-
1
-
-
38049155945
-
Regulation of DNA double-strand break repair pathway choice
-
Shrivastav M., De Haro L.P., Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 2008, 18:134-147.
-
(2008)
Cell Res.
, vol.18
, pp. 134-147
-
-
Shrivastav, M.1
De Haro, L.P.2
Nickoloff, J.A.3
-
2
-
-
65849336044
-
At loose ends: resecting a double-strand break
-
Bernstein K.A., Rothstein R. At loose ends: resecting a double-strand break. Cell 2009, 137:807-810.
-
(2009)
Cell
, vol.137
, pp. 807-810
-
-
Bernstein, K.A.1
Rothstein, R.2
-
3
-
-
77449090212
-
The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
-
Taylor E.M., Cecillon S.M., Bonis A., Chapman J.R., Povirk L.F., Lindsay H.D. The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis. Nucleic Acids Res. 2010, 38:441-454.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 441-454
-
-
Taylor, E.M.1
Cecillon, S.M.2
Bonis, A.3
Chapman, J.R.4
Povirk, L.F.5
Lindsay, H.D.6
-
4
-
-
68249138694
-
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
-
Rass E., Grabarz A., Plo I., Gautier J., Bertrand P., Lopez B.S. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat. Struct. Mol. Biol. 2009, 16:819-824.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 819-824
-
-
Rass, E.1
Grabarz, A.2
Plo, I.3
Gautier, J.4
Bertrand, P.5
Lopez, B.S.6
-
5
-
-
68249146431
-
Role of mammalian Mre11 in classical and alternative nonhomologous end joining
-
Xie A., Kwok A., Scully R. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat. Struct. Mol. Biol. 2009, 16:814-818.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 814-818
-
-
Xie, A.1
Kwok, A.2
Scully, R.3
-
6
-
-
68249135624
-
Multiple functions of MRN in end-joining pathways during isotype class switching
-
Dinkelmann M., Spehalski E., Stoneham T., Buis J., Wu Y., Sekiguchi J.M., Ferguson D.O. Multiple functions of MRN in end-joining pathways during isotype class switching. Nat. Struct. Mol. Biol. 2009, 16:808-813.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 808-813
-
-
Dinkelmann, M.1
Spehalski, E.2
Stoneham, T.3
Buis, J.4
Wu, Y.5
Sekiguchi, J.M.6
Ferguson, D.O.7
-
7
-
-
68249150701
-
Mre11: roles in DNA repair beyond homologous recombination
-
Zha S., Boboila C., Alt F.W. Mre11: roles in DNA repair beyond homologous recombination. Nat. Struct. Mol. Biol. 2009, 16:798-800.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 798-800
-
-
Zha, S.1
Boboila, C.2
Alt, F.W.3
-
8
-
-
0028943378
-
Functions of the yeast meiotic recombination genes, MRE11 and MRE2
-
Ogawa H., Johzuka K., Nakagawa T., Leem S.H., Hagihara A.H. Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Adv. Biophys. 1995, 31:67-76.
-
(1995)
Adv. Biophys.
, vol.31
, pp. 67-76
-
-
Ogawa, H.1
Johzuka, K.2
Nakagawa, T.3
Leem, S.H.4
Hagihara, A.H.5
-
9
-
-
0032567108
-
Complex formation and functional versatility of Mre11 of budding yeast in recombination
-
Usui T., Ohta T., Oshiumi H., Tomizawa J., Ogawa H., Ogawa T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 1998, 95:705-716.
-
(1998)
Cell
, vol.95
, pp. 705-716
-
-
Usui, T.1
Ohta, T.2
Oshiumi, H.3
Tomizawa, J.4
Ogawa, H.5
Ogawa, T.6
-
10
-
-
0029742576
-
Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair
-
Dolganov G.M., Maser R.S., Novikov A., Tosto L., Chong S., Bressan D.A., Petrini J.H. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell Biol. 1996, 16:4832-4841.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 4832-4841
-
-
Dolganov, G.M.1
Maser, R.S.2
Novikov, A.3
Tosto, L.4
Chong, S.5
Bressan, D.A.6
Petrini, J.H.7
-
11
-
-
0032555480
-
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
-
Trujillo K.M., Yuan S.S., Lee E.Y., Sung P. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 1998, 273:21447-21450.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21447-21450
-
-
Trujillo, K.M.1
Yuan, S.S.2
Lee, E.Y.3
Sung, P.4
-
12
-
-
53549093050
-
The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break
-
Hopkins B.B., Paull T.T. The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Cell 2008, 135:250-260.
-
(2008)
Cell
, vol.135
, pp. 250-260
-
-
Hopkins, B.B.1
Paull, T.T.2
-
13
-
-
34948899943
-
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
-
Williams R.S., Williams J.S., Tainer J.A. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 2007, 85:509-520.
-
(2007)
Biochem. Cell Biol.
, vol.85
, pp. 509-520
-
-
Williams, R.S.1
Williams, J.S.2
Tainer, J.A.3
-
14
-
-
0036276388
-
The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling
-
D'Amours D., Jackson S.P. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 2002, 3:317-327.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 317-327
-
-
D'Amours, D.1
Jackson, S.P.2
-
15
-
-
52949149420
-
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair
-
Williams R.S., et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell 2008, 135:97-109.
-
(2008)
Cell
, vol.135
, pp. 97-109
-
-
Williams, R.S.1
-
16
-
-
0035869155
-
DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways
-
de Jager M., Dronkert M.L., Modesti M., Beerens C.E., Kanaar R., van Gent D.C. DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways. Nucleic Acids Res. 2001, 29:1317-1325.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 1317-1325
-
-
de Jager, M.1
Dronkert, M.L.2
Modesti, M.3
Beerens, C.E.4
Kanaar, R.5
van Gent, D.C.6
-
17
-
-
0033563229
-
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
-
Paull T.T., Gellert M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 1999, 13:1276-1288.
-
(1999)
Genes Dev.
, vol.13
, pp. 1276-1288
-
-
Paull, T.T.1
Gellert, M.2
-
18
-
-
0032085295
-
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
-
Paull T.T., Gellert M. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1998, 1:969-979.
-
(1998)
Mol. Cell
, vol.1
, pp. 969-979
-
-
Paull, T.T.1
Gellert, M.2
-
19
-
-
71049189711
-
Exonuclease function of human Mre11 promotes deletional nonhomologous end joining
-
Zhuang J., Jiang G., Willers H., Xia F. Exonuclease function of human Mre11 promotes deletional nonhomologous end joining. J. Biol. Chem. 2009, 284:30565-30573.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 30565-30573
-
-
Zhuang, J.1
Jiang, G.2
Willers, H.3
Xia, F.4
-
20
-
-
71949092988
-
Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes
-
Milman N., Higuchi E., Smith G.R. Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes. Mol. Cell Biol. 2009, 29:5998-6005.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 5998-6005
-
-
Milman, N.1
Higuchi, E.2
Smith, G.R.3
-
21
-
-
67249153681
-
Ctp1 and exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination
-
Farah J.A., Cromie G.A., Smith G.R. Ctp1 and exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination. Proc. Natl. Acad. Sci. USA 2009, 106:9356-9361.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9356-9361
-
-
Farah, J.A.1
Cromie, G.A.2
Smith, G.R.3
-
22
-
-
68249116573
-
DNA end resection: many nucleases make light work
-
Mimitou E.P., Symington L.S. DNA end resection: many nucleases make light work. DNA Repair (Amst) 2009, 8:983-995.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 983-995
-
-
Mimitou, E.P.1
Symington, L.S.2
-
23
-
-
63249083853
-
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering
-
van der Linden E., Sanchez H., Kinoshita E., Kanaar R., Wyman C. RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res. 2009, 37:1580-1588.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 1580-1588
-
-
van der Linden, E.1
Sanchez, H.2
Kinoshita, E.3
Kanaar, R.4
Wyman, C.5
-
24
-
-
0033544724
-
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
-
Stewart G.S., et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 1999, 99:577-587.
-
(1999)
Cell
, vol.99
, pp. 577-587
-
-
Stewart, G.S.1
-
25
-
-
24944576230
-
Rad50 depletion impacts upon ATR-dependent DNA damage responses
-
Zhong H., Bryson A., Eckersdorff M., Ferguson D.O. Rad50 depletion impacts upon ATR-dependent DNA damage responses. Hum. Mol. Genet. 2005, 14:2685-2693.
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2685-2693
-
-
Zhong, H.1
Bryson, A.2
Eckersdorff, M.3
Ferguson, D.O.4
-
26
-
-
0034705293
-
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
-
Hopfner K.P., Karcher A., Shin D.S., Craig L., Arthur L.M., Carney J.P., Tainer J.A. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 2000, 101:789-800.
-
(2000)
Cell
, vol.101
, pp. 789-800
-
-
Hopfner, K.P.1
Karcher, A.2
Shin, D.S.3
Craig, L.4
Arthur, L.M.5
Carney, J.P.6
Tainer, J.A.7
-
27
-
-
0035906860
-
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
-
Hopfner K.P., Karcher A., Craig L., Woo T.T., Carney J.P., Tainer J.A. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 2001, 105:473-485.
-
(2001)
Cell
, vol.105
, pp. 473-485
-
-
Hopfner, K.P.1
Karcher, A.2
Craig, L.3
Woo, T.T.4
Carney, J.P.5
Tainer, J.A.6
-
28
-
-
0035930329
-
Human Rad50/Mre11 is a flexible complex that can tether DNA ends
-
de Jager M., van Noort J., van Gent D.C., Dekker C., Kanaar R., Wyman C. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell 2001, 8:1129-1135.
-
(2001)
Mol. Cell
, vol.8
, pp. 1129-1135
-
-
de Jager, M.1
van Noort, J.2
van Gent, D.C.3
Dekker, C.4
Kanaar, R.5
Wyman, C.6
-
29
-
-
0036682314
-
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
-
Hopfner K.P., et al. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature 2002, 418:562-566.
-
(2002)
Nature
, vol.418
, pp. 562-566
-
-
Hopfner, K.P.1
-
30
-
-
34547688971
-
Dimerization of the Rad50 protein is independent of the conserved hook domain
-
Cahill D., Carney J.P. Dimerization of the Rad50 protein is independent of the conserved hook domain. Mutagenesis 2007, 22:269-274.
-
(2007)
Mutagenesis
, vol.22
, pp. 269-274
-
-
Cahill, D.1
Carney, J.P.2
-
31
-
-
20444468899
-
The Rad50 hook domain is a critical determinant of Mre11 complex functions
-
Wiltzius J.J., Hohl M., Fleming J.C., Petrini J.H. The Rad50 hook domain is a critical determinant of Mre11 complex functions. Nat. Struct. Mol. Biol. 2005, 12:403-407.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 403-407
-
-
Wiltzius, J.J.1
Hohl, M.2
Fleming, J.C.3
Petrini, J.H.4
-
32
-
-
70349470626
-
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
-
Lloyd J., et al. A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 2009, 139:100-111.
-
(2009)
Cell
, vol.139
, pp. 100-111
-
-
Lloyd, J.1
-
33
-
-
70349472553
-
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair
-
Williams R.S., et al. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell 2009, 139:87-99.
-
(2009)
Cell
, vol.139
, pp. 87-99
-
-
Williams, R.S.1
-
34
-
-
0034997651
-
Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
-
Desai-Mehta A., Cerosaletti K.M., Concannon P. Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol. Cell Biol. 2001, 21:2184-2191.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 2184-2191
-
-
Desai-Mehta, A.1
Cerosaletti, K.M.2
Concannon, P.3
-
35
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
36
-
-
20744436198
-
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
-
You Z., Chahwan C., Bailis J., Hunter T., Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell Biol. 2005, 25:5363-5379.
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 5363-5379
-
-
You, Z.1
Chahwan, C.2
Bailis, J.3
Hunter, T.4
Russell, P.5
-
37
-
-
34248579748
-
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
-
Stracker T.H., Morales M., Couto S.S., Hussein H., Petrini J.H.J. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 2007, 447:218-221.
-
(2007)
Nature
, vol.447
, pp. 218-221
-
-
Stracker, T.H.1
Morales, M.2
Couto, S.S.3
Hussein, H.4
Petrini, J.H.J.5
-
38
-
-
0032076248
-
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
-
Carney J.P., et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998, 93:477-486.
-
(1998)
Cell
, vol.93
, pp. 477-486
-
-
Carney, J.P.1
-
39
-
-
0032076190
-
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
-
Varon R., et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 1998, 93:467-476.
-
(1998)
Cell
, vol.93
, pp. 467-476
-
-
Varon, R.1
-
40
-
-
33847655393
-
Nijmegen breakage syndrome and functions of the responsible protein, NBS1
-
Antoccia A., Kobayashi J., Tauchi H., Matsuura S., Komatsu K. Nijmegen breakage syndrome and functions of the responsible protein, NBS1. Genome Dyn. 2006, 1:191-205.
-
(2006)
Genome Dyn.
, vol.1
, pp. 191-205
-
-
Antoccia, A.1
Kobayashi, J.2
Tauchi, H.3
Matsuura, S.4
Komatsu, K.5
-
41
-
-
3242889151
-
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
-
Taylor A.M., Groom A., Byrd P.J. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair (Amst) 2004, 3:1219-1225.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1219-1225
-
-
Taylor, A.M.1
Groom, A.2
Byrd, P.J.3
-
42
-
-
65149095154
-
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder
-
Waltes R., et al. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am. J. Hum. Genet. 2009, 84:605-616.
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 605-616
-
-
Waltes, R.1
-
43
-
-
50049099559
-
The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer
-
Dzikiewicz-Krawczyk A. The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Mutat. Res. 2008, 659:262-273.
-
(2008)
Mutat. Res.
, vol.659
, pp. 262-273
-
-
Dzikiewicz-Krawczyk, A.1
-
44
-
-
0346156075
-
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
-
Theunissen J.-W.F., Kaplan M.I., Hunt P.A., Williams B.R., Ferguson D.O., Alt F.W., Petrini J.H.J. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol. Cell 2003, 12:1511-1523.
-
(2003)
Mol. Cell
, vol.12
, pp. 1511-1523
-
-
Theunissen, J.-W.F.1
Kaplan, M.I.2
Hunt, P.A.3
Williams, B.R.4
Ferguson, D.O.5
Alt, F.W.6
Petrini, J.H.J.7
-
45
-
-
0037086702
-
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
-
Kang J., Bronson R.T., Xu Y. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J. 2002, 21:1447-1455.
-
(2002)
EMBO J.
, vol.21
, pp. 1447-1455
-
-
Kang, J.1
Bronson, R.T.2
Xu, Y.3
-
46
-
-
22144462810
-
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
-
Difilippantonio S., et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat. Cell Biol. 2005, 7:675-685.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 675-685
-
-
Difilippantonio, S.1
-
47
-
-
34249048548
-
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
-
Difilippantonio S., et al. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J. Exp. Med. 2007, 204:1003-1011.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1003-1011
-
-
Difilippantonio, S.1
-
48
-
-
0036713424
-
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice
-
Bender C.F., et al. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 2002, 16:2237-2251.
-
(2002)
Genes Dev.
, vol.16
, pp. 2237-2251
-
-
Bender, C.F.1
-
49
-
-
13444281917
-
Nibrin functions in Ig class-switch recombination
-
Kracker S., et al. Nibrin functions in Ig class-switch recombination. Proc. Natl. Acad. Sci. USA 2005, 102:1584-1589.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1584-1589
-
-
Kracker, S.1
-
50
-
-
18844394291
-
An essential function for NBS1 in the prevention of ataxia and cerebellar defects
-
Frappart P.-O., Tong W.-M., Demuth I., Radovanovic I., Herceg Z., Aguzzi A., Digweed M., Wang Z.-Q. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat. Med. 2005, 11:538-544.
-
(2005)
Nat. Med.
, vol.11
, pp. 538-544
-
-
Frappart, P.-O.1
Tong, W.-M.2
Demuth, I.3
Radovanovic, I.4
Herceg, Z.5
Aguzzi, A.6
Digweed, M.7
Wang, Z.-Q.8
-
51
-
-
13444309097
-
Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
-
Reina-San-Martin B., Nussenzweig M.C., Nussenzweig A., Difilippantonio S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc. Natl. Acad. Sci. USA 2005, 102:1590-1595.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1590-1595
-
-
Reina-San-Martin, B.1
Nussenzweig, M.C.2
Nussenzweig, A.3
Difilippantonio, S.4
-
52
-
-
0037117410
-
A murine model of Nijmegen breakage syndrome
-
Williams B.R., Mirzoeva O.K., Morgan W.F., Lin J., Dunnick W., Petrini J.H.J. A murine model of Nijmegen breakage syndrome. Curr. Biol. 2002, 12:648-653.
-
(2002)
Curr. Biol.
, vol.12
, pp. 648-653
-
-
Williams, B.R.1
Mirzoeva, O.K.2
Morgan, W.F.3
Lin, J.4
Dunnick, W.5
Petrini, J.H.J.6
-
53
-
-
0033594904
-
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
-
Luo G., Yao M.S., Bender C.F., Mills M., Bladl A.R., Bradley A., Petrini J.H. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci. USA 1999, 96:7376-7381.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7376-7381
-
-
Luo, G.1
Yao, M.S.2
Bender, C.F.3
Mills, M.4
Bladl, A.R.5
Bradley, A.6
Petrini, J.H.7
-
54
-
-
33846921007
-
The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis
-
Cherry S.M., Adelman C.A., Theunissen J.W., Hassold T.J., Hunt P.A., Petrini J.H. The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr. Biol. 2007, 17:373-378.
-
(2007)
Curr. Biol.
, vol.17
, pp. 373-378
-
-
Cherry, S.M.1
Adelman, C.A.2
Theunissen, J.W.3
Hassold, T.J.4
Hunt, P.A.5
Petrini, J.H.6
-
55
-
-
33749678963
-
Ataxia-telangiectasia and related diseases
-
Frappart P.O., McKinnon P.J. Ataxia-telangiectasia and related diseases. Neuromol. Med. 2006, 8:495-511.
-
(2006)
Neuromol. Med.
, vol.8
, pp. 495-511
-
-
Frappart, P.O.1
McKinnon, P.J.2
-
56
-
-
67349181294
-
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system
-
Baranes K., et al. Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp. Neurol. 2009, 218:24-32.
-
(2009)
Exp. Neurol.
, vol.218
, pp. 24-32
-
-
Baranes, K.1
-
57
-
-
58849135489
-
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
-
Shull E.R.P., Lee Y., Nakane H., Stracker T.H., Zhao J., Russell H.R., Petrini J.H.J., McKinnon P.J. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 2009, 23:171-180.
-
(2009)
Genes Dev.
, vol.23
, pp. 171-180
-
-
Shull, E.R.P.1
Lee, Y.2
Nakane, H.3
Stracker, T.H.4
Zhao, J.5
Russell, H.R.6
Petrini, J.H.J.7
McKinnon, P.J.8
-
58
-
-
36949013395
-
ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
-
Lavin M.F. ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene 2007, 26:7749-7758.
-
(2007)
Oncogene
, vol.26
, pp. 7749-7758
-
-
Lavin, M.F.1
-
59
-
-
60349095315
-
Double functions for the Mre11 complex during DNA double-strand break repair and replication
-
Borde V., Cobb J. Double functions for the Mre11 complex during DNA double-strand break repair and replication. Int. J. Biochem. Cell Biol. 2009, 41:1249-1253.
-
(2009)
Int. J. Biochem. Cell Biol.
, vol.41
, pp. 1249-1253
-
-
Borde, V.1
Cobb, J.2
-
60
-
-
34547686372
-
The multiple roles of the Mre11 complex for meiotic recombination
-
Borde V. The multiple roles of the Mre11 complex for meiotic recombination. Chromosome Res. 2007, 15:551-563.
-
(2007)
Chromosome Res.
, vol.15
, pp. 551-563
-
-
Borde, V.1
-
61
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
62
-
-
36749022214
-
The DNA damage response: ten years after
-
Harper J.W., Elledge S.J. The DNA damage response: ten years after. Mol. Cell 2007, 28:739-745.
-
(2007)
Mol. Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
63
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
64
-
-
70450224676
-
H2AX: functional roles and potential applications
-
Dickey J.S., Redon C.E., Nakamura A.J., Baird B.J., Sedelnikova O.A., Bonner W.M. H2AX: functional roles and potential applications. Chromosoma 2009, 118:683-692.
-
(2009)
Chromosoma
, vol.118
, pp. 683-692
-
-
Dickey, J.S.1
Redon, C.E.2
Nakamura, A.J.3
Baird, B.J.4
Sedelnikova, O.A.5
Bonner, W.M.6
-
65
-
-
68249093137
-
Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks
-
Schleker T., Nagai S., Gasser S.M. Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks. DNA Repair (Amst) 2009, 8:1089-1100.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1089-1100
-
-
Schleker, T.1
Nagai, S.2
Gasser, S.M.3
-
66
-
-
38049150586
-
The DNA damage response pathways: at the crossroad of protein modifications
-
Huen M.S., Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008, 18:8-16.
-
(2008)
Cell Res.
, vol.18
, pp. 8-16
-
-
Huen, M.S.1
Chen, J.2
-
67
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S., et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
-
68
-
-
0142011461
-
The cellular response to DNA double-strand breaks: defining the sensors and mediators
-
Petrini J.H., Stracker T.H. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 2003, 13:458-462.
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 458-462
-
-
Petrini, J.H.1
Stracker, T.H.2
-
69
-
-
0345732687
-
The Mre11 complex is required for ATM activation and the G2/M checkpoint
-
Carson C.T., Schwartz R.A., Stracker T.H., Lilley C.E., Lee D.V., Weitzman M.D. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003, 22:6610-6620.
-
(2003)
EMBO J.
, vol.22
, pp. 6610-6620
-
-
Carson, C.T.1
Schwartz, R.A.2
Stracker, T.H.3
Lilley, C.E.4
Lee, D.V.5
Weitzman, M.D.6
-
70
-
-
0037142619
-
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest
-
Girard P.M., Riballo E., Begg A.C., Waugh A., Jeggo P.A. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene 2002, 21:4191-4199.
-
(2002)
Oncogene
, vol.21
, pp. 4191-4199
-
-
Girard, P.M.1
Riballo, E.2
Begg, A.C.3
Waugh, A.4
Jeggo, P.A.5
-
71
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T., Lerenthal Y., Moyal L., Andegeko Y., Mittelman L., Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003, 22:5612-5621.
-
(2003)
EMBO J.
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
72
-
-
0030764691
-
HMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
-
Maser R.S., Monsen K.J., Nelms B.E., Petrini J.H. HMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol. Cell Biol. 1997, 17:6087-6096.
-
(1997)
Mol. Cell Biol.
, vol.17
, pp. 6087-6096
-
-
Maser, R.S.1
Monsen, K.J.2
Nelms, B.E.3
Petrini, J.H.4
-
73
-
-
0034749425
-
DNA damage-dependent nuclear dynamics of the Mre11 complex
-
Mirzoeva O.K., Petrini J.H. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell Biol. 2001, 21:281-288.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 281-288
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
74
-
-
0032562595
-
In situ visualization of DNA double-strand break repair in human fibroblasts
-
Nelms B.E., Maser R.S., MacKay J.F., Lagally M.G., Petrini J.H. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 1998, 280:590-592.
-
(1998)
Science
, vol.280
, pp. 590-592
-
-
Nelms, B.E.1
Maser, R.S.2
MacKay, J.F.3
Lagally, M.G.4
Petrini, J.H.5
-
75
-
-
0343280013
-
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
-
Paull T.T., Rogakou E.P., Yamazaki V., Kirchgessner C.U., Gellert M., Bonner W.M. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 2000, 10:886-895.
-
(2000)
Curr. Biol.
, vol.10
, pp. 886-895
-
-
Paull, T.T.1
Rogakou, E.P.2
Yamazaki, V.3
Kirchgessner, C.U.4
Gellert, M.5
Bonner, W.M.6
-
76
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C., Falck J., Bartkova J., Bartek J., Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 2003, 5:255-260.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
77
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
78
-
-
76349099135
-
53BP1 promotes ATM activity through direct interactions with the MRN complex
-
Lee J.H., Goodarzi A.A., Jeggo P.A., Paull T.T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010, 29:574-585.
-
(2010)
EMBO J.
, vol.29
, pp. 574-585
-
-
Lee, J.H.1
Goodarzi, A.A.2
Jeggo, P.A.3
Paull, T.T.4
-
79
-
-
76149146422
-
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
-
So S., Davis A.J., Chen D.J. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J. Cell Biol. 2009, 187:977-990.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 977-990
-
-
So, S.1
Davis, A.J.2
Chen, D.J.3
-
80
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee J.H., Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005, 308:551-554.
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
81
-
-
34447551681
-
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
-
Berkovich E., Monnat R.J., Kastan M.B. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 2007, 9:683-690.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 683-690
-
-
Berkovich, E.1
Monnat, R.J.2
Kastan, M.B.3
-
82
-
-
2942687831
-
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
-
Kitagawa R., Bakkenist C.J., McKinnon P.J., Kastan M.B. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004, 18:1423-1438.
-
(2004)
Genes Dev.
, vol.18
, pp. 1423-1438
-
-
Kitagawa, R.1
Bakkenist, C.J.2
McKinnon, P.J.3
Kastan, M.B.4
-
83
-
-
77950532788
-
Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A
-
Lee J.S. Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A. Cancer Res. Treat. 2007, 39:125-130.
-
(2007)
Cancer Res. Treat.
, vol.39
, pp. 125-130
-
-
Lee, J.S.1
-
84
-
-
77950543537
-
ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
-
Jang E.R., Choi J.D., Park M.A., Jeong G., Cho H., Lee J.S. ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response. Exp. Mol. Med. 2010, 42:195-204.
-
(2010)
Exp. Mol. Med.
, vol.42
, pp. 195-204
-
-
Jang, E.R.1
Choi, J.D.2
Park, M.A.3
Jeong, G.4
Cho, H.5
Lee, J.S.6
-
85
-
-
77953495958
-
Tip60: connecting chromatin to DNA damage signaling
-
Sun Y., Jiang X., Price B.D. Tip60: connecting chromatin to DNA damage signaling. Cell Cycle 2010, 9:930-936.
-
(2010)
Cell Cycle
, vol.9
, pp. 930-936
-
-
Sun, Y.1
Jiang, X.2
Price, B.D.3
-
86
-
-
56449125251
-
ATMINistrating ATM signalling: regulation of ATM by ATMIN
-
Kanu N., Behrens A. ATMINistrating ATM signalling: regulation of ATM by ATMIN. Cell Cycle 2008, 7:3483-3486.
-
(2008)
Cell Cycle
, vol.7
, pp. 3483-3486
-
-
Kanu, N.1
Behrens, A.2
-
87
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri A., Falck J., Lukas C., Bartek J., Smith G.C., Lukas J., Jackson S.P. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 2006, 8:37-45.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
88
-
-
61649093808
-
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
-
Shiotani B., Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol. Cell 2009, 33:547-558.
-
(2009)
Mol. Cell
, vol.33
, pp. 547-558
-
-
Shiotani, B.1
Zou, L.2
-
89
-
-
52949109260
-
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
-
Buis J., et al. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 2008, 135:85-96.
-
(2008)
Cell
, vol.135
, pp. 85-96
-
-
Buis, J.1
-
90
-
-
62649135141
-
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
-
Carson C.T., et al. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J. 2009, 28:652-662.
-
(2009)
EMBO J.
, vol.28
, pp. 652-662
-
-
Carson, C.T.1
-
91
-
-
38349078295
-
NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse
-
Manthey K.C., Opiyo S., Glanzer J.G., Dimitrova D., Elliott J., Oakley G.G. NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J. Cell Sci. 2007, 120:4221-4229.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4221-4229
-
-
Manthey, K.C.1
Opiyo, S.2
Glanzer, J.G.3
Dimitrova, D.4
Elliott, J.5
Oakley, G.G.6
-
92
-
-
34547950170
-
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
-
Olson E., Nievera C.J., Lee A.Y.-L., Chen L., Wu X. The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J. Biol. Chem. 2007, 282:22939-22952.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22939-22952
-
-
Olson, E.1
Nievera, C.J.2
Lee, A.Y.-L.3
Chen, L.4
Wu, X.5
-
93
-
-
13244287780
-
Nbs1 is required for ATR-dependent phosphorylation events
-
Stiff T., Reis C., Alderton G.K., Woodbine L., O'Driscoll M., Jeggo P.A. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J. 2005, 24:199-208.
-
(2005)
EMBO J.
, vol.24
, pp. 199-208
-
-
Stiff, T.1
Reis, C.2
Alderton, G.K.3
Woodbine, L.4
O'Driscoll, M.5
Jeggo, P.A.6
-
94
-
-
47949121598
-
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
-
Jazayeri A., Balestrini A., Garner E., Haber J.E., Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J. 2008, 27:1953-1962.
-
(2008)
EMBO J.
, vol.27
, pp. 1953-1962
-
-
Jazayeri, A.1
Balestrini, A.2
Garner, E.3
Haber, J.E.4
Costanzo, V.5
-
95
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt H.C., Yaffe M.B. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell Biol. 2009, 21:245-255.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
96
-
-
27844607415
-
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae
-
Tsukuda T., Fleming A.B., Nickoloff J.A., Osley M.A. Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature 2005, 438:379-383.
-
(2005)
Nature
, vol.438
, pp. 379-383
-
-
Tsukuda, T.1
Fleming, A.B.2
Nickoloff, J.A.3
Osley, M.A.4
-
97
-
-
70449518412
-
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
-
Sun Y., Jiang X., Xu Y., Ayrapetov M.K., Moreau L.A., Whetstine J.R., Price B.D. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat. Cell Biol. 2009, 11:1376-1382.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1376-1382
-
-
Sun, Y.1
Jiang, X.2
Xu, Y.3
Ayrapetov, M.K.4
Moreau, L.A.5
Whetstine, J.R.6
Price, B.D.7
-
98
-
-
68949207795
-
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae
-
Conde F., Refolio E., Cordon-Preciado V., Cortes-Ledesma F., Aragon L., Aguilera A., San-Segundo P.A. The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae. Genetics 2009, 182:437-446.
-
(2009)
Genetics
, vol.182
, pp. 437-446
-
-
Conde, F.1
Refolio, E.2
Cordon-Preciado, V.3
Cortes-Ledesma, F.4
Aragon, L.5
Aguilera, A.6
San-Segundo, P.A.7
-
99
-
-
72449175818
-
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
-
Galanty Y., Belotserkovskaya R., Coates J., Polo S., Miller K.M., Jackson S.P. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 2009, 462:935-939.
-
(2009)
Nature
, vol.462
, pp. 935-939
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Polo, S.4
Miller, K.M.5
Jackson, S.P.6
-
100
-
-
75549087964
-
The ubiquitin landscape at DNA double-strand breaks
-
Messick T.E., Greenberg R.A. The ubiquitin landscape at DNA double-strand breaks. J. Cell Biol. 2009, 187:319-326.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 319-326
-
-
Messick, T.E.1
Greenberg, R.A.2
-
101
-
-
52049098230
-
Comparison of nonhomologous end joining and homologous recombination in human cells
-
Mao Z., Bozzella M., Seluanov A., Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst) 2008, 7:1765-1771.
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 1765-1771
-
-
Mao, Z.1
Bozzella, M.2
Seluanov, A.3
Gorbunova, V.4
-
102
-
-
39449096135
-
Genome instability: a mechanistic view of its causes and consequences
-
Aguilera A., Gomez-Gonzalez B. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 2008, 9:204-217.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 204-217
-
-
Aguilera, A.1
Gomez-Gonzalez, B.2
-
103
-
-
41149094512
-
Regulation of DNA repair throughout the cell cycle
-
Branzei D., Foiani M. Regulation of DNA repair throughout the cell cycle. Nat. Rev. Mol. Cell Biol. 2008, 9:297-308.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 297-308
-
-
Branzei, D.1
Foiani, M.2
-
104
-
-
70350088548
-
Mechanisms of double-strand break repair in somatic mammalian cells
-
Hartlerode A.J., Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem. J. 2009, 423:157-168.
-
(2009)
Biochem. J.
, vol.423
, pp. 157-168
-
-
Hartlerode, A.J.1
Scully, R.2
-
105
-
-
75149120618
-
From meiosis to postmeiotic events: alignment and recognition of homologous chromosomes in meiosis
-
Ding D.Q., Haraguchi T., Hiraoka Y. From meiosis to postmeiotic events: alignment and recognition of homologous chromosomes in meiosis. FEBS J. 2010, 277:565-570.
-
(2010)
FEBS J.
, vol.277
, pp. 565-570
-
-
Ding, D.Q.1
Haraguchi, T.2
Hiraoka, Y.3
-
106
-
-
77449086623
-
DNA resection in eukaryotes: deciding how to fix the break
-
Huertas P. DNA resection in eukaryotes: deciding how to fix the break. Nat. Struct. Mol. Biol. 2010, 17:11-16.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 11-16
-
-
Huertas, P.1
-
107
-
-
11244269445
-
The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
-
Aylon Y., Liefshitz B., Kupiec M. The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J. 2004, 23:4868-4875.
-
(2004)
EMBO J.
, vol.23
, pp. 4868-4875
-
-
Aylon, Y.1
Liefshitz, B.2
Kupiec, M.3
-
108
-
-
7244220162
-
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
-
Ira G., et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 2004, 431:1011-1017.
-
(2004)
Nature
, vol.431
, pp. 1011-1017
-
-
Ira, G.1
-
109
-
-
0032052815
-
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
-
Dynan W.S., Yoo S. Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res. 1998, 26:1551-1559.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1551-1559
-
-
Dynan, W.S.1
Yoo, S.2
-
110
-
-
70149088145
-
Regulation of repair choice. Cdk1 suppresses recruitment of end joining factors at DNA breaks
-
Zhang Y., Shim E.Y., Davis M., Lee S.E. Regulation of repair choice. Cdk1 suppresses recruitment of end joining factors at DNA breaks. DNA Repair (Amst) 2009, 8:1235-1241.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1235-1241
-
-
Zhang, Y.1
Shim, E.Y.2
Davis, M.3
Lee, S.E.4
-
111
-
-
33644691699
-
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends
-
Clerici M., Mantiero D., Lucchini G., Longhese M.P. The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends. J. Biol. Chem. 2005, 280:38631-38638.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 38631-38638
-
-
Clerici, M.1
Mantiero, D.2
Lucchini, G.3
Longhese, M.P.4
-
112
-
-
36248942617
-
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
-
Lengsfeld B.M., Rattray A.J., Bhaskara V., Ghirlando R., Paull T.T. Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol. Cell 2007, 28:638-651.
-
(2007)
Mol. Cell
, vol.28
, pp. 638-651
-
-
Lengsfeld, B.M.1
Rattray, A.J.2
Bhaskara, V.3
Ghirlando, R.4
Paull, T.T.5
-
113
-
-
23944459784
-
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks
-
Neale M.J., Pan J., Keeney S. Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 2005, 436:1053-1057.
-
(2005)
Nature
, vol.436
, pp. 1053-1057
-
-
Neale, M.J.1
Pan, J.2
Keeney, S.3
-
114
-
-
34948872046
-
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
-
Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 2007, 28:134-146.
-
(2007)
Mol. Cell
, vol.28
, pp. 134-146
-
-
Limbo, O.1
Chahwan, C.2
Yamada, Y.3
de Bruin, R.A.4
Wittenberg, C.5
Russell, P.6
-
115
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
Huertas P., Jackson S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 2009, 284:9558-9565.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
116
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori A.A., et al. Human CtIP promotes DNA end resection. Nature 2007, 450:509-514.
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
-
117
-
-
77954313601
-
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
-
You Z., Bailis J.M. DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol. 2010, 20:402-409.
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 402-409
-
-
You, Z.1
Bailis, J.M.2
-
118
-
-
72149103012
-
CtIP links DNA double-strand break sensing to resection
-
You Z., et al. CtIP links DNA double-strand break sensing to resection. Mol. Cell 2009, 36:954-969.
-
(2009)
Mol. Cell
, vol.36
, pp. 954-969
-
-
You, Z.1
-
119
-
-
53649104599
-
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
-
Mimitou E.P., Symington L.S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 2008, 455:770-774.
-
(2008)
Nature
, vol.455
, pp. 770-774
-
-
Mimitou, E.P.1
Symington, L.S.2
-
120
-
-
51549095956
-
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
-
Zhu Z., Chung W.H., Shim E.Y., Lee S.E., Ira G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 2008, 134:981-994.
-
(2008)
Cell
, vol.134
, pp. 981-994
-
-
Zhu, Z.1
Chung, W.H.2
Shim, E.Y.3
Lee, S.E.4
Ira, G.5
-
121
-
-
53649090109
-
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
-
Gravel S., Chapman J.R., Magill C., Jackson S.P. DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev. 2008, 22:2767-2772.
-
(2008)
Genes Dev.
, vol.22
, pp. 2767-2772
-
-
Gravel, S.1
Chapman, J.R.2
Magill, C.3
Jackson, S.P.4
-
122
-
-
0034674706
-
Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor
-
Yu X., Baer R. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J. Biol. Chem. 2000, 275:18541-18549.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18541-18549
-
-
Yu, X.1
Baer, R.2
-
123
-
-
67349246802
-
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
-
Yun M.H., Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 2009, 459:460-463.
-
(2009)
Nature
, vol.459
, pp. 460-463
-
-
Yun, M.H.1
Hiom, K.2
-
124
-
-
77953572873
-
Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks
-
Dodson G.E., Limbo O., Nieto D., Russell P. Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks. Cell Cycle 2010, 9:1516-1522.
-
(2010)
Cell Cycle
, vol.9
, pp. 1516-1522
-
-
Dodson, G.E.1
Limbo, O.2
Nieto, D.3
Russell, P.4
-
125
-
-
53349162987
-
CDK targets Sae2 to control DNA-end resection and homologous recombination
-
Huertas P., Cortes-Ledesma F., Sartori A.A., Aguilera A., Jackson S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 2008, 455:689-692.
-
(2008)
Nature
, vol.455
, pp. 689-692
-
-
Huertas, P.1
Cortes-Ledesma, F.2
Sartori, A.A.3
Aguilera, A.4
Jackson, S.P.5
-
126
-
-
23744447715
-
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
-
Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 2005, 170:341-347.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 341-347
-
-
Kim, J.S.1
Krasieva, T.B.2
Kurumizaka, H.3
Chen, D.J.4
Taylor, A.M.5
Yokomori, K.6
-
127
-
-
58149151222
-
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae
-
Wasko B.M., Holland C.L., Resnick M.A., Lewis L.K. Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae. DNA Repair (Amst) 2009, 8:162-169.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 162-169
-
-
Wasko, B.M.1
Holland, C.L.2
Resnick, M.A.3
Lewis, L.K.4
-
128
-
-
0035977007
-
Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
-
Fukushima T., et al. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair. J. Biol. Chem. 2001, 276:44413-44418.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44413-44418
-
-
Fukushima, T.1
-
129
-
-
0035105722
-
Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms
-
Clikeman J.A., Khalsa G.J., Barton S.L., Nickoloff J.A. Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics 2001, 157:579-589.
-
(2001)
Genetics
, vol.157
, pp. 579-589
-
-
Clikeman, J.A.1
Khalsa, G.J.2
Barton, S.L.3
Nickoloff, J.A.4
-
130
-
-
34447129653
-
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination
-
Zhang Y., et al. Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat. Struct. Mol. Biol. 2007, 14:639-646.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 639-646
-
-
Zhang, Y.1
-
131
-
-
0035893363
-
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
-
Pierce A.J., Hu P., Han M., Ellis N., Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 2001, 15:3237-3242.
-
(2001)
Genes Dev.
, vol.15
, pp. 3237-3242
-
-
Pierce, A.J.1
Hu, P.2
Han, M.3
Ellis, N.4
Jasin, M.5
-
132
-
-
45149104841
-
Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae
-
Wu D., Topper L.M., Wilson T.E. Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics 2008, 178:1237-1249.
-
(2008)
Genetics
, vol.178
, pp. 1237-1249
-
-
Wu, D.1
Topper, L.M.2
Wilson, T.E.3
-
133
-
-
0036464515
-
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
-
Huang J., Dynan W.S. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res. 2002, 30:667-674.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 667-674
-
-
Huang, J.1
Dynan, W.S.2
-
134
-
-
28544436537
-
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
-
Di Virgilio M., Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J. Cell Biol. 2005, 171:765-771.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 765-771
-
-
Di Virgilio, M.1
Gautier, J.2
-
135
-
-
38049125555
-
The endless tale of non-homologous end-joining
-
Weterings E., Chen D.J. The endless tale of non-homologous end-joining. Cell Res. 2008, 18:114-124.
-
(2008)
Cell Res.
, vol.18
, pp. 114-124
-
-
Weterings, E.1
Chen, D.J.2
-
136
-
-
3242875642
-
The DNA-dependent protein kinase: the director at the end
-
Meek K., Gupta S., Ramsden D.A., Lees-Miller S.P. The DNA-dependent protein kinase: the director at the end. Immunol. Rev. 2004, 200:132-141.
-
(2004)
Immunol. Rev.
, vol.200
, pp. 132-141
-
-
Meek, K.1
Gupta, S.2
Ramsden, D.A.3
Lees-Miller, S.P.4
-
137
-
-
77949658435
-
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis
-
Gu J., et al. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst) 2010, 9:429-437.
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 429-437
-
-
Gu, J.1
-
138
-
-
45549099011
-
Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
-
Yannone S.M., Khan I.S., Zhou R.Z., Zhou T., Valerie K., Povirk L.F. Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Res. 2008, 36:3354-3365.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3354-3365
-
-
Yannone, S.M.1
Khan, I.S.2
Zhou, R.Z.3
Zhou, T.4
Valerie, K.5
Povirk, L.F.6
-
139
-
-
27544434114
-
The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae
-
Zhang X., Paull T.T. The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae. DNA Repair (Amst) 2005, 4:1281-1294.
-
(2005)
DNA Repair (Amst)
, vol.4
, pp. 1281-1294
-
-
Zhang, X.1
Paull, T.T.2
-
140
-
-
77649180958
-
Telomeres: protecting chromosomes against genome instability
-
O'Sullivan R.J., Karlseder J. Telomeres: protecting chromosomes against genome instability. Nat. Rev. Mol. Cell Biol. 2010, 11:171-181.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 171-181
-
-
O'Sullivan, R.J.1
Karlseder, J.2
-
141
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 2008, 42:301-334.
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 301-334
-
-
Palm, W.1
de Lange, T.2
-
142
-
-
68249100919
-
Give me a break: how telomeres suppress the DNA damage response
-
Denchi E.L. Give me a break: how telomeres suppress the DNA damage response. DNA Repair (Amst) 2009, 8:1118-1126.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1118-1126
-
-
Denchi, E.L.1
-
143
-
-
2942644725
-
The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex
-
Larrivee M., LeBel C., Wellinger R.J. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev. 2004, 18:1391-1396.
-
(2004)
Genes Dev.
, vol.18
, pp. 1391-1396
-
-
Larrivee, M.1
LeBel, C.2
Wellinger, R.J.3
-
144
-
-
0242287930
-
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways
-
Lydall D. Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways. J. Cell Sci. 2003, 116:4057-4065.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 4057-4065
-
-
Lydall, D.1
-
145
-
-
0031180154
-
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
-
Kironmai K.M., Muniyappa K. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 1997, 2:443-455.
-
(1997)
Genes Cells
, vol.2
, pp. 443-455
-
-
Kironmai, K.M.1
Muniyappa, K.2
-
146
-
-
0032536861
-
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
-
Boulton S.J., Jackson S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 1998, 17:1819-1828.
-
(1998)
EMBO J.
, vol.17
, pp. 1819-1828
-
-
Boulton, S.J.1
Jackson, S.P.2
-
147
-
-
0033562839
-
Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance
-
Chamankhah M., Xiao W. Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Res. 1999, 27:2072-2079.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 2072-2079
-
-
Chamankhah, M.1
Xiao, W.2
-
148
-
-
0032554797
-
Telomere maintenance is dependent on activities required for end repair of double-strand breaks
-
Nugent C.I., Bosco G., Ross L.O., Evans S.K., Salinger A.P., Moore J.K., Haber J.E., Lundblad V. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 1998, 8:657-660.
-
(1998)
Curr. Biol.
, vol.8
, pp. 657-660
-
-
Nugent, C.I.1
Bosco, G.2
Ross, L.O.3
Evans, S.K.4
Salinger, A.P.5
Moore, J.K.6
Haber, J.E.7
Lundblad, V.8
-
149
-
-
13944265075
-
Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae
-
Takata H., Tanaka Y., Matsuura A. Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol. Cell 2005, 17:573-583.
-
(2005)
Mol. Cell
, vol.17
, pp. 573-583
-
-
Takata, H.1
Tanaka, Y.2
Matsuura, A.3
-
150
-
-
0035806955
-
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
-
Diede S.J., Gottschling D.E. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr. Biol. 2001, 11:1336-1340.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1336-1340
-
-
Diede, S.J.1
Gottschling, D.E.2
-
151
-
-
0032931844
-
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
-
Moreau S., Ferguson J.R., Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell Biol. 1999, 19:556-566.
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 556-566
-
-
Moreau, S.1
Ferguson, J.R.2
Symington, L.S.3
-
152
-
-
0042991423
-
Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres
-
Tomita K., et al. Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol. Cell Biol. 2003, 23:5186-5197.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 5186-5197
-
-
Tomita, K.1
-
153
-
-
0035806977
-
The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
-
Tsukamoto Y., Taggart A.K., Zakian V.A. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr. Biol. 2001, 11:1328-1335.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1328-1335
-
-
Tsukamoto, Y.1
Taggart, A.K.2
Zakian, V.A.3
-
154
-
-
0034192363
-
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres
-
Lombard D.B., Guarente L. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 2000, 60:2331-2334.
-
(2000)
Cancer Res.
, vol.60
, pp. 2331-2334
-
-
Lombard, D.B.1
Guarente, L.2
-
155
-
-
0342561644
-
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
-
Zhu X.D., Kuster B., Mann M., Petrini J.H., de Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat. Genet. 2000, 25:347-352.
-
(2000)
Nat. Genet.
, vol.25
, pp. 347-352
-
-
Zhu, X.D.1
Kuster, B.2
Mann, M.3
Petrini, J.H.4
de Lange, T.5
-
156
-
-
0035954284
-
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
-
Ranganathan V., et al. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr. Biol. 2001, 11:962-966.
-
(2001)
Curr. Biol.
, vol.11
, pp. 962-966
-
-
Ranganathan, V.1
-
157
-
-
33645800789
-
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
-
Chai W., Sfeir A.J., Hoshiyama H., Shay J.W., Wright W.E. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 2006, 7:225-230.
-
(2006)
EMBO Rep.
, vol.7
, pp. 225-230
-
-
Chai, W.1
Sfeir, A.J.2
Hoshiyama, H.3
Shay, J.W.4
Wright, W.E.5
-
158
-
-
27944496124
-
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle
-
Verdun R.E., Crabbe L., Haggblom C., Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol. Cell 2005, 20:551-561.
-
(2005)
Mol. Cell
, vol.20
, pp. 551-561
-
-
Verdun, R.E.1
Crabbe, L.2
Haggblom, C.3
Karlseder, J.4
-
159
-
-
22144490491
-
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
-
Celli G.B., de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 2005, 7:712-718.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 712-718
-
-
Celli, G.B.1
de Lange, T.2
-
160
-
-
70350455474
-
The mre11 complex and the response to dysfunctional telomeres
-
Attwooll C.L., Akpinar M., Petrini J.H. The mre11 complex and the response to dysfunctional telomeres. Mol. Cell Biol. 2009, 29:5540-5551.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 5540-5551
-
-
Attwooll, C.L.1
Akpinar, M.2
Petrini, J.H.3
-
161
-
-
70350441980
-
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2
-
Dimitrova N., de Lange T. Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Mol. Cell Biol. 2009, 29:5552-5563.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 5552-5563
-
-
Dimitrova, N.1
de Lange, T.2
-
162
-
-
68949149732
-
Multiple roles for MRE11 at uncapped telomeres
-
Deng Y., Guo X., Ferguson D.O., Chang S. Multiple roles for MRE11 at uncapped telomeres. Nature 2009, 460:914-918.
-
(2009)
Nature
, vol.460
, pp. 914-918
-
-
Deng, Y.1
Guo, X.2
Ferguson, D.O.3
Chang, S.4
-
163
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai H., Smogorzewska A., de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 2003, 13:1549-1556.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de Lange, T.3
-
164
-
-
0033605145
-
P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T. P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999, 283:1321-1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
165
-
-
19344374569
-
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
-
Karlseder J., Hoke K., Mirzoeva O.K., Bakkenist C., Kastan M.B., Petrini J.H., de Lange T. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol. 2004, 2:E240.
-
(2004)
PLoS Biol.
, vol.2
-
-
Karlseder, J.1
Hoke, K.2
Mirzoeva, O.K.3
Bakkenist, C.4
Kastan, M.B.5
Petrini, J.H.6
de Lange, T.7
-
166
-
-
33847686708
-
Using or abusing: viruses and the cellular DNA damage response
-
Lilley C.E., Schwartz R.A., Weitzman M.D. Using or abusing: viruses and the cellular DNA damage response. Trends Microbiol. 2007, 15:119-126.
-
(2007)
Trends Microbiol.
, vol.15
, pp. 119-126
-
-
Lilley, C.E.1
Schwartz, R.A.2
Weitzman, M.D.3
-
167
-
-
0037130170
-
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
-
Stracker T.H., Carson C.T., Weitzman M.D. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 2002, 418:348-352.
-
(2002)
Nature
, vol.418
, pp. 348-352
-
-
Stracker, T.H.1
Carson, C.T.2
Weitzman, M.D.3
-
168
-
-
18144401244
-
Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication
-
Evans J.D., Hearing P. Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication. J. Virol. 2005, 79:6207-6215.
-
(2005)
J. Virol.
, vol.79
, pp. 6207-6215
-
-
Evans, J.D.1
Hearing, P.2
-
169
-
-
34547686371
-
The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication
-
Mathew S.S., Bridge E. The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Virology 2007, 365:346-355.
-
(2007)
Virology
, vol.365
, pp. 346-355
-
-
Mathew, S.S.1
Bridge, E.2
-
170
-
-
41649088194
-
Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication
-
Mathew S.S., Bridge E. Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication. Virology 2008, 374:11-22.
-
(2008)
Virology
, vol.374
, pp. 11-22
-
-
Mathew, S.S.1
Bridge, E.2
-
171
-
-
50149105185
-
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation
-
Lakdawala S.S., Schwartz R.A., Ferenchak K., Carson C.T., McSharry B.P., Wilkinson G.W., Weitzman M.D. Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J. Virol. 2008, 82:8362-8372.
-
(2008)
J. Virol.
, vol.82
, pp. 8362-8372
-
-
Lakdawala, S.S.1
Schwartz, R.A.2
Ferenchak, K.3
Carson, C.T.4
McSharry, B.P.5
Wilkinson, G.W.6
Weitzman, M.D.7
-
172
-
-
0033604299
-
Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase
-
Boyer J., Rohleder K., Ketner G. Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase. Virology 1999, 263:307-312.
-
(1999)
Virology
, vol.263
, pp. 307-312
-
-
Boyer, J.1
Rohleder, K.2
Ketner, G.3
-
173
-
-
43949088506
-
Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells
-
Zhao X., Madden-Fuentes R.J., Lou B.X., Pipas J.M., Gerhardt J., Rigell C.J., Fanning E. Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. J. Virol. 2008, 82:5316-5328.
-
(2008)
J. Virol.
, vol.82
, pp. 5316-5328
-
-
Zhao, X.1
Madden-Fuentes, R.J.2
Lou, B.X.3
Pipas, J.M.4
Gerhardt, J.5
Rigell, C.J.6
Fanning, E.7
-
174
-
-
2642527155
-
SV40 T antigen interacts with Nbs1 to disrupt DNA replication control
-
Wu X., Avni D., Chiba T., Yan F., Zhao Q., Lin Y., Heng H., Livingston D. SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes Dev. 2004, 18:1305-1316.
-
(2004)
Genes Dev.
, vol.18
, pp. 1305-1316
-
-
Wu, X.1
Avni, D.2
Chiba, T.3
Yan, F.4
Zhao, Q.5
Lin, Y.6
Heng, H.7
Livingston, D.8
-
175
-
-
17644401351
-
DNA repair proteins affect the lifecycle of herpes simplex virus 1
-
Lilley C.E., Carson C.T., Muotri A.R., Gage F.H., Weitzman M.D. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 2005, 102:5844-5849.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5844-5849
-
-
Lilley, C.E.1
Carson, C.T.2
Muotri, A.R.3
Gage, F.H.4
Weitzman, M.D.5
-
176
-
-
40649125286
-
Characterization of mre11 loss following HSV-1 infection
-
Gregory D.A., Bachenheimer S.L. Characterization of mre11 loss following HSV-1 infection. Virology 2008, 373:124-136.
-
(2008)
Virology
, vol.373
, pp. 124-136
-
-
Gregory, D.A.1
Bachenheimer, S.L.2
-
177
-
-
38349008365
-
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
-
Dupre A., et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat. Chem. Biol. 2008, 4:119-125.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 119-125
-
-
Dupre, A.1
|