-
1
-
-
0032079750
-
BXR, an embryonic orphan nuclear receptor activated by novel class of endogenous benzoate metabolites
-
Blumberg B, Kang J, Bolado J, Jr., et al. BXR, an embryonic orphan nuclear receptor activated by novel class of endogenous benzoate metabolites. Genes Dev 1998;12:1269-77.
-
(1998)
Genes Dev
, vol.12
, pp. 1269-1277
-
-
Blumberg, B.1
Kang, J.2
Bolado Jr., J.3
-
2
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W, Jr., Juguilon H, et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 1998;12:3195-205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr., W.2
Juguilon, H.3
-
3
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interaction
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moor JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interaction. J Clin Invest 1998;102:1016-23.
-
(1998)
J Clin Invest
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moor, J.T.5
Kliewer, S.A.6
-
4
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G, Heidrich J, Svensson K, et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 1998;95:12208-13.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
-
5
-
-
13844271333
-
Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues
-
Mild Y, Suzuki T, Kaneko C, Blumberg B, Sasano H. Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol 2005;231:75-85.
-
(2005)
Mol Cell Endocrinol
, vol.231
, pp. 75-85
-
-
Mild, Y.1
Suzuki, T.2
Kaneko, C.3
Blumberg, B.4
Sasano, H.5
-
6
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 2001;276:14581-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
8
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001;7:584-90.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
9
-
-
0035851148
-
Orphan nuclear receptors: The exotics of xenobiotics
-
Xie W, Evans RM. Orphan nuclear receptors: the exotics of xenobiotics. J Biol Chem 2001;276:37739-42.
-
(2001)
J Biol Chem
, vol.276
, pp. 37739-37742
-
-
Xie, W.1
Evans, R.M.2
-
10
-
-
0036592202
-
The nuclear receptor PXR: A master regulator of "homeland" defense
-
Dussault I, Forman BM. The nuclear receptor PXR: a master regulator of "homeland" defense. Crit Rev Eukaryot Gene Expr 2002;12:53-64.
-
(2002)
Crit Rev Eukaryot Gene Expr
, vol.12
, pp. 53-64
-
-
Dussault, I.1
Forman, B.M.2
-
11
-
-
0036799870
-
The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
-
Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 2002;23:687-702.
-
(2002)
Endocr Rev
, vol.23
, pp. 687-702
-
-
Kliewer, S.A.1
Goodwin, B.2
Willson, T.M.3
-
12
-
-
0036239630
-
Induction of cytochrome P4503A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen
-
Desai PB, Nallani SC, Sane RS, et al. Induction of cytochrome P4503A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. Drug Metab Dispos 2002;30:608-12.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 608-612
-
-
Desai, P.B.1
Nallani, S.C.2
Sane, R.S.3
-
14
-
-
0036765785
-
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of gene involved in xenobiotic detoxification
-
Maglich JM, Stoltz CM, Goodwin B, Hawkins-brown D, Moore JT, Kliewer SA. Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of gene involved in xenobiotic detoxification. Mol Pharmacol 2002;62:638-40.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 638-640
-
-
Maglich, J.M.1
Stoltz, C.M.2
Goodwin, B.3
Hawkins-brown, D.4
Moore, J.T.5
Kliewer, S.A.6
-
15
-
-
0027469790
-
Expression of xenobiotic metabolizing enzymes in breast cancer
-
Murray G, Weaver RJ, Paterson PJ, Ewen SWB, Melvin WT, Burke D. Expression of xenobiotic metabolizing enzymes in breast cancer. J Pathol 1993;169:347-53.
-
(1993)
J Pathol
, vol.169
, pp. 347-353
-
-
Murray, G.1
Weaver, R.J.2
Paterson, P.J.3
Ewen, S.W.B.4
Melvin, W.T.5
Burke, D.6
-
16
-
-
0029834242
-
Expression of cytochrome P450 in human breast tissue and tumors
-
Huang Z, Fasco MJ, Figge HL, Keyomarsi K, Kaminsky LS. Expression of cytochrome P450 in human breast tissue and tumors. Drug Metab Dispos 1996;24: 899-8.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 899-908
-
-
Huang, Z.1
Fasco, M.J.2
Figge, H.L.3
Keyomarsi, K.4
Kaminsky, L.S.5
-
17
-
-
0031792505
-
Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties
-
Hellmold H, Rylander T, Magnusson M, Reihnér E, Warner M, Gustafsson J-Å. Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. J Clin Endocrinol Metab 1998;83:886-95.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 886-895
-
-
Hellmold, H.1
Rylander, T.2
Magnusson, M.3
Reihnér, E.4
Warner, M.5
Gustafsson, J.-Å.6
-
18
-
-
0028302746
-
Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorder
-
Sasano H, Nagura H, Harada N, Goukon Y, Kimura M. Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorder. Hum Pathol 1994;25:530-5.
-
(1994)
Hum Pathol
, vol.25
, pp. 530-535
-
-
Sasano, H.1
Nagura, H.2
Harada, N.3
Goukon, Y.4
Kimura, M.5
-
19
-
-
0036331937
-
Differential modulation by Estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells
-
Zampieri L, Blanchi P, Ruff P, Arbuthnot P. Differential modulation by Estradiol of P-glycoprotein drug resistance protein expression in cultured MCF7 and T47D breast cancer cells. Anticancer Res 2002;22: 2253-60.
-
(2002)
Anticancer Res
, vol.22
, pp. 2253-2260
-
-
Zampieri, L.1
Blanchi, P.2
Ruff, P.3
Arbuthnot, P.4
-
20
-
-
0037304032
-
Cancer and phase II drug-metabolizing enzymes
-
Sheweita SA, Tilmisany AK. Cancer and phase II drug-metabolizing enzymes. Curr Drug Metab 2003;4: 45-58.
-
(2003)
Curr Drug Metab
, vol.4
, pp. 45-58
-
-
Sheweita, S.A.1
Tilmisany, A.K.2
-
21
-
-
0141888537
-
The role of ABC transporters in clinical practice
-
Leonard GD, Fojo T, Bates SE. The role of ABC transporters in clinical practice. Oncologist 2003;8: 411-24.
-
(2003)
Oncologist
, vol.8
, pp. 411-424
-
-
Leonard, G.D.1
Fojo, T.2
Bates, S.E.3
-
22
-
-
0032807743
-
The human orphan receptor PXK messenger RNA is expressed in both normal and neoplastic breast tissue
-
Dotzlaw H, Leygue E, Watson P, Murphy LC. The human orphan receptor PXK messenger RNA is expressed in both normal and neoplastic breast tissue. Clin Cancer Res 1999;5:2103-7.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2103-2107
-
-
Dotzlaw, H.1
Leygue, E.2
Watson, P.3
Murphy, L.C.4
-
23
-
-
70449185514
-
Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15 years
-
Bloom HJG, Richardson WW. Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 1957;11:359-77.
-
(1957)
Br J Cancer
, vol.11
, pp. 359-377
-
-
Bloom, H.J.G.1
Richardson, W.W.2
-
24
-
-
0026072872
-
Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer. Expression from a large study with long-term follow-up
-
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer. Expression from a large study with long-term follow-up. Histopathology 1991;19:403-10.
-
(1991)
Histopathology
, vol.19
, pp. 403-410
-
-
Elston, C.W.1
Ellis, I.O.2
-
25
-
-
0021931794
-
Risk factors for breast cancer in women with proliferative breast disease
-
Dupont WD, Page DL. Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 1985;312:146-51.
-
(1985)
N Engl J Med
, vol.312
, pp. 146-151
-
-
Dupont, W.D.1
Page, D.L.2
-
26
-
-
0027076662
-
Ductal carcinoma in situ of the female breast Short-term results of a prospective nationwide study
-
The Danish Breast Cancer Cooperative Group
-
Ottesen GL, Graversen HP, Blichert-Toft M, Zedeler K, Andersen JA. Ductal carcinoma in situ of the female breast Short-term results of a prospective nationwide study. The Danish Breast Cancer Cooperative Group. Am J Surg Pathol 1992;16:1183-96.
-
(1992)
Am J Surg Pathol
, vol.16
, pp. 1183-1196
-
-
Ottesen, G.L.1
Graversen, H.P.2
Blichert-Toft, M.3
Zedeler, K.4
Andersen, J.A.5
-
27
-
-
0036924550
-
Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues
-
Miki Y, Nakata T, Suzuki T, et al. Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. J Clin Endocrinol Metab 2002;87:5760-8.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5760-5768
-
-
Miki, Y.1
Nakata, T.2
Suzuki, T.3
-
28
-
-
0037939776
-
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma
-
Suzuki T, Nakata T, Miki Y, et al. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Cancer Res 2003;63:2762-70.
-
(2003)
Cancer Res
, vol.63
, pp. 2762-2770
-
-
Suzuki, T.1
Nakata, T.2
Miki, Y.3
-
29
-
-
0036827601
-
Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction
-
Alcorn J, Lu X, Moscow JA, Mcnamara PJ. Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 2002;303:487-96.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 487-496
-
-
Alcorn, J.1
Lu, X.2
Moscow, J.A.3
Mcnamara, P.J.4
-
30
-
-
0031915998
-
Prognostic and predictive factors in breast cancer by immunohistochemical analysis
-
Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998;11: 155-68.
-
(1998)
Mod Pathol
, vol.11
, pp. 155-168
-
-
Allred, D.C.1
Harvey, J.M.2
Berardo, M.3
Clark, G.M.4
-
31
-
-
3042699992
-
Estrogen-related receptor a in human breast carcinoma as a potent prognostic factor
-
Suzuki T, Miki Y, Moriya T, et al. Estrogen-related receptor a in human breast carcinoma as a potent prognostic factor. Cancer Res 2004;64:4670-6.
-
(2004)
Cancer Res
, vol.64
, pp. 4670-4676
-
-
Suzuki, T.1
Miki, Y.2
Moriya, T.3
-
32
-
-
0035965342
-
PKCθII, a new isoform of protein kinase C specifically expressed in the seminiferous tubules of mouse testis
-
Niino Y, Irie T, Takaishi M, et al. PKCθII, a new isoform of protein kinase C specifically expressed in the seminiferous tubules of mouse testis. J Biol Chem 2001; 276:36711-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 36711-36717
-
-
Niino, Y.1
Irie, T.2
Takaishi, M.3
-
33
-
-
31644432997
-
Enzyme list, 2. Transferases
-
San Diego: Academic Press
-
Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Enzyme list, 2. Transferases. In: Enzyme nomenclature. San Diego: Academic Press; 1992. p. 155-305.
-
(1992)
Enzyme Nomenclature
, pp. 155-305
-
-
-
34
-
-
33947243477
-
Human membrane transporter database: A Web-accessible relational database for drag transport studies and pharmacogenomics
-
Yan Q, Sadée W. Human membrane transporter database: a Web-accessible relational database for drag transport studies and pharmacogenomics. AAPS PharmSci 2000;2:E20.
-
(2000)
AAPS PharmSci
, vol.2
-
-
Yan, Q.1
Sadée, W.2
-
36
-
-
0035113162
-
Retinoid receptor in human breast carcinoma: Possible modulators of in situ estrogen metabolism
-
Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H. Retinoid receptor in human breast carcinoma: possible modulators of in situ estrogen metabolism. Breast Cancer Res Treat 2001;65:31-40.
-
(2001)
Breast Cancer Res Treat
, vol.65
, pp. 31-40
-
-
Suzuki, T.1
Moriya, T.2
Sugawara, A.3
Ariga, N.4
Takabayashi, H.5
Sasano, H.6
-
37
-
-
0033639286
-
Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesion of the human breast
-
Ariga N, Moriya T, Suzuki T, Kimura M, Ohuchi N, Sasano H. Retinoic acid receptor and retinoid X receptor in ductal carcinoma in situ and intraductal proliferative lesion of the human breast. Jpn J Cancer Res 2000;91: 1169-76.
-
(2000)
Jpn J Cancer Res
, vol.91
, pp. 1169-1176
-
-
Ariga, N.1
Moriya, T.2
Suzuki, T.3
Kimura, M.4
Ohuchi, N.5
Sasano, H.6
-
38
-
-
0037333974
-
Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR
-
Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takada K, Kawajiri K. Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol Pharmacol 2003;63:524-31.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 524-531
-
-
Kawana, K.1
Ikuta, T.2
Kobayashi, Y.3
Gotoh, O.4
Takada, K.5
Kawajiri, K.6
-
39
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A 2001;98:3369-74.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
-
40
-
-
11144357796
-
Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression
-
Hartley DP, Dai X, He YD, Carlini EJ, et al. Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. Mol Pharmacol 2004;65:1159-71.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1159-1171
-
-
Hartley, D.P.1
Dai, X.2
He, Y.D.3
Carlini, E.J.4
-
41
-
-
0034776256
-
Induction of CYP3A4 by 1α,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor
-
Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Watkins PB. Induction of CYP3A4 by 1α,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor. Drug Metab Dispos 2001; 29:1446-53.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1446-1453
-
-
Schmiedlin-Ren, P.1
Thummel, K.E.2
Fisher, J.M.3
Paine, M.F.4
Watkins, P.B.5
-
42
-
-
4644361194
-
Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes
-
Zhou C, Tabb MM, Sadatrafiei A, Grun F, Blumberg B. Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metab Dispos 2004;32:1075-82.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 1075-1082
-
-
Zhou, C.1
Tabb, M.M.2
Sadatrafiei, A.3
Grun, F.4
Blumberg, B.5
-
43
-
-
0029091022
-
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
-
Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995;109:1274-82.
-
(1995)
Gastroenterology
, vol.109
, pp. 1274-1282
-
-
Kullak-Ublick, G.A.1
Hagenbuch, B.2
Stieger, B.3
-
44
-
-
0029820166
-
Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database
-
Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet 1996;5:1649-55.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 1649-1655
-
-
Allikmets, R.1
Gerrard, B.2
Hutchinson, A.3
Dean, M.4
-
45
-
-
0030296680
-
Multispecific amphipathic substrate transport by an organic anion transporter of human liver
-
Bossuyt X, Muller M, Meier PJ. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 1996;25:733-8.
-
(1996)
J Hepatol
, vol.25
, pp. 733-738
-
-
Bossuyt, X.1
Muller, M.2
Meier, P.J.3
-
46
-
-
0037427972
-
The superfamily of organic anion transporting polypeptides
-
Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 2003;1609:1-18.
-
(2003)
Biochim Biophys Acta
, vol.1609
, pp. 1-18
-
-
Hagenbuch, B.1
Meier, P.J.2
-
47
-
-
0027413273
-
Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies
-
Kraemer FB, Patel S, Saedi MS, Szalryd C. Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies. J Lipid Res 1993;34: 663-71.
-
(1993)
J Lipid Res
, vol.34
, pp. 663-671
-
-
Kraemer, F.B.1
Patel, S.2
Saedi, M.S.3
Szalryd, C.4
-
48
-
-
1842855257
-
Hormone-sensitive lipase-new roles for an old enzyme
-
Yeaman SJ. Hormone-sensitive lipase-new roles for an old enzyme. Biochem J 2004;379:11-22.
-
(2004)
Biochem J
, vol.379
, pp. 11-22
-
-
Yeaman, S.J.1
-
49
-
-
0242498469
-
2 regulation of borne homeostasis is mediated by the steroid and xenobiotic receptor SXR
-
2 regulation of borne homeostasis is mediated by the steroid and xenobiotic receptor SXR. J Biol Chem 2003;278:43919-27.
-
(2003)
J Biol Chem
, vol.278
, pp. 43919-43927
-
-
Tabb, M.M.1
Sun, A.2
Zhou, C.3
-
50
-
-
0034809137
-
Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription
-
Takeshita A, Koibuchi N, Oka J, et al. Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. Eur J Endocrinol 2001;145:513-7.
-
(2001)
Eur J Endocrinol
, vol.145
, pp. 513-517
-
-
Takeshita, A.1
Koibuchi, N.2
Oka, J.3
|