Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

Molecular Pharmacology

Volumn 62, Issue 3, 2002, Pages 638-646

  Maglich, Jodi M ^a   Stoltz, Catherine M ^a   Goodwin, Bryan ^a   Hawkins Brown, Diane ^a   Moore, John T ^a   Kliewer, Steven A ^a,b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; CELL RECEPTOR; CYTOCHROME P450; PREGNANE X RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONJUGATION; CONTROLLED STUDY; DETOXIFICATION; ENZYME MECHANISM; ENZYME REGULATION; GENE CONTROL; GENE IDENTIFICATION; HUMAN; HUMAN CELL; LIVER; LIVER CELL; MOUSE; MOUSE STRAIN; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTECTION; PROTEIN FUNCTION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; TRANSPORT KINETICS; UNINDEXED SEQUENCE; XENOBIOTIC METABOLISM;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; INTESTINE, SMALL; LIVER; METABOLIC DETOXICATION, DRUG; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATION-REDUCTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STEROID HYDROXYLASES; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 0036765785     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.3.638     Document Type: Article

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