A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

Drug Metabolism and Disposition

Volumn 36, Issue 12, 2008, Pages 2506-2512

  Ma, Xiaochao ^a,c   Cheung, Connie ^a,d   Krausz, Kristopher W ^a   Shah, Yatrik M ^a   Wang, Ting ^a   Idle, Jeffrey R ^b   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ALPHA HYDROXYMIDAZOLAM; AMPRENAVIR; CYTOCHROME P450 3A4; KETOCONAZOLE; MIDAZOLAM; NELFINAVIR; PREGNANE X RECEPTOR; PROTEINASE INHIBITOR; RIFAMPICIN; SAQUINAVIR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STABILITY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEMALE; GENE EXPRESSION; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPECIES DIFFERENCE; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE; TRANSGENICS; WESTERN BLOTTING;

ANIMALS; CARBAMATES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HIV PROTEASE INHIBITORS; HUMANS; INTESTINE, SMALL; KETOCONAZOLE; LIVER; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSOMES, LIVER; MODELS, ANIMAL; NELFINAVIR; PREGNENOLONE CARBONITRILE; RECEPTORS, STEROID; RIFAMPIN; SAQUINAVIR; SEX CHARACTERISTICS; SULFONAMIDES;

BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS; MUS; MUS MUSCULUS; MYCOBACTERIUM TUBERCULOSIS; RODENTIA;

EID: 57349179929     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.022723     Document Type: Article

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