-
1
-
-
0024394549
-
Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
-
Andersson S, Davis DL, Dahlback H, Jomvall H, and Russell DW (1989) Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J Biol Chem 264:8222-8229.
-
(1989)
J Biol Chem
, vol.264
, pp. 8222-8229
-
-
Andersson, S.1
Davis, D.L.2
Dahlback, H.3
Jomvall, H.4
Russell, D.W.5
-
2
-
-
0037443813
-
Glucuronidation of catechols by human hepatic, gastric and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9 and UGT1B7
-
Antonio L, Czernik P, Xu J, Little JM, Burchell B, Magdalou J, and Radominska-Pandya A (2003) Glucuronidation of catechols by human hepatic, gastric and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9 and UGT1B7. Arch Biochem Biophys 411:251-261.
-
(2003)
Arch Biochem Biophys
, vol.411
, pp. 251-261
-
-
Antonio, L.1
Czernik, P.2
Xu, J.3
Little, J.M.4
Burchell, B.5
Magdalou, J.6
Radominska-Pandya, A.7
-
3
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:122208-122213.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 122208-122213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
4
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Mester CM, Ong ES, and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr., W.2
Juguilon, H.3
Bolado Jr., J.4
Van Mester, C.M.5
Ong, E.S.6
Evans, R.M.7
-
5
-
-
0030867709
-
Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation
-
Burchell B and Coughtrie MWH (1997) Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation. Environ Health Perspect 105: 739-747.
-
(1997)
Environ Health Perspect
, vol.105
, pp. 739-747
-
-
Burchell, B.1
Coughtrie, M.W.H.2
-
7
-
-
0035197725
-
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms
-
Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten C, Miners JO, and Mackenzie PI (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299:998-1006.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 998-1006
-
-
Court, M.H.1
Duan, S.X.2
Von Moltke, L.L.3
Greenblatt, D.J.4
Patten, C.5
Miners, J.O.6
Mackenzie, P.I.7
-
8
-
-
0033815033
-
Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa
-
Czernik PJ, Little JM, Barone GW, Raufman J-P, and Radominska-Pandya A (2000) Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos 28:1210-1216.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 1210-1216
-
-
Czernik, P.J.1
Little, J.M.2
Barone, G.W.3
Raufman, J.-P.4
Radominska-Pandya, A.5
-
9
-
-
0032807743
-
The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
-
Dotzlaw H, Leygue E, Watson P, and Murphy LC (1999) The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin Cancer Res 5:2103-2107.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2103-2107
-
-
Dotzlaw, H.1
Leygue, E.2
Watson, P.3
Murphy, L.C.4
-
10
-
-
0034777488
-
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
-
Hustert E, Zibat A, Presecan-Siedel E, Eiselt R, Mueller R, Fuss C, Brehm I, Brinkmann U, Eichelbaum M, Wojnowski L, and Burk O (2001) Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4. Drug Metab Dispos 29:1454-1459.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1454-1459
-
-
Hustert, E.1
Zibat, A.2
Presecan-Siedel, E.3
Eiselt, R.4
Mueller, R.5
Fuss, C.6
Brehm, I.7
Brinkmann, U.8
Eichelbaum, M.9
Wojnowski, L.10
Burk, O.11
-
11
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, famesoid X-activated receptor and constitutive androstane receptor
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, and Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, famesoid X-activated receptor and constitutive androstane receptor. J Biol Chem 277:2908-2915.
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
12
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
-
13
-
-
0036209248
-
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
-
Kliewer SA and Willson TM (2002) Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res 43:359-364.
-
(2002)
J Lipid Res
, vol.43
, pp. 359-364
-
-
Kliewer, S.A.1
Willson, T.M.2
-
14
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1015-1023.
-
(1998)
J Clin Investig
, vol.102
, pp. 1015-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
15
-
-
0032608371
-
Variability of human hepatic UDP-glucuronosyltransferase activity
-
Little JM, Lester R, Kuipers F, Vonk R, Mackenzie PI, Drake RR, Frame L, and Radominska-Pandya A (1999) Variability of human hepatic UDP-glucuronosyltransferase activity. Acta Biochim Pol 46:351-363.
-
(1999)
Acta Biochim Pol
, vol.46
, pp. 351-363
-
-
Little, J.M.1
Lester, R.2
Kuipers, F.3
Vonk, R.4
Mackenzie, P.I.5
Drake, R.R.6
Frame, L.7
Radominska-Pandya, A.8
-
16
-
-
0036239907
-
Glucuronidation of the dietary fatty acids, phytanic acid and docosahexaenoic acid, by human UDP-glucuronosyltransferases
-
Little JM, Williams L, Xu J, and Radominska-Pandya A (2002) Glucuronidation of the dietary fatty acids, phytanic acid and docosahexaenoic acid, by human UDP-glucuronosyltransferases. Drug Metab Dispos 30:531-533.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 531-533
-
-
Little, J.M.1
Williams, L.2
Xu, J.3
Radominska-Pandya, A.4
-
17
-
-
0033526864
-
Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
-
Pascussi IM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, and Vilarem MJ (1999) Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun 260:377-381.
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 377-381
-
-
Pascussi, I.M.1
Jounaidi, Y.2
Drocourt, L.3
Domergue, J.4
Balabaud, C.5
Maurel, P.6
Vilarem, M.J.7
-
18
-
-
0031732138
-
UDP-glucuronosyltransferases in human intestinal mucosa
-
Radominska-Pandya A, Little JM, Pandya JT, Tephly TR, King CD, Barone GW, and Raufman J-P (1998) UDP-glucuronosyltransferases in human intestinal mucosa. Biochim Biophys Acta 1394:199-208.
-
(1998)
Biochim Biophys Acta
, vol.1394
, pp. 199-208
-
-
Radominska-Pandya, A.1
Little, J.M.2
Pandya, J.T.3
Tephly, T.R.4
King, C.D.5
Barone, G.W.6
Raufman, J.-P.7
-
19
-
-
0026764632
-
Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type 1 patient
-
Ritter JK, Yeatman MT, Ferreira P, and Owens IS (1992) Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type 1 patient. J Clin Investig 90:150-155.
-
(1992)
J Clin Investig
, vol.90
, pp. 150-155
-
-
Ritter, J.K.1
Yeatman, M.T.2
Ferreira, P.3
Owens, I.S.4
-
20
-
-
0030945754
-
Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1α, 25-dihydroxyvitamin D3
-
Schmiedlin-Ren P, Thummel KE, Fisher JM, Paine MF, Lown KS, and Watkins PB (1997) Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1α, 25-dihydroxyvitamin D3. Mol Pharmacol 51:741-754.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 741-754
-
-
Schmiedlin-Ren, P.1
Thummel, K.E.2
Fisher, J.M.3
Paine, M.F.4
Lown, K.S.5
Watkins, P.B.6
-
21
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, et al. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98:3369-3374.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
-
22
-
-
0034680792
-
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
-
Strassburg CP, Kniep S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, and Manns MP (2000) Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164-36171.
-
(2000)
J Biol Chem
, vol.275
, pp. 36164-36171
-
-
Strassburg, C.P.1
Kniep, S.2
Topp, J.3
Obermayer-Straub, P.4
Barut, A.5
Tukey, R.H.6
Manns, M.P.7
-
24
-
-
0030800075
-
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
-
Strassburg CP, Oldhafer K, Manns MP, and Tukey RH (1997) Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol 52:212-220.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 212-220
-
-
Strassburg, C.P.1
Oldhafer, K.2
Manns, M.P.3
Tukey, R.H.4
-
25
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
26
-
-
0035115599
-
Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
-
Tukey RH and Strassburg CP (2001) Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 40:405-414.
-
(2001)
Mol Pharmacol
, vol.40
, pp. 405-414
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
27
-
-
0035103197
-
Relative enzymatic activity, protein stability and tissue distribution of human steroid-metabolizing UGT2B subfamily members
-
Turgeon D, Carrier J-S, Levesques E, Hum DW, and Belanger A (2001) Relative enzymatic activity, protein stability and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology 142:778-787.
-
(2001)
Endocrinology
, vol.142
, pp. 778-787
-
-
Turgeon, D.1
Carrier, J.-S.2
Levesques, E.3
Hum, D.W.4
Belanger, A.5
-
28
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, and Evans RM (2000) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (Lond) 406:435-439.
-
(2000)
Nature (Lond)
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
29
-
-
0037386735
-
Control of steroid, heme, and carcinogen metabolism by nuclear receptors PXR and CAR
-
Xie W, Yeuh M-F, Radominska-Pandya A, Saini SPS, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, and Evans RM (2003) Control of steroid, heme, and carcinogen metabolism by nuclear receptors PXR and CAR. Proc Natl Acad Sci USA 100:4150-4156.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4150-4156
-
-
Xie, W.1
Yeuh, M.-F.2
Radominska-Pandya, A.3
Saini, S.P.S.4
Negishi, Y.5
Bottroff, B.S.6
Cabrera, G.Y.7
Tukey, R.H.8
Evans, R.M.9
|