Identification of Amino Acids in Rat Pregnane X Receptor that Determine Species-Specific Activation

Molecular Pharmacology

Volumn 65, Issue 1, 2004, Pages 36-44

  Tirona, Rommel G ^a   Leake, Brenda F ^a   Podust, Larissa M ^b   Kim, Richard B ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; CYTOCHROME P450 3A; DRUG METABOLIZING ENZYME; HYPERFORIN; HYPOCHOLESTEROLEMIC AGENT; LEUCINE; NIFEDIPINE; PACLITAXEL; PHENYLALANINE; PREGNANE X RECEPTOR; RIFAMPICIN; SR 12813; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BINDING AFFINITY; CHEMICAL STRUCTURE; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG METABOLISM; ENZYME METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RABBIT; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SENSITIVITY ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RABBITS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RECOMBINANT FUSION PROTEINS; RIFAMPIN; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 1642454581     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.1.36     Document Type: Article

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