Identification of the functional vitamin D response elements in the human MDR1 gene

Biochemical Pharmacology

Volumn 76, Issue 4, 2008, Pages 531-542

  Saeki, Mayumi ^a   Kurose, Kouichi ^a   Tohkin, Masahiro ^a   Hasegawa, Ryuichi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

1 ,25 Dihydroxyvitamin D3; Multidrug resistance 1; P glycoprotein (P gp); Vitamin D receptor (VDR); Vitamin D response element (VDRE)

Indexed keywords

CALCITRIOL; HETERODIMER; LUCIFERASE; MULTIDRUG RESISTANCE PROTEIN 1; RETINOID X RECEPTOR ALPHA; VITAMIN D RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN CACO 2; CONTROLLED STUDY; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSACTIVATION; VITAMIN D RESPONSIVE ELEMENT;

BINDING SITES; GENE EXPRESSION REGULATION; GENES, MDR; HUMANS; P-GLYCOPROTEIN; RECEPTORS, CALCITRIOL; RETINOID X RECEPTORS; VITAMIN D; VITAMIN D RESPONSE ELEMENT;

EID: 48149113288     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.05.030     Document Type: Article

References (40)

1. Marchetti S., Mazzanti R., Beijnen J.H., and Schellens J.H. Concise review: clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). Oncologist 12 (2007) 927-941
2. Wacher V.J., Wu C.Y., and Benet L.Z. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 13 (1995) 129-134
3. Geick A., Eichelbaum M., and Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276 (2001) 14581-14587
4. Burk O., Arnold K.A., Geick A., Tegude H., and Eichelbaum M. A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression. Biol Chem 386 (2005) 503-513
5. Bertilsson G., Heidrich J., Svensson K., Asman M., Jendeberg L., Sydow-Backman M., et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95 (1998) 12208-12213
6. Moore L.B., Parks D.J., Jones S.A., Bledsoe R.K., Consler T.G., Stimmel J.B., et al. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275 (2000) 15122-15127
7. Aiba T., Susa M., Fukumori S., and Hashimoto Y. The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180. Drug Metab Pharmacokinet 20 (2005) 268-274
8. Pfrunder A., Gutmann H., Beglinger C., and Drewe J. Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. J Pharm Pharmacol 55 (2003) 59-66
9. Thummel K.E., Brimer C., Yasuda K., Thottassery J., Senn T., Lin Y., et al. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Mol Pharmacol 60 (2001) 1399-1406
10. Patel J., Pal D., Vangal V., Gandhi M., and Mitra A.L. Transport of HIV-protease inhibitors across 1 alpha,25di-hydroxy vitamin D3-treated Calu-3 cell monolayers: modulation of P-glycoprotein activity. Pharm Res 19 (2002) 1696-1703
11. Piwnica-Worms D., Chiu M.L., Budding M., Kronauge J.F., Kramer R.A., and Croop J.M. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res 53 (1993) 977-984
12. Yamaguchi S., Yachiku S., Hashimoto H., Kaneko S., Nishihara M., Niibori D., et al. Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands. World J Surg 26 (2002) 29-34
13. Olaizola I., Zingraff J., Heuguerot C., Fajardo L., Leger A., Lopez J., et al. [(99m)Tc]-sestamibi parathyroid scintigraphy in chronic haemodialysis patients: static and dynamic explorations. Nephrol Dial Transplant 15 (2000) 1201-1206
14. Drocourt L., Ourlin J.C., Pascussi J.M., Maurel P., and Vilarem M.J. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 277 (2002) 25125-25132
15. Schrader M., Nayeri S., Kahlen J.P., Muller K.M., and Carlberg C. Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation. Mol Cell Biol 15 (1995) 1154-1161
16. Tavera-Mendoza L., Wang T.T., Lallemant B., Zhang R., Nagai Y., Bourdeau V., et al. Convergence of vitamin D and retinoic acid signalling at a common hormone response element. EMBO Rep 7 (2006) 180-185
17. Matilainen M., Malinen M., Saavalainen K., and Carlberg C. Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3. Nucleic Acids Res 33 (2005) 5521-5532
18. Seoane S., and Perez-Fernandez R. The vitamin D receptor represses transcription of the pituitary transcription factor Pit-1 gene without involvement of the retinoid X receptor. Mol Endocrinol 20 (2006) 735-748
19. Kurose K., Saeki M., Tohkin M., and Hasegawa R. Thyroid hormone receptor mediates human MDR1 gene expression-identification of the response region essential for gene expression. Arch Biochem Biophys 474 (2008) 82-90
20. Nakamura T., Sakaeda T., Ohmoto N., Tamura T., Aoyama N., Shirakawa T., et al. Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas. Drug Metab Dispos 30 (2002) 4-6
21. Kurose K., Ikeda S., Koyano S., Tohkin M., Hasegawa R., and Sawada J. Identification of regulatory sites in the human PXR (NR1I2) promoter region. Mol Cell Biochem 281 (2006) 35-43
22. Hochman J.H., Chiba M., Nishime J., Yamazaki M., and Lin J.H. Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther 292 (2000) 310-318
23. Pascussi J.M., Gerbal-Chaloin S., Drocourt L., Maurel P., and Vilarem M.J. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 1619 (2003) 243-253
24. Xie W., Barwick J.L., Simon C.M., Pierce A.M., Safe S., Blumberg B., et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14 (2000) 3014-3023
25. Lempiainen H., Molnar F., Macias Gonzalez M., Perakyla M., and Carlberg C. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol Endocrinol 19 (2005) 2258-2272
26. Toell A., Polly P., and Carlberg C. All natural DR3-type vitamin D response elements show a similar functionality in vitro. Biochem J 352 Pt 2 (2000) 301-309
27. Kim S., Yamazaki M., Zella L.A., Shevde N.K., and Pike J.W. Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol Cell Biol 26 (2006) 6469-6486
28. Quack M., and Carlberg C. Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements. J Mol Biol 296 (2000) 743-756
29. Kimmel-Jehan C., Jehan F., and DeLuca H.F. Salt concentration determines 1,25-dihydroxyvitamin D3 dependency of vitamin D receptor-retinoid X receptor-vitamin D-responsive element complex formation. Arch Biochem Biophys 341 (1997) 75-80
30. Engman H.A., Lennernas H., Taipalensuu J., Otter C., Leidvik B., and Artursson P. CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies. J Pharm Sci 90 (2001) 1736-1751
31. Shabahang M., Buras R.R., Davoodi F., Schumaker L.M., Nauta R.J., and Evans S.R. 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res 53 (1993) 3712-3718
32. Ebeling P.R., Sandgren M.E., DiMagno E.P., Lane A.W., DeLuca H.F., and Riggs B.L. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab 75 (1992) 176-182
33. Kinyamu H.K., Gallagher J.C., Prahl J.M., DeLuca H.F., Petranick K.M., and Lanspa S.J. Association between intestinal vitamin D receptor, calcium absorption, and serum 1,25 dihydroxyvitamin D in normal young and elderly women. J Bone Miner Res 12 (1997) 922-928
34. Bises G., Kallay E., Weiland T., Wrba F., Wenzl E., Bonner E., et al. 25-Hydroxyvitamin D3-1alpha-hydroxylase expression in normal and malignant human colon. J Histochem Cytochem 52 (2004) 985-989
35. Tangpricha V., Flanagan J.N., Whitlatch L.W., Tseng C.C., Chen T.C., Holt P.R., et al. 25-Hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue. Lancet 357 (2001) 1673-1674
36. Walters J.R., Balesaria S., Khair U., Sangha S., Banks L., and Berry J.L. The effects of Vitamin D metabolites on expression of genes for calcium transporters in human duodenum. J Steroid Biochem Mol Biol 103 (2007) 509-512
37. Dusso A.S., Brown A.J., and Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 289 (2005) F8-28
38. Hewison M., Burke F., Evans K.N., Lammas D.A., Sansom D.M., Liu P., et al. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol 103 (2007) 316-321
39. Kong J., Zhang Z., Musch M.W., Ning G., Sun J., Hart J., et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 294 (2008) G208-G216
40. Kutuzova G.D., and DeLuca H.F. 1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine. Toxicol Appl Pharmacol 218 (2007) 37-44