Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner

Journal of Nutrition

Volumn 139, Issue 5, 2009, Pages 898-904

  Ricketts, Marie Louise ^a   Li, Yilan ^a   Ross Viola, Jennifer S ^d   Shay, Neil F ^b   Moore, David D ^c  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; DAIDZEIN; EQUOL; GENISTEIN; MESSENGER RNA; PREGNANE X RECEPTOR; SOYBEAN PROTEIN; STEROID RECEPTOR COACTIVATOR 1; CYP3A11 PROTEIN, MOUSE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; ISOFLAVONE DERIVATIVE; MEMBRANE PROTEIN; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPECIES DIFFERENCE; TWO HYBRID SYSTEM; WILD TYPE; ANIMAL; CERCOPITHECUS; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; LIVER CELL CARCINOMA; LIVER TUMOR; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROMOTER REGION; TUMOR CELL LINE;

MAMMALIA; MURINAE; MUS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION; GENISTEIN; HUMANS; ISOFLAVONES; KIDNEY; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RECEPTORS, STEROID; RNA, MESSENGER; SPECIES SPECIFICITY; TRANSFECTION;

EID: 65349184457     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.103572     Document Type: Article

References (37)

1. Demonty I, Lamarche B, Jones PJ. Role of isoflavones in the hypocholesterolemic effect of soy. Nutr Rev. 2003;61:189-203.
2. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr. 2005;81:397-408.
3. Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK, Markkanen MH, Makela TH, Wahala KT, et al. Soybean phytoestrogen intake and cancer risk. J Nutr. 1995; 125 Suppl 3:S757-70.
4. Adlercreutz H, Hamalainen E, Gorbach S, Goldin B. Dietary phytooestrogens and the menopause in Japan. Lancet. 1992;339:1233.
5. Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake and body composition in postmenopausal women. Menopause. 2003; 10:427-32.
6. Lichtenstein AH. Soy protein, isoflavones and cardiovascular disease risk. J Nutr. 1998;128:1589-92.
7. Kim S, Shin HJ, Kim SY, Kim JH, Lee YS, Kim DH, Lee MO. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol. 2004;220:51-8.
8. Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Lowik CW. Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein. J Biol Chem. 2003; 278:962-7.
9. Mezei O, Banz WJ, Steger RW, Peluso MR, Winters TA, Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr. 2003;133:1238-43.
10. Mullen E, Brown RM, Osborne TF, Shay NF. Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBPregulated genes in HepG2 cells. J Nutr. 2004;134:2942-7.
11. Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J Nutr. 2002;132:3577-84.
12. Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature.2000;406:435-9.
13. Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. PNAS 2001;98:3369-74.
14. Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, et al. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol. 2000;14:27-39.
15. Honkakoski P, Sueyoshi T, Negishi M. Drug-activated nuclear receptors CAR and PXR. Ann Med. 2003;35:172-82.
16. Nebert DW, Gonzalez FJ. P450 genes: structure, evolution, and regulation. Annu Rev Biochem. 1987;56:945-93.
17. Ronis MJ, Rowlands JC, Hakkak R, Badger TM. Altered expression and glucocorticoid-inducibility of hepatic CYP3A and CYP2B enzymes in male rats fed diets containing soy protein isolate. J Nutr. 1999;129: 1958-65.
18. Ronis MJ, Chen Y, Jo CH, Simpson P, Badger TM. Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development. J Nutr. 2004; 134:3270-6.
19. Mezei O, Chou CN, Kennedy KJ, Tovar-Palacio C, Shay NF. Hepatic cytochrome p450-2A and phosphoribosylpyrophosphate synthetaseassociated protein mRNA are induced in gerbils after consumption of isoflavone-containing protein. J Nutr. 2002;132:2538-44.
20. Backlund M, Johansson I, Mkrtchian S, Ingelman-Sundberg M. Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. J Biol Chem. 1997;272:31755-63.
21. Luo G, Guenthner T, Gan LS, Humphreys WG. CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development. Curr Drug Metab. 2004;5:483-505.
22. Ricketts ML, Moore DD, Banz WJ, Mezei O, Shay NF. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. J Nutr Biochem. 2005; 16:321-30.
23. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998;92:73-82.
24. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest. 1998;102:1016-23.
25. Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Muller M, Frants RR, Kasanmoentalib S, Post SM, et al. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007;21:1603-16.
26. Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol. 1999;56:1329-39.
27. Li Y, Mezei O, Shay NF. Human and murine hepatic sterol-12- alphahydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones. J Nutr. 2007;137:1705-12.
28. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol. 1976;13:29-83.
29. Mezei O, Li Y, Mullen E, Ross-Viola JS, Shay NF. Dietary isoflavone supplementation modulates lipid metabolism via PPARalpha-dependent and independent mechanisms. Physiol Genomics. 2006;26:8-14.
30. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 1995;9:1033-45.
31. Boyer JL. Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease? Gastroenterology. 2005;129:735-40.
32. Yeung EY, Sueyoshi T, Negishi M, Chang TK. Identification of Ginkgo biloba as a novel activator of pregnane X receptor. Drug Metab Dispos. 2008;36:2270-6.
33. Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos. 2002;30:795-804.
34. Bloedon LT, Jeffcoat AR, Lopaczynski W, Schell MJ, Black TM, Dix KJ, Thomas BF, Albright C, Busby MG, et al. Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr. 2002;76:1126-37.
35. Martin P, Riley R, Back DJ, Owen A. Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. Br J Pharmacol. 2008;153:805-19.
36. Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta. 2003;1609:1-18.
37. Harmsen S, Meijerman I, Beijnen JH, Schellens JH. Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol. Epub 2008 Oct 7.