Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

Biochemical Journal

Volumn 410, Issue 2, 2008, Pages 245-253

  Kaeding, Jenny ^a,b   Bouchaert, Emmanuel ^c   Bélanger, Julie ^a,b   Caron, Patrick ^a,b   Chouinard, Sarah ^a,b   Verreault, Mélanie ^a,b   Larouche, Olivier ^a,b   Pelletier, Georges ^a,b   Staels, Bart ^c   Bélanger, Alain ^a,b   Barbier, Olivier ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c INSERM   (France)

Author keywords

Androgen metabolism; Farnesoid X receptor (FXR); Gene expression; Glucuronidation; Prostate; UDP glucuronosyltransferase (UGT) 2B15 (UGT2B15) and UGT2B17

Indexed keywords

CELL GROWTH; CHOLESTEROL; GENE EXPRESSION; LIPIDS; METABOLISM; METABOLITES;

ANDROGEN METABOLISM; FARNESOID X RECEPTOR (FXR); PROSTATE EPITHELIAL CELLS;

HORMONES;

ANDROGEN; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; GLUCURONOSYLTRANSFERASE; MESSENGER RNA;

ANDROGEN METABOLISM; ARTICLE; CANCER CELL CULTURE; CATALYSIS; GLUCURONIDATION; HORMONAL REGULATION; HORMONE INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

ANDROGENS; ANDROSTERONE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; MALE; POLYMERASE CHAIN REACTION; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA; RNA, MESSENGER; TRANSCRIPTION FACTORS; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 40449116963     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071136     Document Type: Article

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