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Volumn 56, Issue 6, 1999, Pages 1329-1339

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CIS ACTING ELEMENT; CYTOCHROME P450 ISOENZYME; RIFAMPICIN;

EID: 0032702726     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.6.1329     Document Type: Article
Times cited : (601)

References (41)
  • 1
    • 0029992789 scopus 로고    scopus 로고
    • Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes
    • Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH and Guzelian PS (1996) Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 50:10-16.
    • (1996) Mol Pharmacol , vol.50 , pp. 10-16
    • Barwick, J.L.1    Quattrochi, L.C.2    Mills, A.S.3    Potenza, C.4    Tukey, R.H.5    Guzelian, P.S.6
  • 4
    • 0031914323 scopus 로고    scopus 로고
    • The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor
    • Calleja C, Pascussi JM, Mani JC, Maurel P and Vilarem M-J (1998) The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor. Nat Med 4:92-96.
    • (1998) Nat Med , vol.4 , pp. 92-96
    • Calleja, C.1    Pascussi, J.M.2    Mani, J.C.3    Maurel, P.4    Vilarem, M.-J.5
  • 5
    • 0026324036 scopus 로고
    • Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes
    • Daujat M, Pichard L, Fabre I, Pineau T, Fabre G, Bonfils C and Maurel P (1991) Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes. Methods Enzymol 206:345-353.
    • (1991) Methods Enzymol , vol.206 , pp. 345-353
    • Daujat, M.1    Pichard, L.2    Fabre, I.3    Pineau, T.4    Fabre, G.5    Bonfils, C.6    Maurel, P.7
  • 6
    • 0023688694 scopus 로고
    • Structure and expression of the human metallothionein-IG gene: Differential promoter activity of two linked metallothionein-I genes in response to heavy metals
    • Foster R, Jahroudi N, Varshney U and Gedamu L (1988) Structure and expression of the human metallothionein-IG gene: Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. J Biol Chem 263:11528-11535.
    • (1988) J Biol Chem , vol.263 , pp. 11528-11535
    • Foster, R.1    Jahroudi, N.2    Varshney, U.3    Gedamu, L.4
  • 7
    • 0028197552 scopus 로고
    • Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan hormone nuclear receptors
    • Giguère V, Tini M, Flock G, Ong E, Evans RM and Otulakowski G (1994) Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan hormone nuclear receptors. Genes Dev 8:538-553.
    • (1994) Genes Dev , vol.8 , pp. 538-553
    • Giguère, V.1    Tini, M.2    Flock, G.3    Ong, E.4    Evans, R.M.5    Otulakowski, G.6
  • 8
    • 0022893665 scopus 로고
    • Tissue-specific in vitro transcription from the mouse albumin promoter
    • Gorski K, Carneiro M and Schibler U (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47:767-776.
    • (1986) Cell , vol.47 , pp. 767-776
    • Gorski, K.1    Carneiro, M.2    Schibler, U.3
  • 9
    • 0027137429 scopus 로고
    • Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control
    • Hashimoto H, Toide K, Kitamura R, Fujita M, Tagawa S, Itoh S and Kamataki T (1993) Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control. Eur J Biochem 218:585-595.
    • (1993) Eur J Biochem , vol.218 , pp. 585-595
    • Hashimoto, H.1    Toide, K.2    Kitamura, R.3    Fujita, M.4    Tagawa, S.5    Itoh, S.6    Kamataki, T.7
  • 10
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski P, Zelko I, Sueyoshi T and Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658.
    • (1998) Mol Cell Biol , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 11
    • 0032568835 scopus 로고    scopus 로고
    • Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression
    • Huss JM and Kasper CB (1998) Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. J Biol Chem 273:16155-16162
    • (1998) J Biol Chem , vol.273 , pp. 16155-16162
    • Huss, J.M.1    Kasper, C.B.2
  • 12
    • 0032906550 scopus 로고    scopus 로고
    • Rifampicin is not an activator of the glucocorticoid receptor in A549 human alveolar cells
    • Jaffuel D, Demoly P, Gougat C, Mautino G, Bousquet J and Mathieu M (1999) Rifampicin is not an activator of the glucocorticoid receptor in A549 human alveolar cells. Mol Pharmacol 56:841-846.
    • (1999) Mol Pharmacol , vol.56 , pp. 841-846
    • Jaffuel, D.1    Demoly, P.2    Gougat, C.3    Mautino, G.4    Bousquet, J.5    Mathieu, M.6
  • 13
    • 0023649643 scopus 로고
    • Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene
    • Jantzen H-M, Strähle U, Gloss B, Stewart F, Schmid W, Boshart M, Miksicek R and Schütz G (1987) Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 49:29-38.
    • (1987) Cell , vol.49 , pp. 29-38
    • Jantzen, H.-M.1    Strähle, U.2    Gloss, B.3    Stewart, F.4    Schmid, W.5    Boshart, M.6    Miksicek, R.7    Schütz, G.8
  • 14
    • 0027289683 scopus 로고
    • Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-4 (HNF-4)
    • Kimura A, Nishiyori A, Murakami T, Tsukamoto T, Hata S, Osumi T, Okamura R, Mori M and Takiguchi M (1993) Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-4 (HNF-4). J Biol Chem 268:11125-11133.
    • (1993) J Biol Chem , vol.268 , pp. 11125-11133
    • Kimura, A.1    Nishiyori, A.2    Murakami, T.3    Tsukamoto, T.4    Hata, S.5    Osumi, T.6    Okamura, R.7    Mori, M.8    Takiguchi, M.9
  • 16
    • 0028918996 scopus 로고
    • Comparitive analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes
    • Kocarek TA, Schuetz EG, Strom SC, Fisher RA and Guzelian PS (1995) Comparitive analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 23:415-421.
    • (1995) Drug Metab Dispos , vol.23 , pp. 415-421
    • Kocarek, T.A.1    Schuetz, E.G.2    Strom, S.C.3    Fisher, R.A.4    Guzelian, P.S.5
  • 18
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Wilson TM, Moore JT and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, Ma.3    Wilson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 19
    • 0029584276 scopus 로고
    • Substrates of human hepatic cytochrome P450 3A4
    • Li AP, Kaminski DL and Rasmussen A (1995) Substrates of human hepatic cytochrome P450 3A4. Toxicology 104:1-8.
    • (1995) Toxicology , vol.104 , pp. 1-8
    • Li, A.P.1    Kaminski, D.L.2    Rasmussen, A.3
  • 20
    • 0023663915 scopus 로고
    • The interplay of DNA-binding proteins on the promoter of the mouse albumin gene
    • Lichtsteiner S, Wuarin J and Schibler U (1987) The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51:963-973.
    • (1987) Cell , vol.51 , pp. 963-973
    • Lichtsteiner, S.1    Wuarin, J.2    Schibler, U.3
  • 21
    • 0031785886 scopus 로고    scopus 로고
    • Seperate and interactive regulation of cytochrome P450 3A4 by triodothyronine, dexamethasone, and growth hormone in cultured hepatocytes
    • Liddle C, Goodwin BJ, George J, Tapner M and Farrell GC (1998) Seperate and interactive regulation of cytochrome P450 3A4 by triodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 83:2411-2416.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2411-2416
    • Liddle, C.1    Goodwin, B.J.2    George, J.3    Tapner, M.4    Farrell, G.C.5
  • 23
    • 0018846636 scopus 로고
    • Sequencing end-labeled DNA with base-specific chemical cleavages
    • Maxam AM and Gilbert W (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol 65:499-560.
    • (1980) Methods Enzymol , vol.65 , pp. 499-560
    • Maxam, A.M.1    Gilbert, W.2
  • 24
    • 0031975185 scopus 로고    scopus 로고
    • Update: Clinically significant cytochrome P-450 drug interactions
    • Michalets EL (1998) Update: Clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 18:84-112.
    • (1998) Pharmacotherapy , vol.18 , pp. 84-112
    • Michalets, E.L.1
  • 25
    • 0028917364 scopus 로고
    • Transcriptional elements directing a liver-specific expression of P450/6βA (CYP3A2) gene-encoding testosterone 6β-hydrxylase
    • Miyata M, Nagata K, Yamazoe Y and Kata R (1995) Transcriptional elements directing a liver-specific expression of P450/6βA (CYP3A2) gene-encoding testosterone 6β-hydrxylase. Arch Biochem Biophys 318:71-89.
    • (1995) Arch Biochem Biophys , vol.318 , pp. 71-89
    • Miyata, M.1    Nagata, K.2    Yamazoe, Y.3    Kata, R.4
  • 27
    • 0033000991 scopus 로고    scopus 로고
    • A human reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro
    • Ogg MS, Williams JM, Tarbit M, Goldfarb PS, Gray TJ and Gibson GG (1999) A human reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica 29:269-279.
    • (1999) Xenobiotica , vol.29 , pp. 269-279
    • Ogg, M.S.1    Williams, J.M.2    Tarbit, M.3    Goldfarb, P.S.4    Gray, T.J.5    Gibson, G.G.6
  • 28
    • 0033080191 scopus 로고    scopus 로고
    • Hepatocyte nulcear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and vErbA-related protein 3
    • Ogino M, Nagata K, Miyata M and Yamazoe Y (1999) Hepatocyte nulcear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and vErbA-related protein 3. Arch Biochem Biophys 362:32-37.
    • (1999) Arch Biochem Biophys , vol.362 , pp. 32-37
    • Ogino, M.1    Nagata, K.2    Miyata, M.3    Yamazoe, Y.4
  • 29
    • 0028971143 scopus 로고
    • MatInd and MatInspector: New fast and versatile tools for detection of concensus matches in nucleotide sequence data
    • Quandt K, Frech K, Karas H, Wingender E and Werner T (1995) MatInd and MatInspector: New fast and versatile tools for detection of concensus matches in nucleotide sequence data. Nucl Acids Res 23:4878-4884.
    • (1995) Nucl Acids Res , vol.23 , pp. 4878-4884
    • Quandt, K.1    Frech, K.2    Karas, H.3    Wingender, E.4    Werner, T.5
  • 32
    • 0025162338 scopus 로고
    • Ig/EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP
    • Roman C, Platero JS, Shuman J and Clamae K (1990) Ig/EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev 4:1404-1415.
    • (1990) Genes Dev , vol.4 , pp. 1404-1415
    • Roman, C.1    Platero, J.S.2    Shuman, J.3    Clamae, K.4
  • 34
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice
    • Schuetz EG, Schinkel AH, Relling MV and Schuetz JD (1996) P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice. Proc Natl Acad Sci USA 93:4001-4005
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 36
    • 0032478735 scopus 로고    scopus 로고
    • The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness
    • Stoltz C, Vachon M-H, Trottier E, Dubois S, Paquet Y and Anderson A (1998) The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J Biol Chem 14:8528-8536.
    • (1998) J Biol Chem , vol.14 , pp. 8528-8536
    • Stoltz, C.1    Vachon, M.-H.2    Trottier, E.3    Dubois, S.4    Paquet, Y.5    Anderson, A.6
  • 37
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P and Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046.
    • (1999) J Biol Chem , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 38
    • 0033054820 scopus 로고    scopus 로고
    • Evaluation of induction of CYP3A mRNA using the HepG2 cell line and reverse transcription-PCR
    • Sumida A, Yamamoto I, Zhou Q, Morisak IT and Azuma J (1999) Evaluation of induction of CYP3A mRNA using the HepG2 cell line and reverse transcription-PCR. Biol Pharm Bull 22:61-65.
    • (1999) Biol Pharm Bull , vol.22 , pp. 61-65
    • Sumida, A.1    Yamamoto, I.2    Zhou, Q.3    Morisak, I.T.4    Azuma, J.5
  • 39
    • 0028283503 scopus 로고
    • Molecular mechansims of action of steroid/thyroid receptor superfamily members
    • Tsai M-J and O'Malley BW (1994) Molecular mechansims of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486.
    • (1994) Annu Rev Biochem , vol.63 , pp. 451-486
    • Tsai, M.-J.1    O'Malley, B.W.2
  • 41
    • 0022006744 scopus 로고
    • Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 in rat
    • Wrighton SA, Schuetz EG, Watkins PB, Maurel P, Barwick J, Bailey BS, Hartle HT, Young B and Guzelian P (1985) Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 in rat. Mol Pharmacol 28:312-321.
    • (1985) Mol Pharmacol , vol.28 , pp. 312-321
    • Wrighton, S.A.1    Schuetz, E.G.2    Watkins, P.B.3    Maurel, P.4    Barwick, J.5    Bailey, B.S.6    Hartle, H.T.7    Young, B.8    Guzelian, P.9


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