Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

Gastroenterology

Volumn 134, Issue 2, 2008, Pages

  Zhou, Jie ^a   Febbraio, Maria ^b   Wada, Taira ^a   Zhai, Yonggong ^a   Kuruba, Ramalinga ^a   He, Jinhan ^a   Lee, Jung Hoon ^a   Khadem, Shaheen ^a   Ren, Songrong ^a   Li, Song ^a   Silverstein, Roy L ^b   Xie, Wen ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA BINDING; FATTY LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TARGETING; REPORTER GENE;

EID: 38649096259     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.11.037     Document Type: Article

References (47)

1. Repa J.J., Liang G., Ou J., et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev 14 (2000) 2819-2830
2. Schultz J.R., Tu H., Luk A., et al. Role of LXRs in control of lipogenesis. Genes Dev 14 (2000) 2831-2838
3. Peet D.J., Turley S.D., Ma W., et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α. Cell 93 (1998) 693-704
4. Joseph S.B., Laffitte B.A., Patel P.H., et al. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem 277 (2002) 11019-11025
5. Chawla A., Repa J.J., Evans R.M., et al. Nuclear receptors and lipid physiology: opening the X-files. Science 294 (2001) 1866-1870
6. Repa J.J., and Mangelsdorf D.J. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med 8 (2002) 1243-1248
7. Francis G.A., Annicotte J.S., and Auwerx J. Liver X receptors: Xcreting Xol to combat atherosclerosis. Trends Mol Med 8 (2002) 455-458
8. Zelcer N., and Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116 (2006) 607-614
9. Bradbury M.W. Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 290 (2006) G194-G198
10. Seo J.B., Moon H.M., Kim W.S., et al. Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression. Mol Cell Biol 24 (2004) 3430-3444
11. Cha J.Y., and Repa J.J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 282 (2007) 743-751
12. Chu K., Miyazaki M., Man W.C., et al. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol 26 (2006) 6786-6798
13. Zhang Y., Repa J.J., Gauthier K., et al. Regulation of lipoprotein lipase by the oxysterol receptors, LXRα and LXRβ. J Biol Chem 276 (2001) 43018-43024
14. Inoue M., Ohtake T., Motomura W., et al. Increased expression of PPARγ in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 336 (2005) 215-222
15. Yu S., Matsusue K., Kashireddy P., et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression. J Biol Chem 278 (2003) 498-505
16. Schadinger S.E., Bucher N.L.R., Schreiber B.M., et al. PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am J Physiol Endocrinol Metab 288 (2005) E1195-E1205
17. Abumrad N.A., El-Maghrabi M.R., Amri E.Z., et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 268 (1993) 17665-17668
18. Endemann G., Stanton L.W., Madden K.S., et al. CD36 is a receptor for oxidized low-density lipoprotein. J Biol Chem 268 (1993) 11811-11816
19. Cohen P.A., Frazier W.A., Hoff H.F., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105 (2000) 1095-1108
20. Febbraio M., Guy E., Coburn C., et al. The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. Mol Cell Biochem 239 (2002) 193-197
21. Coburn C.T., Knapp Jr. F.F., Febbraio M., et al. Defective uptake and utilization of long-chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem 275 (2000) 32523-32529
22. Febbraio M., Abumrad N.A., Hajjar D.P., et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274 (1999) 19055-19062
23. Febbraio M., Podrez E.A., Smith J.D., et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest 105 (2000) 1049-1056
24. Rahaman S.O., Lennon D.J., Febbraio M., et al. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4 (2006) 211-221
25. Tontonoz P., Nagy L., Alvarez J.G., et al. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 (1998) 241-252
26. Zhou J., Zhai Y., Mu Y., et al. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281 (2006) 15013-15020
27. Gong H., Singh S.V., Singh S.P., et al. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20 (2006) 279-290
28. Uppal H., Saini S.P.S., Moschetta A., et al. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology 45 (2007) 422-432
29. Collins J.L., Fivush A.M., Watson M.A., et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45 (2002) 1963-1966
30. Saini S.P., Mu Y., Gong H., et al. Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. Hepatology 41 (2005) 497-505
31. Uppal H., Toma D., Saini S.P., et al. Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology 41 (2005) 168-176
32. Xie W., Barwick J.L., Simon C.M., et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14 (2000) 3014-3023
33. Saini S.P., Sonoda J., Xu L., et al. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol 65 (2004) 292-300
34. Matsuzaka T., Shimano H., Yahagi N., et al. Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J Lipid Res 43 (2002) 911-920
35. Goudriaan J.R., Dahlmans V.E., Teusink B., et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res 44 (2003) 2270-2277
36. Hajri T., Han X.X., Bonen A., et al. Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest 109 (2002) 1381-1389
37. Deng R., Yang D., Yang J., et al. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. J Pharmacol Exp Ther 317 (2006) 317-325
38. Xie W., Barwick J.L., Downes M., et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406 (2000) 435-439
39. Nassir F., Wilson B., Han X., et al. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem 282 (2007) 19493-19501
40. Kliewer S.A., Moore J.T., Wade L., et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 (1998) 73-82
41. Heron-Mihavet L., Haluzik M., Yakar S., et al. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology 145 (2004) 4667-4676
42. Luiken J.J., Koonen D.P., Coumans W.A., et al. Long-chain fatty acid uptake by skeletal muscle is impaired in homozygous, but not heterozygous, heart-type-FABP null mice. Lipids 38 (2003) 491-496
43. Podrez E.A., Poliakov E., Shen Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem 277 (2002) 38517-38523
44. Marleau S., Harb D., Bujold K., et al. EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. FASEB J 19 (2005) 1869-1871
45. Motojima K., Passilly P., Peters J.M., et al. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J Biol Chem 273 (1998) 16710-16714
46. Chawla A., Boisvert W.A., Lee C.H., et al. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenes. Mol Cell 7 (2001) 161-171
47. Hummasti S., Laffitte B.A., Watson M.A., et al. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res 45 (2004) 616-625