Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1454-1459

  Hustert, Elisabeth ^b   Zibat, Arne ^b   Presecan Siedel, Elena ^b   Eiselt, Regina ^b   Mueller, Romy ^b   Fuß, Christine ^b   Brehm, Ilka ^b   Brinkmann, Ulrich ^b   Eichelbaum, Michel ^a,c   Wojnowski, Leszek ^b   Burk, Oliver ^a  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b Epidauros Biotechnologie AG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; CYTOCHROME P450 3A4; PREGNANE X RECEPTOR; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CAUCASIAN; CELL LINE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; MISSENSE MUTATION; NEGRO; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN VARIANT; REPORTER GENE; TRANSACTIVATION;

AFRICAN CONTINENTAL ANCESTRY GROUP; CYTOCHROME P-450 ENZYME SYSTEM; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; LIVER; MIXED FUNCTION OXYGENASES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0034777488     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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