ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics

Xenobiotica

Volumn 36, Issue 10-11, 2006, Pages 989-1012

  Finkelstein, D ^a   Lamba, V ^a   Assem, M ^a   Rengelshausen, J ^a   Yasuda, K ^a   Strom, S ^b   Schuetz, E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Absorption; Constitutive androstane receptor; Constitutive androstane receptor (CAR); Distribution; Metabolism and excretion (ADME); NR1I3

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1 I3; PHENOBARBITAL; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADME GENE; ARTICLE; CAUCASIAN; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; FEMALE; HISPANIC; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER TRANSPLANTATION; MALE; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RACE DIFFERENCE; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; AGED; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISPANIC AMERICANS; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PHENOBARBITAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TISSUE DONORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; XENOBIOTICS;

EID: 33751573877     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250600861769     Document Type: Article

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