Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C

Biochemical Pharmacology

Volumn 69, Issue 5, 2005, Pages 867-873

  Ding, Xunshan ^a   Staudinger, Jeff L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

CYP3A; Inflammation; PCN; PKC; PMA; Pregnane X receptor

Indexed keywords

CYTOCHROME P450 3A; NUCLEAR RECEPTOR COREPRESSOR; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PREGNANE X RECEPTOR; PROTEIN KINASE C ALPHA; STEROID RECEPTOR COACTIVATOR 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSFECTION; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 13844253850     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.11.025     Document Type: Article

References (34)

1. P. Bankey, A. Carlson, M. Ortiz, R. Singh, and F. Cerra Tumor necrosis factor production by Kupffer cells requires protein kinase C activation J Surg Res 49 3 1990 256 261
2. M.M. Sayeed Alterations in calcium signaling and cellular responses in septic injury New Horiz 4 1 1996 72 86
3. J. Muntane-Relat, J.C. Ourlin, J. Domergue, and P. Maurel Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture Hepatology 22 4 Pt 1 1995 1143 1153
4. Z. Abdel-Razzak, P. Loyer, A. Fautrel, J.C. Gautier, L. Corcos, and B. Turlin Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture Mol Pharmacol 44 4 1993 707 715
5. C.E. Haas, D.C. Kaufman, C.E. Jones, A.H. Burstein, and W. Reiss Cytochrome P4503A4 activity after surgical stress Crit Care Med 31 5 2003 1338 1346
6. E.L. Michalets Update: clinically significant cytochrome P-450 drug interactions Pharmacotherapy 18 1 1998 84 112
7. C. Rochette-Egly Nuclear receptors: integration of multiple signalling pathways through phosphorylation Cell Signal 15 4 2003 355 366
8. J.E. Bodwell, E. Orti, J.M. Coull, D.J. Pappin, L.I. Smith, and F. Swift Identification of phosphorylated sites in the mouse glucocorticoid receptor J Biol Chem 266 12 1991 7549 7555
9. W. Bai, and N.L. Weigel Phosphorylation of Ser211 in the chicken progesterone receptor modulates its transcriptional activity J Biol Chem 271 22 1996 12801 12806
10. S.F. Arnold, J.D. Obourn, M.R. Yudt, T.H. Carter, and A.C. Notides In vivo and in vitro phosphorylation of the human estrogen receptor J Steroid Biochem Mol Biol 52 2 1995 159 171
11. D. Katz, M.J. Reginato, and M.A. Lazar Functional regulation of thyroid hormone receptor variant TR alpha 2 by phosphorylation Mol Cell Biol 15 5 1995 2341 2348
12. J.C. Hsieh, P.W. Jurutka, S. Nakajima, M.A. Galligan, C.A. Haussler, and Y. Shimizu Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site J Biol Chem 268 20 1993 15118 15126
13. H. Hara, Y. Yasunami, and T. Adachi Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells Biochem Biophys Res Commun 296 1 2002 182 188
14. B. Blumberg, W. Sabbagh Jr., H. Juguilon, J. Bolado Jr., C.M. van Meter, and E.S. Ong SXR, a novel steroid and xenobiotic-sensing nuclear receptor Genes Dev 12 20 1998 3195 3205
15. G. Bertilsson, J. Heidrich, K. Svensson, M. Asman, L. Jendeberg, and M. Sydow-Backman Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction Proc Natl Acad Sci USA 95 21 1998 12208 12213
16. S.A. Kliewer, J.T. Moore, L. Wade, J.L. Staudinger, M.A. Watson, and S.A. Jones An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 92 1 1998 73 82
17. J.M. Lehmann, D.D. McKee, M.A. Watson, T.M. Willson, J.T. Moore, and S.A. Kliewer The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions J Clin Invest 102 5 1998 1016 1023
18. B. Goodwin, E. Hodgson, and C. Liddle The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module Mol Pharmacol 56 6 1999 1329 1339
19. L.B. Moore, J.M. Maglich, D.D. McKee, B. Wisely, T.M. Willson, and S.A. Kliewer Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors Mol Endocrinol 16 5 2002 977 986
20. E.L. LeCluyse Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation Eur J Pharm Sci 13 4 2001 343 368
21. G. James, and E. Olson Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting J Cell Biol 116 4 1992 863 874
22. T.W. Synold, I. Dussault, and B.M. Forman The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux Nat Med 7 5 2001 584 590
23. D.E. Brobst, X. Ding, K.L. Creech, B. Goodwin, B. Kelley, and J.L. Staudinger Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor J Pharmacol Exp Ther 310 2 2004 528 535
24. Ding X, Staudinger J. Induction of drug metabolism by forskolin, the role of the pregnane X receptor and the PKA signal transduction pathway. J Pharmacol Exp Ther, in press; doi:10.1124/jpet.104.076331.
25. H. Sterling, D.H. Lin, Y.J. Chen, Y. Wei, Z.J. Wang, and J. Lai PKC expression is regulated by dietary K intake and mediates internalization of SK channels in the CCD Am J Physiol Renal Physiol 286 6 2004 F1072 F1078
26. T. Kawamoto, T. Sueyoshi, I. Zelko, R. Moore, K. Washburn, and M. Negishi Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene Mol Cell Biol 19 9 1999 6318 6322
27. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, and A. LaTour The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc Natl Acad Sci USA 98 6 2001 3369 3374
28. A. Takeshita, M. Taguchi, N. Koibuchi, and Y. Ozawa Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics J Biol Chem 277 36 2002 32453 32458
29. E.T. Morgan Regulation of cytochromes P450 during inflammation and infection Drug Metab Rev 29 4 1997 1129 1188
30. A.J. Horlein, A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, and R. Kurokawa Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor Nature 377 6548 1995 397 404
31. H.J. Huang, J.D. Norris, and D.P. McDonnell Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists Mol Endocrinol 16 8 2002 1778 1792
32. L. Alland, R. Muhle, H. Hou Jr., J. Potes, L. Chin, and N. Schreiber-Agus Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression Nature 387 6628 1997 49 55
33. M. Ishaq, G. DeGray, and V. Natarajan Protein kinase C theta modulates nuclear receptor-corepressor interaction during T cell activation J Biol Chem 278 41 2003 39296 39302
34. J.M. Pascussi, S. Gerbal-Chaloin, L. Pichard-Garcia, M. Daujat, J.M. Fabre, and P. Maurel Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes Biochem Biophys Res Commun 274 3 2000 707 713