Identification of gene-selective modulators of the bile acid receptor FXR

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7027-7033

  Dussault, Isabelle ^a   Beard, Rick ^c   Lin, Min ^a   Hollister, Kevin ^a   Chen, Jasmine ^a   Xiao, Jia Hao ^c   Chandraratna, Rosh ^c   Foman, Barry M ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Gonda Research Center   (United States)

^c ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GENES; LIPIDS;

BILE ACID RECEPTORS (BAR);

BIOCHEMISTRY;

AGN 29; AGN 31; AGN 34; BILE ACID; BILE ACID RECEPTOR FXR; BILE ACID RECEPTOR MODULATOR; BINDING PROTEIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; GENE SELECTIVE BILE ACID RECEPTOR MODULATOR; HYPOCHOLESTEROLEMIC AGENT; ILEAL BILE ACID BINDING PROTEIN; LIPID; REGULATOR PROTEIN; SMALL HETERODIMER PARTNER PROTEIN; UNCLASSIFIED DRUG; AGN 34 COMPOUND; CELL RECEPTOR; DIPHENYL ETHER DERIVATIVE; DNA BINDING PROTEIN; FARNESOID X RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; LIGAND; OCTANOIC ACID DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BILE ACID METABOLISM; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENE ACTIVATION; GENE CONTROL; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPID METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; REPORTER GENE; TRANSCRIPTION REGULATION; ANIMAL; BINDING COMPETITION; CHEMICAL MODEL; DOSE RESPONSE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; METABOLISM; NORTHERN BLOTTING; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

ANIMALS; BILE ACIDS AND SALTS; BINDING, COMPETITIVE; BLOTTING, NORTHERN; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; LIGANDS; MODELS, CHEMICAL; OCTANOIC ACIDS; PHENYL ETHERS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0037470079     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209863200     Document Type: Article

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