Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts

Biochemical and Biophysical Research Communications

Volumn 310, Issue 3, 2003, Pages 824-829

  Hayashi, Asako ^a   Suzuki, Hiroshi ^a   Itoh, Ken ^b   Yamamoto, Masayuki ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Induction; Mrp1; Nrf2; Oxidative stress

Indexed keywords

2,4 DINITROPHENYL S GLUTATHIONE; GLUTATHIONE DERIVATIVE; MALEIC ACID DIETHYL ESTER; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEAR FACTOR ERYTHROID 2 P45 RELATED FACTOR 2; TRANSCRIPTION FACTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONJUGATE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; WILD TYPE;

EID: 0141534255     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.086     Document Type: Article

References (24)

1. Ishikawa T., Li Z.S., Lu Y.P., Rea P.A. The GS-X pump in plant, yeast, and animal cells: structure, function, and gene expression. Biosci. Rep. 17:1997;189-207.
2. Suzuki H., Sugiyama Y. Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur. J. Pharm. Sci. 12:2000;3-12.
3. Suzuki H., Sugiyama Y. Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. Adv. Drug Deliv. Rev. 54:2002;1311-1331.
4. Keppler D., König J. Hepatic secretion of conjugated drugs and endogenous substances. Semin. Liver Dis. 20:2000;265-272.
5. Ishikawa T., Bao J.J., Yamane Y., Akimaru K., Frindrich K., Wright C.D., Kuo M.T. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J. Biol. Chem. 271:1996;14981-14988.
6. Kuo M.T., Bao J.J., Curley S.A., Ikeguchi M., Johnston D.A., Ishikawa T. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res. 56:1996;3642-3644.
7. Yamane Y., Furuichi M., Song R., Van N.T., Mulcahy R.T., Ishikawa T., Kuo M.T. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. J. Biol. Chem. 273:1998;31075-31085.
8. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236:1997;313-322.
9. Hayes J.D., McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 174:2001;103-113.
10. Hayes J.D., Chanas S.A., Henderson C.J., McMahon M., Sun C., Moffat G.J., Wolf C.R., Yamamoto M. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem. Soc. Trans. 28:2000;33-41.
11. Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., Yamamoto M. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J. Biol. Chem. 275:2000;16023-16029.
12. Enomoto A., Itoh K., Nagayoshi E., Haruta J., Kimura T., O'Connor T., Harada T., Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59:2001;169-177.
13. Chan J.Y., Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim. Biophys. Acta. 1517:2000;19-26.
14. McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., Wolf C.R., Cavin C., Hayes J.D. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 61:2001;3299-3307.
15. Ramos-Gomez M., Kwak M.K., Dolan P.M., Itoh K., Yamamoto M., Talalay P., Kensler T.W. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. USA. 98:2001;3410-3415.
16. Chanas S.A., Jiang Q., McMahon M., McWalter G.K., McLellan L.I., Elcombe C.R., Henderson C.J., Wolf C.R., Moffat G.J., Itoh K., Yamamoto M., Hayes J.D. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem. J. 365:2002;405-416.
17. Sasaki H., Sato H., Kuriyama-Matsumura K., Sato K., Maebara K., Wang H., Tamba M., Ktoh K., Yamamoto M., Bannai S. Electrophile responsible element-mediated induction of the cystine/glutamate exchange transporter gene expression. J. Biol. Chem. 277:2002;44765-44771.
18. Kauffmann H.M., Pfannschmidt S., Zoller H., Benz A., Vorderstemann B., Webster J.I., Schrenk D. Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 171:2002;137-146.
19. Suzuki M., Suzuki H., Sugimoto Y., Sugiyama Y. ABCG2 transports sulfated conjugates of steroids and xenobiotics. J. Biol. Chem. 278:2003;22644-22649.
20. Motohashi H., O'Connor T., Katsuoka F., Engel J.E., Yamamoto M. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene. 294:2002;1-12.
21. Leslie E.M., Deeley R.G., Cole S.P. Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. Toxicology. 167:2001;3-23.
22. Borst P., Elferink R.O. Mammalian ABC transporters in health and disease. Annu. Rev. Biochem. 71:2002;537-592.
23. Wijnholds J., Evers R., van Leusden M.R., Mol C.A., Zaman G.J., Mayer U., Beijnen J.H., van der Valk M., Krimpenfort P., Borst P. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat. Med. 3:1997;1275-1279.
24. Lorico A., Rappa G., Finch R.A., Yang D., Flavell R.A., Sartorelli A.C. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 57:1997;5238-5242.