The essential functions of NEDD8 are mediated via distinct surface regions, and not by polyneddylation in schizosaccharomyces pombe

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Girdwood, David ^a   Xirodimas, Dimitris P ^b   Gordon, Colin ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; LYSINE; NEDD8 PROTEIN; UBIQUITIN PROTEIN LIGASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; UBIQUITIN;

ALANINE SCANNING MUTAGENESIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONJUGATION; CONTROLLED STUDY; ENZYME REGULATION; FUNGAL VIABILITY; GENE MUTATION; GENETIC CONSERVATION; HYDROPHOBICITY; MUTAGENESIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN MODIFICATION; SCHIZOSACCHAROMYCES POMBE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SCHIZOSACCHAROMYCES;

EUKARYOTA; SCHIZOSACCHAROMYCES POMBE;

CELL SURVIVAL; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; UBIQUITINS;

EID: 79957837864     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020089     Document Type: Article

References (40)

1. Xirodimas DP, (2008) Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem Soc Trans 36: 802-806.
2. Kurz T, Ozlu N, Rudolf F, O'Rourke SM, Luke B, et al. (2005) The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature 435: 1257-1261.
3. Xirodimas DP, Saville MK, Bourdon JC, Hay RT, Lane DP, (2004) Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118: 83-97.
4. Morimoto M, Nishida T, Nagayama Y, Yasuda H, (2003) Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability. Biochem Biophys Res Commun 301: 392-398.
5. Mendoza HM, Shen LN, Botting C, Lewis A, Chen J, et al. (2003) NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem 278: 25637-25643.
6. Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, et al. (2003) DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem 278: 28882-28891.
7. Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, et al. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298: 608-611.
8. Saha A, Deshaies RJ, (2008) Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell 32: 21-31.
9. Osaka F, Saeki M, Katayama S, Aida N, Toh EA, et al. (2000) Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. Embo J 19: 3475-3484.
10. Liu J, Furukawa M, Matsumoto T, Xiong Y, (2002) NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell 10: 1511-1518.
11. Sakata E, Yamaguchi Y, Miyauchi Y, Iwai K, Chiba T, et al. (2007) Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. Nat Struct Mol Biol 14: 167-168.
12. Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, et al. (2008) Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci U S A 105: 12230-12235.
13. Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, et al. (2008) Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134: 995-1006.
14. Cook WJ, Jeffrey LC, Kasperek E, Pickart CM, (1994) Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J Mol Biol 236: 601-609.
15. Hicke L, Schubert HL, Hill CP, (2005) Ubiquitin-binding domains. Nat Rev Mol Cell Biol 6: 610-621.
16. Dikic I, Wakatsuki S, Walters KJ, (2009) Ubiquitin-binding domains- from structures to functions. Nat Rev Mol Cell Biol 10: 659-671.
17. Winget JM, Mayor T, (2010) The diversity of ubiquitin recognition: hot spots and varied specificity. Mol Cell 38: 627-635.
18. Sloper-Mould KE, Jemc JC, Pickart CM, Hicke L, (2001) Distinct functional surface regions on ubiquitin. J Biol Chem 276: 30483-30489.
19. Hofmann RM, Pickart CM, (2001) In vitro assembly and recognition of Lys-63 polyubiquitin chains. J Biol Chem 276: 27936-27943.
20. Spence J, Sadis S, Haas AL, Finley D, (1995) A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol Cell Biol 15: 1265-1273.
21. Deng L, Wang C, Spencer E, Yang L, Braun A, et al. (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361.
22. Galan JM, Haguenauer-Tsapis R, (1997) Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. Embo J 16: 5847-5854.
23. Spence J, Gali RR, Dittmar G, Sherman F, Karin M, et al. (2000) Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell 102: 67-76.
24. Welchman RL, Gordon C, Mayer RJ, (2005) Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 6: 599-609.
25. Kerscher O, Felberbaum R, Hochstrasser M, (2006) Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol 22: 159-180.
26. Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, et al. (2008) Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep 9: 280-286.
27. Jones J, Wu K, Yang Y, Guerrero C, Nillegoda N, et al. (2008) A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. J Proteome Res 7: 1274-1287.
28. Whitby FG, Xia G, Pickart CM, Hill CP, (1998) Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J Biol Chem 273: 34983-34991.
29. Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, et al. (2003) The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell 12: 1427-1437.
30. Shen LN, Liu H, Dong C, Xirodimas D, Naismith JH, et al. (2005) Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. Embo J 24: 1341-1351.
31. Reverter D, Wu K, Erdene TG, Pan ZQ, Wilkinson KD, et al. (2005) Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol 345: 141-151.
32. Sundqvist A, Liu G, Mirsaliotis A, Xirodimas DP, (2009) Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep 10: 1132-1139.
33. Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, et al. (1998) A new NEDD8-ligating system for cullin-4A. Genes Dev 12: 2263-2268.
34. Vijay-Kumar S, Bugg CE, Cook WJ, (1987) Structure of ubiquitin refined at 1.8 A resolution. J Mol Biol 194: 531-544.
35. Beal R, Deveraux Q, Xia G, Rechsteiner M, Pickart C, (1996) Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting. Proc Natl Acad Sci U S A 93: 861-866.
36. Wu K, Chen A, Tan P, Pan ZQ, (2002) The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. J Biol Chem 277: 516-527.
37. Siergiejuk E, Scott DC, Schulman BA, Hofmann K, Kurz T, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. Embo J 28: 3845-3856.
38. Moreno S, Klar A, Nurse P, (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194: 795-823.
39. Hentges P, Van Driessche B, Tafforeau L, Vandenhaute J, Carr AM, (2005) Three novel antibiotic marker cassettes for gene disruption and marker switching in Schizosaccharomyces pombe. Yeast 22: 1013-1019.
40. Caspari T, Dahlen M, Kanter-Smoler G, Lindsay HD, Hofmann K, et al. (2000) Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9. Mol Cell Biol 20: 1254-1262.