-
1
-
-
82955233157
-
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
-
Acs, K., M.S. Luijsterburg, L. Ackermann, F.A. Salomons, T. Hoppe, and N.P. Dantuma. 2011. The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat. Struct. Mol. Biol. 18:1345-1350. http://dx.doi.org/10.1038/nsmb.2188
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 1345-1350
-
-
Acs, K.1
Luijsterburg, M.S.2
Ackermann, L.3
Salomons, F.A.4
Hoppe, T.5
Dantuma, N.P.6
-
2
-
-
78649450619
-
Assembly and function of DNA doublestrand break repair foci in mammalian cells
-
Bekker-Jensen, S., and N. Mailand. 2010. Assembly and function of DNA doublestrand break repair foci in mammalian cells. DNA Repair (Amst.). 9:1219- 1228. http://dx.doi.org/10.1016/j.dnarep.2010.09.010
-
(2010)
DNA Repair (Amst. )
, vol.9
, pp. 1219-1228
-
-
Bekker-Jensen, S.1
Mailand, N.2
-
3
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen, S., C. Lukas, R. Kitagawa, F. Melander, M.B. Kastan, J. Bartek, and J. Lukas. 2006. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173:195-206. http://dx.doi.org/10.1083/jcb.200510130
-
(2006)
J. Cell Biol
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
Melander, F.4
Kastan, M.B.5
Bartek, J.6
Lukas, J.7
-
4
-
-
77951057068
-
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
-
Bothmer, A., D.F. Robbiani, N. Feldhahn, A. Gazumyan, A. Nussenzweig, and M.C. Nussenzweig. 2010. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J. Exp. Med. 207:855-865. http://dx.doi.org/10.1084/jem.20100244
-
(2010)
J. Exp. Med
, vol.207
, pp. 855-865
-
-
Bothmer, A.1
Robbiani, D.F.2
Feldhahn, N.3
Gazumyan, A.4
Nussenzweig, A.5
Nussenzweig, M.C.6
-
5
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P., A. Aly, J.M. Escandell, M. Pieterse, J. Bartkova, H. van der Gulden, S. Hiddingh, M. Thanasoula, A. Kulkarni, Q. Yang, et al. 2010. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol. 17:688-695. http://dx.doi.org/10.1038/nsmb.1831
-
(2010)
Nat. Struct. Mol. Biol
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
Aly, A.2
Escandell, J.M.3
Pieterse, M.4
Bartkova, J.5
van der Gulden, H.6
Hiddingh, S.7
Thanasoula, M.8
Kulkarni, A.9
Yang, Q.10
-
6
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S.F., E. Callén, N. Wong, H.T. Chen, F. Polato, A. Gunn, A. Bothmer, N. Feldhahn, O. Fernandez-Capetillo, L. Cao, et al. 2010. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 141:243-254. http://dx.doi.org/10.1016/j.cell.2010.03.012
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callén, E.2
Wong, N.3
Chen, H.T.4
Polato, F.5
Gunn, A.6
Bothmer, A.7
Feldhahn, N.8
Fernandez-Capetillo, O.9
Cao, L.10
-
7
-
-
78649336706
-
The DNA damage response: making it safe to play with knives
-
Ciccia, A., and S.J. Elledge. 2010. The DNA damage response: making it safe to play with knives. Mol. Cell. 40:179-204. http://dx.doi.org/10.1016/j.molcel.2010.09.019
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
8
-
-
79953869356
-
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection
-
Coleman, K.A., and R.A. Greenberg. 2011. The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection. J. Biol. Chem. 286:13669-13680. http://dx.doi.org/10.1074/jbc.M110.213728
-
(2011)
J. Biol. Chem
, vol.286
, pp. 13669-13680
-
-
Coleman, K.A.1
Greenberg, R.A.2
-
9
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
Doil, C., N. Mailand, S. Bekker-Jensen, P. Menard, D.H. Larsen, R. Pepperkok, J. Ellenberg, S. Panier, D. Durocher, J. Bartek, et al. 2009. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell. 136:435-446. http://dx.doi.org/10.1016/j.cell.2008.12.041
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
Ellenberg, J.7
Panier, S.8
Durocher, D.9
Bartek, J.10
-
10
-
-
72449175818
-
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
-
Galanty, Y., R. Belotserkovskaya, J. Coates, S. Polo, K.M. Miller, and S.P. Jackson. 2009. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature. 462:935-939. http://dx.doi.org/10.1038/nature08657
-
(2009)
Nature
, vol.462
, pp. 935-939
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Polo, S.4
Miller, K.M.5
Jackson, S.P.6
-
11
-
-
79954528832
-
RAP80- directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
-
Hu, Y., R. Scully, B. Sobhian, A. Xie, E. Shestakova, and D.M. Livingston. 2011. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 25:685-700. http://dx.doi.org/10.1101/gad.2011011
-
(2011)
Genes Dev
, vol.25
, pp. 685-700
-
-
Hu, Y.1
Scully, R.2
Sobhian, B.3
Xie, A.4
Shestakova, E.5
Livingston, D.M.6
-
12
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
Huen, M.S., R. Grant, I. Manke, K. Minn, X. Yu, M.B. Yaffe, and J. Chen. 2007. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 131:901-914. http://dx.doi.org/10.1016/j.cell.2007.09.041
-
(2007)
Cell
, vol.131
, pp. 901-914
-
-
Huen, M.S.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.5
Yaffe, M.B.6
Chen, J.7
-
13
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson, S.P., and J. Bartek. 2009. The DNA-damage response in human biology and disease. Nature. 461:1071-1078. http://dx.doi.org/10.1038/nature08467
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
14
-
-
34249950879
-
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
-
Kim, H., J. Chen, and X. Yu. 2007. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science. 316:1202-1205. http://dx.doi.org/10.1126/science.1139621
-
(2007)
Science
, vol.316
, pp. 1202-1205
-
-
Kim, H.1
Chen, J.2
Yu, X.3
-
15
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
Kolas, N.K., J.R. Chapman, S. Nakada, J. Ylanko, R. Chahwan, F.D. Sweeney, S. Panier, M. Mendez, J. Wildenhain, T.M. Thomson, et al. 2007. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science. 318:1637-1640. http://dx.doi.org/10.1126/science.1150034
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
Panier, S.7
Mendez, M.8
Wildenhain, J.9
Thomson, T.M.10
-
16
-
-
38049115657
-
The mechanism of human nonhomologous DNA end joining
-
Lieber, M.R. 2008. The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283:1-5. http://dx.doi.org/10.1074/jbc.R700039200
-
(2008)
J. Biol. Chem
, vol.283
, pp. 1-5
-
-
Lieber, M.R.1
-
18
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas, C., J. Falck, J. Bartkova, J. Bartek, and J. Lukas. 2003. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5:255-260. http://dx.doi.org/10.1038/ncb945
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
19
-
-
33746429958
-
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand, N., S. Bekker-Jensen, J. Bartek, and J. Lukas. 2006. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell. 23:307-318. http://dx.doi.org/10.1016/j.molcel.2006.06.016
-
(2006)
Mol. Cell
, vol.23
, pp. 307-318
-
-
Mailand, N.1
Bekker-Jensen, S.2
Bartek, J.3
Lukas, J.4
-
20
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand, N., S. Bekker-Jensen, H. Faustrup, F. Melander, J. Bartek, C. Lukas, and J. Lukas. 2007. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell. 131:887-900. http://dx.doi.org/10.1016/j.cell.2007.09.040
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
21
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
Misteli, T., and E. Soutoglou. 2009. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell Biol. 10:243- 254. http://dx.doi.org/10.1038/nrm2651
-
(2009)
Nat. Rev. Mol. Cell Biol
, vol.10
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
22
-
-
72449163470
-
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
-
Morris, J.R., C. Boutell, M. Keppler, R. Densham, D. Weekes, A. Alamshah, L. Butler, Y. Galanty, L. Pangon, T. Kiuchi, et al. 2009. The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature. 462:886-890. http://dx.doi.org/10.1038/nature08593
-
(2009)
Nature
, vol.462
, pp. 886-890
-
-
Morris, J.R.1
Boutell, C.2
Keppler, M.3
Densham, R.4
Weekes, D.5
Alamshah, A.6
Butler, L.7
Galanty, Y.8
Pangon, L.9
Kiuchi, T.10
-
23
-
-
77955867565
-
Non- canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
-
Nakada, S., I. Tai, S. Panier, A. Al-Hakim, S. Iemura, Y.C. Juang, L. O'Donnell, A. Kumakubo, M. Munro, F. Sicheri, et al. 2010. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature. 466:941-946. http://dx.doi.org/10.1038/nature09297
-
(2010)
Nature
, vol.466
, pp. 941-946
-
-
Nakada, S.1
Tai, I.2
Panier, S.3
Al-Hakim, A.4
Iemura, S.5
Juang, Y.C.6
O'Donnell, L.7
Kumakubo, A.8
Munro, M.9
Sicheri, F.10
-
24
-
-
36049036216
-
Human USP3 is a chromatin modifier required for S phase progression and genome stability
-
Nicassio, F., N. Corrado, J.H. Vissers, L.B. Areces, S. Bergink, J.A. Marteijn, B. Geverts, A.B. Houtsmuller, W. Vermeulen, P.P. Di Fiore, and E. Citterio. 2007. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr. Biol. 17:1972-1977. http://dx.doi.org/10.1016/j.cub.2007.10.034
-
(2007)
Curr. Biol
, vol.17
, pp. 1972-1977
-
-
Nicassio, F.1
Corrado, N.2
Vissers, J.H.3
Areces, L.B.4
Bergink, S.5
Marteijn, J.A.6
Geverts, B.7
Houtsmuller, A.B.8
Vermeulen, W.9
Di Fiore, P.P.10
Citterio, E.11
-
25
-
-
79955613209
-
Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors
-
Ogiwara, H., A. Ui, A. Otsuka, H. Satoh, I. Yokomi, S. Nakajima, A. Yasui, J. Yokota, and T. Kohno. 2011. Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene. 30:2135-2146. http://dx.doi.org/10.1038/onc.2010.592
-
(2011)
Oncogene
, vol.30
, pp. 2135-2146
-
-
Ogiwara, H.1
Ui, A.2
Otsuka, A.3
Satoh, H.4
Yokomi, I.5
Nakajima, S.6
Yasui, A.7
Yokota, J.8
Kohno, T.9
-
26
-
-
63049101044
-
Regulatory ubiquitylation in response to DNA double-strand breaks
-
Panier, S., and D. Durocher. 2009. Regulatory ubiquitylation in response to DNA double-strand breaks. DNA Repair (Amst.). 8:436-443. http://dx.doi.org/10.1016/j.dnarep.2009.01.013
-
(2009)
DNA Repair (Amst. )
, vol.8
, pp. 436-443
-
-
Panier, S.1
Durocher, D.2
-
27
-
-
33646036373
-
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
-
Penengo, L., M. Mapelli, A.G. Murachelli, S. Confalonieri, L. Magri, A. Musacchio, P.P. Di Fiore, S. Polo, and T.R. Schneider. 2006. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell. 124:1183-1195. http://dx.doi.org/10.1016/j.cell.2006.02.020
-
(2006)
Cell
, vol.124
, pp. 1183-1195
-
-
Penengo, L.1
Mapelli, M.2
Murachelli, A.G.3
Confalonieri, S.4
Magri, L.5
Musacchio, A.6
Di Fiore, P.P.7
Polo, S.8
Schneider, T.R.9
-
28
-
-
50649100744
-
Mechanism of eukaryotic homologous recombination
-
San Filippo, J., P. Sung, and H. Klein. 2008. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77:229-257. http://dx.doi.org/10.1146/annurev.biochem.77.061306.125255
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 229-257
-
-
San Filippo, J.1
Sung, P.2
Klein, H.3
-
29
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori, A.A., C. Lukas, J. Coates, M. Mistrik, S. Fu, J. Bartek, R. Baer, J. Lukas, and S.P. Jackson. 2007. Human CtIP promotes DNA end resection. Nature. 450:509-514. http://dx.doi.org/10.1038/nature06337
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
Baer, R.7
Lukas, J.8
Jackson, S.P.9
-
30
-
-
38049155945
-
Regulation of DNA double-strand break repair pathway choice
-
Shrivastav, M., L.P. De Haro, and J.A. Nickoloff. 2008. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18:134-147. http://dx.doi.org/10.1038/cr.2007.111
-
(2008)
Cell Res
, vol.18
, pp. 134-147
-
-
Shrivastav, M.1
De Haro, L.P.2
Nickoloff, J.A.3
-
31
-
-
34249949779
-
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
-
Sobhian, B., G. Shao, D.R. Lilli, A.C. Culhane, L.A. Moreau, B. Xia, D.M. Livingston, and R.A. Greenberg. 2007. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 316:1198-1202. http://dx.doi.org/10.1126/science.1139516
-
(2007)
Science
, vol.316
, pp. 1198-1202
-
-
Sobhian, B.1
Shao, G.2
Lilli, D.R.3
Culhane, A.C.4
Moreau, L.A.5
Xia, B.6
Livingston, D.M.7
Greenberg, R.A.8
-
32
-
-
33747889217
-
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
-
Sonoda, E., H. Hochegger, A. Saberi, Y. Taniguchi, and S. Takeda. 2006. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst.). 5:1021- 1029. http://dx.doi.org/10.1016/j.dnarep.2006.05.022
-
(2006)
DNA Repair (Amst. ).
, vol.5
, pp. 1021-1029
-
-
Sonoda, E.1
Hochegger, H.2
Saberi, A.3
Taniguchi, Y.4
Takeda, S.5
-
33
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
-
Stewart, G.S., S. Panier, K. Townsend, A.K. Al-Hakim, N.K. Kolas, E.S. Miller, S. Nakada, J. Ylanko, S. Olivarius, M. Mendez, et al. 2009. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell. 136:420-434. http://dx.doi.org/10.1016/j.cell.2008.12.042
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
Nakada, S.7
Ylanko, J.8
Olivarius, S.9
Mendez, M.10
-
34
-
-
34249946686
-
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
-
Wang, B., S. Matsuoka, B.A. Ballif, D. Zhang, A. Smogorzewska, S.P. Gygi, and S.J. Elledge. 2007. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 316:1194-1198. http://dx.doi.org/10.1126/science.1139476
-
(2007)
Science
, vol.316
, pp. 1194-1198
-
-
Wang, B.1
Matsuoka, S.2
Ballif, B.A.3
Zhang, D.4
Smogorzewska, A.5
Gygi, S.P.6
Elledge, S.J.7
-
35
-
-
59249095962
-
Histone ubiquitination associates with BRCA1-dependent DNA damage response
-
Wu, J., M.S. Huen, L.Y. Lu, L. Ye, Y. Dou, M. Ljungman, J. Chen, and X. Yu. 2009. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol. Cell. Biol. 29:849-860. http://dx.doi.org/10.1128/MCB.01302-08
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 849-860
-
-
Wu, J.1
Huen, M.S.2
Lu, L.Y.3
Ye, L.4
Dou, Y.5
Ljungman, M.6
Chen, J.7
Yu, X.8
-
36
-
-
33845604556
-
DNA double-strand break repair: all's well that ends well
-
Wyman, C., and R. Kanaar. 2006. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 40:363-383. http://dx.doi.org/10.1146/annurev.genet.40.110405.090451
-
(2006)
Annu. Rev. Genet
, vol.40
, pp. 363-383
-
-
Wyman, C.1
Kanaar, R.2
|