CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Drug Metabolism and Disposition

Volumn 30, Issue 7, 2002, Pages 795-804

  Luo, Gang ^a   Cunningham, Mark ^b   Kim, Sean ^a   Burn, Tim ^a   Lin, Jianrong ^c   Sinz, Michael ^d   Hamilton, Geraldine ^a   Rizzo, Christopher ^a   Jolley, Summer ^a   Gilbert, Darryl ^a   Downey, April ^a   Mudra, Daniel ^a   Graham, Richard ^a   Carroll, Kathy ^a   Xie, Jindong ^c   Madan, Ajay ^a   Parkinson, Andrew ^c   Christ, Dave ^d   Selling, Bernard ^a   Lecluyse, Edward ^a   Gan, Liang Shang ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

^b Bristol Myers Squibb Pharma Company ^*

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d XenoTech LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CLOTRIMAZOLE; CYTOCHROME P450 3A4; DEXAMETHASONE; DEXAMETHASONE DERIVATIVE; DEXAMETHASONE TERT BUTYL ACETATE; MESSENGER RNA; METHOTREXATE; PACLITAXEL; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; PROBENECID; RIFAMPICIN; RITONAVIR; SULFADIMIDINE; SULFINPYRAZONE; TROLEANDOMYCIN; UNCLASSIFIED DRUG; CELL RECEPTOR; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; DRUG; STEROID RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MALE; NORTHERN BLOTTING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CHILD; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; LIVER CELL; METABOLISM; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; CELLS, CULTURED; CHILD; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; FEMALE; GENES, REPORTER; HEPATOCYTES; HUMAN; MALE; MIDDLE AGE; PHARMACEUTICAL PREPARATIONS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; HUMANS; MIDDLE AGED;

EID: 0035987895     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.7.795     Document Type: Article

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