Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7

Biochemical and Biophysical Research Communications

Volumn 280, Issue 1, 2001, Pages 139-144

  Bertilsson, Göran ^a   Berkenstam, Anders ^b   Blomquist, Patrik ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Pharmacia Corporation   (Sweden)

Author keywords

CAR; CYP3A4; CYP3A7; NR1I2; NR1I3; Nuclear receptor; PAR; PXR; SXR; Xenobiotic response element module

Indexed keywords

CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHORME P450 3A7; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; XENOBIOTIC METABOLISM;

RICKETTSIA SP. PAR;

EID: 0034811083     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4066     Document Type: Article

References (25)

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3. Update: Clinically significant cytochrome P-450 drug interactions
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6. CYP3A gene expression in human gut epithelium
7. Cytochrome P450 CYP3A in human renal cell cancer
8. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta
9. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
10. The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture
11. Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes
12. An orphan nuclear receptor activated by pregnanes defines a novel steroiid signaling pathway
13. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
14. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
15. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
16. CXR, a chicken xenobiotic-sensing orphan nuclear receptor is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)
17. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
18. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
19. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
20. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
21. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
22. Humanized xenobiotic response in mice expressing nuclear receptor SXR
23. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
24. A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy
25. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta