A natural product that lowers cholesterol as an antagonist ligand for FXR

Science

Volumn 296, Issue 5573, 2002, Pages 1703-1706

  Urizar, Nancy L ^a   Liverman, Amy B ^a   Dodds, D'Nette T ^a   Silva, Frank Valentin ^a   Ordentlich, Peter ^a   Yan, Yingzhuo ^a   Gonzalez, Frank J ^a   Heyman, Richard A ^a   Mangelsdorf, David J ^a   Moore, David D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; HORMONES; RESINS;

NUCLEAR HARMONE RECEPTORS;

CHOLESTEROL;

BILE ACID; CHOLESTEROL; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR ANTAGONIST; GUGGULSTERONE[4,17 (20)PREGNADIENE 3,16 DIONE]; HORMONE RECEPTOR; HYPOCHOLESTEROLEMIC AGENT; NATURAL PRODUCT; PHYTOSTEROL; UNCLASSIFIED DRUG;

MEDICINAL PLANT; RESIN; TREE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL DIET; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; COMMIPHORA; CONTROLLED STUDY; LIGAND BINDING; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TREE;

ANIMALS; ANTILIPEMIC AGENTS; BINDING SITES; CACO-2 CELLS; CARRIER PROTEINS; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLESTEROL, DIETARY; DNA; DNA-BINDING PROTEINS; HEPATOCYTES; HISTONE ACETYLTRANSFERASES; HUMANS; HYDROXYSTEROID DEHYDROGENASES; LIGANDS; LIVER; MEMBRANE GLYCOPROTEINS; MICE; PREGNENEDIONES; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; COMMIPHORA;

EID: 0037205046     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1072891     Document Type: Article

References (45)