Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 39411-39418

  Schuetz, Erin G ^a   Strom, Stephen ^b   Yasuda, Kazuto ^a   Lecureur, Valerie ^a   Assem, Mahfoud ^a   Brimer, Cynthia ^a   Lamba, Jatinder ^a   Kim, Richard B ^d   Ramachandran, Vinod ^c   Komoroski, Bernard J ^c   Venkataramanan, Raman ^b,c   Cai, Hongbo ^b   Sinal, Christopher J ^e   Gonzalez, Frank J ^e   Schuetz, John D ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERS; ENZYMES; HORMONES; METABOLISM; TOXICITY;

HEPATIC TRANSPORTERS; NUCLEAR HORMONE RECEPTORS;

BIOCHEMISTRY;

BILE ACID; BILE ACID RECEPTOR; BILE SALT; CHOLIC ACID; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; FARNESYL RECEPTOR; GLYCOPROTEIN P; HORMONE RECEPTOR; LIGAND; NUCLEAR HORMONE RECEPTOR; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; XENOBIOTIC RECEPTOR; ABC TRANSPORTER; ABCB11 PROTEIN, HUMAN; ABCB11 PROTEIN, MOUSE; ABCC4 PROTEIN, HUMAN; ABCC4 PROTEIN, MOUSE; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; LUCIFERASE; MIXED FUNCTION OXIDASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; RIBOSOME PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHOBICITY; LIVER CELL CULTURE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; TRANSCRIPTION INITIATION; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CELL NUCLEUS; CHEMISTRY; DIMERIZATION; DOSE RESPONSE; DOWN REGULATION; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; LIVER; LIVER CELL; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BILE ACIDS AND SALTS; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENES, REPORTER; HEPATOCYTES; HUMANS; IMMUNOBLOTTING; LIGANDS; LIVER; LUCIFERASES; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSFECTION; UP-REGULATION; URSODEOXYCHOLIC ACID;

EID: 0035914467     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106340200     Document Type: Article

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