Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme

British Journal of Clinical Pharmacology

Volumn 67, Issue 2, 2009, Pages 255-261

  Wang, Xue Ding ^c   Li, Jia Li ^c   Su, Qi Biao ^c   Guan, Su ^c   Chen, Jie ^d   Du, Jun ^e   He, Yu Wen ^e   Zeng, Jun ^e   Zhang, Jin Xin ^a   Chen, Xiao ^d   Huang, Min ^a,b   Zhou, Shu Feng ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b RMIT UNIVERSITY   (Australia)

^c Sun Yat Sen University East Campus   (China)

^d First Affiliated Hospital   (China)

^e Centre of Microbiology Biochemistry and Pharmacology

Author keywords

CYP3A4; Haplotype; Induction; PXR; St John's wort

Indexed keywords

CYTOCHROME P450 3A4; DEHYDRONIFEDIPINE; NIFEDIPINE; PREGNANE X RECEPTOR;

ADULT; ARTICLE; CHINESE; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENE; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; HYPERICUM PERFORATUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PXR GENE; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM;

AREA UNDER CURVE; BICYCLO COMPOUNDS; CYTOCHROME P-450 CYP3A; FEMALE; HAPLOTYPES; HUMANS; HYPERICUM; MALE; PERYLENE; PHLOROGLUCINOL; PLANT PREPARATIONS; RECEPTORS, STEROID; TERPENES; YOUNG ADULT;

EID: 61349163526     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2008.03344.x     Document Type: Article

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