A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

Journal of Biological Chemistry

Volumn 278, Issue 16, 2003, Pages 14146-14152

  Wang, Hongbing ^a   Faucette, Stephanie ^a   Sueyoshi, Tatsuya ^b   Moore, Rick ^b   Ferguson, Stephen ^b   Negishi, Masahiko ^b   LeCluyse, Edward L ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; CHEMICAL ACTIVATION; DRUG PRODUCTS; METABOLISM;

XENOBIOTICS;

GENETIC ENGINEERING;

ANDROSTANE DERIVATIVE; ANDROSTANE RECEPTOR; CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B6; DEXAMETHASONE; HORMONE RECEPTOR; IFOSFAMIDE; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; LIGAND; LUCIFERASE; N DEMETHYLASE; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG METABOLISM; ENHANCER REGION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; PHENOBARBITAL RESPONSIVE ENHANCER MODULE; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM; ANIMAL; BIOSYNTHESIS; DIMERIZATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; LIVER; LIVER MICROSOME; METABOLISM; MOUSE; PLASMID; PROTEIN BINDING; PROTEIN MOTIF; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION; WESTERN BLOTTING;

AMINO ACID MOTIFS; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOPHOSPHAMIDE; DIMERIZATION; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPATOCYTES; HUMANS; IFOSFAMIDE; LIGANDS; LIVER; LUCIFERASES; MICE; MICROSOMES, LIVER; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RIFAMPIN; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; XENOBIOTICS;

EID: 0037515661     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212482200     Document Type: Article

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