HIV Protease Inhibitor Induces Fatty Acid and Sterol Biosynthesis in Liver and Adipose Tissues Due to the Accumulation of Activated Sterol Regulatory Element-binding Proteins in the Nucleus

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37514-37519

  Riddle, Tara M ^a   Kuhel, David G ^a   Woollett, Laura A ^a   Fichtenbaum, Carl J ^a   Hui, David Y ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BIOSYNTHESIS; CHOLESTEROL; FATTY ACIDS; GENES; OILS AND FATS; RNA; VIRUSES;

METABOLISM GENES;

BIOCHEMISTRY;

CHOLESTEROL; FATTY ACID; MESSENGER RNA; PROTEINASE INHIBITOR; RITONAVIR; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; SREBF1 PROTEIN, MOUSE; SREBF2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADIPOSE TISSUE; ADOLESCENT; ADVERSE DRUG REACTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION; HEPATOMEGALY; HYPERLIPIDEMIA; LIPID DIET; LIPID METABOLISM; LIPODYSTROPHY; LIVER LEVEL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEROL SYNTHESIS; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; HISTOLOGY; LIVER; METABOLISM;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

ADIPOSE TISSUE; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL NUCLEUS; DNA-BINDING PROTEINS; FATTY ACIDS; HIV PROTEASE INHIBITORS; LIVER; MALE; MICE; MICE, INBRED C57BL; RITONAVIR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROLS; TRANSCRIPTION FACTORS;

EID: 0035813195     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104557200     Document Type: Article

References (52)

1. Kempf, D. J., Sham, H. L., Marsh, K. C., Flentge, C. A., Betebenner, D., Green, B. E., McDonald, E., Vasavanonda, S., Saldivar, A., Wideburg, N. E., Kati, W. M., Ruiz, L., Zhao, C. F. (1998) J. Med. Chem. 41, 602-617
2. Flexner, C. (1998) N. Engl. J. Med. 338, 1281-1292
3. Carr, A., Samaras, K., Burton, S., Law, M., Freund, J., Chisholm, D. J., and Cooper, D. A. (1998) AIDS 12, F51-F58
4. Carr, A., Samaras, K., Chisholm, D. J., and Cooper, D. A. (1998) Lancet 351, 1881-1883
5. Roth, V. R., Kravcik, S., and Angel, J. B. (1998) Clin. Infect. Dis. 27, 65-67
6. Echevarria, K. L., Hardin, T. C., and Smith, J. A. (1999) Ann. Pharmacother. 33, 859-863
7. Safrin, S., and Grunfeld, C. (1999) AIDS 13, 2493-2505
8. SoRelle, R. (1998) Circulation 9, 829-830
9. Vittecoq, D., Escaut, L., and Monsuez, J. J. (1998) Lancet 351, 1959
10. Zhang, B., MacNaul, K., Szalkowski, D., Li, Z., Berger, J., and Moller, D. E. (1999) J. Clin. Endocrinol. Metab. 84, 4274-4277
11. Wentworth, J. M., Burris, T. P., and Chatterjee, V. K. K. (2000) J. Endocrinol. 164, R7-R10
12. Dowell, P., Flexner, C., Kwiterovich, P. O., and Lane, M. D. (2000) J. Biol. Chem. 275, 41325-41332
13. Nguyen, A. T., Gagnon, A. M., Angel, J. B., and Sorisky, A. (2000) AIDS 14, 2467-2473
14. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156
15. MacDonald, O. A., and Lane, M. D. (1995) Ann. Rev. Biochem. 64, 345-373
16. Kim, J. B., and Spiegelman, B. M. (1996) Genes and Dev. 10, 1096-1107
17. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
18. Periard, D., Telenti, A., Sudre, P., Cheseaux, J. J., Halfon, P., Reymond, M. J., Marcovina, S. M., Glauser, M. P., Nicod, P., Darioli, R., and Mooser, V. (1999) Circulation 100, 700-705
19. Walli, R., Herfort, O., Michl, G. M., Demant, T., Jager, H., Dieterle, C., Bogner, J. R., Landgraf, R., and Goebel, F. D. (1998) AIDS 12, F167-F173
20. Sullivan, A. K., and Nelson, M. R. (1997) AIDS 11, 938-939
21. Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., and Shimano, H. (1998) J. Clin. Invest. 101, 2331-2339
22. Osono, Y., Woollett, L. A., Herz, J., and Dietschy, J. M. (1995) J. Clin. Invest. 95, 1124-1132
23. Sheng, Z., Otani, H., Brown, M. S., and Goldstein, J. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 935-938
24. Sato, R., Yang, J., Wang, X., Evans, M. J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1994) J. Biol. Chem. 269, 17267-17273
25. Yang, J., Brown, M. S., Ho, Y. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 12152-12161
26. Kissel, J. A., Fontaine, R. N., Turck, C., Brockman, H. L., and Hui, D. Y. (1989) Biochim. Biophys. Acta 1006, 227-236
27. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., and Goldstein, J. L. (1996) J. Clin. Invest. 98, 1575-1584
28. Tso, J. Y., Sun, X. H., Kao, T. H., Reece, K. S., and Wu, R. (1985) Nucleic Acids Res. 13, 2485-2502
29. Huang, Y., and Hui, D. Y. (1994) Biochim. Biophys. Acta 1214, 317-322
30. Gould, R. G., Taylor, C. B., Hagerman, J. S., Warner, I., and Campbell, D. J. (1953) J. Biol. Chem. 201, 519-523
31. Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., and Goldstein, J. L. (1997) J. Clin. Invest. 99, 846-854
32. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11041-11048
33. Shimano, H., Shimomura, I., Hammer, R. E., Herz, J., Goldstein, J. L., Brown, M. S., and Horton, J. D. (1997) J. Clin. Invest. 100, 2115-2124
34. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., and Brown, M. S. (1998) Genes and Dev. 12, 3182-3194
35. Shimomura, I., Bashmakov, Y., and Horton, J. D. (1999) J. Biol. Chem. 274, 30028-30032
36. Fatkenheuer, G., Hoetelmans, R. M., Hunn, N., Schwenk, A., Franzen, C., Reiser, M., Jutte, A., Rockstroh, J., Diehl, V., and Salzberger, B. (1999) AIDS 13, 1485-1489
37. Carr, A., Miller, J., Law, M., and Cooper, D. A. (2000) AIDS 14, F25-F32
38. Sakai, J., Duncan, E. A., Rawson, R. B., Hua, X., Brown, M. S., and Goldstein, J. L. (1996) Cell 85, 1037-1046
39. Sakai, J., Nohturfft, A., Cheng, D., Ho, Y. K., Brown, M. S., and Goldstein, J. L. (1997) J. Biol. Chem. 272, 20213-20221
40. Sakai, J., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1998) J. Biol. Chem. 273, 5785-5793
41. Duncan, E. A., Brown, M. S., Goldstein, J. L., and Sakai, J. (1997) J. Biol. Chem. 272, 12778-12785
42. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
43. Horton, J. D., and Shimomura, I. (1999) Curr. Opin. Lipidol. 10, 143-150
44. Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., and Goldstein, J. L. (1999) Nature 401, 73-76
45. Van Steenbergen, W., and Lanckmans, S. (1995) Int. J. Obes. Relat. Metab. Disord. 19, S27-S36
46. Korn, B. S., Shimomura, I., Bashmakov, Y., Hammer, R. E., Horton, J. D., Goldstein, J. L., and Brown, M. S. (1998) J. Clin. Invest. 102, 2050-2060
47. Andre, P., Groettrup, M., Klenerman, P., de Giuli, R., Booth, B. L., Cerundolo, V., Bonneville, M., Jotereau, F., Zinkernagel, R. M., and Lotteau, V. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13120-13124
48. Xu, J., Teran-Garcia, M., Park, J. H. Y., Nakamura, M. T., and Clarke, S. D. (2001) J. Biol. Chem. 276, 9800-9807
49. Dooley, K. A., Millinder, S., and Osborne, T. F. (1998) J. Biol. Chem. 273, 1349-1356
50. Jackson, S. M., Ericsson, J., Mantovani, R., and Edwards, P. A. (1998) J. Lipid Res. 39, 767-776
51. Oliner, J. D., Andresen, J. M., Hansen, S. K., Zhou, S., and Tijan, R. (1996) Genes Dev. 10, 2903-2911
52. Ericsson, J., and Edwards, P. A. (1998) J. Biol. Chem. 273, 17865-17870