Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor

European Journal of Biochemistry

Volumn 268, Issue 24, 2001, Pages 6346-6358

  Pascussi, Jean Marc ^a   Drocourt, Lionel ^a   Gerbal Chaloin, Sabine ^a   Fabre, Jean Michel ^b   Maurel, Patrick ^a   Vilarem, Marie José ^a  

^a INSERM   (France)

^b HÔPITAL SAINT ELOI   (France)

Author keywords

Cytochrome p450 3A4; Glucocorticoids; Human hepatocytes; Nuclear receptors; Transcriptional regulation

Indexed keywords

CYCLOHEXIMIDE; CYTOCHROME P450 3A4; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MIFEPRISTONE; PREGNANE X RECEPTOR; RECEPTOR; RIFAMPICIN; TYROSINE AMINOTRANSFERASE; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA VECTOR; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INDUCTION; ENZYME KINETICS; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALIA;

EID: 0035659943     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02540.x     Document Type: Article

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