Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats

Toxicological Sciences

Volumn 84, Issue 2, 2005, Pages 232-242

  Wong, Harvey ^a,b,f   Lehman McKeeman, Lois D ^b,f   Grubb, Mary F ^b,f   Grossman, Scott J ^b,f   Bhaskaran, Vasanthi M ^b,f   Solon, Eric G ^b,c,f   Shen, Helen S ^b,c,f   Gerson, Ronald J ^b,d,f   Car, Bruce D ^b,f   Zhao, Bitao ^b,e,f   Gemzik, Brian ^b,f  

^a GENENTECH INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c Quest Pharmaceutical Services   (United States)

^d Endo Pharmaceuticals   (United States)

^e Experimental Station   (United States)

^f NONE   (United States)

Author keywords

Biliary clearance; Hepatic transporters; Oatp2; Rat; Thyroid stimulating hormone; Thyroxine; Triiodothyronine

Indexed keywords

4 (3 PENTYLAMINO) 2,7 DIMETHYL 8 (2 METHYL 4 METHOXYPHENYL)PYRAZOLO[1,5 A]PYRIMIDINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CYTOCHROME P450 2B1; CYTOCHROME P450 3A1; DMP 904; GLUCURONOSYLTRANSFERASE 1A1; LIOTHYRONINE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PHENOBARBITAL; PREGNANE X RECEPTOR; PROPYLTHIOURACIL; THYROTROPIN; THYROXINE; THYROXINE I 125; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CARCINOGENESIS; CELL HYPERPLASIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; GENE SEQUENCE; HEPATOBILIARY SYSTEM; HOMEOSTASIS; LIVER; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THYROID FOLLICLE CELL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; AUTORADIOGRAPHY; BILE; CORTICOTROPIN-RELEASING HORMONE; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONOSYLTRANSFERASE; HOMEOSTASIS; LIVER; MALE; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 20244363792     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi094     Document Type: Article

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