The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR

Hepatology

Volumn 33, Issue 5, 2001, Pages 1232-1238

  Sugatani, Junko ^a   Kojima, Hiroyuki ^a   Ueda, Akiko ^a   Kakizaki, Satoru ^a   Yoshinari, Kouichi ^a   Gong, Qi Hui ^b   Owens, Ida S ^b   Negishi, Masahiko ^a   Sueyoshi, Tatsuya ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ACTIVE RECEPTOR; DNA; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; PHENOBARBITAL; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DETOXIFICATION; DRUG RESPONSE; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSFECTION; GLUCURONIDATION; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; MOUSE; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN MOTIF;

EID: 0035029401     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.24172     Document Type: Article

References (22)

1. Some aspects of bile pigment metabolism
2. Direct-reacting bilirubin, bilirubin glucuronide, in serum, bile, and urine
3. The excretion of bilirubin as diglucuronide giving the direct van den Bergh reaction
4. Congenital familial non-hemolytic jaundice with kernicterus
5. Hereditary acholuric jaundice
6. Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency: Clinical, biochemical, pharmacologic, and genetic evidence for heterogeneity
7. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar disease
8. Hereditary jaundice and disorders of bilirubin metabolism
9. Human UDP-glucuronsyltransferases: Metabolism, expression, and disease
10. Enhancement of glucuronide-conjugating capacity in a hyperbilirubinemic infant due to apparent enzyme induction by phenobarbital
11. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini
12. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B1O gene
13. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
14. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
15. Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najiar type I disease
16. Analysis of the promoter of human bilirubin UDP-glucuronosyltransferase gene (UGT1*1) in relevance to Gilbert's syndrome
17. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
18. Discrimination between Crigle-Najjar Type I and II by expression of mutant bilirubin uridinediphosphate-glucuronosyltransferase
19. The genetic bases of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
20. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome
21. Racial variability in the UDP-glucuronsyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
22. Delayed response to phenobarbital treatment of a Crigler-Najjar Type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene. A case report