Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: Roles of hepatocyte nuclear factor 4α and pregnane X receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 2, 2007, Pages 586-598

  Fang, Hai Lin ^a   Strom, Stephen C ^b   Ellis, Ewa ^b   Duanmu, Zhengbo ^a   Fu, Jiaqi ^a   Duniec Dmuchowski, Zofia ^a   Falany, Charles N ^c   Falany, Josie L ^c   Kocarek, Thomas A ^a   Runge Morris, Melissa ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c The Purdue Univ Univ of Alabama at Birmingham Botanical Center for Age Related Disease   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYDROXYSTEROID SULFOTRANSFERASE; LIVER ENZYME; PREGNANE X RECEPTOR; RIFAMPICIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 ENZYME SYSTEM; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; PROMOTER REGIONS (GENETICS); RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; SULFOTRANSFERASES; TRANSCRIPTION, GENETIC;

EID: 35548997887     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.124610     Document Type: Article

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