Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9674-9680

  Takagi, Shingo ^a   Nakajima, Miki ^a   Mohri, Takuya ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MODULATION; NUCLEIC ACIDS; PROTEINS; RNA; TRANSCRIPTION FACTORS;

CYTOCHROME P450 3A4; EXPRESSION LEVELS; HUMAN LIVERS; INDUCIBLE EXPRESSIONS; MRNA LEVELS; OVEREXPRESSION; PREGNANE X RECEPTORS; PROTEIN LEVELS; RECOGNITION ELEMENTS; REPORTER ASSAYS; TRANSCRIPTIONAL REGULATIONS; TRANSLATIONAL EFFICIENCIES; UNTRANSLATED REGIONS;

ANIMAL CELL CULTURE;

CYTOCHROME P450 3A4; MICRORNA; PREGNANE X RECEPTOR; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; STEROID RECEPTOR;

3' UNTRANSLATED REGION; ARTICLE; ENZYME MECHANISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER METABOLISM; MOLECULAR RECOGNITION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; BIOSYNTHESIS; CELL STRAIN CACO 2; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; PHYSIOLOGY; PROTEIN SYNTHESIS;

3' UNTRANSLATED REGIONS; CACO-2 CELLS; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIVER; MICRORNAS; PROTEIN BIOSYNTHESIS; RECEPTORS, STEROID;

EID: 44349182094     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709382200     Document Type: Article

References (30)

1. Kliewer, S. A., Goodwin, B., and Willson, T. M. (2002) Endocr. Rev. 23, 687-702
2. Meijerman, I., Beijnen, J. H., and Schellens, J. H. (2006) Oncologist 11, 742-752
3. Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., Willson, T. M., Koller, B. H., and Kliewer, S. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3369-3374
4. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3375-3380
5. Blumberg, B., Sabbagh, W., Jr., Juguilon, H., Bolado, J., Jr., van Meter, C. M., Ong, E. S., and Evans, R. M. (1998) Genes Dev. 12, 3195-3205
6. Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., and Kliewer, S. A. (1998) J. Clin. Invest. 102, 1016-1023
7. Goodwin, B., Hodgson, E., and Liddle, C. (1999) Mol. Pharmacol. 56, 1329-1339
8. Ozdemir, V., Kalowa, W., Tang, B. K., Paterson, A. D., Walker, S. E., Endrenyi, L., and Kashuba, A. D. (2000) Pharmacogenetics 10, 373-388
9. Lamba, J. K., Lin, Y. S., Thummel, K., Daly, A., Watkins, P. B., Strom, S., Zhang, J., and Schuetz, E. G. (2002) Pharmacogenetics 12, 121-132
10. Floyd, M. D., Gervasini, G., Masica, A. L., Mayo, G., George, A. L., Jr., Bhat, K., Kim, R. B., and Wilkinson, G. R. (2003) Pharmacogenetics 13, 595-606
11. Martínez-Jiménez, C. P., Jover, R., Donato, M. T., Castell, J. V., and Gómez-Lechón, M. J. (2007) Curr. Drug Metab. 8, 185-194
12. Kretschmer, X. C., and Baldwin, W. S. (2005) Chem. Biol. Interact. 155, 111-128
13. Pascussi, J. M., Drocourt, L., Fabre, J. M., Maurel, P., and Vilarem, M. J. (2000) Mol. Pharmacol. 58, 361-372
14. Aouabdi, S., Gibson, G., and Plant, N. (2006) Drug Metab. Dispos. 34, 138-144
15. Griffiths-Jones, S. (2004) Nucleic Acids Res. 32, D109-D111
16. Bartel, D. P. (2004) Cell 116, 281-297
17. Lewis, B. P., Burge, C. B., and Bartel, D. P. (2005) Cell 120, 15-20
18. Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., and Kellis, M. (2005) Nature 434, 338-345
19. Tsuchiya, Y., Nakajima, M., Kyo, S., Kanaya, T., Inoue, M., and Yokoi, T. (2004) Cancer Res. 64, 3119-3125
20. Tsuchiya, Y., Nakajima, M., Takagi, S., Taniya, T., and Yokoi, T. (2006) Cancer Res. 66, 9090-9098
21. Takada, T., Ogino, M., Miyata, M., Shimada, M., Nagata, K., and Yamazoe, Y. (2004) Drug Metab. Pharmacokinet. 19, 103-113
22. Barad, O., Meiri, E., Avniel, A., Aharonov, R., Barzilai, A., Bentwich, I., Einav, U., Gilad, S., Hurban, P., Karov, Y., Lobenhofer, E. K., Sharon, E., Shiboleth, Y. M., Shtutman, M., Bentwich, Z., and Einat, P. (2004) Genome Res. 14, 2486-2494
23. Rehmsmeier, M., Steffen, P., Hochsmann, M., and Giegerich, R. (2004) RNA 10, 1507-1517
24. Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P., and Berkenstam, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12208-12213
25. Dotzlaw, H., Leygue, E., Watson, P., and Murphy, L. C. (1999) Clin. Cancer Res. 5, 2103-2107
26. Lamba, V., Yasuda, K., Lamba, J. K., Assem, M., Davila, J., Strom, S., and Schuetz, E. G. (2004) Toxicol. Appl. Pharmacol. 199, 251-265
27. Synold, T. W., Dussault, I., and Forman, B. M. (2001) Nat. Med. 7, 584-590
28. Goodwin, B., Moore, L. B., Stoltz, C. M., McKee, D. D., and Kliewer, S. A. (2001) Mol. Pharmacol. 60, 427-431
29. Westlind-Johnsson, A., Malmebo, S., Johansson, A., Otter, C., Andersson, T. B., Johansson, I., Edwards, R. J., Boobis, A. R., and Ingelman-Sundberg, M. (2003) Drug Metab. Dispos. 31, 755-761
30. Watanabe, M., Kumai, T., Matsumoto, N., Tanaka, M., Suzuki, S., Satoh, T., and Kobayashi, S. (2004) J. Pharmacol. Sci. 94, 459-462