Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction

Drug Metabolism and Disposition

Volumn 36, Issue 6, 2008, Pages 1046-1055

  Hariparsad, Niresh ^a   Carr, Brian A ^a   Evers, Raymond ^a   Chu, Xiaoyan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 CHLOROPHENYL)IMIDAZO[2,1 B][1,3] THIAZOLE 5 CARBALDEHYDE O (3,4-DICHLOROBENZYL)OXIME; AROMATIC HYDROCARBON RECEPTOR; ARTEMISININ; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; EFAVIRENZ; MESSENGER RNA; OMEPRAZOLE; OXIME DERIVATIVE; PHENACETIN; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; RIFAMPICIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; CELL IMMORTALIZATION; CELL TYPE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG DISPOSITION; DRUG METABOLISM; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELIABILITY; UNINDEXED SEQUENCE;

CELL LINE; CELLS, CULTURED; CRYOPRESERVATION; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; HEPATOCYTES; HUMANS; MEMBRANE TRANSPORT PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFERASES;

EID: 44149104931     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.020677     Document Type: Article

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