-
1
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J. 2009 The DNA-damage response in human biology and disease. Nature 461, 1071-1078. (doi:10.1038/nature08467)
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
2
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia A, Elledge SJ. 2010 The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204. (doi:10.1016/j.molcel.2010.09.019)
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
3
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
-
Polo SE, Jackson SP. 2011 Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 25, 409-433. (doi:10.1101/gad.2021311)
-
(2011)
Genes Dev.
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
4
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T. 1993 Instability and decay of the primary structure of DNA. Nature 22, 709-715. (doi:10.1038/362709a0)
-
(1993)
Nature
, vol.22
, pp. 709-715
-
-
Lindahl, T.1
-
5
-
-
3242881500
-
The cellular response to general and programmed DNA double strand breaks
-
Bassing CH, Alt FW. 2004 The cellular response to general and programmed DNA double strand breaks. DNA Repair 3, 781-796. (doi:10.1016/j.dnarep.2004.06.001)
-
(2004)
DNA Repair
, vol.3
, pp. 781-796
-
-
Bassing, C.H.1
Alt, F.W.2
-
6
-
-
33745121244
-
Leukemia and lymphoma: A cost of doing business for adaptive immunity
-
Schlissel MS, Kaffer CR, Curry JD. 2006 Leukemia and lymphoma: a cost of doing business for adaptive immunity. Genes Dev. 20, 1539-1544. (doi:10.1101/gad.1446506)
-
(2006)
Genes Dev.
, vol.20
, pp. 1539-1544
-
-
Schlissel, M.S.1
Kaffer, C.R.2
Curry, J.D.3
-
7
-
-
3242880404
-
The role of the DNA double-strand break response network in meiosis
-
Richardson C, Horikoshi N, Pandita TK. 2004 The role of the DNA double-strand break response network in meiosis. DNA Repair 3, 1149-1164. (doi:10.1016/j.dnarep.2004.05.007)
-
(2004)
DNA Repair
, vol.3
, pp. 1149-1164
-
-
Richardson, C.1
Horikoshi, N.2
Pandita, T.K.3
-
8
-
-
84859864552
-
Targeting the DNA damage response in oncology: Past, present and future perspectives
-
Basu B, Yap TA, Molife LR, de Bono JS. 2012 Targeting the DNA damage response in oncology: past, present and future perspectives. Curr. Opin. Oncol. 24, 316-324. (doi:10.1097/CCO.0b013e32835280c6)
-
(2012)
Curr. Opin. Oncol.
, vol.24
, pp. 316-324
-
-
Basu, B.1
Yap, T.A.2
Molife, L.R.3
De Bono, J.S.4
-
9
-
-
84870218588
-
DNA repair dysregulation from cancer driver to therapeutic target
-
Curtin NJ. 2012 DNA repair dysregulation from cancer driver to therapeutic target. Nat. Rev. Cancer 12, 801-817. (doi:10.1038/nrc3399)
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 801-817
-
-
Curtin, N.J.1
-
10
-
-
84874107696
-
Targeting DNA repair mechanisms in cancer
-
Furgason JM, Bahassi EM. 2013 Targeting DNA repair mechanisms in cancer. Pharmacol. Ther. 137, 298-308. (doi:10.1016/j.pharmthera.2012.10.009)
-
(2013)
Pharmacol. Ther.
, vol.137
, pp. 298-308
-
-
Furgason, J.M.1
Bahassi, E.M.2
-
11
-
-
0026570651
-
Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA
-
Griffith AJ, Blier PR, Mimori T, Hardin JA. 1992 Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA. J. Biol. Chem. 267, 331-338.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 331-338
-
-
Griffith, A.J.1
Blier, P.R.2
Mimori, T.3
Hardin, J.A.4
-
12
-
-
0023018810
-
Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders
-
Mimori T, Hardin JA, Steitz JA. 1986 Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem. 261, 2274-2278.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 2274-2278
-
-
Mimori, T.1
Hardin, J.A.2
Steitz, J.A.3
-
13
-
-
0028112944
-
Restoration of X-ray resistance and V(D) J recombination in mutant cells by Ku cDNA
-
Smider V, Rathmell WK, Lieber MR, Chu G. 1994 Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291. (doi:10.1126/science.7939667)
-
(1994)
Science
, vol.266
, pp. 288-291
-
-
Smider, V.1
Rathmell, W.K.2
Lieber, M.R.3
Chu, G.4
-
14
-
-
0028025020
-
Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D) J recombination
-
Taccioli GE et al. 1994 Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442-1445. (doi:10.1126/science.8073286)
-
(1994)
Science
, vol.265
, pp. 1442-1445
-
-
Taccioli, G.E.1
-
15
-
-
33845484385
-
Dynamic assembly of endjoining complexes requires interaction between Ku70/80 and XRCC4
-
Mari P-O et al. 2006 Dynamic assembly of endjoining complexes requires interaction between Ku70/80 and XRCC4. Proc. Natl Acad. Sci. USA 103, 18 597-18 602. (doi:10.1073/pnas.0609061103)
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18597-18602
-
-
Mari, P.-O.1
-
16
-
-
84884254858
-
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
-
Britton S, Coates J, Jackson SP. 2013 A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J. Cell Biol. 202, 579-595. (doi:10.1083/jcb.201303073)
-
(2013)
J. Cell Biol.
, vol.202
, pp. 579-595
-
-
Britton, S.1
Coates, J.2
Jackson, S.P.3
-
17
-
-
34247477667
-
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA doublestrand breaks
-
Uematsu N et al. 2007 Autophosphorylation of DNA-PKCS regulates its dynamics at DNA doublestrand breaks. J. Cell Biol. 177, 219-229. (doi:10.1083/jcb.200608077)
-
(2007)
J. Cell Biol.
, vol.177
, pp. 219-229
-
-
Uematsu, N.1
-
18
-
-
0032518680
-
Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
-
Ramsden DA, Gellert M. 1998 Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J. 17, 609-614. (doi:10.1093/emboj/17.2.609)
-
(1998)
EMBO J.
, vol.17
, pp. 609-614
-
-
Ramsden, D.A.1
Gellert, M.2
-
19
-
-
0030903145
-
DNA looping by Ku and the DNA-dependent protein kinase
-
Cary RB, Peterson SR, Wang J, Bear DG, Bradbury EM, Chen DJ. 1997 DNA looping by Ku and the DNA-dependent protein kinase. Proc. Natl Acad. Sci. USA 94, 4267-4272. (doi:10.1073/pnas.94.9.4267)
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4267-4272
-
-
Cary, R.B.1
Peterson, S.R.2
Wang, J.3
Bear, D.G.4
Bradbury, E.M.5
Chen, D.J.6
-
20
-
-
0024356877
-
HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
-
De Vries E, van Driel W, Bergsma WG, Arnberg AC, van der Vliet PC. 1989 HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. Mol. Biol. 208, 65-78. (doi:10.1016/0022-2836(89)90088-0)
-
(1989)
J. Mol. Biol.
, vol.208
, pp. 65-78
-
-
De Vries, E.1
Van Driel, W.2
Bergsma, W.G.3
Arnberg, A.C.4
Van Der Vliet, P.C.5
-
21
-
-
0027397867
-
The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
-
Gottlieb T, Jackson S. 1993 The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142. (doi:10.1016/0092-8674(93)90057-W)
-
(1993)
Cell
, vol.72
, pp. 131-142
-
-
Gottlieb, T.1
Jackson, S.2
-
22
-
-
0033560796
-
The DNA-dependent protein kinase
-
Smith GC, Jackson SP. 1999 The DNA-dependent protein kinase. Genes Dev. 13, 916-934. (doi:10.1101/gad.13.8.916)
-
(1999)
Genes Dev.
, vol.13
, pp. 916-934
-
-
Smith, G.C.1
Jackson, S.P.2
-
23
-
-
34247602569
-
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
-
Costantini S, Woodbine L, Andreoli L, Jeggo PA, Vindigni A. 2007 Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair 6, 712-722. (doi:10.1016/j.dnarep.2006.12.007)
-
(2007)
DNA Repair
, vol.6
, pp. 712-722
-
-
Costantini, S.1
Woodbine, L.2
Andreoli, L.3
Jeggo, P.A.4
Vindigni, A.5
-
24
-
-
0037187199
-
Defining interactions between DNA-PK and ligase IV/XRCC4
-
Hsu HL, Yannone SM, Chen DJ. 2002 Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair 1, 225-235. (doi:10.1016/S1568-7864(01)00018-0)
-
(2002)
DNA Repair
, vol.1
, pp. 225-235
-
-
Hsu, H.L.1
Yannone, S.M.2
Chen, D.J.3
-
25
-
-
37849018404
-
Ku recruits XLF to DNA double-strand breaks
-
Yano K, Morotomi-Yano K, Wang S-Y, Uematsu N, Lee K-J, Asaithamby A, Weterings E, Chen DJ. 2008 Ku recruits XLF to DNA double-strand breaks. EMBO Rep. 9, 91-96. (doi:10.1038/sj.embor.7401137)
-
(2008)
EMBO Rep.
, vol.9
, pp. 91-96
-
-
Yano, K.1
Morotomi-Yano, K.2
Wang, S.-Y.3
Uematsu, N.4
Lee, K.-J.5
Asaithamby, A.6
Weterings, E.7
Chen, D.J.8
-
26
-
-
84922384279
-
2015 PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA doublestrand break repair
-
Ochi T et al. 2015 PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA doublestrand break repair. Science 347, 185-188. (doi:10.1126/science.1261971)
-
Science
, vol.347
, pp. 185-188
-
-
Ochi, T.1
-
27
-
-
84923107266
-
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
-
Xing M et al. 2015 Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat. Commun. 6, 6233. (doi:10.1038/ncomms7233)
-
(2015)
Nat. Commun.
, vol.6
, pp. 6233
-
-
Xing, M.1
-
28
-
-
0029742576
-
Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
-
Dolganov GM, Maser RS, Novikov A, Tosto L, Chong S, Bressan DA, Petrini JH. 1996 Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16, 4832-4841.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4832-4841
-
-
Dolganov, G.M.1
Maser, R.S.2
Novikov, A.3
Tosto, L.4
Chong, S.5
Bressan, D.A.6
Petrini, J.H.7
-
29
-
-
0028943378
-
Functions of the yeast meiotic recombination genes, MRE11 and MRE2
-
Ogawa H, Johzuka K, Nakagawa T, Leem SH, Hagihara AH. 1995 Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Adv. Biophys. 31, 67-76. (doi:10.1016/0065-227X(95) 99383-Z)
-
(1995)
Adv. Biophys.
, vol.31
, pp. 67-76
-
-
Ogawa, H.1
Johzuka, K.2
Nakagawa, T.3
Leem, S.H.4
Hagihara, A.H.5
-
30
-
-
0032555480
-
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
-
Trujillo KM, Yuan SS, Lee EY, Sung P. 1998 Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273, 21 447-21 450. (doi:10.1074/jbc.273.34.21447)
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21447-21450
-
-
Trujillo, K.M.1
Yuan, S.S.2
Lee, E.Y.3
Sung, P.4
-
31
-
-
0032567108
-
Complex formation and functional versatility of Mre11 of budding yeast in recombination
-
Usui T, Ohta T, Oshiumi H, Tomizawa J, Ogawa H, Ogawa T. 1998 Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95, 705-716. (doi:10.1016/S0092-8674(00)81640-2)
-
(1998)
Cell
, vol.95
, pp. 705-716
-
-
Usui, T.1
Ohta, T.2
Oshiumi, H.3
Tomizawa, J.4
Ogawa, H.5
Ogawa, T.6
-
32
-
-
0035869155
-
DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways
-
De Jager M, Dronkert ML, Modesti M, Beerens CE, Kanaar R, van Gent DC. 2001 DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. Nucleic Acids Res. 29, 1317-1325. (doi:10.1093/nar/29.6.1317)
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 1317-1325
-
-
De Jager, M.1
Dronkert, M.L.2
Modesti, M.3
Beerens, C.E.4
Kanaar, R.5
Van Gent, D.C.6
-
33
-
-
0032085295
-
The 30 to 50 exonuclease activity of Mre 11 facilitates repair of DNA doublestrand breaks
-
Paull TT, Gellert M. 1998 The 30 to 50 exonuclease activity of Mre 11 facilitates repair of DNA doublestrand breaks. Mol. Cell 1, 969-979. (doi:10.1016/S1097-2765(00)80097-0)
-
(1998)
Mol. Cell
, vol.1
, pp. 969-979
-
-
Paull, T.T.1
Gellert, M.2
-
34
-
-
0033563229
-
Nbs1 potentiates ATPdriven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
-
Paull TT, Gellert M. 1999 Nbs1 potentiates ATPdriven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 13, 1276-1288. (doi:10.1101/gad.13.10.1276)
-
(1999)
Genes Dev.
, vol.13
, pp. 1276-1288
-
-
Paull, T.T.1
Gellert, M.2
-
35
-
-
30344463835
-
ATM- and cell cycledependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GCM, Lukas J, Jackson SP. 2006 ATM- and cell cycledependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45. (doi:10.1038/ncb1337)
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.M.5
Lukas, J.6
Jackson, S.P.7
-
36
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori A, Lukas C, Coates J, Mistrik M, Fu S. 2007 Human CtIP promotes DNA end resection. Nature 450, 509-514. (doi:10.1038/nature06337)
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
-
37
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson SP. 2005 Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611. (doi:10.1038/nature03442)
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
38
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. 2003 Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22, 5612-5621. (doi:10.1093/emboj/cdg541)
-
(2003)
EMBO J.
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
39
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee J-H, Paull TT. 2005 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554. (doi:10.1126/science.1108297)
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.-H.1
Paull, T.T.2
-
40
-
-
77955841725
-
The MRN complex in double-strand break repair and telomere maintenance
-
Lamarche BJ, Orazio NI, Weitzman MD. 2010 The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett. 584, 3682-3695. (doi:10.1016/j.febslet.2010.07.029)
-
(2010)
FEBS Lett.
, vol.584
, pp. 3682-3695
-
-
Lamarche, B.J.1
Orazio, N.I.2
Weitzman, M.D.3
-
41
-
-
0030996538
-
Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks
-
Weinfeld M, Chaudhry MA, D'Amours D, Pelletier JD, Poirier GG, Povirk LF, Lees-Miller SP. 1997 Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiat. Res. 148, 22-28. (doi:10.2307/3579534)
-
(1997)
Radiat. Res.
, vol.148
, pp. 22-28
-
-
Weinfeld, M.1
Chaudhry, M.A.2
D'amours, D.3
Pelletier, J.D.4
Poirier, G.G.5
Povirk, L.F.6
Lees-Miller, S.P.7
-
42
-
-
0027432789
-
Poly(ADP-ribose) polymerase can bind melphalan damaged DNA
-
Bramson J, Pre?vost J, Malapetsa A, Noë AJ, Poirier GG, DesNoyers S, Alaoui-Jamali M, Panasci L. 1993 Poly(ADP-ribose) polymerase can bind melphalan damaged DNA. Cancer Res. 53, 5370-5373.
-
(1993)
Cancer Res.
, vol.53
, pp. 5370-5373
-
-
Bramson, J.1
Prevost, J.2
Malapetsa, A.3
Noë, A.J.4
Poirier, G.G.5
Desnoyers, S.6
Alaoui-Jamali, M.7
Panasci, L.8
-
43
-
-
0033001635
-
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions
-
D'Silva I, Pelletier JD, Lagueux J, D'Amours D, Chaudhry MA, Weinfeld M, Lees-Miller SP, Poirier GG. 1999 Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochim. Biophys. Acta 1430, 119-126. (doi:10.1016/S0167-4838(98) 00278-7)
-
(1999)
Biochim. Biophys. Acta
, vol.1430
, pp. 119-126
-
-
D'silva, I.1
Pelletier, J.D.2
Lagueux, J.3
D'amours, D.4
Chaudhry, M.A.5
Weinfeld, M.6
Lees-Miller, S.P.7
Poirier, G.G.8
-
44
-
-
0142009654
-
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
-
El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW. 2003 A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 31, 5526-5533. (doi:10.1093/nar/gkg761)
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 5526-5533
-
-
El-Khamisy, S.F.1
Masutani, M.2
Suzuki, H.3
Caldecott, K.W.4
-
45
-
-
33746801232
-
Differential recruitment of DNA ligase i and III to DNA repair sites
-
Mortusewicz O, Rothbauer U, Cardoso MC, Leonhardt H. 2006 Differential recruitment of DNA ligase I and III to DNA repair sites. Nucleic Acids Res. 34, 3523-3532. (doi:10.1093/nar/gkl492)
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 3523-3532
-
-
Mortusewicz, O.1
Rothbauer, U.2
Cardoso, M.C.3
Leonhardt, H.4
-
46
-
-
33845657443
-
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
-
Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. 2006 PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34, 6170-6182. (doi:10.1093/nar/gkl840)
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 6170-6182
-
-
Wang, M.1
Wu, W.2
Wu, W.3
Rosidi, B.4
Zhang, L.5
Wang, H.6
Iliakis, G.7
-
47
-
-
84865364870
-
Playing the end game: DNA double-strand break repair pathway choice
-
Chapman JR, Taylor MRG, Boulton SJ. 2012 Playing the end game: DNA double-strand break repair pathway choice. Mol. Cell 47, 497-510. (doi:10.1016/j.molcel.2012.07.029)
-
(2012)
Mol. Cell
, vol.47
, pp. 497-510
-
-
Chapman, J.R.1
Taylor, M.R.G.2
Boulton, S.J.3
-
48
-
-
84905564315
-
SET-ting the stage for DNA repair
-
Jha DK, Pfister SX, Humphrey TC, Strahl BD. 2014 SET-ting the stage for DNA repair. Nat. Struct. Mol. Biol. 21, 655-657. (doi:10.1038/nsmb.2866)
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 655-657
-
-
Jha, D.K.1
Pfister, S.X.2
Humphrey, T.C.3
Strahl, B.D.4
-
49
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim S-T, Lim D-S, Canman CE, Kastan MB. 1999 Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274, 37 538-37 453. (doi:10.1074/jbc.274.53.37538)
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37538-37453
-
-
Kim, S.-T.1
Lim, D.-S.2
Canman, C.E.3
Kastan, M.B.4
-
50
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S et al. 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166. (doi:10.1126/science.1140321)
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
-
51
-
-
59849089955
-
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
-
Mahaney BL, Meek K, Lees-Miller SP. 2009 Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 417, 639-650. (doi:10.1042/BJ20080413)
-
(2009)
Biochem. J.
, vol.417
, pp. 639-650
-
-
Mahaney, B.L.1
Meek, K.2
Lees-Miller, S.P.3
-
52
-
-
84880615973
-
Detection and repair of ionizing radiation-induced DNA double strand breaks: New developments in nonhomologous end joining
-
Wang C, Lees-Miller SP. 2013 Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int. J. Radiat. Oncol. Biol. Phys. 86, 440-449. (doi:10.1016/j.ijrobp.2013.01.011)
-
(2013)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.86
, pp. 440-449
-
-
Wang, C.1
Lees-Miller, S.P.2
-
53
-
-
84878677036
-
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
-
Kaidi A, Jackson SP. 2013 KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-74. (doi:10.1038/nature12201)
-
(2013)
Nature
, vol.498
, pp. 70-74
-
-
Kaidi, A.1
Jackson, S.P.2
-
54
-
-
0037245862
-
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
-
Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. 2003 An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11, 203-213. (doi:10.1016/S1097-2765(02)00799-2)
-
(2003)
Mol. Cell
, vol.11
, pp. 203-213
-
-
Costanzo, V.1
Shechter, D.2
Lupardus, P.J.3
Cimprich, K.A.4
Gottesman, M.5
Gautier, J.6
-
55
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ. 2003 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548. (doi:10.1126/science.1083430)
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
56
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich KA, Cortez D. 2008 ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9, 616-627. (doi:10.1038/nrm2450)
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
57
-
-
79957690359
-
ATR signalling: More than meeting at the fork
-
Nam EA, Cortez D. 2011 ATR signalling: more than meeting at the fork. Biochem. J. 436, 527-536. (doi:10.1042/BJ20102162)
-
(2011)
Biochem. J.
, vol.436
, pp. 527-536
-
-
Nam, E.A.1
Cortez, D.2
-
58
-
-
0030797708
-
Recombinant ATM protein complements the cellular A-T phenotype
-
Ziv Y, Bar-Shira A, Pecker I, Russell P, Jorgensen TJ, Tsarfati I, Shiloh Y. 1997 Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 15, 159-167. (doi:10.1038/sj.onc.1201319)
-
(1997)
Oncogene
, vol.15
, pp. 159-167
-
-
Ziv, Y.1
Bar-Shira, A.2
Pecker, I.3
Russell, P.4
Jorgensen, T.J.5
Tsarfati, I.6
Shiloh, Y.7
-
59
-
-
84919401699
-
ATM: Expanding roles as a chief guardian of genome stability
-
Shiloh Y. 2014 ATM: expanding roles as a chief guardian of genome stability. Exp. Cell Res. 329, 154-161. (doi:10.1016/j.yexcr.2014.09.002)
-
(2014)
Exp. Cell Res.
, vol.329
, pp. 154-161
-
-
Shiloh, Y.1
-
60
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. 2003 A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501. (doi:10.1038/ng1129)
-
(2003)
Nat. Genet.
, vol.33
, pp. 497-501
-
-
O'driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
61
-
-
3242881897
-
An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
-
O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. 2004 An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair 3, 1227-1235. (doi:10.1016/j.dnarep.2004.03.025)
-
(2004)
DNA Repair
, vol.3
, pp. 1227-1235
-
-
O'driscoll, M.1
Gennery, A.R.2
Seidel, J.3
Concannon, P.4
Jeggo, P.A.5
-
62
-
-
0028897304
-
DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA doublestrand break repair
-
Finnie N, Gottlieb T. 1995 DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA doublestrand break repair. Proc. Natl Acad. Sci. USA 92, 320-324. (doi:10.1073/pnas.92.1.320)
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 320-324
-
-
Finnie, N.1
Gottlieb, T.2
-
63
-
-
0028960511
-
Defective DNA-dependent protein kinase activity is linked to V(D) J recombination and DNA repair defects associated with the murine scid mutation
-
Blunt T et al. 1995 Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823. (doi:10.1016/0092-8674(95)90360-7)
-
(1995)
Cell
, vol.80
, pp. 813-823
-
-
Blunt, T.1
-
64
-
-
0032938747
-
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
-
Kurimasa A, Kumano S. 1999 Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol. Cell. Biol. 19, 3877.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3877
-
-
Kurimasa, A.1
Kumano, S.2
-
65
-
-
61749104245
-
A DNA-PKcs mutation in a radiosensitive T - B- SCID patient inhibits Artemis activation and nonhomologous end-joining
-
Van der Burg M et al. 2009 A DNA-PKcs mutation in a radiosensitive T - B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J. Clin. Invest. 119, 91-98. (doi:10.1172/JCI37141)
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 91-98
-
-
Van Der Burg, M.1
-
66
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E, Pilch D, Orr A, Ivanova V, Bonner W. 1998 DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868. (doi:10.1074/jbc.273.10.5858)
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.1
Pilch, D.2
Orr, A.3
Ivanova, V.4
Bonner, W.5
-
67
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff T, Driscoll MO, Rief N, Iwabuchi K, Lo M, Jeggo PA. 2004 ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396. (doi:10.1158/0008-5472.CAN-03-3207)
-
(2004)
Cancer Res.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
Driscoll, M.O.2
Rief, N.3
Iwabuchi, K.4
Lo, M.5
Jeggo, P.A.6
-
68
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. 2005 MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123, 1213-1226. (doi:10.1016/j.cell.2005.09.038)
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
69
-
-
68249126215
-
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
-
Stracker TH, Usui T, Petrini JHJ. 2009 Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair 8, 1047-1054. (doi:10.1016/j.dnarep.2009.04.012)
-
(2009)
DNA Repair
, vol.8
, pp. 1047-1054
-
-
Stracker, T.H.1
Usui, T.2
Petrini, J.H.J.3
-
70
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J, Lukas J. 2003 Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429. (doi:10.1016/S1535-6108(03)00110-7)
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
71
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt H, Yaffe M. 2009 Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell Biol. 21, 245-255. (doi:10.1016/j.ceb.2009.01.018)
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 245-255
-
-
Reinhardt, H.1
Yaffe, M.2
-
72
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATMindependent manner
-
Hirao A et al. 2002 Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATMindependent manner. Mol. Cell. Biol. 22, 6521-6532. (doi:10.1128/MCB.22.18.6521-6532.2002)
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
-
73
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai H et al. 2002 Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205. (doi:10.1093/emboj/cdf506)
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
74
-
-
11344286593
-
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation
-
Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AEH, Yaffe MB. 2005 MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell 17, 37-48. (doi:10.1016/j.molcel.2004.11.021)
-
(2005)
Mol. Cell
, vol.17
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
75
-
-
33846821915
-
P53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. 2007 p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11, 175-189. (doi:10.1016/j.ccr.2006.11.024)
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
76
-
-
84907151091
-
A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response
-
Blasius M, Wagner S. 2014 A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response. Genes Dev. 28, 1977-1982. (doi:10.1101/gad.246272.114)
-
(2014)
Genes Dev.
, vol.28
, pp. 1977-1982
-
-
Blasius, M.1
Wagner, S.2
-
77
-
-
84888626405
-
Modernizing the nonhomologous end-joining repertoire: Alternative and classical NHEJ share the stage
-
Deriano L, Roth DB. 2013 Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage. Annu. Rev. Genet. 47, 433-455. (doi:10.1146/annurev-genet-110711-155540)
-
(2013)
Annu. Rev. Genet.
, vol.47
, pp. 433-455
-
-
Deriano, L.1
Roth, D.B.2
-
78
-
-
34748863465
-
IgH class switching and translocations use a robust non-classical end-joining pathway
-
Yan CT et al. 2007 IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449, 478-482. (doi:10.1038/nature06020)
-
(2007)
Nature
, vol.449
, pp. 478-482
-
-
Yan, C.T.1
-
79
-
-
84900439412
-
Alternative end-joining pathway(s): Bricolage at DNA breaks
-
Frit P, Barboule N, Yuan Y, Gomez D, Calsou P. 2014 Alternative end-joining pathway(s): bricolage at DNA breaks. DNA Repair 17, 81-97. (doi:10.1016/j.dnarep.2014.02.007)
-
(2014)
DNA Repair
, vol.17
, pp. 81-97
-
-
Frit, P.1
Barboule, N.2
Yuan, Y.3
Gomez, D.4
Calsou, P.5
-
80
-
-
84905271717
-
PALB2: The hub of a network of tumor suppressors involved in DNA damage responses
-
Park J-Y, Zhang F, Andreassen PR. 2014 PALB2: the hub of a network of tumor suppressors involved in DNA damage responses. Biochim. Biophys. Acta 1846, 263-275. (doi:10.1016/j.bbcan.2014.06.003)
-
(2014)
Biochim. Biophys. Acta
, vol.1846
, pp. 263-275
-
-
Park, J.-Y.1
Zhang, F.2
Andreassen, P.R.3
-
81
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H et al. 2005 Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917-921. (doi:10.1038/nature03445)
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
-
82
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADPribose) polymerase
-
Bryant HE et al. 2005 Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADPribose) polymerase. Nature 434, 913-917. (doi:10.1038/nature03443)
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
-
83
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong P et al. 2009 Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134. (doi:10.1056/NEJMoa0900212)
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 123-134
-
-
Fong, P.1
-
84
-
-
80052168685
-
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
-
Helleday T. 2011 The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol. Oncol. 5, 387-393. (doi:10.1016/j.molonc.2011.07.001)
-
(2011)
Mol. Oncol.
, vol.5
, pp. 387-393
-
-
Helleday, T.1
-
85
-
-
33646187811
-
The multifaceted mismatch-repair system
-
Jiricny J. 2006 The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 7, 335-346. (doi:10.1038/nrm1907)
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 335-346
-
-
Jiricny, J.1
-
86
-
-
48249095920
-
Single-strand break repair and genetic disease
-
Caldecott KW. 2008 Single-strand break repair and genetic disease. Nat. Rev. Genet. 9, 619-631. (doi:10.1038/nrg2380)
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 619-631
-
-
Caldecott, K.W.1
-
87
-
-
84876016461
-
Mammalian base excision repair: The forgotten archangel
-
Dianov GL, Hu?bscher U. 2013 Mammalian base excision repair: the forgotten archangel. Nucleic Acids Res. 41, 3483-3490. (doi:10.1093/nar/gkt076)
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 3483-3490
-
-
Dianov, G.L.1
Hubscher, U.2
-
88
-
-
38049178545
-
Transcriptioncoupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects
-
Fousteri M, Mullenders LHF. 2008 Transcriptioncoupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res. 18, 73-84. (doi:10.1038/cr.2008.6)
-
(2008)
Cell Res.
, vol.18
, pp. 73-84
-
-
Fousteri, M.1
Mullenders, L.H.F.2
-
89
-
-
84863100045
-
Competition, collaboration and coordination-determining how cells bypass DNA damage
-
Sale JE. 2012 Competition, collaboration and coordination-determining how cells bypass DNA damage. J. Cell Sci. 125, 1633-1643. (doi:10.1242/jcs.094748)
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1633-1643
-
-
Sale, J.E.1
-
90
-
-
79959635260
-
DNA interstrand crosslink repair and cancer
-
Deans AJ, West SC. 2011 DNA interstrand crosslink repair and cancer. Nat. Rev. Cancer 11, 467-480. (doi:10.1038/nrc3088)
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 467-480
-
-
Deans, A.J.1
West, S.C.2
-
91
-
-
0018187738
-
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes
-
Ciehanover A, Hod Y, Hershko A. 1978 A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem. Biophys. Res. 81, 1100-1105. (doi:10.1016/0006-291X(78)91249-4)
-
(1978)
Biochem. Biophys. Res.
, vol.81
, pp. 1100-1105
-
-
Ciehanover, A.1
Hod, Y.2
Hershko, A.3
-
92
-
-
0019000271
-
Proposed role of ATP in protein breakdown: Conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis
-
Hershko A, Ciechanover A. 1980 Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc. Natl Acad. Sci. USA 77, 1783-1786. (doi:10.1073/pnas.77.4.1783)
-
(1980)
Proc. Natl Acad. Sci. USA
, vol.77
, pp. 1783-1786
-
-
Hershko, A.1
Ciechanover, A.2
-
93
-
-
0019174693
-
Ubiquitin is the ATP-dependent proteolysis factor i of rabbit reticulocytes
-
Wilkinson K, Urban M, Haas A. 1980 Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. J. Biol. Chem. 1, 7529-7532.
-
(1980)
J. Biol. Chem.
, vol.1
, pp. 7529-7532
-
-
Wilkinson, K.1
Urban, M.2
Haas, A.3
-
94
-
-
0023336183
-
The yeast ubiquitin genes: A family of natural gene fusions
-
Ozkaynak E, Finley D. 1987 The yeast ubiquitin genes: a family of natural gene fusions. EMBO J. 6, 1429-1439.
-
(1987)
EMBO J.
, vol.6
, pp. 1429-1439
-
-
Ozkaynak, E.1
Finley, D.2
-
95
-
-
0023119757
-
The human ubiquitin gene family: Structure of a gene and pseudogenes from the Ub B subfamily
-
Baker RT, Board PG. 1987 The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res. 15, 443-463. (doi:10.1093/nar/15.2.443)
-
(1987)
Nucleic Acids Res.
, vol.15
, pp. 443-463
-
-
Baker, R.T.1
Board, P.G.2
-
96
-
-
0022033183
-
The human ubiquitin multigene family: Some genes contain multiple directly repeated ubiquitin coding sequences
-
Wiborg O, Pedersen M, Wind A. 1985 The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. EMBO J. 4, 755-759.
-
(1985)
EMBO J.
, vol.4
, pp. 755-759
-
-
Wiborg, O.1
Pedersen, M.2
Wind, A.3
-
97
-
-
0021099710
-
Components of ubiquitin-protein ligase system resolution, affinity purification
-
Hershkos A, Heller H, Elias S, Ciechanover A. 1983 Components of ubiquitin-protein ligase system resolution, affinity purification. J. Biol. Chem. 258, 8206-8214.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 8206-8214
-
-
Hershkos, A.1
Heller, H.2
Elias, S.3
Ciechanover, A.4
-
98
-
-
0020478687
-
Covalent affinity purification of ubiquitin-activating enzyme
-
Ciechanover A, Elias S, Heller H, Hershko A. 1982 'Covalent affinity' purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 2537-2542
-
-
Ciechanover, A.1
Elias, S.2
Heller, H.3
Hershko, A.4
-
99
-
-
0028235968
-
Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1)
-
Pickart CM, Kasperek EM, Beal R, Kim A. 1994 Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1). J. Biol. Chem. 269, 7115-7123.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 7115-7123
-
-
Pickart, C.M.1
Kasperek, E.M.2
Beal, R.3
Kim, A.4
-
100
-
-
67349256160
-
Ubiquitin-like protein activation by E1 enzymes: The apex for downstream signalling pathways
-
Schulman BA, Harper JW. 2009 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat. Rev. Mol. Cell Biol. 10, 319-331. (doi:10.1038/nrm2673)
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 319-331
-
-
Schulman, B.A.1
Harper, J.W.2
-
101
-
-
77951651753
-
The family of ubiquitin-conjugating enzymes (E2s): Deciding between life and death of proteins
-
Van Wijk SJL, Timmers HTM. 2010 The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins. FASEB J. 24, 981-993. (doi:10.1096/fj.09-136259)
-
(2010)
FASEB J.
, vol.24
, pp. 981-993
-
-
Van Wijk, S.J.L.1
Timmers, H.T.M.2
-
102
-
-
84898754901
-
New insights into ubiquitin E3 ligase mechanism
-
Berndsen CE, Wolberger C. 2014 New insights into ubiquitin E3 ligase mechanism. Nat. Struct. Mol. Biol. 21, 301-307. (doi:10.1038/nsmb.2780)
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 301-307
-
-
Berndsen, C.E.1
Wolberger, C.2
-
103
-
-
84898734084
-
Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways
-
Mattiroli F, Sixma TK. 2014 Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat. Struct. Mol. Biol. 21, 308-316. (doi:10.1038/nsmb.2792)
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 308-316
-
-
Mattiroli, F.1
Sixma, T.K.2
-
104
-
-
67649964217
-
RING domain E3 ubiquitin ligases
-
Deshaies RJ, Joazeiro CAP. 2009 RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78, 399-434. (doi:10.1146/annurev.biochem.78. 101807.093809)
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 399-434
-
-
Deshaies, R.J.1
Joazeiro, C.A.P.2
-
105
-
-
84865781586
-
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
-
Plechanovová A, Jaffray EG, Tatham MH, Naismith JH, Hay RT. 2012 Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature 489, 115-120. (doi:10.1038/nature11376)
-
(2012)
Nature
, vol.489
, pp. 115-120
-
-
Plechanovová, A.1
Jaffray, E.G.2
Tatham, M.H.3
Naismith, J.H.4
Hay, R.T.5
-
106
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S. 1999 A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96, 635-644. (doi:10.1016/S0092-8674(00) 80574-7)
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
-
107
-
-
0035980094
-
U box proteins as a new family of ubiquitin-protein ligases
-
Hatakeyama S, Yada M, Matsumoto M, Ishida N, Nakayama KI. 2001 U box proteins as a new family of ubiquitin-protein ligases. J. Biol. Chem. 276, 33 111-33 120. (doi:10.1074/jbc.M102755200)
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33111-33120
-
-
Hatakeyama, S.1
Yada, M.2
Matsumoto, M.3
Ishida, N.4
Nakayama, K.I.5
-
108
-
-
68049084674
-
Breaking the chains: Structure and function of the deubiquitinases
-
Komander D, Clague MJ, Urbé S. 2009 Breaking the chains: structure and function of the deubiquitinases. Nat. Rev. Mol. Cell Biol. 10, 550-563. (doi:10.1038/nrm2731)
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 550-563
-
-
Komander, D.1
Clague, M.J.2
Urbé, S.3
-
109
-
-
67650620318
-
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes
-
Turcu F, Ventii K, Wilkinson K. 2009 Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu. Rev. Biochem. 78, 363-397. (doi:10.1146/annurev.biochem.78.082307.091526)
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 363-397
-
-
Turcu, F.1
Ventii, K.2
Wilkinson, K.3
-
110
-
-
33846471122
-
Proteasomeindependent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay D, Riezman H. 2007 Proteasomeindependent functions of ubiquitin in endocytosis and signaling. Science 315, 201-205. (doi:10.1126/science.1127085)
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
111
-
-
29144499065
-
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
-
Bienko M et al. 2005 Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 310, 1821-1824. (doi:10.1126/science. 1120615)
-
(2005)
Science
, vol.310
, pp. 1821-1824
-
-
Bienko, M.1
-
112
-
-
33750219981
-
A ubiquitin ligase complex assembles linear polyubiquitin chains
-
Kirisako T et al. 2006 A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 25, 4877-4887. (doi:10.1038/sj.emboj.7601360)
-
(2006)
EMBO J.
, vol.25
, pp. 4877-4887
-
-
Kirisako, T.1
-
113
-
-
84872820481
-
Linear ubiquitination: A newly discovered regulator of cell signaling
-
Rieser E, Cordier SM, Walczak H. 2013 Linear ubiquitination: a newly discovered regulator of cell signalling. Trends Biochem. Sci. 38, 94-102. (doi:10.1016/j.tibs.2012.11.007)
-
(2013)
Trends Biochem. Sci.
, vol.38
, pp. 94-102
-
-
Rieser, E.1
Cordier, S.M.2
Walczak, H.3
-
114
-
-
0031657807
-
The ubiquitin system
-
Hershko A, Ciechanover A. 1998 The ubiquitin system. Annu. Rev. Biochem. 67, 425-479. (doi:10.1146/annurev.biochem.67.1.425)
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 425-479
-
-
Hershko, A.1
Ciechanover, A.2
-
115
-
-
63049125531
-
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
-
Xu P et al. 2009 Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 137, 133-145. (doi:10.1016/j.cell.2009.01.041)
-
(2009)
Cell
, vol.137
, pp. 133-145
-
-
Xu, P.1
-
116
-
-
33750555919
-
Ubiquitin-binding domains
-
Hurley JH, Lee S, Prag G. 2006 Ubiquitin-binding domains. Biochem. J. 399, 361-372. (doi:10.1042/BJ20061138)
-
(2006)
Biochem. J.
, vol.399
, pp. 361-372
-
-
Hurley, J.H.1
Lee, S.2
Prag, G.3
-
117
-
-
84861783400
-
Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions
-
Husnjak K, Dikic I. 2012 Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions. Annu. Rev. Biochem. 81, 291-322. (doi:10.1146/annurev-biochem-051810-094654)
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 291-322
-
-
Husnjak, K.1
Dikic, I.2
-
118
-
-
70350150000
-
The emerging complexity of protein ubiquitination
-
Komander D. 2009 The emerging complexity of protein ubiquitination. Biochem. Soc. Trans. 37, 937-953. (doi:10.1042/BST0370937)
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 937-953
-
-
Komander, D.1
-
119
-
-
84861877407
-
The ubiquitin code
-
Komander D, Rape M. 2012 The ubiquitin code. Annu. Rev. Biochem. 81, 203-229. (doi:10.1146/annurev-biochem-060310-170328)
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 203-229
-
-
Komander, D.1
Rape, M.2
-
120
-
-
63649113699
-
Origin and function of ubiquitin-like proteins
-
Hochstrasser M. 2009 Origin and function of ubiquitin-like proteins. Nature 458, 422-429. (doi:10.1038/nature07958)
-
(2009)
Nature
, vol.458
, pp. 422-429
-
-
Hochstrasser, M.1
-
122
-
-
0023236126
-
The yeast DNA repair gene RAD6 encodes a ubiquitinconjugating enzyme
-
Jentsch S, McGrath J, Varshavsky A. 1986 The yeast DNA repair gene RAD6 encodes a ubiquitinconjugating enzyme. Nature 329, 131-134. (doi:10.1038/329131a0)
-
(1986)
Nature
, vol.329
, pp. 131-134
-
-
Jentsch, S.1
McGrath, J.2
Varshavsky, A.3
-
123
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege C, Pfander B, Moldovan G-L, Pyrowolakis G, Jentsch S. 2002 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-141. (doi:10.1038/nature00991)
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.-L.3
Pyrowolakis, G.4
Jentsch, S.5
-
124
-
-
2442417331
-
Interaction of human DNA polymerase h with monoubiquitinated PCNA
-
Kannouche PL, Wing J, Lehmann AR. 2004 Interaction of human DNA polymerase h with monoubiquitinated PCNA. Mol. Cell 14, 491-500. (doi:10.1016/S1097-2765(04)00259-X)
-
(2004)
Mol. Cell
, vol.14
, pp. 491-500
-
-
Kannouche, P.L.1
Wing, J.2
Lehmann, A.R.3
-
125
-
-
6344288785
-
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
-
Watanabe K, Tateishi S, Kawasuji M, Tsurimoto T, Inoue H, Yamaizumi M. 2004 Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J. 23, 3886-3896. (doi:10.1038/sj.emboj.7600383)
-
(2004)
EMBO J.
, vol.23
, pp. 3886-3896
-
-
Watanabe, K.1
Tateishi, S.2
Kawasuji, M.3
Tsurimoto, T.4
Inoue, H.5
Yamaizumi, M.6
-
126
-
-
33749510488
-
RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40
-
Simpson LJ, Ross A-L, Szu?ts D, Alviani CA, Oestergaard VH, Patel KJ, Sale JE. 2006 RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40. EMBO Rep. 7, 927-932. (doi:10.1038/sj.embor.7400777)
-
(2006)
EMBO Rep.
, vol.7
, pp. 927-932
-
-
Simpson, L.J.1
Ross, A.-L.2
Szuts, D.3
Alviani, C.A.4
Oestergaard, V.H.5
Patel, K.J.6
Sale, J.E.7
-
127
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
Stewart GS et al. 2009 The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell 136, 420-434. (doi:10.1016/j.cell.2008.12.042)
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
-
128
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil C et al. 2009 RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136, 435-446. (doi:10.1016/j.cell.2008.12.041)
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
-
129
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
Kolas NK et al. 2007 Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318, 1637-1640. (doi:10.1126/science.1150034)
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
-
130
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
Huen MSY, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. 2007 RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131, 901-914. (doi:10.1016/j.cell.2007.09.041)
-
(2007)
Cell
, vol.131
, pp. 901-914
-
-
Huen, M.S.Y.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.5
Yaffe, M.B.6
Chen, J.7
-
131
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J. 2007 RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131, 887-900. (doi:10.1016/j.cell.2007.09.040)
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
132
-
-
84862986431
-
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
-
Bekker-Jensen S, Danielsen JR, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N. 2010 HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat. Cell Biol. 12, 80-86. (doi:10.1038/ncb2008)
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 80-86
-
-
Bekker-Jensen, S.1
Danielsen, J.R.2
Fugger, K.3
Gromova, I.4
Nerstedt, A.5
Lukas, C.6
Bartek, J.7
Lukas, J.8
Mailand, N.9
-
133
-
-
84868198362
-
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells
-
Oestergaard VH, Pentzold C, Pedersen RT, Iosif S, Alpi A, Bekker-Jensen S, Mailand N, Lisby M. 2012 RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells. DNA Repair 11, 892-905. (doi:10.1016/j.dnarep.2012.08.005)
-
(2012)
DNA Repair
, vol.11
, pp. 892-905
-
-
Oestergaard, V.H.1
Pentzold, C.2
Pedersen, R.T.3
Iosif, S.4
Alpi, A.5
Bekker-Jensen, S.6
Mailand, N.7
Lisby, M.8
-
134
-
-
78751682842
-
UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway
-
Pinato S, Gatti M, Scandiuzzi C, Confalonieri S, Penengo L. 2011 UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway. Mol. Cell. Biol. 31, 118-126. (doi:10.1128/MCB.00818-10)
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 118-126
-
-
Pinato, S.1
Gatti, M.2
Scandiuzzi, C.3
Confalonieri, S.4
Penengo, L.5
-
135
-
-
84866388311
-
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling
-
Mattiroli F, Vissers JHA, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK. 2012 RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 150, 1182-1195. (doi:10.1016/j.cell.2012.08.005)
-
(2012)
Cell
, vol.150
, pp. 1182-1195
-
-
Mattiroli, F.1
Vissers, J.H.A.2
Van Dijk, W.J.3
Ikpa, P.4
Citterio, E.5
Vermeulen, W.6
Marteijn, J.A.7
Sixma, T.K.8
-
136
-
-
84898725334
-
The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A
-
Mattiroli F, Uckelmann M, Sahtoe DD, van Dijk WJ, Sixma TK. 2014 The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. Nat. Commun. 5, 3291. (doi:10.1038/ncomms4291)
-
(2014)
Nat. Commun.
, vol.5
, pp. 3291
-
-
Mattiroli, F.1
Uckelmann, M.2
Sahtoe, D.D.3
Van Dijk, W.J.4
Sixma, T.K.5
-
137
-
-
84864919890
-
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks
-
Panier S, Ichijima Y, Fradet-Turcotte A, Leung CCY, Kaustov L, Arrowsmith CH, Durocher D. 2012 Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Mol. Cell 47, 383-395. (doi:10.1016/j.molcel.2012.05.045)
-
(2012)
Mol. Cell
, vol.47
, pp. 383-395
-
-
Panier, S.1
Ichijima, Y.2
Fradet-Turcotte, A.3
Leung, C.C.Y.4
Kaustov, L.5
Arrowsmith, C.H.6
Durocher, D.7
-
138
-
-
36749029369
-
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
-
Stewart GS et al. 2007 RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc. Natl Acad. Sci. USA 104, 16 910-16 915. (doi:10.1073/pnas. 0708408104)
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16910-16915
-
-
Stewart, G.S.1
-
139
-
-
79959550548
-
Insights into the B cell specific process of immunoglobulin class switch recombination
-
Kracker S, Durandy A. 2011 Insights into the B cell specific process of immunoglobulin class switch recombination. Immunol. Lett. 138, 97-103. (doi:10.1016/j.imlet.2011.02.004)
-
(2011)
Immunol. Lett.
, vol.138
, pp. 97-103
-
-
Kracker, S.1
Durandy, A.2
-
140
-
-
82955233817
-
The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection
-
Rai R, Li J, Zheng H, Lok G. 2011 The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection. Nat. Struct. 18, 1400-1407. (doi:10.1038/nsmb.2172)
-
(2011)
Nat. Struct.
, vol.18
, pp. 1400-1407
-
-
Rai, R.1
Li, J.2
Zheng, H.3
Lok, G.4
-
141
-
-
80052491304
-
DNA-damage response and repair activities at uncapped telomeres depend on RNF8
-
Peuscher MH, Jacobs JJL. 2011 DNA-damage response and repair activities at uncapped telomeres depend on RNF8. Nat. Cell Biol. 13, 1139-1145. (doi:10.1038/ncb2326)
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1139-1145
-
-
Peuscher, M.H.1
Jacobs, J.J.L.2
-
142
-
-
77953720192
-
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
-
Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. 2010 ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 141, 970-981. (doi:10.1016/j.cell.2010.04.038)
-
(2010)
Cell
, vol.141
, pp. 970-981
-
-
Shanbhag, N.M.1
Rafalska-Metcalf, I.U.2
Balane-Bolivar, C.3
Janicki, S.M.4
Greenberg, R.A.5
-
143
-
-
77954997032
-
DNA damage signaling in response to double-strand breaks during mitosis
-
Giunta S, Belotserkovskaya R, Jackson SP. 2010 DNA damage signaling in response to double-strand breaks during mitosis. J. Cell Biol. 190, 197-207. (doi:10.1083/jcb.200911156)
-
(2010)
J. Cell Biol.
, vol.190
, pp. 197-207
-
-
Giunta, S.1
Belotserkovskaya, R.2
Jackson, S.P.3
-
144
-
-
84898052474
-
Mitosis inhibits DNA doublestrand break repair to guard against telomere fusions
-
Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D. 2014 Mitosis inhibits DNA doublestrand break repair to guard against telomere fusions. Science 344, 189-193. (doi:10.1126/science.1248024)
-
(2014)
Science
, vol.344
, pp. 189-193
-
-
Orthwein, A.1
Fradet-Turcotte, A.2
Noordermeer, S.M.3
Canny, M.D.4
Brun, C.M.5
Strecker, J.6
Escribano-Diaz, C.7
Durocher, D.8
-
145
-
-
84860389035
-
53BP1-mediated DNA double strand break repair: Insert bad pun here
-
Noon AT, Goodarzi AA. 2011 53BP1-mediated DNA double strand break repair: insert bad pun here. DNA Repair 10, 1071-1076. (doi:10.1016/j.dnarep.2011.07.012)
-
(2011)
DNA Repair
, vol.10
, pp. 1071-1076
-
-
Noon, A.T.1
Goodarzi, A.A.2
-
146
-
-
84866608818
-
Links between genome integrity and BRCA1 tumor suppression
-
Li M, Greenberg R. 2012 Links between genome integrity and BRCA1 tumor suppression. Trends Biochem. Sci. 37, 418-424. (doi:10.1016/j.tibs.2012.06.007)
-
(2012)
Trends Biochem. Sci.
, vol.37
, pp. 418-424
-
-
Li, M.1
Greenberg, R.2
-
147
-
-
9244252580
-
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
-
Huyen Y, Zgheib O. 2004 Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406-411. (doi:10.1038/nature03114)
-
(2004)
Nature
, vol.432
, pp. 406-411
-
-
Huyen, Y.1
Zgheib, O.2
-
148
-
-
84879888213
-
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte A et al. 2013 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 499, 50-54. (doi:10.1038/nature12318)
-
(2013)
Nature
, vol.499
, pp. 50-54
-
-
Fradet-Turcotte, A.1
-
149
-
-
79954528832
-
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
-
Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM. 2011 RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 25, 685-700. (doi:10.1101/gad.2011011)
-
(2011)
Genes Dev.
, vol.25
, pp. 685-700
-
-
Hu, Y.1
Scully, R.2
Sobhian, B.3
Xie, A.4
Shestakova, E.5
Livingston, D.M.6
-
150
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. 2006 Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206. (doi:10.1083/jcb.200510130)
-
(2006)
J. Cell Biol.
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
Melander, F.4
Kastan, M.B.5
Bartek, J.6
Lukas, J.7
-
151
-
-
84870760201
-
RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage
-
Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ. 2012 RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci. Signal. 5, ra88. (doi:10.1126/scisignal.2003485)
-
(2012)
Sci. Signal.
, vol.5
, pp. ra88
-
-
Guzzo, C.M.1
Berndsen, C.E.2
Zhu, J.3
Gupta, V.4
Datta, A.5
Greenberg, R.A.6
Wolberger, C.7
Matunis, M.J.8
-
152
-
-
84864076551
-
Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates
-
Hu X, Paul A, Wang B. 2012 Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J. Biol. Chem. 287, 25 510-25 519. (doi:10.1074/jbc.M112.374116)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 25510-25519
-
-
Hu, X.1
Paul, A.2
Wang, B.3
-
153
-
-
75149189204
-
BRCA1 and its toolbox for the maintenance of genome integrity
-
Huen MSY, Sy SMH, Chen J. 2010 BRCA1 and its toolbox for the maintenance of genome integrity. Nat. Rev. Mol. Cell Biol. 11, 138-148. (doi:10.1038/nrm2831)
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 138-148
-
-
Huen, M.S.Y.1
Sy, S.M.H.2
Chen, J.3
-
154
-
-
58549098527
-
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks
-
Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng J-T, Jasin M, Baer R, Ludwig T. 2008 E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc. Natl Acad. Sci. USA 105, 20 876-20 881. (doi:10.1073/pnas.0811203106)
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 20876-20881
-
-
Reid, L.J.1
Shakya, R.2
Modi, A.P.3
Lokshin, M.4
Cheng, J.-T.5
Jasin, M.6
Baer, R.7
Ludwig, T.8
-
155
-
-
80055092789
-
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity
-
Shakya R et al. 2011 BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science 334, 525-528. (doi:10.1126/science.1209909)
-
(2011)
Science
, vol.334
, pp. 525-528
-
-
Shakya, R.1
-
156
-
-
83455229693
-
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
-
Drost R et al. 2011 BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell 20, 797-809. (doi:10.1016/j.ccr.2011.11.014)
-
(2011)
Cancer Cell
, vol.20
, pp. 797-809
-
-
Drost, R.1
-
157
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting SF et al. 2010 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141, 243-254. (doi:10.1016/j.cell.2010.03.012)
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
-
158
-
-
84876855215
-
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
-
Chapman JR et al. 2013 RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell 49, 858-871. (doi:10.1016/j.molcel.2013. 01.002)
-
(2013)
Mol. Cell
, vol.49
, pp. 858-871
-
-
Chapman, J.R.1
-
159
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Díaz C et al. 2013 A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell 49, 872-883. (doi:10.1016/j.molcel.2013.01.001)
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Díaz, C.1
-
160
-
-
84883458147
-
Deubiquitylating enzymes and DNA damage response pathways
-
Jacq X, Kemp M, Martin NMB, Jackson SP. 2013 Deubiquitylating enzymes and DNA damage response pathways. Cell Biochem. Biophys. 67, 25-43. (doi:10.1007/s12013-013-9635-3)
-
(2013)
Cell Biochem. Biophys.
, vol.67
, pp. 25-43
-
-
Jacq, X.1
Kemp, M.2
Martin, N.M.B.3
Jackson, S.P.4
-
161
-
-
84861948252
-
Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks
-
Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N. 2012 Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. J. Cell Biol. 197, 189-199. (doi:10.1083/jcb.201109100)
-
(2012)
J. Cell Biol.
, vol.197
, pp. 189-199
-
-
Poulsen, M.1
Lukas, C.2
Lukas, J.3
Bekker-Jensen, S.4
Mailand, N.5
-
162
-
-
84864977706
-
Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage
-
Chen J, Feng W, Jiang J, Deng Y, Huen MSY. 2012 Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage. J. Biol. Chem. 287, 27 715-27 722. (doi:10.1074/jbc.M112.373530)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27715-27722
-
-
Chen, J.1
Feng, W.2
Jiang, J.3
Deng, Y.4
Huen, M.S.Y.5
-
163
-
-
84865232294
-
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
-
Gudjonsson T et al. 2012 TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell 150, 697-709. (doi:10.1016/j.cell.2012.06.039)
-
(2012)
Cell
, vol.150
, pp. 697-709
-
-
Gudjonsson, T.1
-
164
-
-
79951971464
-
Regulation of homologous recombination by RNF20-dependent H2B ubiquitination
-
Nakamura K et al. 2011 Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Mol. Cell 41, 515-528. (doi:10.1016/j.molcel.2011.02.002)
-
(2011)
Mol. Cell
, vol.41
, pp. 515-528
-
-
Nakamura, K.1
-
165
-
-
79951974992
-
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
-
Moyal L et al. 2011 Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol. Cell 41, 529-542. (doi:10.1016/j.molcel.2011.02.015)
-
(2011)
Mol. Cell
, vol.41
, pp. 529-542
-
-
Moyal, L.1
-
166
-
-
0141484612
-
A novel ubiquitin ligase is deficient in Fanconi anemia
-
Meetei AR et al. 2003 A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet. 35, 165-170. (doi:10.1038/ng1241)
-
(2003)
Nat. Genet.
, vol.35
, pp. 165-170
-
-
Meetei, A.R.1
-
167
-
-
33746957852
-
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation
-
Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD, Dutta A. 2006 UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol. Cell 23, 589-596. (doi:10.1016/j.molcel.2006.06.024)
-
(2006)
Mol. Cell
, vol.23
, pp. 589-596
-
-
Machida, Y.J.1
Machida, Y.2
Chen, Y.3
Gurtan, A.M.4
Kupfer, G.M.5
D'andrea, A.D.6
Dutta, A.7
-
168
-
-
77954274685
-
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
-
MacKay C et al. 2010 Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell 142, 65-76. (doi:10.1016/j.cell.2010.06.021)
-
(2010)
Cell
, vol.142
, pp. 65-76
-
-
Mackay, C.1
-
169
-
-
77954279611
-
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents
-
Kratz K et al. 2010 Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142, 77-88. (doi:10.1016/j.cell.2010.06.022)
-
(2010)
Cell
, vol.142
, pp. 77-88
-
-
Kratz, K.1
-
170
-
-
77954286076
-
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
-
Smogorzewska A et al. 2010 A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol. Cell 39, 36-47. (doi:10.1016/j.molcel.2010.06.023)
-
(2010)
Mol. Cell
, vol.39
, pp. 36-47
-
-
Smogorzewska, A.1
-
171
-
-
84901281433
-
FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks
-
Murina O, von Aesch C, Karakus U, Ferretti LP, Bolck HA, Hänggi K, Sartori AA. 2014 FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks. Cell Rep. 7, 1030-1038. (doi:10.1016/j.celrep.2014. 03.069)
-
(2014)
Cell Rep.
, vol.7
, pp. 1030-1038
-
-
Murina, O.1
Von Aesch, C.2
Karakus, U.3
Ferretti, L.P.4
Bolck, H.A.5
Hänggi, K.6
Sartori, A.A.7
-
172
-
-
69949120911
-
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint
-
Zhang N, Kaur R, Akhter S, Legerski RJ. 2009 Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint. EMBO Rep. 10, 1029-1035. (doi:10.1038/embor.2009.122)
-
(2009)
EMBO Rep.
, vol.10
, pp. 1029-1035
-
-
Zhang, N.1
Kaur, R.2
Akhter, S.3
Legerski, R.J.4
-
173
-
-
84892895021
-
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry
-
Marechal A et al. 2014 PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol. Cell 53, 235-246. (doi:10.1016/j.molcel.2013.11.002)
-
(2014)
Mol. Cell
, vol.53
, pp. 235-246
-
-
Marechal, A.1
-
174
-
-
84896758119
-
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasiamutated and RAD3-related (ATR)
-
Wan L, Huang J. 2014 The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasiamutated and RAD3-related (ATR). J. Biol. Chem. 289, 6619-6626. (doi:10.1074/jbc.M113.543439)
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 6619-6626
-
-
Wan, L.1
Huang, J.2
-
175
-
-
79959346617
-
E3 ligase RFWD3 participates in replication checkpoint control
-
Gong Z, Chen J. 2011 E3 ligase RFWD3 participates in replication checkpoint control. J. Biol. Chem. 286, 22 308-22 313. (doi:10.1074/jbc.M111.222869)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22308-22313
-
-
Gong, Z.1
Chen, J.2
-
176
-
-
79959361651
-
RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPAmediated DNA damage response
-
Liu S, Chu J, Yucer N, Leng M, Wang SY, Chen BPC, Hittelman WN, Wang Y. 2011 RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPAmediated DNA damage response. J. Biol. Chem. 286, 22 314-22 322. (doi:10.1074/jbc.M111.222802)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22314-22322
-
-
Liu, S.1
Chu, J.2
Yucer, N.3
Leng, M.4
Wang, S.Y.5
Chen, B.P.C.6
Hittelman, W.N.7
Wang, Y.8
-
177
-
-
77949522982
-
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
-
Fu X et al. 2010 RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Proc. Natl Acad. Sci. USA 107, 4579-4584. (doi:10.1073/pnas.0912094107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4579-4584
-
-
Fu, X.1
-
178
-
-
0141924550
-
The Prp19p-associated complex in spliceosome activation
-
Chan S-P, Kao D-I, Tsai W-Y, Cheng S-C. 2003 The Prp19p-associated complex in spliceosome activation. Science 302, 279-282. (doi:10.1126/science.1086602)
-
(2003)
Science
, vol.302
, pp. 279-282
-
-
Chan, S.-P.1
Kao, D.-I.2
Tsai, W.-Y.3
Cheng, S.-C.4
-
179
-
-
34648840192
-
SUMO-targeted ubiquitin ligases in genome stability
-
Prudden J, Pebernard S, Raffa G, Slavin DA, Perry JJP, Tainer JA, McGowan CH, Boddy MN. 2007 SUMO-targeted ubiquitin ligases in genome stability. EMBO J. 26, 4089-4101. (doi:10.1038/sj. emboj.7601838)
-
(2007)
EMBO J.
, vol.26
, pp. 4089-4101
-
-
Prudden, J.1
Pebernard, S.2
Raffa, G.3
Slavin, D.A.4
Perry, J.J.P.5
Tainer, J.A.6
McGowan, C.H.7
Boddy, M.N.8
-
180
-
-
84861784690
-
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
-
Yin Y, Seifert A, Chua JS, Maure J-F, Golebiowski F, Hay RT. 2012 SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev. 26, 1196-1208. (doi:10.1101/gad.189274.112)
-
(2012)
Genes Dev.
, vol.26
, pp. 1196-1208
-
-
Yin, Y.1
Seifert, A.2
Chua, J.S.3
Maure, J.-F.4
Golebiowski, F.5
Hay, R.T.6
-
181
-
-
84861765707
-
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
-
Galanty Y, Belotserkovskaya R, Coates J, Jackson SP. 2012 RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev. 26, 1179-1195. (doi:10.1101/gad.188284.112)
-
(2012)
Genes Dev.
, vol.26
, pp. 1179-1195
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Jackson, S.P.4
-
182
-
-
84920415516
-
2015 Ubiquitin-SUMO circuitry controls activated Fanconi anemia ID complex dosage in response to DNA damage
-
Gibbs-Seymour I et al. 2015 Ubiquitin-SUMO circuitry controls activated Fanconi anemia ID complex dosage in response to DNA damage. Mol. Cell 57, 150-164. (doi:10.1016/j.molcel.2014.12.001)
-
Mol. Cell
, vol.57
, pp. 150-164
-
-
Gibbs-Seymour, I.1
-
183
-
-
84896375470
-
SUMO chaininduced dimerization activates RNF4
-
Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT. 2014 SUMO chaininduced dimerization activates RNF4. Mol. Cell 53, 880-892. (doi:10.1016/j.molcel.2014.02.031)
-
(2014)
Mol. Cell
, vol.53
, pp. 880-892
-
-
Rojas-Fernandez, A.1
Plechanovová, A.2
Hattersley, N.3
Jaffray, E.4
Tatham, M.H.5
Hay, R.T.6
-
184
-
-
84880032059
-
RNF111/Arkadia is a SUMOtargeted ubiquitin ligase that facilitates the DNA damage response
-
Poulsen SL et al. 2013 RNF111/Arkadia is a SUMOtargeted ubiquitin ligase that facilitates the DNA damage response. J. Cell Biol. 201, 797-807. (doi:10.1083/jcb.201212075)
-
(2013)
J. Cell Biol.
, vol.201
, pp. 797-807
-
-
Poulsen, S.L.1
-
185
-
-
65649115267
-
Recognition and processing of ubiquitin-protein conjugates by the proteasome
-
Finley D. 2009 Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 78, 477-513. (doi:10.1146/annurev.biochem.78.081507.101607)
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 477-513
-
-
Finley, D.1
-
186
-
-
84867101138
-
The proteasomal deubiquitinating enzyme POH1 promotes the double-strand DNA break response
-
Butler LR et al. 2012 The proteasomal deubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J. 31, 3918-3934. (doi:10.1038/emboj.2012.232)
-
(2012)
EMBO J.
, vol.31
, pp. 3918-3934
-
-
Butler, L.R.1
-
187
-
-
0034232093
-
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
-
Molinari M, Mercurio C, Dominguez J, Goubin F, Draetta GF. 2000 Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 1, 71-79. (doi:10.1093/embo-reports/kvd018)
-
(2000)
EMBO Rep.
, vol.1
, pp. 71-79
-
-
Molinari, M.1
Mercurio, C.2
Dominguez, J.3
Goubin, F.4
Draetta, G.F.5
-
188
-
-
77955347759
-
HERC2 is an E3 ligase that targets BRCA1 for degradation
-
Wu W, Sato K, Koike A, Nishikawa H, Koizumi H, Venkitaraman AR, Ohta T. 2010 HERC2 is an E3 ligase that targets BRCA1 for degradation. Cancer Res. 70, 6384-6392. (doi:10.1158/0008-5472.CAN-10-1304)
-
(2010)
Cancer Res.
, vol.70
, pp. 6384-6392
-
-
Wu, W.1
Sato, K.2
Koike, A.3
Nishikawa, H.4
Koizumi, H.5
Venkitaraman, A.R.6
Ohta, T.7
-
189
-
-
57649130600
-
Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation
-
Shi W, Ma Z, Willers H, Akhtar K, Scott SP, Zhang J, Powell S, Zhang J. 2008 Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation. J. Biol. Chem. 283, 31 608-31 616. (doi:10.1074/jbc.M801082200)
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31608-31616
-
-
Shi, W.1
Ma, Z.2
Willers, H.3
Akhtar, K.4
Scott, S.P.5
Zhang, J.6
Powell, S.7
Zhang, J.8
-
190
-
-
84856474838
-
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
-
Meyer H, Bug M, Bremer S. 2012 Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat. Cell Biol. 14, 117-123. (doi:10.1038/ncb2407)
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 117-123
-
-
Meyer, H.1
Bug, M.2
Bremer, S.3
-
191
-
-
84919385184
-
Should i stay or should i go: VCP/p97-mediated chromatin extraction in the DNA damage response
-
Dantuma NP, Acs K, Luijsterburg MS. 2014 Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response. Exp. Cell Res 329, 9-17. (doi:10.1016/j.yexcr.2014.08.025)
-
(2014)
Exp. Cell Res
, vol.329
, pp. 9-17
-
-
Dantuma, N.P.1
Acs, K.2
Luijsterburg, M.S.3
-
192
-
-
84899627951
-
Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
-
Puumalainen M-R, Lessel D, Rüthemann P, Kaczmarek N, Bachmann K, Ramadan K, Naegeli H. 2014 Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nat. Commun. 5, 3695. (doi:10.1038/ncomms4695)
-
(2014)
Nat. Commun.
, vol.5
, pp. 3695
-
-
Puumalainen, M.-R.1
Lessel, D.2
Rüthemann, P.3
Kaczmarek, N.4
Bachmann, K.5
Ramadan, K.6
Naegeli, H.7
-
193
-
-
80053583606
-
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction
-
Raman M, Havens CG, Walter JC, Harper JW. 2011 A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction. Mol. Cell 44, 72-84. (doi:10.1016/j.molcel.2011.06.036)
-
(2011)
Mol. Cell
, vol.44
, pp. 72-84
-
-
Raman, M.1
Havens, C.G.2
Walter, J.C.3
Harper, J.W.4
-
194
-
-
80455145246
-
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
-
Meerang M et al. 2011 The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat. Cell Biol. 13, 1376-1382. (doi:10.1038/ncb2367)
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1376-1382
-
-
Meerang, M.1
-
195
-
-
84869093163
-
DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage
-
Davis EJ, Lachaud C, Appleton P, Macartney TJ, Näthke I, Rouse J. 2012 DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. Nat. Struct. Mol. Biol. 19, 1093-1100. (doi:10.1038/nsmb.2394)
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 1093-1100
-
-
Davis, E.J.1
Lachaud, C.2
Appleton, P.3
Macartney, T.J.4
Näthke, I.5
Rouse, J.6
-
196
-
-
84869086918
-
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
-
Mosbech A et al. 2012 DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat. Struct. Mol. Biol. 19, 1084-1092. (doi:10.1038/nsmb.2395)
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 1084-1092
-
-
Mosbech, A.1
-
197
-
-
84923385382
-
Spartan deficiency causes genomic instability and progeroid phenotypes
-
Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ. 2014 Spartan deficiency causes genomic instability and progeroid phenotypes. Nat. Commun. 5, 5744. (doi:10.1038/ncomms6744)
-
(2014)
Nat. Commun.
, vol.5
, pp. 5744
-
-
Maskey, R.S.1
Kim, M.S.2
Baker, D.J.3
Childs, B.4
Malureanu, L.A.5
Jeganathan, K.B.6
Machida, Y.7
Van Deursen, J.M.8
Machida, Y.J.9
-
198
-
-
84908674649
-
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
-
Lessel D et al. 2014 Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat. Genet. 46, 1239-1244. (doi:10.1038/ng.3103)
-
(2014)
Nat. Genet.
, vol.46
, pp. 1239-1244
-
-
Lessel, D.1
-
199
-
-
84865475874
-
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMOtargeted ubiquitin ligase-mediated genome stability functions
-
Nie M, Aslanian A, Prudden J, Heideker J, Vashisht AA, Wohlschlegel JA, Yates JR, Boddy MN. 2012 Dual recruitment of Cdc48 ( p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMOtargeted ubiquitin ligase-mediated genome stability functions. J. Biol. Chem. 287, 29 610-29 619. (doi:10.1074/jbc.M112.379768)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29610-29619
-
-
Nie, M.1
Aslanian, A.2
Prudden, J.3
Heideker, J.4
Vashisht, A.A.5
Wohlschlegel, J.A.6
Yates, J.R.7
Boddy, M.N.8
-
200
-
-
84877585813
-
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction
-
Bergink S, Ammon T, Kern M, Schermelleh L, Leonhardt H, Jentsch S. 2013 Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat. Cell Biol. 15, 526-532. (doi:10.1038/ncb2729)
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 526-532
-
-
Bergink, S.1
Ammon, T.2
Kern, M.3
Schermelleh, L.4
Leonhardt, H.5
Jentsch, S.6
-
201
-
-
84856415004
-
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
-
Sun X-X, Challagundla KB, Dai M-S. 2011 Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J. 31, 576-592. (doi:10.1038/emboj.2011.434)
-
(2011)
EMBO J.
, vol.31
, pp. 576-592
-
-
Sun, X.-X.1
Challagundla, K.B.2
Dai, M.-S.3
-
202
-
-
77955867565
-
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
-
Nakada S et al. 2010 Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 466, 941-946. (doi:10.1038/nature09297)
-
(2010)
Nature
, vol.466
, pp. 941-946
-
-
Nakada, S.1
-
203
-
-
84856801739
-
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function
-
Juang Y-C et al. 2012 OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol. Cell 45, 384-397. (doi:10.1016/j.molcel.2012.01.011)
-
(2012)
Mol. Cell
, vol.45
, pp. 384-397
-
-
Juang, Y.-C.1
-
204
-
-
84862806447
-
The mechanism of OTUB1-mediated inhibition of ubiquitination
-
Wiener R, Zhang X, Wang T, Wolberger C. 2012 The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature 483, 618-622. (doi:10.1038/nature10911)
-
(2012)
Nature
, vol.483
, pp. 618-622
-
-
Wiener, R.1
Zhang, X.2
Wang, T.3
Wolberger, C.4
-
205
-
-
84878758649
-
The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
-
Mosbech A, Lukas C, Bekker-Jensen S, Mailand N. 2013 The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. J. Biol. Chem. 288, 16 579-16 587. (doi:10.1074/jbc.M113.459917)
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 16579-16587
-
-
Mosbech, A.1
Lukas, C.2
Bekker-Jensen, S.3
Mailand, N.4
-
206
-
-
84870562210
-
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
-
Zhang Y, Foreman O, Wigle DA, Kosari F, Vasmatzis G, Salisbury JL, van Deursen J, Galardy PJ. 2012 USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J. Clin. Invest. 122, 4362-4374. (doi:10.1172/JCI63084)
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4362-4374
-
-
Zhang, Y.1
Foreman, O.2
Wigle, D.A.3
Kosari, F.4
Vasmatzis, G.5
Salisbury, J.L.6
Van Deursen, J.7
Galardy, P.J.8
-
207
-
-
34247376926
-
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
-
Stegmeier F et al. 2007 Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 446, 876-881. (doi:10.1038/nature05694)
-
(2007)
Nature
, vol.446
, pp. 876-881
-
-
Stegmeier, F.1
-
208
-
-
13244291457
-
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
-
Nijman SMB, Huang TT, Dirac AMG, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R. 2005 The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol. Cell 17, 331-339. (doi:10.1016/j.molcel.2005.01.008)
-
(2005)
Mol. Cell
, vol.17
, pp. 331-339
-
-
Nijman, S.M.B.1
Huang, T.T.2
Dirac, A.M.G.3
Brummelkamp, T.R.4
Kerkhoven, R.M.5
D'andrea, A.D.6
Bernards, R.7
-
209
-
-
36749100034
-
Deubiquitination of FANCD2 is required for DNA crosslink repair
-
Oestergaard VH et al. 2007 Deubiquitination of FANCD2 is required for DNA crosslink repair. Mol. Cell 28, 798-809. (doi:10.1016/j.molcel.2007.09.020)
-
(2007)
Mol. Cell
, vol.28
, pp. 798-809
-
-
Oestergaard, V.H.1
-
210
-
-
33746766974
-
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
-
Zhang D, Zaugg K, Mak TW, Elledge SJ. 2006 A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126, 529-542. (doi:10.1016/j.cell.2006.06.039)
-
(2006)
Cell
, vol.126
, pp. 529-542
-
-
Zhang, D.1
Zaugg, K.2
Mak, T.W.3
Elledge, S.J.4
-
211
-
-
84899880562
-
USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in doublestrand break metabolism
-
Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP, Stracker TH. 2014 USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in doublestrand break metabolism. Mol. Cell. Biol. 34, 2062-2074. (doi:10.1128/MCB.00197-14)
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 2062-2074
-
-
Knobel, P.A.1
Belotserkovskaya, R.2
Galanty, Y.3
Schmidt, C.K.4
Jackson, S.P.5
Stracker, T.H.6
-
212
-
-
84875446642
-
BAP1 and cancer
-
Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G. 2013 BAP1 and cancer. Nat. Rev. Cancer 13, 153-159. (doi:10.1038/nrc3459)
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 153-159
-
-
Carbone, M.1
Yang, H.2
Pass, H.I.3
Krausz, T.4
Testa, J.R.5
Gaudino, G.6
-
213
-
-
84905995383
-
Germline mutations in BAP1 impair its function in DNA double-strand break repair
-
Ismail IH, Davidson R, Gagné JP, Xu ZZ, Poirier GG, Hendzel MJ. 2014 Germline mutations in BAP1 impair its function in DNA double-strand break repair. Cancer Res. 74, 4282-4294. (doi:10.1158/0008-5472.CAN-13-3109)
-
(2014)
Cancer Res.
, vol.74
, pp. 4282-4294
-
-
Ismail, I.H.1
Davidson, R.2
Gagné, J.P.3
Xu, Z.Z.4
Poirier, G.G.5
Hendzel, M.J.6
-
214
-
-
84891912266
-
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
-
Yu H et al. 2014 Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc. Natl Acad. Sci. USA 111, 285-290. (doi:10.1073/pnas.1309085110)
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 285-290
-
-
Yu, H.1
-
215
-
-
84922010371
-
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
-
Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP. 2014 Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat. Cell Biol. 16, 1016-1026. (doi:10.1038/ncb3028)
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 1016-1026
-
-
Nishi, R.1
Wijnhoven, P.2
Le Sage, C.3
Tjeertes, J.4
Galanty, Y.5
Forment, J.V.6
Clague, M.J.7
Urbé, S.8
Jackson, S.P.9
-
216
-
-
0026763128
-
Identification of a set of genes with developmentally downregulated expression in the mouse brain
-
Kumar S, Tomooka Y, Noda M. 1992 Identification of a set of genes with developmentally downregulated expression in the mouse brain. Biochem. Biophys. Res. 185, 1155-1161. (doi:10.1016/0006-291X(92)91747-E)
-
(1992)
Biochem. Biophys. Res.
, vol.185
, pp. 1155-1161
-
-
Kumar, S.1
Tomooka, Y.2
Noda, M.3
-
217
-
-
0030695339
-
Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein
-
Kamitani T, Kito K, Nguyen HP, Yeh ETH. 1997 Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J. Biol. Chem. 272, 28 557-28 562. (doi:10.1074/jbc. 272.45.28557)
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28557-28562
-
-
Kamitani, T.1
Kito, K.2
Nguyen, H.P.3
Yeh, E.T.H.4
-
218
-
-
0032567528
-
Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes
-
Whitby FG, Xia G, Pickart CM, Hill CP. 1998 Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J. Biol. Chem. 273, 34 983-34 991. (doi:10.1074/jbc.273.52.34983)
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 34983-34991
-
-
Whitby, F.G.1
Xia, G.2
Pickart, C.M.3
Hill, C.P.4
-
219
-
-
0032522382
-
A novel protein modification pathway related to the ubiquitin system
-
Liakopoulos D, Doenges G, Matuschewski K, Jentsch S. 1998 A novel protein modification pathway related to the ubiquitin system. EMBO J. 17, 2208-2214. (doi:10.1093/emboj/17.8.2208)
-
(1998)
EMBO J.
, vol.17
, pp. 2208-2214
-
-
Liakopoulos, D.1
Doenges, G.2
Matuschewski, K.3
Jentsch, S.4
-
220
-
-
0032053829
-
Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex
-
Lammer D, Mathias N, Laplaza JM, Jiang W, Liu Y, Callis J, Goebl M, Estelle M. 1998 Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex. Genes Dev. 12, 914-926. (doi:10.1101/gad. 12.7.914)
-
(1998)
Genes Dev.
, vol.12
, pp. 914-926
-
-
Lammer, D.1
Mathias, N.2
Laplaza, J.M.3
Jiang, W.4
Liu, Y.5
Callis, J.6
Goebl, M.7
Estelle, M.8
-
221
-
-
0038491277
-
NEDP1, a highly conserved cysteine protease that deNEDDylates cullins
-
Mendoza HM, Shen L-N, Botting C, Lewis A, Chen J, Ink B, Hay RT. 2003 NEDP1, a highly conserved cysteine protease that deNEDDylates cullins. J. Biol. Chem. 278, 25 637-25 643. (doi:10.1074/jbc.M212948200)
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25637-25643
-
-
Mendoza, H.M.1
Shen, L.-N.2
Botting, C.3
Lewis, A.4
Chen, J.5
Ink, B.6
Hay, R.T.7
-
222
-
-
0032578855
-
Cleavage of the C-terminus of NEDD8 by UCH-L3
-
Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T. 1998 Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochem. Biophys. Res. Commun. 251, 688-692. (doi:10.1006/bbrc.1998.9532)
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 688-692
-
-
Wada, H.1
Kito, K.2
Caskey, L.S.3
Yeh, E.T.4
Kamitani, T.5
-
223
-
-
0028308828
-
Site-directed mutagenesis of ubiquitin. Differential roles for arginine in the interaction with ubiquitin-activating enzyme
-
Burch TJ, Haas AL. 1994 Site-directed mutagenesis of ubiquitin. Differential roles for arginine in the interaction with ubiquitin-activating enzyme. Biochemistry 33, 7300-7308. (doi:10.1021/bi00189a035)
-
(1994)
Biochemistry
, vol.33
, pp. 7300-7308
-
-
Burch, T.J.1
Haas, A.L.2
-
224
-
-
50149089376
-
Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD80s E1
-
Souphron J, Waddell MB, Paydar A, Tokgöz-Gromley Z, Roussel MF, Schulman BA. 2008 Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD80s E1. Biochemistry 47, 8961-8969. (doi:10.1021/bi800604c)
-
(2008)
Biochemistry
, vol.47
, pp. 8961-8969
-
-
Souphron, J.1
Waddell, M.B.2
Paydar, A.3
Tokgöz-Gromley, Z.4
Roussel, M.F.5
Schulman, B.A.6
-
225
-
-
0347416977
-
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
-
Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA. 2003 The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol. Cell 12, 1427-1437. (doi:10.1016/S1097-2765(03)00452-0)
-
(2003)
Mol. Cell
, vol.12
, pp. 1427-1437
-
-
Walden, H.1
Podgorski, M.S.2
Huang, D.T.3
Miller, D.W.4
Howard, R.J.5
Minor, D.L.6
Holton, J.M.7
Schulman, B.A.8
-
226
-
-
0037697382
-
Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer
-
Bohnsack RN, Haas AL. 2003 Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J. Biol. Chem. 278, 26 823-26 830. (doi:10.1074/jbc.M303177200)
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 26823-26830
-
-
Bohnsack, R.N.1
Haas, A.L.2
-
227
-
-
13244249669
-
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD80s E1
-
Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA. 2005 Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD80s E1. Mol. Cell 17, 341-350. (doi:10.1016/j.molcel.2004.12.020)
-
(2005)
Mol. Cell
, vol.17
, pp. 341-350
-
-
Huang, D.T.1
Paydar, A.2
Zhuang, M.3
Waddell, M.B.4
Holton, J.M.5
Schulman, B.A.6
-
228
-
-
84858724149
-
The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions
-
Leidecker O, Matic I, Mahata B, Pion E, Xirodimas DP. 2012 The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions. Cell Cycle 11, 1142-1150. (doi:10.4161/cc.11.6.19559)
-
(2012)
Cell Cycle
, vol.11
, pp. 1142-1150
-
-
Leidecker, O.1
Matic, I.2
Mahata, B.3
Pion, E.4
Xirodimas, D.P.5
-
229
-
-
84862908377
-
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
-
Hjerpe R, Thomas Y, Chen J, Zemla A, Curran S, Shpiro N, Dick LR, Kurz T. 2012 Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes. Biochem. J. 441, 927-936. (doi:10.1042/BJ20111671)
-
(2012)
Biochem. J.
, vol.441
, pp. 927-936
-
-
Hjerpe, R.1
Thomas, Y.2
Chen, J.3
Zemla, A.4
Curran, S.5
Shpiro, N.6
Dick, L.R.7
Kurz, T.8
-
230
-
-
0033597126
-
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
-
Gong L, Yeh ETH. 1999 Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J. Biol. Chem. 274, 12 036-12 042. (doi:10.1074/jbc.274.17.12036)
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12036-12042
-
-
Gong, L.1
Yeh, E.T.H.2
-
231
-
-
0032146145
-
A new NEDD8-ligating system for cullin-4A
-
Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S. 1998 A new NEDD8-ligating system for cullin-4A. Genes Dev. 12, 2263-2268. (doi:10.1101/gad.12.15.2263)
-
(1998)
Genes Dev.
, vol.12
, pp. 2263-2268
-
-
Osaka, F.1
Kawasaki, H.2
Aida, N.3
Saeki, M.4
Chiba, T.5
Kawashima, S.6
Tanaka, K.7
Kato, S.8
-
232
-
-
60549091914
-
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
-
Huang DT et al. 2009 E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol. Cell 33, 483-495. (doi:10.1016/j.molcel.2009.01.011)
-
(2009)
Mol. Cell
, vol.33
, pp. 483-495
-
-
Huang, D.T.1
-
233
-
-
77956500977
-
A dual E3 mechanism for Rub1 ligation to Cdc53
-
Scott DC, Monda JK, Grace CRR, Duda DM, Kriwacki RW, Kurz T, Schulman BA. 2010 A dual E3 mechanism for Rub1 ligation to Cdc53. Mol. Cell 39, 784-796. (doi:10.1016/j.molcel.2010.08.030)
-
(2010)
Mol. Cell
, vol.39
, pp. 784-796
-
-
Scott, D.C.1
Monda, J.K.2
Grace, C.R.R.3
Duda, D.M.4
Kriwacki, R.W.5
Kurz, T.6
Schulman, B.A.7
-
234
-
-
0032727343
-
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
-
Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW. 1999 The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev. 13, 2928-2933. (doi:10.1101/gad.13.22.2928)
-
(1999)
Genes Dev.
, vol.13
, pp. 2928-2933
-
-
Kamura, T.1
Conrad, M.N.2
Yan, Q.3
Conaway, R.C.4
Conaway, J.W.5
-
235
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski MD, Deshaies RJ. 2005 Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6, 9-20. (doi:10.1038/nrm1547)
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
236
-
-
21744455599
-
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. Elegans and S. Cerevisiae
-
Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M. 2005 The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature 435, 1257-1261. (doi:10.1038/nature03662)
-
(2005)
Nature
, vol.435
, pp. 1257-1261
-
-
Kurz, T.1
Ozlü, N.2
Rudolf, F.3
O'rourke, S.M.4
Luke, B.5
Hofmann, K.6
Hyman, A.A.7
Bowerman, B.8
Peter, M.9
-
237
-
-
57749112107
-
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation
-
Kim AY et al. 2008 SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. J. Biol. Chem. 283, 33 211-33 220. (doi:10.1074/jbc.M804440200)
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33211-33220
-
-
Kim, A.Y.1
-
238
-
-
38149035042
-
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation
-
Kurz T, Chou Y-C, Willems AR, Meyer-Schaller N, Hecht M-L, Tyers M, Peter M, Sicheri F. 2008 Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol. Cell 29, 23-35. (doi:10.1016/j.molcel.2007.12.012)
-
(2008)
Mol. Cell
, vol.29
, pp. 23-35
-
-
Kurz, T.1
Chou, Y.-C.2
Willems, A.R.3
Meyer-Schaller, N.4
Hecht, M.-L.5
Tyers, M.6
Peter, M.7
Sicheri, F.8
-
239
-
-
68149084883
-
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes
-
Meyer-Schaller N et al. 2009 The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc. Natl Acad. Sci. USA 106, 12 365-12 370. (doi:10.1073/pnas.0812528106)
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12365-12370
-
-
Meyer-Schaller, N.1
-
240
-
-
84872154184
-
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes
-
Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA. 2013 Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure 21, 42-53. (doi:10.1016/j.str.2012.10.013)
-
(2013)
Structure
, vol.21
, pp. 42-53
-
-
Monda, J.K.1
Scott, D.C.2
Miller, D.J.3
Lydeard, J.4
King, D.5
Harper, J.W.6
Bennett, E.J.7
Schulman, B.A.8
-
241
-
-
80053213947
-
Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1
-
Wu K, Yan H, Fang L, Wang X, Pfleger C, Jiang X, Huang L, Pan Z-Q. 2011 Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1. J. Biol. Chem. 286, 34 060-34 070. (doi:10.1074/jbc.M111.273045)
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 34060-34070
-
-
Wu, K.1
Yan, H.2
Fang, L.3
Wang, X.4
Pfleger, C.5
Jiang, X.6
Huang, L.7
Pan, Z.-Q.8
-
242
-
-
79957837864
-
The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe
-
Girdwood D, Xirodimas DP, Gordon C. 2011 The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in Schizosaccharomyces pombe. PLoS ONE 6, e20089. (doi:10.1371/journal.pone.0020089)
-
(2011)
PLoS ONE
, vol.6
-
-
Girdwood, D.1
Xirodimas, D.P.2
Gordon, C.3
-
243
-
-
40249111681
-
Ribosomal proteins are targets for the NEDD8 pathway
-
Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT. 2008 Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 9, 280-286. (doi:10.1038/embor.2008.10)
-
(2008)
EMBO Rep.
, vol.9
, pp. 280-286
-
-
Xirodimas, D.P.1
Sundqvist, A.2
Nakamura, A.3
Shen, L.4
Botting, C.5
Hay, R.T.6
-
244
-
-
44449129585
-
A targeted proteomic analysis of the ubiquitin-like modifier Nedd8 and associated proteins
-
Jones J, Wu K, Yang Y, Guerrero C. 2008 A targeted proteomic analysis of the ubiquitin-like modifier Nedd8 and associated proteins. J. Proteome 7, 1274-1287. (doi:10.1021/pr700749v)
-
(2008)
J. Proteome
, vol.7
, pp. 1274-1287
-
-
Jones, J.1
Wu, K.2
Yang, Y.3
Guerrero, C.4
-
245
-
-
0027022309
-
COP9: A new genetic locus involved in light-regulated development and gene expression in arabidopsis
-
Wei N, Deng XW. 1992 COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. Plant Cell 4, 1507-1518. (doi:10.1105/tpc.4.12.1507)
-
(1992)
Plant Cell
, vol.4
, pp. 1507-1518
-
-
Wei, N.1
Deng, X.W.2
-
246
-
-
0037131242
-
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
-
Cope GA, Suh GSB, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ. 2002 Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611. (doi:10.1126/science.1075901)
-
(2002)
Science
, vol.298
, pp. 608-611
-
-
Cope, G.A.1
Suh, G.S.B.2
Aravind, L.3
Schwarz, S.E.4
Zipursky, S.L.5
Koonin, E.V.6
Deshaies, R.J.7
-
247
-
-
58149191374
-
Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality
-
Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson CV. 2009 Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure 17, 31-40. (doi:10.1016/j.str.2008.10.012)
-
(2009)
Structure
, vol.17
, pp. 31-40
-
-
Sharon, M.1
Mao, H.2
Boeri Erba, E.3
Stephens, E.4
Zheng, N.5
Robinson, C.V.6
-
248
-
-
84906238422
-
Crystal structure of the human COP9 signalosome
-
Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH. 2014 Crystal structure of the human COP9 signalosome. Nature 512, 161-165. (doi:10.1038/nature13566)
-
(2014)
Nature
, vol.512
, pp. 161-165
-
-
Lingaraju, G.M.1
Bunker, R.D.2
Cavadini, S.3
Hess, D.4
Hassiepen, U.5
Renatus, M.6
Fischer, E.S.7
Thomä, N.H.8
-
249
-
-
53249154203
-
Function and regulation of protein neddylation. 'Protein modifications: Beyond the usual suspects' review series
-
Rabut G, Peter M. 2008 Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 9, 969-976. (doi:10.1038/embor.2008.183)
-
(2008)
EMBO Rep.
, vol.9
, pp. 969-976
-
-
Rabut, G.1
Peter, M.2
-
250
-
-
84889084791
-
Building and remodelling Cullin-RING E3 ubiquitin ligases
-
Lydeard JR, Schulman BA, Harper JW. 2013 Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep. 14, 1050-1061. (doi:10.1038/embor.2013.173)
-
(2013)
EMBO Rep.
, vol.14
, pp. 1050-1061
-
-
Lydeard, J.R.1
Schulman, B.A.2
Harper, J.W.3
-
252
-
-
64749098830
-
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
-
Soucy TA et al. 2009 An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458, 732-736. (doi:10.1038/nature07884)
-
(2009)
Nature
, vol.458
, pp. 732-736
-
-
Soucy, T.A.1
-
253
-
-
79960290203
-
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex
-
Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A. 2011 Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol. Cell. Biol. 31, 3136-3145. (doi:10.1128/MCB.05496-11)
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3136-3145
-
-
Shibata, E.1
Abbas, T.2
Huang, X.3
Wohlschlegel, J.A.4
Dutta, A.5
-
254
-
-
34250318465
-
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
-
Lee J, Zhou P. 2007 DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Mol. Cell 26, 775-780. (doi:10.1016/j.molcel.2007.06.001)
-
(2007)
Mol. Cell
, vol.26
, pp. 775-780
-
-
Lee, J.1
Zhou, P.2
-
255
-
-
78649974984
-
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics
-
Bennett EJ, Rush J, Gygi SP, Harper JW. 2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 143, 951-965. (doi:10.1016/j.cell.2010.11.017)
-
(2010)
Cell
, vol.143
, pp. 951-965
-
-
Bennett, E.J.1
Rush, J.2
Gygi, S.P.3
Harper, J.W.4
-
256
-
-
79960068470
-
Structure and function of WD40 domain proteins
-
Xu C, Min J. 2011 Structure and function of WD40 domain proteins. Protein Cell 2, 202-214. (doi:10.1007/s13238-011-1018-1)
-
(2011)
Protein Cell
, vol.2
, pp. 202-214
-
-
Xu, C.1
Min, J.2
-
257
-
-
80054694510
-
Global identification of modular cullin-RING ligase substrates
-
Emanuele MJ et al. 2011 Global identification of modular cullin-RING ligase substrates. Cell 147, 459-474. (doi:10.1016/j.cell.2011.09.019)
-
(2011)
Cell
, vol.147
, pp. 459-474
-
-
Emanuele, M.J.1
-
258
-
-
84857968983
-
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway
-
M111.014407
-
Larance M, Kirkwood KJ, Xirodimas DP, Lundberg E, Uhlen M, Lamond AI. 2011 Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. Mol. Cell. Proteomics 11, M111.014407. (doi:10.1074/mcp.M111.014407)
-
(2011)
Mol. Cell. Proteomics
, vol.11
-
-
Larance, M.1
Kirkwood, K.J.2
Xirodimas, D.P.3
Lundberg, E.4
Uhlen, M.5
Lamond, A.I.6
-
259
-
-
50449108516
-
Structural insights into NEDD8 activation of cullin-RING ligases: Conformational control of conjugation
-
Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, Schulman BA. 2008 Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134, 995-1006. (doi:10.1016/j.cell.2008.07.022)
-
(2008)
Cell
, vol.134
, pp. 995-1006
-
-
Duda, D.M.1
Borg, L.A.2
Scott, D.C.3
Hunt, H.W.4
Hammel, M.5
Schulman, B.A.6
-
260
-
-
0036924046
-
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
-
Zheng J et al. 2002 CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol. Cell 10, 1519-1526. (doi:10.1016/S1097-2765(02)00784-0)
-
(2002)
Mol. Cell
, vol.10
, pp. 1519-1526
-
-
Zheng, J.1
-
261
-
-
0036929129
-
NEDD8 modification of CUL1 dissociates p120, an inhibitor of CUL1-SKP1 binding and SCF ligases
-
Liu J, Furukawa M, Matsumoto T, Xiong Y, Hill C, Carolina N. 2002 NEDD8 modification of CUL1 dissociates p120, an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol. Cell 10, 1511-1518. (doi:10.1016/S1097-2765(02)00783-9)
-
(2002)
Mol. Cell
, vol.10
, pp. 1511-1518
-
-
Liu, J.1
Furukawa, M.2
Matsumoto, T.3
Xiong, Y.4
Hill, C.5
Carolina, N.6
-
262
-
-
84875768399
-
CSN- and CAND1-dependent remodelling of the budding yeast SCF complex
-
Zemla A, Thomas Y, Kedziora S, Knebel A, Wood NT, Rabut G, Kurz T. 2013 CSN- and CAND1-dependent remodelling of the budding yeast SCF complex. Nat. Commun. 4, 1641. (doi:10.1038/ncomms2628)
-
(2013)
Nat. Commun.
, vol.4
, pp. 1641
-
-
Zemla, A.1
Thomas, Y.2
Kedziora, S.3
Knebel, A.4
Wood, N.T.5
Rabut, G.6
Kurz, T.7
-
263
-
-
84875724907
-
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins
-
Pierce NW et al. 2013 Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell 153, 206-215. (doi:10.1016/j.cell.2013.02.024)
-
(2013)
Cell
, vol.153
, pp. 206-215
-
-
Pierce, N.W.1
-
264
-
-
84875777183
-
CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire
-
Wu S, Zhu W, Nhan T, Toth JI, Petroski MD, Wolf DA. 2013 CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire. Nat. Commun. 4, 1642. (doi:10.1038/ncomms2636)
-
(2013)
Nat. Commun.
, vol.4
, pp. 1642
-
-
Wu, S.1
Zhu, W.2
Nhan, T.3
Toth, J.I.4
Petroski, M.D.5
Wolf, D.A.6
-
265
-
-
0037509945
-
Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p
-
Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA. 2003 Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol. Cell 11, 927-938. (doi:10.1016/S1097-2765(03)00136-9)
-
(2003)
Mol. Cell
, vol.11
, pp. 927-938
-
-
Zhou, C.1
Wee, S.2
Rhee, E.3
Naumann, M.4
Dubiel, W.5
Wolf, D.A.6
-
266
-
-
81855227619
-
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation
-
Fischer ES et al. 2011 The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Cell 147, 1024-1039. (doi:10.1016/j.cell.2011.10.035)
-
(2011)
Cell
, vol.147
, pp. 1024-1039
-
-
Fischer, E.S.1
-
267
-
-
84865527126
-
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism
-
Emberley ED, Mosadeghi R, Deshaies RJ. 2012 Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J. Biol. Chem. 287, 29 679-29 689. (doi:10.1074/jbc.M112.352484)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29679-29689
-
-
Emberley, E.D.1
Mosadeghi, R.2
Deshaies, R.J.3
-
268
-
-
84866905506
-
Structural basis for a reciprocal regulation between SCF and CSN
-
Enchev RI, Scott DC, da Fonseca PCA, Schreiber A, Monda JK, Schulman BA, Peter M, Morris EP. 2012 Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep. 2, 616-627. (doi:10.1016/j.celrep.2012.08.019)
-
(2012)
Cell Rep.
, vol.2
, pp. 616-627
-
-
Enchev, R.I.1
Scott, D.C.2
Da Fonseca, P.C.A.3
Schreiber, A.4
Monda, J.K.5
Schulman, B.A.6
Peter, M.7
Morris, E.P.8
-
269
-
-
69749123290
-
F-box-directed CRL complex assembly and regulation by the CSN and CAND1
-
Schmidt MW, McQuary PR, Wee S, Hofmann K, Wolf DA. 2009 F-box-directed CRL complex assembly and regulation by the CSN and CAND1. Mol. Cell 35, 586-597. (doi:10.1016/j.molcel.2009.07.024)
-
(2009)
Mol. Cell
, vol.35
, pp. 586-597
-
-
Schmidt, M.W.1
McQuary, P.R.2
Wee, S.3
Hofmann, K.4
Wolf, D.A.5
-
270
-
-
34447135496
-
Substrate-mediated regulation of cullin neddylation
-
Chew E-H, Hagen T. 2007 Substrate-mediated regulation of cullin neddylation. J. Biol. Chem. 282, 17 032-17 040. (doi:10.1074/jbc.M701153200)
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17032-17040
-
-
Chew, E.-H.1
Hagen, T.2
-
271
-
-
79953068658
-
Structural regulation of cullin-RING ubiquitin ligase complexes
-
Duda DM, Scott DC, Calabrese MF, Zimmerman ES, Zheng N, Schulman BA. 2011 Structural regulation of cullin-RING ubiquitin ligase complexes. Curr. Opin. Struct. Biol. 21, 257-264. (doi:10.1016/j.sbi.2011.01.003)
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 257-264
-
-
Duda, D.M.1
Scott, D.C.2
Calabrese, M.F.3
Zimmerman, E.S.4
Zheng, N.5
Schulman, B.A.6
-
272
-
-
79751469547
-
NEDD8 pathways in cancer, Sine Quibus Non
-
Watson IR, Irwin MS, Ohh M. 2011 NEDD8 pathways in cancer, Sine Quibus Non. Cancer Cell 19, 168-176. (doi:10.1016/j.ccr.2011.01.002)
-
(2011)
Cancer Cell
, vol.19
, pp. 168-176
-
-
Watson, I.R.1
Irwin, M.S.2
Ohh, M.3
-
273
-
-
77954614896
-
Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
-
Melchor L et al. 2009 Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes. Breast Cancer Res. 11, R86. (doi:10.1186/bcr2456)
-
(2009)
Breast Cancer Res.
, vol.11
, pp. R86
-
-
Melchor, L.1
-
274
-
-
73649110303
-
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: The NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ
-
Brownell JE et al. 2010 Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol. Cell 37, 102-111. (doi:10.1016/j.molcel.2009.12.024)
-
(2010)
Mol. Cell
, vol.37
, pp. 102-111
-
-
Brownell, J.E.1
-
275
-
-
78650355357
-
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
-
Lin JJ, Milhollen MA, Smith PG, Narayanan U, Dutta A. 2010 NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. Cancer Res. 70, 10 310-10 320. (doi:10.1158/0008-5472.CAN-10-2062)
-
(2010)
Cancer Res.
, vol.70
, pp. 10310-10320
-
-
Lin, J.J.1
Milhollen, M.A.2
Smith, P.G.3
Narayanan, U.4
Dutta, A.5
-
276
-
-
84880482918
-
Flipping the switch from G1 to S phase with E3 ubiquitin ligases
-
Rizzardi LF, Cook JG. 2012 Flipping the switch from G1 to S phase with E3 ubiquitin ligases. Genes Cancer 3, 634-648. (doi:10.1177/1947601912473307)
-
(2012)
Genes Cancer
, vol.3
, pp. 634-648
-
-
Rizzardi, L.F.1
Cook, J.G.2
-
277
-
-
77957378110
-
CRL4Cdt2 regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
-
Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A. 2010 CRL4Cdt2 regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol. Cell 40, 9-21. (doi:10.1016/j.molcel.2010.09.014)
-
(2010)
Mol. Cell
, vol.40
, pp. 9-21
-
-
Abbas, T.1
Shibata, E.2
Park, J.3
Jha, S.4
Karnani, N.5
Dutta, A.6
-
278
-
-
78149281634
-
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
-
Tardat M, Brustel J, Kirsh O, Lefevbre C, Callanan M, Sardet C, Julien E. 2010 The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat. Cell Biol. 12, 1086-1093. (doi:10.1038/ncb2113)
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1086-1093
-
-
Tardat, M.1
Brustel, J.2
Kirsh, O.3
Lefevbre, C.4
Callanan, M.5
Sardet, C.6
Julien, E.7
-
279
-
-
33745050138
-
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication
-
Zhu W, Dutta A. 2006 An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol. Cell. Biol. 26, 4601-4611. (doi:10.1128/MCB.02141-05)
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4601-4611
-
-
Zhu, W.1
Dutta, A.2
-
280
-
-
79954611863
-
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover
-
Milhollen MA, Narayanan U, Soucy TA, Veiby PO, Smith PG, Amidon B. 2011 Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. Cancer Res. 71, 3042-3051. (doi:10.1158/0008-5472.CAN-10-2122)
-
(2011)
Cancer Res.
, vol.71
, pp. 3042-3051
-
-
Milhollen, M.A.1
Narayanan, U.2
Soucy, T.A.3
Veiby, P.O.4
Smith, P.G.5
Amidon, B.6
-
281
-
-
79958165085
-
Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression
-
Jia L, Li H. 2011 Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression. Neoplasia (New York, NY) 13, 561-569. (doi:10.1593/neo.11420)
-
(2011)
Neoplasia (New York, NY)
, vol.13
, pp. 561-569
-
-
Jia, L.1
Li, H.2
-
282
-
-
84908257634
-
Polyubiquitylation drives replisome disassembly at the termination of DNA replication
-
Priego Moreno S, Bailey R, Campion N, Herron S, Gambus A. 2014 Polyubiquitylation drives replisome disassembly at the termination of DNA replication. Science 346, 477-481. (doi:10.1126/science.1253585)
-
(2014)
Science
, vol.346
, pp. 477-481
-
-
Priego Moreno, S.1
Bailey, R.2
Campion, N.3
Herron, S.4
Gambus, A.5
-
283
-
-
84908248970
-
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
-
Maric M, Maculins T, De Piccoli G, Labib K. 2014 Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science 346, 1253596. (doi:10.1126/science.1253596)
-
(2014)
Science
, vol.346
, pp. 1253596
-
-
Maric, M.1
Maculins, T.2
De Piccoli, G.3
Labib, K.4
-
284
-
-
22544470259
-
Disruption of mechanisms that prevent rereplication triggers a DNA damage response
-
Archambault V, Ikui A, Drapkin B, Cross F. 2005 Disruption of mechanisms that prevent rereplication triggers a DNA damage response. Mol. Cell 25, 6707-6721. (doi:10.1128/MCB.25.15.6707-6721.2005)
-
(2005)
Mol. Cell
, vol.25
, pp. 6707-6721
-
-
Archambault, V.1
Ikui, A.2
Drapkin, B.3
Cross, F.4
-
285
-
-
84871962551
-
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
-
Blank JL et al. 2013 Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924. Cancer Res. 73, 225-234. (doi:10.1158/0008-5472.CAN-12-1729)
-
(2013)
Cancer Res.
, vol.73
, pp. 225-234
-
-
Blank, J.L.1
-
286
-
-
84904261166
-
Targeting neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
-
Zhao Y, Morgan MA, Sun Y. 2014 Targeting neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxid. Redox Signal. 21, 2383-2400. (doi:10.1089/ars.2013.5795)
-
(2014)
Antioxid. Redox Signal.
, vol.21
, pp. 2383-2400
-
-
Zhao, Y.1
Morgan, M.A.2
Sun, Y.3
-
287
-
-
84928426387
-
Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: A phase 1 study
-
In press
-
Swords RT et al. In press. Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study. Br. J. Haematol. (doi:10.1111/bjh.13323)
-
Br. J. Haematol.
-
-
Swords, R.T.1
-
288
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas DP, Saville MK, Bourdon J-C, Hay RT, Lane DP. 2004 Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118, 83-97. (doi:10.1016/j.cell.2004.06.016)
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.-C.3
Hay, R.T.4
Lane, D.P.5
-
289
-
-
70449697971
-
Regulation of nucleolar signalling to p53 through NEDDylation of L11
-
Sundqvist A, Liu G, Mirsaliotis A, Xirodimas DP. 2009 Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep. 10, 1132-1139. (doi:10.1038/embor.2009.178)
-
(2009)
EMBO Rep.
, vol.10
, pp. 1132-1139
-
-
Sundqvist, A.1
Liu, G.2
Mirsaliotis, A.3
Xirodimas, D.P.4
-
290
-
-
84876849263
-
RNF111-dependent neddylation activates DNA damage-induced ubiquitination
-
Ma T, Chen Y, Zhang F, Yang C, Wang S, Yu X. 2013 RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol. Cell 49, 897-907. (doi:10.1016/j.molcel.2013.01.006)
-
(2013)
Mol. Cell
, vol.49
, pp. 897-907
-
-
Ma, T.1
Chen, Y.2
Zhang, F.3
Yang, C.4
Wang, S.5
Yu, X.6
-
292
-
-
65649105790
-
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis
-
Liu L et al. 2009 CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol. Cell 34, 451-460. (doi:10.1016/j.molcel.2009.04.020)
-
(2009)
Mol. Cell
, vol.34
, pp. 451-460
-
-
Liu, L.1
-
293
-
-
79959865171
-
The E3 ubiquitin ligase cullin 4A regulates meiotic progression in mouse spermatogenesis
-
Yin Y et al. 2011 The E3 ubiquitin ligase cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev. Biol. 356, 51-62. (doi:10.1016/j.ydbio.2011.05.661)
-
(2011)
Dev. Biol.
, vol.356
, pp. 51-62
-
-
Yin, Y.1
-
294
-
-
33846639529
-
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor
-
Tarpey PS et al. 2007 Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am. J. Hum. Genet. 80, 345-352. (doi:10.1086/511134)
-
(2007)
Am. J. Hum. Genet.
, vol.80
, pp. 345-352
-
-
Tarpey, P.S.1
-
295
-
-
84864984482
-
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis
-
Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P. 2012 Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res. 22, 1258-1269. (doi:10.1038/cr.2012.48)
-
(2012)
Cell Res.
, vol.22
, pp. 1258-1269
-
-
Liu, L.1
Yin, Y.2
Li, Y.3
Prevedel, L.4
Lacy, E.H.5
Ma, L.6
Zhou, P.7
-
296
-
-
0037509859
-
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
-
Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y. 2003 The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357-367. (doi:10.1016/S0092-8674(03)00316-7)
-
(2003)
Cell
, vol.113
, pp. 357-367
-
-
Groisman, R.1
Polanowska, J.2
Kuraoka, I.3
Sawada, J.4
Saijo, M.5
Drapkin, R.6
Kisselev, A.F.7
Tanaka, K.8
Nakatani, Y.9
-
297
-
-
84867376482
-
Damaged DNA induced UVdamaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair
-
Yeh JI et al. 2012 Damaged DNA induced UVdamaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair. Proc. Natl Acad. Sci. USA 109, E2737-E2746. (doi:10.1073/pnas.1110067109)
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E2737-E2746
-
-
Yeh, J.I.1
-
298
-
-
21044442126
-
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex
-
Sugasawa K et al. 2005 UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 121, 387-400. (doi:10.1016/j.cell.2005.02.035)
-
(2005)
Cell
, vol.121
, pp. 387-400
-
-
Sugasawa, K.1
-
299
-
-
33744781568
-
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
-
Wang H, Zhai L, Xu J, Joo H-Y, Jackson S, Erdjument-Bromage H, Tempst P, Xiong Y, Zhang Y. 2006 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol. Cell 22, 383-394. (doi:10.1016/j.molcel.2006.03.035)
-
(2006)
Mol. Cell
, vol.22
, pp. 383-394
-
-
Wang, H.1
Zhai, L.2
Xu, J.3
Joo, H.-Y.4
Jackson, S.5
Erdjument-Bromage, H.6
Tempst, P.7
Xiong, Y.8
Zhang, Y.9
-
300
-
-
0037031210
-
Xeroderma pigmentosum complementation group e and UV-damaged DNAbinding protein
-
Tang J, Chu G. 2002 Xeroderma pigmentosum complementation group E and UV-damaged DNAbinding protein. DNA Repair 1, 601-616. (doi:10.1016/S1568-7864(02)00052-6)
-
(2002)
DNA Repair
, vol.1
, pp. 601-616
-
-
Tang, J.1
Chu, G.2
-
301
-
-
57749198023
-
Structural basis of UV DNAdamage recognition by the DDB1-DDB2 complex
-
Scrima A et al. 2008 Structural basis of UV DNAdamage recognition by the DDB1-DDB2 complex. Cell 135, 1213-1223. (doi:10.1016/j.cell.2008.10.045)
-
(2008)
Cell
, vol.135
, pp. 1213-1223
-
-
Scrima, A.1
-
302
-
-
62349130094
-
DNA repair in mammalian cells: Transcription-coupled DNA repair: Directing your effort where it's most needed
-
Tornaletti S. 2009 DNA repair in mammalian cells: transcription-coupled DNA repair: directing your effort where it's most needed. Cell. Mol. Life Sci. 66, 1010-1020. (doi:10.1007/s00018-009-8738-x)
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 1010-1020
-
-
Tornaletti, S.1
-
303
-
-
80051525031
-
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase
-
Havens CG, Walter JC. 2011 Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes Dev. 25, 1568-1582. (doi:10.1101/gad.2068611)
-
(2011)
Genes Dev.
, vol.25
, pp. 1568-1582
-
-
Havens, C.G.1
Walter, J.C.2
-
304
-
-
84898745559
-
Two-way communications between ubiquitin-like modifiers and DNA
-
Ulrich HD. 2014 Two-way communications between ubiquitin-like modifiers and DNA. Nat. Struct. Mol. Biol. 21, 317-324. (doi:10.1038/nsmb.2805)
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 317-324
-
-
Ulrich, H.D.1
-
305
-
-
3943107573
-
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
-
Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. 2004 Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85. (doi:10.1146/annurev. biochem.73.011303.073723)
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 39-85
-
-
Sancar, A.1
Lindsey-Boltz, L.A.2
Unsal-Kaçmaz, K.3
Linn, S.4
-
306
-
-
33746429958
-
Destruction of Claspin by SCFbTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand N, Bekker-Jensen S, Bartek J, Lukas J. 2006 Destruction of Claspin by SCFbTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23, 307-318. (doi:10.1016/j.molcel.2006.06.016)
-
(2006)
Mol. Cell
, vol.23
, pp. 307-318
-
-
Mailand, N.1
Bekker-Jensen, S.2
Bartek, J.3
Lukas, J.4
-
307
-
-
33746413746
-
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
-
Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M. 2006 SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23, 319-329. (doi:10.1016/j.molcel.2006.06.013)
-
(2006)
Mol. Cell
, vol.23
, pp. 319-329
-
-
Peschiaroli, A.1
Dorrello, N.V.2
Guardavaccaro, D.3
Venere, M.4
Halazonetis, T.5
Sherman, N.E.6
Pagano, M.7
-
308
-
-
84874609470
-
An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation
-
Postow L, Funabiki H. 2013 An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation. Cell Cycle 12, 587-595. (doi:10.4161/cc.23408)
-
(2013)
Cell Cycle
, vol.12
, pp. 587-595
-
-
Postow, L.1
Funabiki, H.2
-
309
-
-
49749093073
-
Ku80 removal from DNA through double strand break-induced ubiquitylation
-
Postow L, Ghenoiu C, Woo EM, Krutchinsky AN, Chait BT, Funabiki H. 2008 Ku80 removal from DNA through double strand break-induced ubiquitylation. J. Cell Biol. 182, 467-479. (doi:10.1083/jcb.200802146)
-
(2008)
J. Cell Biol.
, vol.182
, pp. 467-479
-
-
Postow, L.1
Ghenoiu, C.2
Woo, E.M.3
Krutchinsky, A.N.4
Chait, B.T.5
Funabiki, H.6
-
310
-
-
80052765854
-
Destroying the ring: Freeing DNA from Ku with ubiquitin
-
Postow L. 2012 Destroying the ring: freeing DNA from Ku with ubiquitin. FEBS Lett. 585, 2876-2882. (doi:10.1016/j.febslet.2011.05.046)
-
(2012)
FEBS Lett.
, vol.585
, pp. 2876-2882
-
-
Postow, L.1
-
311
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker JR, Corpina RA, Goldberg J. 2001 Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412, 607-614. (doi:10.1038/35088000)
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
312
-
-
0034680789
-
Ku entry into DNA inhibits inward DNA transactions in vitro
-
Frit P, Li RY, Arzel D, Salles B, Calsou P. 2000 Ku entry into DNA inhibits inward DNA transactions in vitro. J. Biol. Chem. 275, 35 684-35 691. (doi:10.1074/jbc.M004315200)
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35684-35691
-
-
Frit, P.1
Li, R.Y.2
Arzel, D.3
Salles, B.4
Calsou, P.5
-
313
-
-
0030174531
-
Ku is a general inhibitor of DNA-protein complex formation and transcription
-
Ono M, Tucker PW, Capra JD. 1996 Ku is a general inhibitor of DNA-protein complex formation and transcription. Mol. Immunol. 33, 787-796. (doi:10.1016/0161-5890(96)00030-2)
-
(1996)
Mol. Immunol.
, vol.33
, pp. 787-796
-
-
Ono, M.1
Tucker, P.W.2
Capra, J.D.3
-
314
-
-
84902667412
-
Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2 and chromatin dynamics pathways
-
Garcia K et al. 2014 Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2 and chromatin dynamics pathways. Mol. Cancer Ther. 13, 1625-1635. (doi:10.1158/1535-7163.MCT-13-0634)
-
(2014)
Mol. Cancer Ther.
, vol.13
, pp. 1625-1635
-
-
Garcia, K.1
-
315
-
-
84866493830
-
The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation
-
Guihard S, Ramolu L, Macabre C, Wasylyk B, Noël G, Abecassis J, Jung AC. 2012 The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation. Int. J. Oncol. 41, 1531-1540. (doi:10.3892/ijo.2012.1584)
-
(2012)
Int. J. Oncol.
, vol.41
, pp. 1531-1540
-
-
Guihard, S.1
Ramolu, L.2
Macabre, C.3
Wasylyk, B.4
Noël, G.5
Abecassis, J.6
Jung, A.C.7
-
316
-
-
84885674162
-
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924
-
Jazaeri A et al. 2013 Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924. Mol. Cancer Ther 12, 1958-1967. (doi:10.1158/1535-7163.MCT-12-1028)
-
(2013)
Mol. Cancer Ther
, vol.12
, pp. 1958-1967
-
-
Jazaeri, A.1
-
317
-
-
84863370346
-
Inhibition of the Nedd8 system sensitizes cells to DNA interstrand crosslinking agents
-
Kee Y, Huang M, Chang S, Moreau LA, Park E, Smith PG, D'Andrea AD. 2012 Inhibition of the Nedd8 system sensitizes cells to DNA interstrand crosslinking agents. Mol. Cancer Res. 10, 369-377. (doi:10.1158/1541-7786.MCR-11-0497)
-
(2012)
Mol. Cancer Res.
, vol.10
, pp. 369-377
-
-
Kee, Y.1
Huang, M.2
Chang, S.3
Moreau, L.A.4
Park, E.5
Smith, P.G.6
D'andrea, A.D.7
-
318
-
-
84879849959
-
Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer
-
Nawrocki ST et al. 2013 Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer. Clin. Cancer Res. 19, 3577. (doi:10.1158/1078-0432.CCR-12-3212)
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 3577
-
-
Nawrocki, S.T.1
-
319
-
-
84885609279
-
Ubiquitin E3 ligase CRL4CDT2/DCAF2 as a potential chemotherapeutic target for ovarian surface epithelial cancer
-
Pan W-W, Zhou J-J, Yu C, Xu Y, Guo L-J, Zhang H-Y, Zhou D, Song F-Z, Fan H-Y. 2013 Ubiquitin E3 ligase CRL4CDT2/DCAF2 as a potential chemotherapeutic target for ovarian surface epithelial cancer. J. Biol. Chem. 288, 29 680-29 691. (doi:10.1074/jbc.M113.495069)
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 29680-29691
-
-
Pan, W.-W.1
Zhou, J.-J.2
Yu, C.3
Xu, Y.4
Guo, L.-J.5
Zhang, H.-Y.6
Zhou, D.7
Song, F.-Z.8
Fan, H.-Y.9
-
320
-
-
84855411991
-
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor
-
Wei D, Li H, Yu J, Sebolt JT, Zhao L, Lawrence TS, Smith PG, Morgan MA, Sun Y. 2011 Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer Res. 72, 282-293. (doi:10.1158/0008-5472.CAN-11-2866)
-
(2011)
Cancer Res.
, vol.72
, pp. 282-293
-
-
Wei, D.1
Li, H.2
Yu, J.3
Sebolt, J.T.4
Zhao, L.5
Lawrence, T.S.6
Smith, P.G.7
Morgan, M.A.8
Sun, Y.9
-
321
-
-
84863380384
-
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme
-
Yang D, Tan M, Wang G, Sun Y. 2012 The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PLoS ONE 7, e34079. (doi:10.1371/journal.pone.0034079)
-
(2012)
PLoS ONE
, vol.7
-
-
Yang, D.1
Tan, M.2
Wang, G.3
Sun, Y.4
-
322
-
-
10744228283
-
Arkadia amplifies TGF-b superfamily signalling through degradation of Smad7
-
Koinuma D, Shinozaki M, Komuro A. 2003 Arkadia amplifies TGF-b superfamily signalling through degradation of Smad7. EMBO J. 22, 6458-6470. (doi:10.1093/emboj/cdg632)
-
(2003)
EMBO J.
, vol.22
, pp. 6458-6470
-
-
Koinuma, D.1
Shinozaki, M.2
Komuro, A.3
-
323
-
-
84878986048
-
Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation
-
Erker Y, Neyret-Kahn H, Seeler JS, Dejean A, Atfi A, Levy L. 2013 Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. Mol. Cell. Biol. 33, 2163-2177. (doi:10.1128/MCB.01019-12)
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2163-2177
-
-
Erker, Y.1
Neyret-Kahn, H.2
Seeler, J.S.3
Dejean, A.4
Atfi, A.5
Levy, L.6
-
324
-
-
84903125623
-
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8
-
Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA. 2014 Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8. Cell 157, 1671-1684. (doi:10.1016/j.cell.2014.04.037)
-
(2014)
Cell
, vol.157
, pp. 1671-1684
-
-
Scott, D.C.1
Sviderskiy, V.O.2
Monda, J.K.3
Lydeard, J.R.4
Cho, S.E.5
Harper, J.W.6
Schulman, B.A.7
-
325
-
-
84860740820
-
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1
-
Wu J et al. 2012 Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol. Cell 46, 1-11. (doi:10.1016/j.molcel.2012.03.022)
-
(2012)
Mol. Cell
, vol.46
, pp. 1-11
-
-
Wu, J.1
-
326
-
-
84871559319
-
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination
-
Lu C-S et al. 2012 The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. J. Biol. Chem. 287, 43 984-43 994. (doi:10.1074/jbc.M112.421545)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 43984-43994
-
-
Lu, C.-S.1
-
327
-
-
84941032259
-
2015 Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice
-
Jimeno S, Fernandez-Avila MJ, Cruz-Garcia A, Cepeda-Garcia C, Gomez-Cabello D, Huertas P. 2015 Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice. Nucleic Acids Res 43, 987-999. (doi:10.10. 1093/nar/gku1384)
-
Nucleic Acids Res
, vol.43
, pp. 987-999
-
-
Jimeno, S.1
Fernandez-Avila, M.J.2
Cruz-Garcia, A.3
Cepeda-Garcia, C.4
Gomez-Cabello, D.5
Huertas, P.6
-
328
-
-
84900790137
-
RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair
-
Li T, Guan J, Huang Z, Hu X, Zheng X. 2014 RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair. J. Cell Sci. 127, 2238-2248. (doi:10.1242/jcs.138891)
-
(2014)
J. Cell Sci.
, vol.127
, pp. 2238-2248
-
-
Li, T.1
Guan, J.2
Huang, Z.3
Hu, X.4
Zheng, X.5
-
329
-
-
84876886904
-
Regulation of DNA damage responses by ubiquitin and SUMO
-
Jackson SP, Durocher D. 2013 Regulation of DNA damage responses by ubiquitin and SUMO. Mol. Cell 49, 795-807. (doi:10.1016/j.molcel.2013.01.017)
-
(2013)
Mol. Cell
, vol.49
, pp. 795-807
-
-
Jackson, S.P.1
Durocher, D.2
-
330
-
-
84913594397
-
The new frontier of genome engineering with CRISPR-Cas9
-
Doudna JA, Charpentier E. 2014 The new frontier of genome engineering with CRISPR-Cas9. Science 346, 1258096. (doi:10.1126/science.1258096)
-
(2014)
Science
, vol.346
, pp. 1258096
-
-
Doudna, J.A.1
Charpentier, E.2
-
331
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu PD, Lander ES, Zhang F. 2014 Development and applications of CRISPR-Cas9 for genome engineering. Cell 157, 1262-1278. (doi:10.1016/j.cell.2014.05.010)
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
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