The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

Molecular and Cellular Biology

Volumn 18, Issue 10, 1998, Pages 5652-5658

  Honkakoski, Paavo ^a,b   Zelko, Igor ^a   Sueyoshi, Tatsuya ^a   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; PHENOBARBITAL; RETINOID X RECEPTOR;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; BINDING SITE; CELL TRANSFORMATION; CONTAMINATION; DIMERIZATION; DNA SEQUENCE; DRUG RECEPTOR BINDING; ENHANCER REGION; GENE ACTIVATION; GENE INDUCTION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031682988     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.10.5652     Document Type: Article

References (26)

1. Baes, M., T. Gulick, H. Choi, M. Martinoli, D. Simha, and D. D. Moore. 1994. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell. Biol. 14:1544-1552.
2. Choi, H.-S., M. Chung, I. Tzameli, D. Simha, Y.-K. Lee, W. Seol, and D. D. Moore. 1997. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J. Biol. Chem. 272:23565-23571.
3. Conney, A. H. 1967. Pharmacological implications of microsomal enzyme induction. Pharmacol. Rev. 19:317-366.
4. Denison, M. S., and J. P. Whitlock, Jr. 1995. Xenobiotic-inducible transcription of cytochrome P450 genes. J. Biol. Chem. 270:18175-18178.
5. Forman, B. M., B. Ruan, J. Chen, G. J. Scroepfer, Jr., and R. M. Evans. 1997. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism. Proc. Natl. Acad. Sci. 94:10588-10593.
6. Hankinson, O. 1995. The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35:307-340.
7. Honkakoski, P., R. Moore, J. Gynther, and M. Negishi. 1996. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. J. Biol. Chem. 271:9746-9753.
8. Honkakoski, P., and M. Negishi. 1997. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J. Biol. Chem. 272:14443-14949.
9. Honkakoski, P., and M. Negishi. 1998. Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J. Biochem. Mol. Toxicol. 12:3-9.
10. Honkakoski, P., R. Moore, K. Washbum, and M. Negishi. 1998. Activation by diverse xenochemicals of the 51-bp phenobarbital-responsive enhancer module of the Cyp2b10 gene. Mol. Pharmacol. 53:597-601.
11. Honkakoski, P., and M. Negishi. 1998 Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem. J. 330:889-895.
12. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor by peroxisome proliferators. Nature 347:645-650.
13. Johnson, E. J., C. A. Palmer, K.J. Griffin, and M.-H. Hsu. 1996. Role of the peroxisome proliferator-activating receptor in cytochrome P450 4A gene regulation. FASEB J. 10:1241-1248.
14. 13a. Kliwere, S. A., J. T. Moore, L. Wada, J. L. Staudinger, M. A. Watson, S. A. Jones, D. D. McKee, B. B. Oliver, T. M. Wilson, R. H. Zetterstrom, T. Permann, and J. M. Lehmann. 1998. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
15. Lubet, R. A., K. H. Dragnev, D. P. Chauhan, R. W. Nims, B. A. Diwan, J. M. Ward, C. R. Jones, J. M. Rice, and M. S. Miller. 1992. A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat: effects of chemicals of varied structure. Biochem. Pharmacol. 43:1067-1078.
16. Luckow, B., and G. Schütz. 1987, CAT construction with multiple unique restriction sites for the functional analysis of eucaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490.
17. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R. M. Evans. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835-839.
18. Mangelsdorf, D. J., and R. M. Evans. 1995. The RXR heterodimers and orphan receptors. Cell 83:841-850.
19. Park, Y., H. Li, and B. Kemper. 1996. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J. Biol. Chem. 271:23725-23728.
20. Porter, T. D., and M. J. Coon. 1991. Cytochrome P-450: multiplicity of isoforms. substrates, and catalytic and regulatory mechanism. J. Biol. Chem. 266:13469-13472.
21. Seol, W., H.-S. Choi, and D. D. Moore. 1996. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272:1336-1339.
22. Sidhu, J. S., and C. J. Omiecinski. 1995. cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary hepatocyte cultures. J. Biol. Chem. 270:12762-12773.
23. Sueyoshi, T., R. Kobayashi, K. Nishio, K. Aida, R. Moore, T. Wada, H. Handa, and M. Negishi. 1995. A nuclear factor (NF2d9) that binds to the male-specific P-450 (Cyp2d-9) in mouse liver. Mol. Cell. Biol. 15:4158-4166.
24. Trottier, E., A. Belzil, C. Stoltz, and A. Anderson. 1995. Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene. Gene 158:263-268.
25. Waxman, D. J., and L. Azaroff. 1992. Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281:577-592.
26. Yokomori, N., R. Kobayashi, R. Moore, T. Sueyoshi, and M. Negishi. 1995. DNA methylation site in the male-specific P-450 (Cyp2d-9) promoter and the heteromeric transcription factor GABP. Mol. Cell. Biol. 15:5355-5362.