A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane X receptor

Drug Metabolism and Disposition

Volumn 37, Issue 4, 2009, Pages 719-730

  Pondugula, Satyanarayana R ^a   Brimer Cline, Cynthia ^a   Wu, Jing ^a   Schuetz, Erin G ^a   Tyagi, Rakesh K ^b   Chen, Taosheng ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; PREGNANE X RECEPTOR; PROTEIN P70; S6 KINASE; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; THREONINE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL NUCLEUS; CYTOCHROME P-450 CYP3A; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR MIMICRY; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECEPTORS, STEROID; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; THREONINE; TRANSCRIPTIONAL ACTIVATION;

MAMMALIA;

EID: 63849272898     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.024695     Document Type: Article

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