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Volumn 33, Issue 9, 1996, Pages 787-796

Ku is a general inhibitor of DNA-protein complex formation and transcription

Author keywords

DNA binding protein; Ku antigen; Transcription inhibition

Indexed keywords

AUTOANTIGEN; DNA BINDING PROTEIN; DNA FRAGMENT; KU ANTIGEN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0030174531     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/0161-5890(96)00030-2     Document Type: Article
Times cited : (29)

References (30)
  • 1
    • 0025347665 scopus 로고
    • Characterization of the 70kDa component of the human Ku autoantigen expressed in insect cell nuclei using a recombinant baculovirus vector
    • Allaway G. P., Vivino A. A., Kohn L. D., Notkins A. L. and Prabhakar B. S. (1990) Characterization of the 70kDa component of the human Ku autoantigen expressed in insect cell nuclei using a recombinant baculovirus vector. Biochem. biophys. Res. Comm. 168, 747-755.
    • (1990) Biochem. Biophys. Res. Comm. , vol.168 , pp. 747-755
    • Allaway, G.P.1    Vivino, A.A.2    Kohn, L.D.3    Notkins, A.L.4    Prabhakar, B.S.5
  • 2
    • 0011778021 scopus 로고
    • Purification and partial characterization of 70kD and 92kD proteins associated with OTF-1
    • Carayannopoulos L., Hanke J. H., Johnson D. G., Tucker P. W. and Capra J. D. (1990) Purification and partial characterization of 70kD and 92kD proteins associated with OTF-1. J. Pro. Chem. 9, 347-348.
    • (1990) J. Pro. Chem. , vol.9 , pp. 347-348
    • Carayannopoulos, L.1    Hanke, J.H.2    Johnson, D.G.3    Tucker, P.W.4    Capra, J.D.5
  • 4
    • 0026571874 scopus 로고
    • Role of a major autoepitope in forming the DNA binding site of the p70(Ku) antigen
    • Chou C. H., Wang J., Kunth M. W. and Reeves W. H. (1992) Role of a major autoepitope in forming the DNA binding site of the p70(Ku) antigen. J. exp. Med. 175, 1677-1684.
    • (1992) J. Exp. Med. , vol.175 , pp. 1677-1684
    • Chou, C.H.1    Wang, J.2    Kunth, M.W.3    Reeves, W.H.4
  • 5
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleic
    • Dignam J. D., Lebovitz R. M. and Roeder R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleic. Nucl. Acids Res. 11, 1475-1489.
    • (1983) Nucl. Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 6
    • 0027048773 scopus 로고
    • Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymarase II
    • Dvir A., Peterson S. R., Kunth M. W., Lu H. and Dynan W. S. (1992) Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymarase II. Proc. natn. Acad. Sci. U.S.A. 89, 11920-11924.
    • (1992) Proc. Natn. Acad. Sci. U.S.A. , vol.89 , pp. 11920-11924
    • Dvir, A.1    Peterson, S.R.2    Kunth, M.W.3    Lu, H.4    Dynan, W.S.5
  • 7
    • 0028363754 scopus 로고
    • Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant
    • Gett R. C. and Stamato T. D. (1994) Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J. biol. Chem. 269, 15981-15984.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15981-15984
    • Gett, R.C.1    Stamato, T.D.2
  • 8
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb T. M. and Jackson S. P. (1993) The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 9
    • 0026570651 scopus 로고
    • Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA
    • Griffith A. J., Blier P. R., Mimori T. and Hardin J. A. (1992) Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA. J. biol. Chem. 267, 331-338.
    • (1992) J. Biol. Chem. , vol.267 , pp. 331-338
    • Griffith, A.J.1    Blier, P.R.2    Mimori, T.3    Hardin, J.A.4
  • 10
    • 0025128876 scopus 로고
    • The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes
    • Johnson D. G., Carayannopoulos L., Capra J. D., Tucker P. W. and Hanke J. H. (1990) The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes. Molec. cell. Biol. 10, 982-990.
    • (1990) Molec. Cell. Biol. , vol.10 , pp. 982-990
    • Johnson, D.G.1    Carayannopoulos, L.2    Capra, J.D.3    Tucker, P.W.4    Hanke, J.H.5
  • 12
    • 0027223736 scopus 로고
    • The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription
    • Kuhn A., Stefanowsky V. and Grummt I. (1993) The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription. Nucl. Acid Res. 21, 2057-2063.
    • (1993) Nucl. Acid Res. , vol.21 , pp. 2057-2063
    • Kuhn, A.1    Stefanowsky, V.2    Grummt, I.3
  • 13
    • 0026651978 scopus 로고
    • Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations
    • Lai J. S. and Herr W. (1992) Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc. natn. Acad. Sci. U.S.A. 89, 6958-6962.
    • (1992) Proc. Natn. Acad. Sci. U.S.A. , vol.89 , pp. 6958-6962
    • Lai, J.S.1    Herr, W.2
  • 14
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen
    • Lees-Miller S. P., Chen Y. and Anderson C. W. (1990) Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53 and the human Ku autoantigen. Molec. cell. Biol. 10, 6472-6481.
    • (1990) Molec. Cell. Biol. , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.2    Anderson, C.W.3
  • 16
    • 0019374013 scopus 로고
    • Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap
    • Mimori T., Akizuki M., Yamagata H., Inada S., Yoshida S. and Homma M. (1981) Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. clin. Invest. 68, 611-620.
    • (1981) J. Clin. Invest. , vol.68 , pp. 611-620
    • Mimori, T.1    Akizuki, M.2    Yamagata, H.3    Inada, S.4    Yoshida, S.5    Homma, M.6
  • 17
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori T. and Hardin J. A. (1986) Mechanism of interaction between Ku protein and DNA. J. biol. Chem. 261, 10375-10379.
    • (1986) J. Biol. Chem. , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 18
    • 0028147898 scopus 로고
    • Production and characterization of recombinant human Ku antigen
    • Ono M., Tucker P. W. and Capra J. D. (1994) Production and characterization of recombinant human Ku antigen. Nucl. Acids Res. 22, 3918-3924.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 3918-3924
    • Ono, M.1    Tucker, P.W.2    Capra, J.D.3
  • 19
    • 0026045833 scopus 로고
    • Analysis of the mechanism of interaction of simian Ku protein with DNA
    • Paillard S. and Strauss F. (1991) Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucl. Acids Res. 19, 5619-5624.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 5619-5624
    • Paillard, S.1    Strauss, F.2
  • 20
    • 0027966126 scopus 로고
    • Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks
    • Rathmell W. K. and Chu G. (1994) Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc. natn. Acad. Sci. U.S.A. 91, 7623-7627.
    • (1994) Proc. Natn. Acad. Sci. U.S.A. , vol.91 , pp. 7623-7627
    • Rathmell, W.K.1    Chu, G.2
  • 21
    • 0026505959 scopus 로고
    • Antibodies to the p70/p80(Ku) antigens in systemic lupus erythematosus
    • Reeves W. H. (1992) Antibodies to the p70/p80(Ku) antigens in systemic lupus erythematosus. Rheum. Dis. Clinic. N. Am. 18, 391-414.
    • (1992) Rheum. Dis. Clinic. N. Am. , vol.18 , pp. 391-414
    • Reeves, W.H.1
  • 22
    • 0024524581 scopus 로고
    • Molecular cloning of cDNA encording the p70(Ku) lupus autoantigen
    • Reeves W. H. and Sthoeger Z. M. (1989) Molecular cloning of cDNA encording the p70(Ku) lupus autoantigen. J. biol. Chem. 264, 5047-5052
    • (1989) J. Biol. Chem. , vol.264 , pp. 5047-5052
    • Reeves, W.H.1    Sthoeger, Z.M.2
  • 23
    • 0000647604 scopus 로고
    • Factors ivolved in specific transcription by human RNA polymerase II: Analysis by a rapid and quantitative in vitro assay
    • Sawadogo M. and Roeder R. G. (1985) Factors ivolved in specific transcription by human RNA polymerase II: Analysis by a rapid and quantitative in vitro assay. Proc. natn. Acad. Sci. U.S.A. 82, 4394-4398.
    • (1985) Proc. Natn. Acad. Sci. U.S.A. , vol.82 , pp. 4394-4398
    • Sawadogo, M.1    Roeder, R.G.2
  • 24
    • 0028112944 scopus 로고
    • Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
    • Smider V., Rathmell W. K., Lieber M. R. and Chu G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.R.3    Chu, G.4
  • 25
    • 0024251459 scopus 로고
    • The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain
    • Strum R. A. and Das G., Herr W. (1988) The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 2, 1582-1599.
    • (1988) Genes Dev. , vol.2 , pp. 1582-1599
    • Strum, R.A.1    Das, G.2    Herr, W.3
  • 28
    • 0024356877 scopus 로고
    • Hela nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
    • de Vries E., van Driel W., Bergsma W. G., Arnberg A. C., van der Vliet P. C. (1989) Hela nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. molec. Biol. 208, 65-78.
    • (1989) J. Molec. Biol. , vol.208 , pp. 65-78
    • De Vries, E.1    Van Driel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    Van Der Vliet, P.C.5
  • 29
    • 0024374896 scopus 로고
    • cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen
    • Yaneva M., Wen J., Ayala A. and Cook R. (1989) cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. J. biol. Chem. 264, 13407-13411.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13407-13411
    • Yaneva, M.1    Wen, J.2    Ayala, A.3    Cook, R.4
  • 30
    • 0026698728 scopus 로고
    • On the mechanisms of Ku protein binding to DNA
    • Zhang W. W. and Yaneva M. (1992) On the mechanisms of Ku protein binding to DNA. Biochem. biophys. Res. Comm. 186, 574-579.
    • (1992) Biochem. Biophys. Res. Comm. , vol.186 , pp. 574-579
    • Zhang, W.W.1    Yaneva, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.