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Volumn 13, Issue 8, 1999, Pages 916-934

The DNA-dependent protein kinase

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE;

EID: 0033560796     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.8.916     Document Type: Review
Times cited : (776)

References (234)
  • 1
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A. and D.G. Schatz. 1997. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 89: 43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 2
    • 0029041514 scopus 로고
    • Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL 60) cells and lymphocytes undergoing apoptosis
    • Ajmani, A.K., M. Satoh, E. Reap, P.L. Cohen, and W.H. Reeves. 1995. Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL 60) cells and lymphocytes undergoing apoptosis. J. Exp. Med. 181: 2049-2058.
    • (1995) J. Exp. Med. , vol.181 , pp. 2049-2058
    • Ajmani, A.K.1    Satoh, M.2    Reap, E.3    Cohen, P.L.4    Reeves, W.H.5
  • 4
    • 0032214124 scopus 로고    scopus 로고
    • Broad, but not universal, transcriptional requirement for yTAF(II)17, a histone H3-like TAF(II) present in TFIID and SAGA
    • Apone, L.M., C.A. Virbasius, F.C.P. Holstege, J. Wang, R.A. Young, and M.R. Green. 1998. Broad, but not universal, transcriptional requirement for yTAF(II)17, a histone H3-like TAF(II) present in TFIID and SAGA. Mol. Cell 2: 653-661.
    • (1998) Mol. Cell , vol.2 , pp. 653-661
    • Apone, L.M.1    Virbasius, C.A.2    Holstege, F.C.P.3    Wang, J.4    Young, R.A.5    Green, M.R.6
  • 6
    • 0033611465 scopus 로고    scopus 로고
    • Yeast cell-type regulation of DNA repair
    • Åström, S.U., S.M. Okamura, and J. Rine. 1999. Yeast cell-type regulation of DNA repair. Nature 397: 310.
    • (1999) Nature , vol.397 , pp. 310
    • Åström, S.U.1    Okamura, S.M.2    Rine, J.3
  • 8
    • 0027230415 scopus 로고
    • c-jun is phosphorylated by the DNA-dependent protein kinase in vitro: Definition of the minimal kinase recognition motif
    • Bannister, A.J., T.M. Gottleib, T. Kouzarides, and S.P. Jackson. 1993. c-jun is phosphorylated by the DNA-dependent protein kinase in vitro: Definition of the minimal kinase recognition motif. Nucleic Acids Res. 21: 1289-1295.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1289-1295
    • Bannister, A.J.1    Gottleib, T.M.2    Kouzarides, T.3    Jackson, S.P.4
  • 9
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • Barnes, D.E., G. Stamp, I. Rosewell, A. Denzel, and T. Lindahl. 1998. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 8: 1395-1398.
    • (1998) Curr. Biol. , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 10
    • 0032564469 scopus 로고    scopus 로고
    • DNA end-joining catalyzed by human cell-free extracts
    • Baumann, P. and S.C. West. 1998. DNA end-joining catalyzed by human cell-free extracts. Proc. Natl. Acad. Sci. 95: 14066-14070.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 14066-14070
    • Baumann, P.1    West, S.C.2
  • 11
    • 0029913226 scopus 로고    scopus 로고
    • Drosophila IRBP/Ku p70 corresponds to the mutagen sensitive mus309 gene and is involved in P-element excision in vivo
    • Beall, E.L. and D.C. Rio. 1996. Drosophila IRBP/Ku p70 corresponds to the mutagen sensitive mus309 gene and is involved in P-element excision in vivo. Genes & Dev. 10: 921-933.
    • (1996) Genes & Dev. , vol.10 , pp. 921-933
    • Beall, E.L.1    Rio, D.C.2
  • 13
    • 0026071588 scopus 로고
    • SCID mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
    • Biedermann, K.A., J.R. Sun, A.J. Giaccia, L.M. Tosto, and J.M. Brown. 1991. SCID mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. 88: 1394-1397.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 1394-1397
    • Biedermann, K.A.1    Sun, J.R.2    Giaccia, A.J.3    Tosto, L.M.4    Brown, J.M.5
  • 14
    • 0031054975 scopus 로고    scopus 로고
    • Ku selectively transfers between DNA molecules with homologous ends
    • Bliss, T.M. and D.P. Lane. 1997. Ku selectively transfers between DNA molecules with homologous ends. J. Biol. Chem. 272: 5765-5773.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5765-5773
    • Bliss, T.M.1    Lane, D.P.2
  • 16
    • 0029788520 scopus 로고    scopus 로고
    • Identification of a nonsense mutation in the carboxyl terminal region of DNA-dependent protein kinase catalytic subunit in the SCID mouse
    • Blunt, T., D. Gell, M. Fox, G.E. Taccioli, A.R. Lehmann, S.P. Jackson, and P.A. Jeggo. 1996. Identification of a nonsense mutation in the carboxyl terminal region of DNA-dependent protein kinase catalytic subunit in the SCID mouse. Proc. Natl. Acad. Sci. 93: 10285-10290.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 10285-10290
    • Blunt, T.1    Gell, D.2    Fox, M.3    Taccioli, G.E.4    Lehmann, A.R.5    Jackson, S.P.6    Jeggo, P.A.7
  • 17
    • 0029881698 scopus 로고    scopus 로고
    • p53 is required for both radiation induced differentiation and rescue of V(D)J rearrangement in SCID mouse thymocytes
    • Bogue, M.A., C.M. Zhu, E. AguilarCordova, L.A. Donehower, and D.B. Roth. 1996. p53 is required for both radiation induced differentiation and rescue of V(D)J rearrangement in SCID mouse thymocytes. Genes & Dev. 10: 553-565.
    • (1996) Genes & Dev. , vol.10 , pp. 553-565
    • Bogue, M.A.1    Zhu, C.M.2    Aguilarcordova, E.3    Donehower, L.A.4    Roth, D.B.5
  • 18
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • Bogue, M.A., C.Y. Wang, C.M. Zhu, and D.B. Roth. 1997. V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation. Immunity 7: 37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.Y.2    Zhu, C.M.3    Roth, D.B.4
  • 19
    • 0032438115 scopus 로고    scopus 로고
    • Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK independent pathways for both signal and coding joint formation
    • Bogue, M.A., C. Jhappan, and D.B. Roth. 1998. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK independent pathways for both signal and coding joint formation. Proc. Natl. Acad. Sci. 95: 15559-15564.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 15559-15564
    • Bogue, M.A.1    Jhappan, C.2    Roth, D.B.3
  • 20
    • 0025811882 scopus 로고
    • The SCID mouse mutant definition, characterization, and potential uses
    • Bosma, M.J. and A.M. Carroll. 1991. The SCID mouse mutant definition, characterization, and potential uses. Annu. Rev. Immunol. 9: 323-350.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 323-350
    • Bosma, M.J.1    Carroll, A.M.2
  • 21
    • 0029143646 scopus 로고
    • SCID cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase
    • Boubnov, N.V. and D.T. Weaver. 1995. SCID cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol. Cell. Biol. 15: 5700-5706.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5700-5706
    • Boubnov, N.V.1    Weaver, D.T.2
  • 23
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a Saccharomyces cerevisiae Ku80 homolog: Roles in DNA double-strand break rejoining and in telomeric maintenance
    • Boulton, S.J. and S.P. Jackson. 1996a. Identification of a Saccharomyces cerevisiae Ku80 homolog: Roles in DNA double-strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24: 4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 24
    • 0029791694 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error prone DNA repair pathways
    • _. 1996b. Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error prone DNA repair pathways. EMBO J. 15: 5093-5103.
    • (1996) EMBO J. , vol.15 , pp. 5093-5103
  • 25
    • 0032536861 scopus 로고    scopus 로고
    • Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
    • _. 1998. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17: 1819-1828.
    • (1998) EMBO J. , vol.17 , pp. 1819-1828
  • 26
    • 0029803485 scopus 로고    scopus 로고
    • Wortmannin is a potent inhibitor of DNA double-strand break but not single-strand break repair in Chinese hamster ovary cells
    • Boulton, S., S. Kyle, L. Yalcintepe, and B.W. Durkacz. 1996. Wortmannin is a potent inhibitor of DNA double-strand break but not single-strand break repair in Chinese hamster ovary cells. Carcinogenesis 17: 2285-2290.
    • (1996) Carcinogenesis , vol.17 , pp. 2285-2290
    • Boulton, S.1    Kyle, S.2    Yalcintepe, L.3    Durkacz, B.W.4
  • 29
    • 0028607553 scopus 로고
    • The DNA-activated protein kinase is required for the phosphorylation of replication protein-A during simian-virus-40 DNA-replication
    • Brush, G.S., C.W. Anderson, and T.J. Kelly. 1994. The DNA-activated protein kinase is required for the phosphorylation of replication protein-A during simian-virus-40 DNA-replication. Proc. Natl. Acad. Sci. 91: 12520-12524.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 12520-12524
    • Brush, G.S.1    Anderson, C.W.2    Kelly, T.J.3
  • 30
    • 0028158320 scopus 로고
    • Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues
    • Cai, Q.Q., A. Plet, J. Imbert, M. Lafagepochitaloff, C. Cerdan, and J.M. Blanchard. 1994. Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues. Cytogen. Cell Gen. 65: 221-227.
    • (1994) Cytogen. Cell Gen. , vol.65 , pp. 221-227
    • Cai, Q.Q.1    Plet, A.2    Imbert, J.3    Lafagepochitaloff, M.4    Cerdan, C.5    Blanchard, J.M.6
  • 31
    • 0345244825 scopus 로고    scopus 로고
    • p53-dependent apoptosis and transcription of p21(waf1/cip1/sdi1) in SCID mice following gamma irradiation
    • Candeias, S.M., S.K. Durum, and K. Muegge. 1997. p53-dependent apoptosis and transcription of p21(waf1/cip1/sdi1) in SCID mice following gamma irradiation. Biochimie 79: 607-612.
    • (1997) Biochimie , vol.79 , pp. 607-612
    • Candeias, S.M.1    Durum, S.K.2    Muegge, K.3
  • 33
    • 0028141785 scopus 로고
    • DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen
    • Cao, Q.P., S. Pitt, J. Leszyk, and E.F. Baril. 1994. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. Biochemistry 33: 8548-8557.
    • (1994) Biochemistry , vol.33 , pp. 8548-8557
    • Cao, Q.P.1    Pitt, S.2    Leszyk, J.3    Baril, E.F.4
  • 34
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney, J.P., R.S. Maser, H. Olivares, E.M. Davis, M. LeBeau, J.R. Yates, L. Hays, W.F. Morgan, and J.H.J. Petrini. 1998. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    LeBeau, M.5    Yates, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.J.9
  • 35
    • 0024208636 scopus 로고
    • DNA-stimulated protein phosphorylation In HeLa whole-cell and nuclear extracts
    • Carter, T.H., C.R. Kopman, and C.B.L. James. 1988. DNA-stimulated protein phosphorylation In HeLa whole-cell and nuclear extracts. Biochem. Biophys. Res. Comm. 157: 535-540.
    • (1988) Biochem. Biophys. Res. Comm. , vol.157 , pp. 535-540
    • Carter, T.H.1    Kopman, C.R.2    James, C.B.L.3
  • 38
    • 0032519378 scopus 로고    scopus 로고
    • A central region of Ku80 mediates interaction with Ku70 in vivo
    • Cary, R.B., F.Q. Chen, Z.Y. Shen, and D.J. Chen. 1998. A central region of Ku80 mediates interaction with Ku70 in vivo. Nucleic Acids Res. 26: 974-979.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 974-979
    • Cary, R.B.1    Chen, F.Q.2    Shen, Z.Y.3    Chen, D.J.4
  • 39
    • 0028881847 scopus 로고
    • DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
    • Casciolarosen, L.A., G.J. Anhalt, and A. Rosen. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182: 1625-1634.
    • (1995) J. Exp. Med. , vol.182 , pp. 1625-1634
    • Casciolarosen, L.A.1    Anhalt, G.J.2    Rosen, A.3
  • 41
    • 0030009738 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
    • Chan, D.W. and S.P. Lees-Miller. 1996. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol Chem. 271: 8936-8941.
    • (1996) J. Biol Chem. , vol.271 , pp. 8936-8941
    • Chan, D.W.1    Lees-Miller, S.P.2
  • 42
    • 0030367822 scopus 로고    scopus 로고
    • Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta
    • Chan, D.W., C.H. Mody, N.S.Y. Ting, and S.P. Lees-Miller. 1996. Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta. Biochem. Cell Biol. Biochim. Biol. Cell 74: 67-73.
    • (1996) Biochem. Cell Biol. Biochim. Biol. Cell , vol.74 , pp. 67-73
    • Chan, D.W.1    Mody, C.H.2    Ting, N.S.Y.3    Lees-Miller, S.P.4
  • 43
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12-rapamycin complex
    • Chiu, M.I., H. Katz, and V. Berlin. 1994. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12-rapamycin complex. Proc. Natl. Acad. Sci. 91: 12574-12578.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 44
    • 0032509097 scopus 로고    scopus 로고
    • Cryo EM imaging of the catalytic subunit of the DNA-dependent protein kinase
    • Chiu, C.Y., R.B. Cary, D.J. Chen, S.R. Peterson, and P.L. Stewart. 1998. Cryo EM imaging of the catalytic subunit of the DNA-dependent protein kinase. J. Mol. Biol. 284: 1075-1081.
    • (1998) J. Mol. Biol. , vol.284 , pp. 1075-1081
    • Chiu, C.Y.1    Cary, R.B.2    Chen, D.J.3    Peterson, S.R.4    Stewart, P.L.5
  • 45
    • 0030783087 scopus 로고    scopus 로고
    • Double-strand break repair
    • Chu, G. 1997. Double-strand break repair. J. Biol. Chem. 272: 24097-24100.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24097-24100
    • Chu, G.1
  • 46
    • 9244229490 scopus 로고    scopus 로고
    • cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
    • Cimprich, K.A., T.B. Shin, C.T. Keith, and S.L. Schreiber. 1996. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc. Natl Acad. Sci. 93: 2850-2855.
    • (1996) Proc. Natl Acad. Sci. , vol.93 , pp. 2850-2855
    • Cimprich, K.A.1    Shin, T.B.2    Keith, C.T.3    Schreiber, S.L.4
  • 47
    • 0030579121 scopus 로고    scopus 로고
    • Alternate splice site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs
    • Connelly, M.A., H. Zhang, J. Kieleczawa, and C.W. Anderson. 1996. Alternate splice site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs. Gene 175: 271-273.
    • (1996) Gene , vol.175 , pp. 271-273
    • Connelly, M.A.1    Zhang, H.2    Kieleczawa, J.3    Anderson, C.W.4
  • 48
    • 0031912460 scopus 로고    scopus 로고
    • The promoters for human DNA PKcs (PRKDC) and MCM4: Divergently transcribed genes located at chromosome 8 band q11
    • _. 1998. The promoters for human DNA PKcs (PRKDC) and MCM4: Divergently transcribed genes located at chromosome 8 band q11. Genomics 47: 71-83.
    • (1998) Genomics , vol.47 , pp. 71-83
  • 50
    • 0031214080 scopus 로고    scopus 로고
    • Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
    • Critchlow, S.E., R.P. Bowater, and S.P. Jackson. 1997. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7: 588-598.
    • (1997) Curr. Biol. , vol.7 , pp. 588-598
    • Critchlow, S.E.1    Bowater, R.P.2    Jackson, S.P.3
  • 51
    • 0022257878 scopus 로고
    • Severe combined immunodeficiency (SCID) in the mouse: Pathology, reconstitution, neoplasms
    • Custer, A.M., G.C. Bosma, and G.C. Bosma. 1985. Severe combined immunodeficiency (SCID) in the mouse: Pathology, reconstitution, neoplasms. Amer. J. Path. 120: 464-477.
    • (1985) Amer. J. Path. , vol.120 , pp. 464-477
    • Custer, A.M.1    Bosma, G.C.2    Bosma, G.C.3
  • 52
    • 0032566142 scopus 로고    scopus 로고
    • Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression
    • Dabrowski, M., E. Robinson, S.V. Hughes, R. Bland, and M. Hewison. 1998. Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression. Mol. Cell. Endocrinol. 142: 131-139.
    • (1998) Mol. Cell. Endocrinol. , vol.142 , pp. 131-139
    • Dabrowski, M.1    Robinson, E.2    Hughes, S.V.3    Bland, R.4    Hewison, M.5
  • 53
    • 0028151601 scopus 로고
    • Rescue of T cell-specific V(D)J recombination in SCID mice by DNA damaging agents
    • Danska, J.S., F. Pflumio, C.J. Williams, O. Huner, J.E. Dick, and C.J. Guidos. 1994. Rescue of T cell-specific V(D)J recombination in SCID mice by DNA damaging agents. Science 266: 450-455.
    • (1994) Science , vol.266 , pp. 450-455
    • Danska, J.S.1    Pflumio, F.2    Williams, C.J.3    Huner, O.4    Dick, J.E.5    Guidos, C.J.6
  • 54
    • 0029791450 scopus 로고    scopus 로고
    • Biochemical and genetic defects in the DNA-dependent protein kinase in murine SCID lymphocytes
    • Danska, J.S., D.P. Holland, S. Mariathasan, K.M. Williams, and C.J. Guidos. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine SCID lymphocytes. Mol. Cell. Biol. 16: 5507-5517.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5507-5517
    • Danska, J.S.1    Holland, D.P.2    Mariathasan, S.3    Williams, K.M.4    Guidos, C.J.5
  • 55
    • 0024356877 scopus 로고
    • HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA multimeric protein complex
    • Devries, E., W. Vandriel, W.G. Bergsma, A.C. Arnberg, and P.C. Vandervliet. 1989. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA multimeric protein complex. J. Mol. Biol. 208: 65-78.
    • (1989) J. Mol. Biol. , vol.208 , pp. 65-78
    • Devries, E.1    Vandriel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    Vandervliet, P.C.5
  • 56
    • 0027048773 scopus 로고
    • Ku autoantigen is the regulatory component of a template associated protein kinase that phosphorylates RNA polymerase II
    • Dvir, A., S.R. Peterson, M.W. Knuth, H. Lu, and W.S. Dynan. 1992. Ku autoantigen is the regulatory component of a template associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. 89: 11920-11924.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 11920-11924
    • Dvir, A.1    Peterson, S.R.2    Knuth, M.W.3    Lu, H.4    Dynan, W.S.5
  • 57
    • 0027246193 scopus 로고
    • Purification and characterization of a template associated protein kinase that phosphorylates RNA polymerase II
    • Dvir, A., L.Y. Stein, B.L. Calore, and W.S. Dynan. 1993. Purification and characterization of a template associated protein kinase that phosphorylates RNA polymerase II. J. Biol. Chem. 268: 10440-10447.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10440-10447
    • Dvir, A.1    Stein, L.Y.2    Calore, B.L.3    Dynan, W.S.4
  • 58
    • 0032052815 scopus 로고    scopus 로고
    • Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
    • Dynan, W.S. and S. Yoo. 1998. Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res. 26: 1551-1559.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1551-1559
    • Dynan, W.S.1    Yoo, S.2
  • 59
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S.J. 1996. Cell cycle checkpoints: Preventing an identity crisis. Science 274: 1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 60
    • 0029928176 scopus 로고    scopus 로고
    • Ku86 defines thje genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants
    • Errami, A., V. Smider, W.K. Rathmell, D.M. He, E.A. Hendrickson, M.Z. Zdzienicka, and G. Chu. 1996. Ku86 defines thje genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol. Cell. Biol. 16: 1519-1526.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1519-1526
    • Errami, A.1    Smider, V.2    Rathmell, W.K.3    He, D.M.4    Hendrickson, E.A.5    Zdzienicka, M.Z.6    Chu, G.7
  • 61
    • 0032188862 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of new x-ray sensitive hamster cell mutants defective in Ku80
    • Errami, A., N.J. Finnie, B. Morolli, S.P. Jackson, P.H.M. Lohmann, and M.Z. Zdzienicka. 1998a. Molecular and biochemical characterization of new x-ray sensitive hamster cell mutants defective in Ku80. Nucleic Acids Res. 26: 4332-4338.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 4332-4338
    • Errami, A.1    Finnie, N.J.2    Morolli, B.3    Jackson, S.P.4    Lohmann, P.H.M.5    Zdzienicka, M.Z.6
  • 64
    • 0027156140 scopus 로고
    • Ebp 80, a transcription factor closely resembling the human autoantigen Ku, recognizes single strand to double-strand transitions in DNA
    • Falzon, M., J.W. Fewell, and E.L. Kuff. 1993. Ebp 80, a transcription factor closely resembling the human autoantigen Ku, recognizes single strand to double-strand transitions in DNA. J. Biol. Chem. 268: 10546-10552.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10546-10552
    • Falzon, M.1    Fewell, J.W.2    Kuff, E.L.3
  • 65
    • 0032572731 scopus 로고    scopus 로고
    • DNA repair: The Nijmegen breakage syndrome protein
    • Featherstone, C. and S.P. Jackson. 1998. DNA repair: The Nijmegen breakage syndrome protein. Curr. Biol. 8: R622-R625.
    • (1998) Curr. Biol. , vol.8
    • Featherstone, C.1    Jackson, S.P.2
  • 67
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs 6 cells implications for site-specific recombination and DNA double-strand break repair
    • Finnie, N.J., T.M. Gottlieb, T. Blunt, P.A. Jeggo, and S.P. Jackson. 1995. DNA-dependent protein kinase activity is absent in xrs 6 cells implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. 92: 320-324.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 71
    • 0025011134 scopus 로고
    • The SCID mutation in mice causes a general defect in DNA repair
    • Fulop, G.M. and R.A. Phillips. 1990. The SCID mutation in mice causes a general defect in DNA repair. Nature 347: 479-482.
    • (1990) Nature , vol.347 , pp. 479-482
    • Fulop, G.M.1    Phillips, R.A.2
  • 72
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse, M., Y. Nagase, H. Tsubouchi, K. MurakamiMurofushi, T. Shibata, and K. Ohta. 1998. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17: 6412-6425.
    • (1998) EMBO J. , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    MurakamiMurofushi, K.4    Shibata, T.5    Ohta, K.6
  • 73
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination
    • Gao, Y., J. Chaudhuri, C. Zhu, L. Davidson, D.T. Weaver, and F.W. Alt. 1998. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for Ku in V(D)J recombination. Immunity 9: 367-376.
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 74
    • 0028363754 scopus 로고
    • Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant
    • Getts, R.C. and T.D. Stamato. 1994. Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J. Biol. Chem. 269: 15981-15984.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15981-15984
    • Getts, R.C.1    Stamato, T.D.2
  • 75
    • 0029988716 scopus 로고    scopus 로고
    • Sequence-specific DNA binding by Ku autoantigen and its effects on transcription
    • Giffin, W., H. Torrance, D.J. Rodda, G.G. Prefontaine, L. Pope, and R.J.G. Hache. 1996. Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. Nature 380: 265-268.
    • (1996) Nature , vol.380 , pp. 265-268
    • Giffin, W.1    Torrance, H.2    Rodda, D.J.3    Prefontaine, G.G.4    Pope, L.5    Hache, R.J.G.6
  • 76
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase requirement for DNA ends and association with Ku antigen
    • Gottlieb, T.M. and S.P. Jackson. 1993. The DNA-dependent protein kinase requirement for DNA ends and association with Ku antigen. Cell 72: 131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 77
    • 0032504104 scopus 로고    scopus 로고
    • A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
    • Grant, P.A., D. Schieltz, M.G. PrayGrant, D.J. Steger, J.C. Reese, J.R. Yates, and J.L. Workman. 1998. A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94: 45-53.
    • (1998) Cell , vol.94 , pp. 45-53
    • Grant, P.A.1    Schieltz, D.2    PrayGrant, M.G.3    Steger, D.J.4    Reese, J.C.5    Yates, J.R.6    Workman, J.L.7
  • 78
    • 0032076127 scopus 로고    scopus 로고
    • Yeast Ku as a regulator of chromosomal DNA end structure
    • Gravel, S., M. Larrivee, P. Labrecque, and R.J. Wellinger. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science 280: 741-744.
    • (1998) Science , vol.280 , pp. 741-744
    • Gravel, S.1    Larrivee, M.2    Labrecque, P.3    Wellinger, R.J.4
  • 79
    • 0029916062 scopus 로고    scopus 로고
    • Expression of DNA-dependent protein kinase holoenzyme upon induction of lymphocyte differentiation and V(D)J recombination
    • Grawunder, U., N. Finnie, S.P. Jackson, B. Riwar, and R. Jessberger. 1996. Expression of DNA-dependent protein kinase holoenzyme upon induction of lymphocyte differentiation and V(D)J recombination. Eur. J. Biochem. 241: 931-940.
    • (1996) Eur. J. Biochem. , vol.241 , pp. 931-940
    • Grawunder, U.1    Finnie, N.2    Jackson, S.P.3    Riwar, B.4    Jessberger, R.5
  • 80
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • Grawunder, U., M. Wilm, X.T. Wu, P. Kulesza, T.E. Wilson, M. Mann, and M.R. Lieber. 1997. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388: 492-495.
    • (1997) Nature , vol.388 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.T.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.R.7
  • 81
    • 0032185230 scopus 로고    scopus 로고
    • DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
    • Grawunder, U., D. Zimmer, S. Fugmann, K. Schwarz, and M.R. Lieber. 1998. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2: 477-484.
    • (1998) Mol. Cell , vol.2 , pp. 477-484
    • Grawunder, U.1    Zimmer, D.2    Fugmann, S.3    Schwarz, K.4    Lieber, M.R.5
  • 82
    • 0029088371 scopus 로고
    • Tell, a gene involved in controlling telomere length in Saccharomyces cerevisiae, is homologous to the human ataxia telangiectasia gene
    • Greenwell, P.W., S.L. Kronmal, S.E. Porter, J. Gassenhuber, B. Obermaier, and T.D. Petes. 1995. Tell, a gene involved in controlling telomere length in Saccharomyces cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82: 823-829.
    • (1995) Cell , vol.82 , pp. 823-829
    • Greenwell, P.W.1    Kronmal, S.L.2    Porter, S.E.3    Gassenhuber, J.4    Obermaier, B.5    Petes, T.D.6
  • 83
    • 0026570651 scopus 로고
    • Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA
    • Griffith, A.J., P.R. Blier, T. Mimori, and J.A. Hardin. 1992. Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA. J. Biol. Chem. 267: 331-338.
    • (1992) J. Biol. Chem. , vol.267 , pp. 331-338
    • Griffith, A.J.1    Blier, P.R.2    Mimori, T.3    Hardin, J.A.4
  • 84
    • 0030990291 scopus 로고    scopus 로고
    • Molecular model for telomeric heterochromatin in yeast
    • Grunstein, M. 1997. Molecular model for telomeric heterochromatin in yeast. Curr. Opin. Cell Biol. 9: 383-387.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 383-387
    • Grunstein, M.1
  • 85
    • 0029840338 scopus 로고    scopus 로고
    • End joining of free radical mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceeding removal of damaged 3′ termini
    • Gu, X.Y., R.A.O. Bennett, and L.F. Povirk. 1996. End joining of free radical mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceeding removal of damaged 3′ termini. J. Biol. Chem. 271: 19660-19663.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19660-19663
    • Gu, X.Y.1    Bennett, R.A.O.2    Povirk, L.F.3
  • 86
    • 0032493488 scopus 로고    scopus 로고
    • Implication of DNA-dependent protein kinase in an early, essential, local phosphorylation event during end joining of DNA double-strand breaks in vitro
    • Gu, X.Y., M.A. Weinfeld, and L.F. Povirk. 1998. Implication of DNA-dependent protein kinase in an early, essential, local phosphorylation event during end joining of DNA double-strand breaks in vitro. Biochemistry 37: 9827-9835.
    • (1998) Biochemistry , vol.37 , pp. 9827-9835
    • Gu, X.Y.1    Weinfeld, M.A.2    Povirk, L.F.3
  • 87
    • 0030858967 scopus 로고    scopus 로고
    • Ku70 deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end binding activity, and inability to support V(D)J recombination
    • Gu, Y.S., S.F. Jin, Y.J. Gao, D.T. Weaver, and F.W. Alt. 1997a. Ku70 deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end binding activity, and inability to support V(D)J recombination. Proc. Natl. Acad. Sci. 94: 8076-8081.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 8076-8081
    • Gu, Y.S.1    Jin, S.F.2    Gao, Y.J.3    Weaver, D.T.4    Alt, F.W.5
  • 89
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in SCID lymphocyte precursors
    • Guidos, C.J., C.J. Williams, I. Grandal, G. Knowles, M.T.F. Huang, and J.S. Danska. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in SCID lymphocyte precursors. Genes & Dev. 10: 2038-2054.
    • (1996) Genes & Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1    Williams, C.J.2    Grandal, I.3    Knowles, G.4    Huang, M.T.F.5    Danska, J.S.6
  • 90
    • 0031930488 scopus 로고    scopus 로고
    • DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
    • Hammarsten, O. and G. Chu. 1998. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl. Acad. Sci. 95: 525-530.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 525-530
    • Hammarsten, O.1    Chu, G.2
  • 92
    • 0030934860 scopus 로고    scopus 로고
    • Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products
    • Han, J.O., S.B. Steen, and D.B. Roth. 1997. Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products. Mol. Cell. Biol. 17: 2226-2234.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2226-2234
    • Han, J.O.1    Steen, S.B.2    Roth, D.B.3
  • 93
    • 0029089618 scopus 로고
    • The Mei 41 gene of Diosophila melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
    • Hari, K.L., A. Santerre, J.J. Sekelsky, K.S. McKim, J.B. Boyd, and R.S. Hawley. 1995. The Mei 41 gene of Diosophila melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell 82: 815-821.
    • (1995) Cell , vol.82 , pp. 815-821
    • Hari, K.L.1    Santerre, A.2    Sekelsky, J.J.3    McKim, K.S.4    Boyd, J.B.5    Hawley, R.S.6
  • 96
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 97
    • 0025776523 scopus 로고
    • Targets for cell-cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J., N.R. Movva, and M.N. Hall. 1991. Targets for cell-cycle arrest by the immunosuppressant rapamycin in yeast. Science 253: 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 98
    • 0028137771 scopus 로고
    • Tor1 and Tor2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologs in yeast
    • Helliwell, S.B., P. Wagner, J. Kunz, M. Deuter-Reinhard, R. Henriquez, and M.N. Hall. 1994. Tor1 and Tor2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologs in yeast. Mol. Biol. Cell 5: 105-118.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 105-118
    • Helliwell, S.B.1    Wagner, P.2    Kunz, J.3    Deuter-Reinhard, M.4    Henriquez, R.5    Hall, M.N.6
  • 100
    • 0032528066 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4
    • Herrmann, G., T. Lindahl, and P. Schar. 1998. Saccharomyces cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J. 17: 4188-4198.
    • (1998) EMBO J. , vol.17 , pp. 4188-4198
    • Herrmann, G.1    Lindahl, T.2    Schar, P.3
  • 102
    • 0029941651 scopus 로고    scopus 로고
    • p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase deficient mouse fibroblasts
    • Huang, L.C., K.C. Clarkin, and G.M. Wahl. 1996. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase deficient mouse fibroblasts. Cancer Res. 56: 2940-2944.
    • (1996) Cancer Res. , vol.56 , pp. 2940-2944
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 103
    • 0030771917 scopus 로고    scopus 로고
    • Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase
    • Huang, J.R., A. Nueda, S. Yoo, and W.S. Dynan. 1997. Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase. J. Biol. Chem. 272: 26009-26016.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26009-26016
    • Huang, J.R.1    Nueda, A.2    Yoo, S.3    Dynan, W.S.4
  • 104
    • 0033152759 scopus 로고    scopus 로고
    • Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
    • in press
    • Izzard, R.A., S.P. Jackson, and G.C.M. Smith. 1999. Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res. (in press).
    • (1999) Cancer Res.
    • Izzard, R.A.1    Jackson, S.P.2    Smith, G.C.M.3
  • 105
    • 0030442683 scopus 로고    scopus 로고
    • DNA damage detection by DNA-dependent protein kinase and related enzymes
    • Jackson, S.P. 1996. DNA damage detection by DNA-dependent protein kinase and related enzymes. Cancer Surv. 28: 261-279.
    • (1996) Cancer Surv. , vol.28 , pp. 261-279
    • Jackson, S.P.1
  • 106
    • 0025037502 scopus 로고
    • GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
    • Jackson, S.P., J.J. Macdonald, S. Lees-Miller, and R. Tjian. 1990. GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63: 155-165.
    • (1990) Cell , vol.63 , pp. 155-165
    • Jackson, S.P.1    Macdonald, J.J.2    Lees-Miller, S.3    Tjian, R.4
  • 108
    • 0026636130 scopus 로고
    • The Rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair
    • Jimenez, G., J. Yucel, R. Rowley, and S. Subramani. 1992. The Rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair. Proc. Natl. Acad. Sci. 89: 4952-4956.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 4952-4956
    • Jimenez, G.1    Yucel, J.2    Rowley, R.3    Subramani, S.4
  • 109
    • 0030733163 scopus 로고    scopus 로고
    • Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions
    • Jin, S.F. and D.T. Weaver. 1997. Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions. EMBO J. 16: 6874-6885.
    • (1997) EMBO J. , vol.16 , pp. 6874-6885
    • Jin, S.F.1    Weaver, D.T.2
  • 110
    • 0031926509 scopus 로고    scopus 로고
    • Differential etoposide sensitivity of cells deficient in the Ku and DNA PKcs components of the DNA-dependent protein kinase
    • Jin, S.F., S. Inoue, and D.T. Weaver. 1998. Differential etoposide sensitivity of cells deficient in the Ku and DNA PKcs components of the DNA-dependent protein kinase. Carcinogenesis 19: 965-971.
    • (1998) Carcinogenesis , vol.19 , pp. 965-971
    • Jin, S.F.1    Inoue, S.2    Weaver, D.T.3
  • 111
    • 0030771841 scopus 로고    scopus 로고
    • Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
    • Jin, S.F., S. Kharbanda, B. Mayer, D. Kufe, and D.T. Weaver. 1997. Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. J. Biol. Chem. 272: 24763-24766.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24763-24766
    • Jin, S.F.1    Kharbanda, S.2    Mayer, B.3    Kufe, D.4    Weaver, D.T.5
  • 112
    • 0030786912 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation
    • Jongmans, W., M. Vuillaume, K. Chrzanowska, D. Smeets, K. Sperling, and J. Hall. 1997. Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol. Cell. Biol. 17: 5016-5022.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5016-5022
    • Jongmans, W.1    Vuillaume, M.2    Chrzanowska, K.3    Smeets, D.4    Sperling, K.5    Hall, J.6
  • 113
  • 114
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and Gadd45 is defective in ataxia telangiectasia
    • Kastan, M.B. 1992 A mammalian cell cycle checkpoint pathway utilizing p53 and Gadd45 is defective in ataxia telangiectasia. Cell 71: 587-597.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 115
    • 0027971222 scopus 로고
    • An essential gene, Esr1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae
    • Kato, R. and H. Ogawa. 1994. An essential gene, Esr1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 22: 3104-3112.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3104-3112
    • Kato, R.1    Ogawa, H.2
  • 119
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L.C. and C. Prives. 1996. p53: Puzzle and paradigm. Genes & Dev. 10: 1054-1072.
    • (1996) Genes & Dev. , vol.10 , pp. 1054-1072
    • Ko, L.C.1    Prives, C.2
  • 120
    • 0027655089 scopus 로고
    • Morphological characterization of the radiation sensitive cell line, xrs 5
    • Korte, C.C. and L.S. Yasui. 1993. Morphological characterization of the radiation sensitive cell line, xrs 5. Scanning Microsc. 7: 943-951.
    • (1993) Scanning Microsc. , vol.7 , pp. 943-951
    • Korte, C.C.1    Yasui, L.S.2
  • 121
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M.H.G., S.N. Jones, and K.H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387: 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 122
    • 0028855064 scopus 로고
    • DNA-dependent protein kinase a potent inhibitor of transcription by RNA polymerase I
    • Kühn, A., T.M. Gottlieb, S.P. Jackson, and I. Grummt. 1995. DNA-dependent protein kinase a potent inhibitor of transcription by RNA polymerase I. Genes & Dev. 9: 193-203.
    • (1995) Genes & Dev. , vol.9 , pp. 193-203
    • Kühn, A.1    Gottlieb, T.M.2    Jackson, S.P.3    Grummt, I.4
  • 124
    • 0027311858 scopus 로고
    • Target of rapamycin, TOR2, is an essential phosphatidylinositol kinase homolog required for G(I) progression
    • Kunz, J., R. Henriquez, V. Schneider, M. Deuterreinhard, N.R. Movva, and M.N. Hall. 1993. Target of rapamycin, TOR2, is an essential phosphatidylinositol kinase homolog required for G(I) progression. Cell 73: 585-596.
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, V.3    Deuterreinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 125
    • 0028905581 scopus 로고
    • DNA-dependent protein kinase specifically represses promoter directed transcription initiation by RNA polymerase I
    • Labhart, P. 1995. DNA-dependent protein kinase specifically represses promoter directed transcription initiation by RNA polymerase I. Proc. Natl. Acad. Sci. 92: 2934-2938.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 2934-2938
    • Labhart, P.1
  • 126
    • 0030859726 scopus 로고    scopus 로고
    • mRNA encoding the catalytic subunit of DNA-dependent protein kinase is widely expressed in Xenopus cells
    • _. 1997. mRNA encoding the catalytic subunit of DNA-dependent protein kinase is widely expressed in Xenopus cells. Gene 203: 235-240.
    • (1997) Gene , vol.203 , pp. 235-240
  • 128
    • 0030933152 scopus 로고    scopus 로고
    • The genetic defect in ataxiatelangiectasia
    • Lavin, M.F. and Y. Shiloh. 1997. The genetic defect in ataxiatelangiectasia. Annu. Rev. Immunol. 15: 177-202.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 177-202
    • Lavin, M.F.1    Shiloh, Y.2
  • 129
    • 0031939411 scopus 로고    scopus 로고
    • The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase
    • Leber, R., T.W. Wise, R. Mizuta, and K. Meek. 1998. The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J. Biol. Chem. 273: 1794-1801.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1794-1801
    • Leber, R.1    Wise, T.W.2    Mizuta, R.3    Meek, K.4
  • 130
    • 0000391880 scopus 로고    scopus 로고
    • Evidence for DNA-PK-dependent and independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle
    • Lee, S.E., R.A. Mitchell, A. Cheng, and E.A. Hendrickson. 1997. Evidence for DNA-PK-dependent and independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol. Cell. Biol. 17: 1425-1433.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1425-1433
    • Lee, S.E.1    Mitchell, R.A.2    Cheng, A.3    Hendrickson, E.A.4
  • 131
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T-antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller, S.P., Y.R. Chen, and C.W. Anderson. 1990. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T-antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 10: 6472-6481.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.R.2    Anderson, C.W.3
  • 132
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serine 15 and serine 37 in the amino terminal transactivation domain of human p53
    • Lees-Miller, S.P., K. Sakaguchi, S.J. Ullrich, E. Appella, and C.W. Anderson. 1992. Human DNA-activated protein kinase phosphorylates serine 15 and serine 37 in the amino terminal transactivation domain of human p53. Mol. Cell. Biol. 12: 5041-5049.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5041-5049
    • Lees-Miller, S.P.1    Sakaguchi, K.2    Ullrich, S.J.3    Appella, E.4    Anderson, C.W.5
  • 134
    • 0029798373 scopus 로고    scopus 로고
    • Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0
    • Lees-Miller, S.P., M.C. Long, M.A. Kilvert, V. Lam, S.A. Rice, and C.A. Spencer. 1996. Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. J. Virol. 70: 7471-7477.
    • (1996) J. Virol. , vol.70 , pp. 7471-7477
    • Lees-Miller, S.P.1    Long, M.C.2    Kilvert, M.A.3    Lam, V.4    Rice, S.A.5    Spencer, C.A.6
  • 135
    • 0030447538 scopus 로고    scopus 로고
    • Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts
    • LeRomancer, M., S.C. Cosulich, S.P. Jackson, and P.R. Clarke. 1996. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. J. Cell Sci. 109: 3121-3127.
    • (1996) J. Cell Sci. , vol.109 , pp. 3121-3127
    • LeRomancer, M.1    Cosulich, S.C.2    Jackson, S.P.3    Clarke, P.R.4
  • 136
    • 0033104498 scopus 로고    scopus 로고
    • Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
    • Leuther, K.K., O. Hammarstan, R.D. Kornberg, and G. Chu. 1999. Structure of DNA-dependent protein kinase: Implications for its regulation by DNA. EMBO J.18:1114-1123.
    • (1999) EMBO J. , vol.18 , pp. 1114-1123
    • Leuther, K.K.1    Hammarstan, O.2    Kornberg, R.D.3    Chu, G.4
  • 138
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • Li, Z.Y., T. Otevrel, Y.J. Gao, H.L. Cheng, B. Seed, T.D. Stamato, G.E. Taccioli, and F.W. Alt. 1995. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83: 1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.Y.1    Otevrel, T.2    Gao, Y.J.3    Cheng, H.L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 139
    • 15844385545 scopus 로고    scopus 로고
    • Ku80 deficient cells exhibit excess degradation of extrachromosomal DNA
    • Liang, F. and M. Jasin. 1996. Ku80 deficient cells exhibit excess degradation of extrachromosomal DNA. J. Biol. Chem. 271: 14405-14411.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14405-14411
    • Liang, F.1    Jasin, M.2
  • 140
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber, M.R., J.E. Hesse, S. Lewis, G.C. Bosma, N. Rosenberg, K. Mizuuchi, M.J. Bosma, and M. Gellert. 1988. The defect in murine severe combined immune deficiency joining of signal sequences but not coding segments in V(D)J recombination. Cell 55: 7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 141
    • 0029922114 scopus 로고    scopus 로고
    • Involvement of the Saccharomyces cerevisiae hdf1 gene in DNA double-strand break repair and recombination
    • Mages, G.J., H.M. Feldmann, and E.L. Winnacker. 1996. Involvement of the Saccharomyces cerevisiae hdf1 gene in DNA double-strand break repair and recombination. J. Biol. Chem. 271: 7910-7915.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7910-7915
    • Mages, G.J.1    Feldmann, H.M.2    Winnacker, E.L.3
  • 143
    • 0030764691 scopus 로고    scopus 로고
    • hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
    • Maser, R.S., K.J. Monsen, B.E. Nelms, and J.H.J. Petrini. 1997. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell. Biol. 17: 6087-6096.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6087-6096
    • Maser, R.S.1    Monsen, K.J.2    Nelms, B.E.3    Petrini, J.H.J.4
  • 146
    • 0030665146 scopus 로고    scopus 로고
    • Mdm-2 phosphorylation by DNA-dependent protein kinase prevens interaction with p53
    • Mayo, L.D., J.J. Turchi, and S.J. Berberich. 1997. Mdm-2 phosphorylation by DNA-dependent protein kinase prevens interaction with p53. Cancer Res. 57: 5013-5016.
    • (1997) Cancer Res. , vol.57 , pp. 5013-5016
    • Mayo, L.D.1    Turchi, J.J.2    Berberich, S.J.3
  • 147
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane, J.F., D.C. Vangent, D.A. Ramsden, C. Romeo, C.A. Cuomo, M. Gellert, and M.A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Vangent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 148
    • 0032493894 scopus 로고    scopus 로고
    • The novel ATM-related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins
    • McMahon, S.B., H.A. VanBuskirk, K.A. Dugan, T.D. Copeland, and M.D. Cole. 1998. The novel ATM-related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins. Cell 94: 363-374.
    • (1998) Cell , vol.94 , pp. 363-374
    • McMahon, S.B.1    VanBuskirk, H.A.2    Dugan, K.A.3    Copeland, T.D.4    Cole, M.D.5
  • 149
    • 0029954821 scopus 로고    scopus 로고
    • Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
    • Milne, G.T., S. Jin, K.B. Shannon, and D.T. Weaver. 1996. Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 4189-4198.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4189-4198
    • Milne, G.T.1    Jin, S.2    Shannon, K.B.3    Weaver, D.T.4
  • 150
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori, T. and J.A. Hardin. 1986. Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261: 375-379.
    • (1986) J. Biol. Chem. , vol.261 , pp. 375-379
    • Mimori, T.1    Hardin, J.A.2
  • 151
    • 0019374013 scopus 로고
    • Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis scleroderma overlap
    • Mimori, T., M. Akizuki, H. Yamagata, S. Inada, S. Yoshida, and M. Homma. 1981. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis scleroderma overlap. J. Clin. Invest. 68: 611-620.
    • (1981) J. Clin. Invest. , vol.68 , pp. 611-620
    • Mimori, T.1    Akizuki, M.2    Yamagata, H.3    Inada, S.4    Yoshida, S.5    Homma, M.6
  • 152
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau, S., J.R. Ferguson, and L.S. Symington. 1999. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19: 556-566.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 153
    • 0030679762 scopus 로고    scopus 로고
    • Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
    • Morrison, C., G.C.M. Smith, L. Stingl, S.P. Jackson, E.F. Wagner, and Z.Q. Wang. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat. Genet. 17: 479-482.
    • (1997) Nat. Genet. , vol.17 , pp. 479-482
    • Morrison, C.1    Smith, G.C.M.2    Stingl, L.3    Jackson, S.P.4    Wagner, E.F.5    Wang, Z.Q.6
  • 154
    • 0029150855 scopus 로고
    • Tell, a Saccharomyces cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene Mec1
    • Morrow, D.M., M. Morrow, D.A. Tagle, Y. Shiloh, F.S. Collins, and P. Hieter. 1995. Tell, a Saccharomyces cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene Mec1. Cell 82: 831-840.
    • (1995) Cell , vol.82 , pp. 831-840
    • Morrow, D.M.1    Morrow, M.2    Tagle, D.A.3    Shiloh, Y.4    Collins, F.S.5    Hieter, P.6
  • 155
    • 0030925492 scopus 로고    scopus 로고
    • KARP 1 : A novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity
    • Myung, K., D.M. He, S.E. Lee, and E.A. Hendrickson. 1997. KARP 1 : A novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. EMBO J. 16: 3172-3184.
    • (1997) EMBO J. , vol.16 , pp. 3172-3184
    • Myung, K.1    He, D.M.2    Lee, S.E.3    Hendrickson, E.A.4
  • 156
    • 0032560473 scopus 로고    scopus 로고
    • KARP 1 is induced by DNA damage in a p53 and ataxia telangiectasia mutated dependent fashion
    • Myung, K., C. Braastad, D.M. He, and E.A. Hendrickson. 1998. KARP 1 is induced by DNA damage in a p53 and ataxia telangiectasia mutated dependent fashion. Proc. Natl. Acad. Sci. 95: 7664-7669.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 7664-7669
    • Myung, K.1    Braastad, C.2    He, D.M.3    Hendrickson, E.A.4
  • 158
    • 0031686574 scopus 로고    scopus 로고
    • Circular chromosome formation in a fission yeast mutant defective in two ATM homologs
    • Naito, T., A. Matsuura, and F. Ishikawa. 1998. Circular chromosome formation in a fission yeast mutant defective in two ATM homologs. Nat. Genet. 20: 203-206.
    • (1998) Nat. Genet. , vol.20 , pp. 203-206
    • Naito, T.1    Matsuura, A.2    Ishikawa, F.3
  • 159
    • 0032214089 scopus 로고    scopus 로고
    • yTAF(II)61 has a general role in RNA polymerase II transcription and is required by GCN4p to recruit the SAGA coactivator complex
    • Natarajan, K., B.M. Jackson, E. Rhee, and A.G. Hinnebusch. 1998. yTAF(II)61 has a general role in RNA polymerase II transcription and is required by GCN4p to recruit the SAGA coactivator complex. Mol. Cell 2: 683-692.
    • (1998) Mol. Cell , vol.2 , pp. 683-692
    • Natarajan, K.1    Jackson, B.M.2    Rhee, E.3    Hinnebusch, A.G.4
  • 160
    • 0032562595 scopus 로고    scopus 로고
    • In situ visualization of DNA double-strand break repair in human fibroblasts
    • Nelms, B.E., R.S. Maser, J.F. MacKay, M.G. Lagally, and J.H.J. Petrini. 1998. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 280: 590-592.
    • (1998) Science , vol.280 , pp. 590-592
    • Nelms, B.E.1    Maser, R.S.2    Mackay, J.F.3    Lagally, M.G.4    Petrini, J.H.J.5
  • 163
    • 0031471226 scopus 로고    scopus 로고
    • Hypersensitivity of Ku80 deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development
    • Nussenzweig, A., K. Sokol, P. Burgman, L.G. Li, and G.G. Li. 1997. Hypersensitivity of Ku80 deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development. Proc. Natl. Acad. Sci. 94: 13588-13593.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 13588-13593
    • Nussenzweig, A.1    Sokol, K.2    Burgman, P.3    Li, L.G.4    Li, G.G.5
  • 165
    • 0018843376 scopus 로고
    • Mouse spleen cell nuclear protein kinases and the stimulating effect of dsDNA on NHP phosphorylation by cyclic AMP-independent protein kinase in vitro
    • Ohtsuki, K., E. Yamada, M. Nakamura, and N. Ishida. 1980. Mouse spleen cell nuclear protein kinases and the stimulating effect of dsDNA on NHP phosphorylation by cyclic AMP-independent protein kinase in vitro. J. Biochem. 87: 35-45.
    • (1980) J. Biochem. , vol.87 , pp. 35-45
    • Ohtsuki, K.1    Yamada, E.2    Nakamura, M.3    Ishida, N.4
  • 166
    • 0028147898 scopus 로고
    • Production and characterization of recombinant human Ku antigen
    • Ono, M., P.W. Tucker, and J.D. Capra. 1994. Production and characterization of recombinant human Ku antigen. Nucleic Acids Res. 22: 3918-3924.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 3918-3924
    • Ono, M.1    Tucker, P.W.2    Capra, J.D.3
  • 167
    • 0030827906 scopus 로고    scopus 로고
    • Defining the minimal domain of Ku80 for interaction with Ku70
    • Osipovich, O., S.K. Durum, and K. Muegge. 1997. Defining the minimal domain of Ku80 for interaction with Ku70. J. Biol. Chem. 272: 27259-27265.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27259-27265
    • Osipovich, O.1    Durum, S.K.2    Muegge, K.3
  • 169
    • 0026045833 scopus 로고
    • Analysis of the mechanism of interaction of simian Ku protein with DNA
    • Paillard, S. and F. Strauss. 1991. Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res. 19: 5619-5624.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 5619-5624
    • Paillard, S.1    Strauss, F.2
  • 170
    • 0032889431 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 immediate-early protein Vmw110 induces the proteosome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase
    • Parkinson, J., S.P. Lees-Miller, and R.D. Everett. 1999. Herpes simplex virus type 1 immediate-early protein Vmw110 induces the proteosome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. J. Virol. 73: 650-657.
    • (1999) J. Virol. , vol.73 , pp. 650-657
    • Parkinson, J.1    Lees-Miller, S.P.2    Everett, R.D.3
  • 171
    • 0032085295 scopus 로고    scopus 로고
    • The 3′-to-5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
    • Paull, T.T. and M. Gellert. 1998. The 3′-to-5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol. Cell 1: 969-979.
    • (1998) Mol. Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 172
    • 0027245559 scopus 로고
    • V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair
    • Pergola, F., M.Z. Zdzienicka, and M.R. Lieber. 1993. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13: 3464-3471.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3464-3471
    • Pergola, F.1    Zdzienicka, M.Z.2    Lieber, M.R.3
  • 173
    • 0028819481 scopus 로고
    • Stimulation of the DNA-dependent protein kinase by RNA Polymerase II transcriptional activator proteins
    • Peterson, S.R., S.A. Jesch, T.N. Chamberlin, A. Dvir, S.K. Rabindran, C. Wu, and W.S. Dynan. 1995a. Stimulation of the DNA-dependent protein kinase by RNA Polymerase II transcriptional activator proteins. J. Biol. Chem. 270: 1449-1454.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1449-1454
    • Peterson, S.R.1    Jesch, S.A.2    Chamberlin, T.N.3    Dvir, A.4    Rabindran, S.K.5    Wu, C.6    Dynan, W.S.7
  • 174
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells
    • Peterson, S.R., A. Kurimasa, M. Oshimura, W.S. Dynan, E.M. Bradbury, and D.J. Chen. 1995b. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells. Proc. Natl. Acad. Sci. 92: 3171-3174.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 175
    • 0030899377 scopus 로고    scopus 로고
    • Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits
    • Peterson, S.R., M. Stackhouse, M.J. Waltman, F.Q. Chen, K. Sato, and D.J. Chen. 1997. Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits. J. Biol. Chem. 272: 10227-10231.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10227-10231
    • Peterson, S.R.1    Stackhouse, M.2    Waltman, M.J.3    Chen, F.Q.4    Sato, K.5    Chen, D.J.6
  • 176
    • 0032474732 scopus 로고    scopus 로고
    • The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
    • Polotnianka, R.M., J. Li, and A.J. Lustig. 1998. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol. 8: 831-834.
    • (1998) Curr. Biol. , vol.8 , pp. 831-834
    • Polotnianka, R.M.1    Li, J.2    Lustig, A.J.3
  • 177
    • 0028788816 scopus 로고
    • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases
    • Poltoratsky, V.P., X.Y. Shi, J.D. York, M.R. Lieber, and T.H. Carter. 1995. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J. Immunol 155: 4529-4533.
    • (1995) J. Immunol , vol.155 , pp. 4529-4533
    • Poltoratsky, V.P.1    Shi, X.Y.2    York, J.D.3    Lieber, M.R.4    Carter, T.H.5
  • 178
    • 0029919650 scopus 로고    scopus 로고
    • The DNA binding protein Hdf1p (a putative Ku homolog) is required for maintaining normal telomere length in Saccharomyces cerevisiae
    • Porter, S.E., P.W. Greenwell, K.B. Ritchie, and T.D. Petes. 1996. The DNA binding protein Hdf1p (a putative Ku homolog) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res. 24: 582-585.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 582-585
    • Porter, S.E.1    Greenwell, P.W.2    Ritchie, K.B.3    Petes, T.D.4
  • 179
    • 0030066023 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
    • Price, B.D. and M.B. Youmell. 1996. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res. 56: 246-250.
    • (1996) Cancer Res. , vol.56 , pp. 246-250
    • Price, B.D.1    Youmell, M.B.2
  • 181
    • 0032534538 scopus 로고    scopus 로고
    • Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOROO5c, a homolg of mammalian DNA ligase IV
    • Ramos, W., G. Liu, C.N. Giroux, and A.E. Tomkinson. 1998. Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOROO5c, a homolg of mammalian DNA ligase IV. Nucleic Acids Res. 26: 5676-5683.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 5676-5683
    • Ramos, W.1    Liu, G.2    Giroux, C.N.3    Tomkinson, A.E.4
  • 182
    • 0032518680 scopus 로고    scopus 로고
    • Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
    • Ramsden, D.A. and M. Gellert. 1998. Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks. EMBO J. 17: 609-614.
    • (1998) EMBO J. , vol.17 , pp. 609-614
    • Ramsden, D.A.1    Gellert, M.2
  • 183
    • 0031045205 scopus 로고    scopus 로고
    • Specificity in V(D)J recombination: New lessons from biochemistry and genetics
    • Ramsden, D.A., D.C. van Gent, and M. Gellert. 1997. Specificity in V(D)J recombination: New lessons from biochemistry and genetics. Curr. Opin. Immunol. 9: 114-120.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 114-120
    • Ramsden, D.A.1    Van Gent, D.C.2    Gellert, M.3
  • 184
    • 0028342645 scopus 로고
    • A DNA end binding factor involved in double-strand break repair and V(D)J recombination
    • Rathmell, W.K. and G. Chu. 1994. A DNA end binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol. 14: 4741-4748.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4741-4748
    • Rathmell, W.K.1    Chu, G.2
  • 185
    • 0031025079 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
    • Rathmell, W.K., W.K. Kaufmann, J.C. Hurt, L.L. Byrd, and G. Chu. 1997. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res. 57: 68-74.
    • (1997) Cancer Res. , vol.57 , pp. 68-74
    • Rathmell, W.K.1    Kaufmann, W.K.2    Hurt, J.C.3    Byrd, L.L.4    Chu, G.5
  • 186
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for S μ-S ∈ heavy chain class switching
    • Rolink, A., F. Melchers, and J. Andersson. 1996. The SCID but not the RAG-2 gene product is required for S μ-S ∈ heavy chain class switching. Immunity 5: 319-330.
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 187
    • 0030814125 scopus 로고    scopus 로고
    • Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors Wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G(2) M delay
    • Rosenzweig, K.E., M.B. Youmell, S.T. Palayoor, and B.D. Price. 1997. Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors Wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G(2) M delay. Clin. Cancer Res. 3: 1149-1156.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3    Price, B.D.4
  • 188
    • 0031663617 scopus 로고    scopus 로고
    • ATM: From gene to function
    • Rotman, G. and Y. Shiloh. 1998. ATM: From gene to function. Hum. Mol. Genet. 7: 1555-1563.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1555-1563
    • Rotman, G.1    Shiloh, Y.2
  • 190
    • 0028239893 scopus 로고
    • RAFT1-A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast Tors
    • Sabatini, D.M., H. Erdjument-Bromage, M. Liu, P. Tempst, and S.H. Snyder. 1994. RAFT1-A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast Tors. Cell 78: 35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Liu, M.3    Tempst, P.4    Snyder, S.H.5
  • 192
    • 0030749258 scopus 로고    scopus 로고
    • A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks
    • Schar, P., G. Herrmann, G. Daly, and T. Lindahl. 1997. A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes & Dev. 11: 1912-1924.
    • (1997) Genes & Dev. , vol.11 , pp. 1912-1924
    • Schar, P.1    Herrmann, G.2    Daly, G.3    Lindahl, T.4
  • 193
    • 0026686944 scopus 로고
    • Isolation and characterization of the Schizosaccharomyces pombe Rad3 gene, involved in the DNA damage and DNA synthesis checkpoints
    • Seaton, B.L., J. Yucel, P. Sunnerhagen, and S. Subramani. 1992. Isolation and characterization of the Schizosaccharomyces pombe Rad3 gene, involved in the DNA damage and DNA synthesis checkpoints. Gene 119: 83-89.
    • (1992) Gene , vol.119 , pp. 83-89
    • Seaton, B.L.1    Yucel, J.2    Sunnerhagen, P.3    Subramani, S.4
  • 194
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S.Y., M. Ikeda, Y. Taya, and C. Prives. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91: 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 195
    • 0031569608 scopus 로고    scopus 로고
    • A kinase negative mutation of DNA-PKcs in equine SCID results in defective coding and signal joint formation
    • Shin, E.K., L.E. Perryman, and K. Meek. 1997. A kinase negative mutation of DNA-PKcs in equine SCID results in defective coding and signal joint formation. J. Immunol. 158: 3565-3569.
    • (1997) J. Immunol. , vol.158 , pp. 3565-3569
    • Shin, E.K.1    Perryman, L.E.2    Meek, K.3
  • 196
    • 0032544276 scopus 로고    scopus 로고
    • Telomeres - Unsticky ends
    • Shore, D. 1998. Telomeres - unsticky ends. Science 281: 1818-1819.
    • (1998) Science , vol.281 , pp. 1818-1819
    • Shore, D.1
  • 197
    • 0030033061 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Ku autoantigen homolog affects radiosensitivity only in the absence of homologous recombination
    • Siede, W., A.A. Friedl, I. Dianova, F. Eckardt-Schupp, and E.C. Friedberg. 1996. The Saccharomyces cerevisiae Ku autoantigen homolog affects radiosensitivity only in the absence of homologous recombination. Genetics 142: 91-102.
    • (1996) Genetics , vol.142 , pp. 91-102
    • Siede, W.1    Friedl, A.A.2    Dianova, I.3    Eckardt-Schupp, F.4    Friedberg, E.C.5
  • 199
    • 0028112944 scopus 로고
    • Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
    • Smider, V., W.K. Rathmell, M.R. Lieber, and G. Chu. 1994. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266: 288-291.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.R.3    Chu, G.4
  • 200
    • 0031741234 scopus 로고    scopus 로고
    • Failure of hairpin ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination
    • Smider, V., W.K. Rathmell, G. Brown, S. Lewis, and G. Chu. 1998. Failure of hairpin ended and nicked DNA to activate DNA-dependent protein kinase: Implications for V(D)J recombination. Mol. Cell. Biol. 18: 6853-6858.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6853-6858
    • Smider, V.1    Rathmell, W.K.2    Brown, G.3    Lewis, S.4    Chu, G.5
  • 203
    • 0028263785 scopus 로고
    • DNA-dependent protein kinase (Ku protein p350 complex) assembles on double-stranded DNA
    • Suwa, A., M. Hirakata, Y. Takeda, S.A. Jesch, T. Mimori, and J.A. Hardin. 1994. DNA-dependent protein kinase (Ku protein p350 complex) assembles on double-stranded DNA. Proc. Natl. Acad. Sci. 91: 6904-6908.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 6904-6908
    • Suwa, A.1    Hirakata, M.2    Takeda, Y.3    Jesch, S.A.4    Mimori, T.5    Hardin, J.A.6
  • 204
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G.E., G. Rathbun, E. Oltz, T. Stamato, P.A. Jeggo, and F.W. Alt. 1993. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260: 207-210.
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 208
    • 0029979313 scopus 로고    scopus 로고
    • DNA-dependent protein kinase inhibitor (OK 1035) suppresses p21 expression in Hct116 cells containing wild-type p53 induced by adriamycin
    • Take, Y., M. Kumano, H. Teraoka, S. Nishimura, and A. Okuyama. 1996. DNA-dependent protein kinase inhibitor (OK 1035) suppresses p21 expression in Hct116 cells containing wild-type p53 induced by adriamycin. Biochem. Biophys. Res. Commun. 221: 207-212.
    • (1996) Biochem. Biophys. Res. Commun. , vol.221 , pp. 207-212
    • Take, Y.1    Kumano, M.2    Teraoka, H.3    Nishimura, S.4    Okuyama, A.5
  • 209
    • 0030849085 scopus 로고    scopus 로고
    • Identification of Saccharomyces cerevisiae DNA ligase IV: Involvement in DNA double-strand break repair
    • Teo, S.H. and S.P. Jackson. 1997. Identification of Saccharomyces cerevisiae DNA ligase IV: Involvement in DNA double-strand break repair. EMBO J. 16: 4788-4795.
    • (1997) EMBO J. , vol.16 , pp. 4788-4795
    • Teo, S.H.1    Jackson, S.P.2
  • 210
    • 0029121551 scopus 로고
    • Nomenclature of human genes involved in ionizing radiation sensitivity
    • Thompson, L.H. and P.A. Jeggo. 1995. Nomenclature of human genes involved in ionizing radiation sensitivity. Mut. Res. DNA Rep. 337: 131-134.
    • (1995) Mut. Res. Dna Rep. , vol.337 , pp. 131-134
    • Thompson, L.H.1    Jeggo, P.A.2
  • 212
    • 0030992837 scopus 로고    scopus 로고
    • Signaling through the lipid products of phosphoinositide-3-OH kinase
    • Toker, A. and L.C. Cantley. 1997. Signaling through the lipid products of phosphoinositide-3-OH kinase. Nature 387: 673-676.
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 213
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • Trujillo, K.M., S.S.F. Yuan, E. Lee, and P. Sung. 1998. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273: 21447-21450.
    • (1998) J. Biol. Chem. , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.F.2    Lee, E.3    Sung, P.4
  • 214
    • 0030964526 scopus 로고    scopus 로고
    • Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae
    • Tsukamoto, Y., J. Kato, and H. Ikeda. 1997. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388: 900-903.
    • (1997) Nature , vol.388 , pp. 900-903
    • Tsukamoto, Y.1    Kato, J.2    Ikeda, H.3
  • 217
    • 0021980039 scopus 로고
    • Double-stranded DNA induces the phosphorylation of several proteins including the 90,000 mol wt heat shock protein in animal cell extracts
    • Walker, A.I., T. Hunt, R.J. Jackson, and C.W. Anderson. 1985. Double-stranded DNA induces the phosphorylation of several proteins including the 90,000 mol wt heat shock protein in animal cell extracts. EMBO J. 4: 139-145.
    • (1985) EMBO J. , vol.4 , pp. 139-145
    • Walker, A.I.1    Hunt, T.2    Jackson, R.J.3    Anderson, C.W.4
  • 218
    • 0031974492 scopus 로고    scopus 로고
    • Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding
    • Wang, J.S., X.W. Dong, K.J. Myung, E.A. Hendrickson, and W.H. Reeves. 1998. Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding. J. Biol. Chem. 273: 842-848.
    • (1998) J. Biol. Chem. , vol.273 , pp. 842-848
    • Wang, J.S.1    Dong, X.W.2    Myung, K.J.3    Hendrickson, E.A.4    Reeves, W.H.5
  • 219
    • 0027937302 scopus 로고
    • Stimulation of DNA-dependent protein kinase activity by high mobility group protein 1 and protein 2
    • Watanabe, F., H. Shirakawa, M. Yoshida, K. Tsukada, and H. Teraoka. 1994. Stimulation of DNA-dependent protein kinase activity by high mobility group protein 1 and protein 2. Biochem. Biophys. Res. Commun. 202: 736-742.
    • (1994) Biochem. Biophys. Res. Commun. , vol.202 , pp. 736-742
    • Watanabe, F.1    Shirakawa, H.2    Yoshida, M.3    Tsukada, K.4    Teraoka, H.5
  • 220
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T.A., G.L. Kiser, and L.H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes & Dev. 8: 652-665.
    • (1994) Genes & Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 221
    • 0031708232 scopus 로고    scopus 로고
    • Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
    • West, R.B., M. Yaneva, and M.R. Lieber. 1998. Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini. Mol. Cell. Biol. 18: 5908-5920.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5908-5920
    • West, R.B.1    Yaneva, M.2    Lieber, M.R.3
  • 222
    • 0029582791 scopus 로고
    • Equine severe combined immunodeficiency a defect in V(D)J recombination and DNA-dependent protein kinase activity
    • Wiler, R., R. Leber, B.B. Moore, L.F. Vandyk, L.E. Perryman, and K. Meek. 1995. Equine severe combined immunodeficiency a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc. Natl. Acad. Sci. 92: 11485-11489.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 11485-11489
    • Wiler, R.1    Leber, R.2    Moore, B.B.3    Vandyk, L.F.4    Perryman, L.E.5    Meek, K.6
  • 223
    • 0030811523 scopus 로고    scopus 로고
    • Yeast DNA ligase IV mediates non-homologous DNA end joining
    • Wilson, T.E., U. Grawunder, and M.R. Lieber. 1997. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388: 495-498.
    • (1997) Nature , vol.388 , pp. 495-498
    • Wilson, T.E.1    Grawunder, U.2    Lieber, M.R.3
  • 224
    • 0032514485 scopus 로고    scopus 로고
    • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
    • Woo, R.A., K.G. McLure, S.P. Lees-Miller, D.E. Rancourt, and P.W.K. Lee. 1998. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature 394: 700-704.
    • (1998) Nature , vol.394 , pp. 700-704
    • Woo, R.A.1    McLure, K.G.2    Lees-Miller, S.P.3    Rancourt, D.E.4    Lee, P.W.K.5
  • 225
    • 0029740571 scopus 로고    scopus 로고
    • Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70 Ku86
    • Wu, X.T. and M.R. Lieber. 1996. Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70 Ku86. Mol. Cell. Biol. 16: 5186-5193.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5186-5193
    • Wu, X.T.1    Lieber, M.R.2
  • 226
    • 0031278299 scopus 로고    scopus 로고
    • Ig Sγ3 DNA-specific double-strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination
    • Wuerffel, R.A., J. Du, R.J. Thompson, and A.L. Kenter. 1997. Ig Sγ3 DNA-specific double-strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination. J. Immunol. 159: 4139-4144.
    • (1997) J. Immunol. , vol.159 , pp. 4139-4144
    • Wuerffel, R.A.1    Du, J.2    Thompson, R.J.3    Kenter, A.L.4
  • 227
    • 0030746109 scopus 로고    scopus 로고
    • Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic force microscopy studies
    • Yaneva, M., T. Kowalewski, and M.R. Lieber. 1997. Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic force microscopy studies. EMBO J. 16: 5098-5112.
    • (1997) EMBO J. , vol.16 , pp. 5098-5112
    • Yaneva, M.1    Kowalewski, T.2    Lieber, M.R.3
  • 228
    • 0026377241 scopus 로고
    • Changes in the nuclear structure in the radiation sensitive CHO mutant cell, xrs 5
    • Yasui, L.S., L. Lingindeck, B. Johnsonwint, T.J. Fink, and D. Molsen. 1991. Changes in the nuclear structure in the radiation sensitive CHO mutant cell, xrs 5. Radiat. Res. 127: 269-277.
    • (1991) Radiat. Res. , vol.127 , pp. 269-277
    • Yasui, L.S.1    Lingindeck, L.2    Johnsonwint, B.3    Fink, T.J.4    Molsen, D.5
  • 229
    • 0032528228 scopus 로고    scopus 로고
    • DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D
    • Yavuzer, U., G.C.M. Smith, T. Bliss, D. Werner, and S.P. Jackson. 1998. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes & Dev. 12: 2188-2199.
    • (1998) Genes & Dev. , vol.12 , pp. 2188-2199
    • Yavuzer, U.1    Smith, G.C.M.2    Bliss, T.3    Werner, D.4    Jackson, S.P.5
  • 230
    • 0032477744 scopus 로고    scopus 로고
    • Characterization of the RNA binding properties of Ku protein
    • Yoo, S. and W.S. Dynan. 1998. Characterization of the RNA binding properties of Ku protein. Biochemistry 37: 1336-1343.
    • (1998) Biochemistry , vol.37 , pp. 1336-1343
    • Yoo, S.1    Dynan, W.S.2
  • 231
    • 0031696265 scopus 로고    scopus 로고
    • High mobility group proteins 1 and 2 can function as DNA binding regulatory components for DNA-dependent protein kinase in vitro
    • Yumoto, Y., H. Shirakawa, M. Yoshida, A. Suwa, F. Watanabe, and H. Teraoka. 1998. High mobility group proteins 1 and 2 can function as DNA binding regulatory components for DNA-dependent protein kinase in vitro. J. Biol. Chem. 124: 519-527.
    • (1998) J. Biol. Chem. , vol.124 , pp. 519-527
    • Yumoto, Y.1    Shirakawa, H.2    Yoshida, M.3    Suwa, A.4    Watanabe, F.5    Teraoka, H.6
  • 232
    • 0029127643 scopus 로고
    • ATM related genes: What do they tell us about functions of the human gene?
    • Zakian, V.A. 1995. ATM related genes: What do they tell us about functions of the human gene? Cell 82: 685-687.
    • (1995) Cell , vol.82 , pp. 685-687
    • Zakian, V.A.1
  • 233
    • 0028960865 scopus 로고
    • Mammalian mutants defective in the response to ionizing radiation-induced DNA damage
    • Zdzienicka, M.Z. 1995. Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mut. Res. DNA Rep. 336: 203-213.
    • (1995) Mut. Res. DNA Rep. , vol.336 , pp. 203-213
    • Zdzienicka, M.Z.1
  • 234
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu, C.M., M.A. Bogue, D.S. Lim, P. Hasty, and D.B. Roth. 1996. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86: 379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.M.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5


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