARTICLE; BASE PAIRING; BINDING SITE; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENE TARGETING; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; LIVER; LIVER CELL; LIVER CELL CULTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN DONOR; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HEPATOCYTES; HUMANS; INTRONS; LIVER; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, STEROID; RIFAMPIN; SEX CHARACTERISTICS;

RODENTIA;

EID: 37549010733     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016600     Document Type: Article

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