-
1
-
-
51849114713
-
Activation of ATR and related PIKKs
-
Mordes, D. A. and Cortez, D. (2008) Activation of ATR and related PIKKs. Cell Cycle 7, 2809-2812
-
(2008)
Cell Cycle
, vol.7
, pp. 2809-2812
-
-
Mordes, D.A.1
Cortez, D.2
-
2
-
-
70350324640
-
Emerging common themes in regulation of PIKKs and PI3Ks
-
Lempiainen, H. and Halazonetis, T. D. (2009) Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 28, 3067-3073
-
(2009)
EMBO J.
, vol.28
, pp. 3067-3073
-
-
Lempiainen, H.1
Halazonetis, T.D.2
-
3
-
-
68249113593
-
Common mechanisms of PIKK regulation
-
Lovejoy, C. A. and Cortez, D. (2009) Common mechanisms of PIKK regulation. DNA Repair 8, 1004-1008
-
(2009)
DNA Repair
, vol.8
, pp. 1004-1008
-
-
Lovejoy, C.A.1
Cortez, D.2
-
4
-
-
47749141560
-
ATR: An essential regulator of genome integrity
-
Cimprich, K. A. and Cortez, D. (2008) ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9, 616-627
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
5
-
-
0033527717
-
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
-
Cortez, D., Wang, Y., Qin, J. and Elledge, S. J. (1999) Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286, 1162-1166
-
(1999)
Science
, vol.286
, pp. 1162-1166
-
-
Cortez, D.1
Wang, Y.2
Qin, J.3
Elledge, S.J.4
-
6
-
-
17844372453
-
SQ/TQ cluster domains: Concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
-
DOI 10.1002/bies.20204
-
Traven, A. and Heierhorst, J. (2005) SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins. BioEssays 27, 397-407 (Pubitemid 40592596)
-
(2005)
BioEssays
, vol.27
, Issue.4
, pp. 397-407
-
-
Traven, A.1
Heierhorst, J.2
-
7
-
-
0035941021
-
ATR and ATRIP: Partners in checkpoint signaling
-
DOI 10.1126/science.1065521
-
Cortez, D., Guntuku, S., Qin, J. and Elledge, S. J. (2001) ATR and ATRIP: partners in checkpoint signaling. Science 294, 1713-1716 (Pubitemid 33104841)
-
(2001)
Science
, vol.294
, Issue.5547
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
8
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown, E. J. and Baltimore, D. (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397-402 (Pubitemid 30131885)
-
(2000)
Genes and Development
, vol.14
, Issue.4
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
9
-
-
0034177408
-
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein, A., Muijtjens, M., van Os, R., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R. and Hoeijmakers, J. H. (2000) Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10, 479-482
-
(2000)
Curr. Biol.
, vol.10
, pp. 479-482
-
-
De Klein, A.1
Muijtjens, M.2
Van Os, R.3
Verhoeven, Y.4
Smit, B.5
Carr, A.M.6
Lehmann, A.R.7
Hoeijmakers, J.H.8
-
10
-
-
39449096135
-
Genome instability: A mechanistic view of its causes and consequences
-
Aguilera, A. and Gomez-Gonzalez, B. (2008) Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9, 204-217
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 204-217
-
-
Aguilera, A.1
Gomez-Gonzalez, B.2
-
11
-
-
77649165394
-
Maintaining genome stability at the replication fork
-
Branzei, D. and Foiani, M. (2010) Maintaining genome stability at the replication fork. Nat. Rev. Mol. Cell Biol. 11, 208-219
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 208-219
-
-
Branzei, D.1
Foiani, M.2
-
12
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A. and Goodship, J. A. (2003) A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501
-
(2003)
Nat. Genet.
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
13
-
-
4143051517
-
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
-
Fang, Y., Tsao, C. C., Goodman, B. K., Furumai, R., Tirado, C. A., Abraham, R. T. and Wang, X. F. (2004) ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J. 23, 3164-3174
-
(2004)
EMBO J.
, vol.23
, pp. 3164-3174
-
-
Fang, Y.1
Tsao, C.C.2
Goodman, B.K.3
Furumai, R.4
Tirado, C.A.5
Abraham, R.T.6
Wang, X.F.7
-
14
-
-
23844442111
-
Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance
-
Lewis, K. A., Mullany, S., Thomas, B., Chien, J., Loewen, R., Shridhar, V. and Cliby, W. A. (2005) Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. Cancer Res. 65, 7091-7095
-
(2005)
Cancer Res.
, vol.65
, pp. 7091-7095
-
-
Lewis, K.A.1
Mullany, S.2
Thomas, B.3
Chien, J.4
Loewen, R.5
Shridhar, V.6
Cliby, W.A.7
-
15
-
-
67650306169
-
ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
-
Zighelboim, I., Schmidt, A. P., Gao, F., Thaker, P. H., Powell, M. A., Rader, J. S., Gibb, R. K., Mutch, D. G. and Goodfellow, P. J. (2009) ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes. J. Clin. Oncol. 27, 3091-3096
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3091-3096
-
-
Zighelboim, I.1
Schmidt, A.P.2
Gao, F.3
Thaker, P.H.4
Powell, M.A.5
Rader, J.S.6
Gibb, R.K.7
Mutch, D.G.8
Goodfellow, P.J.9
-
16
-
-
0035503171
-
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability
-
Menoyo, A., Alazzouzi, H., Espin, E., Armengol, M., Yamamoto, H. and Schwartz, Jr, S. (2001) Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Cancer Res. 61, 7727-7730 (Pubitemid 33049356)
-
(2001)
Cancer Research
, vol.61
, Issue.21
, pp. 7727-7730
-
-
Menoyo, A.1
Alazzouzi, H.2
Espin, E.3
Armengol, M.4
Yamamoto, H.5
Schwartz Jr., S.6
-
17
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
DOI 10.1038/nature03482
-
Bartkova, J., Horejsi, Z., Koed, K., Kramer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C. et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (Pubitemid 40558993)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zleger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
18
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
DOI 10.1038/nature03485
-
Gorgoulis, V. G., Vassiliou, L. V., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., Ditullio, Jr, R. A., Kastrinakis, N. G., Levy, B. et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (Pubitemid 40559004)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.-V.F.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
DiTullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
19
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L. V., Kolettas, E., Niforou, K., Zoumpourlis, V. C. et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444, 633-637
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.V.7
Kolettas, E.8
Niforou, K.9
Zoumpourlis, V.C.10
-
20
-
-
40449120350
-
An oncogene-induced DNA damage model for cancer development
-
DOI 10.1126/science.1140735
-
Halazonetis, T. D., Gorgoulis, V. G. and Bartek, J. (2008) An oncogene-induced DNA damage model for cancer development. Science 319, 1352-1355 (Pubitemid 351354863)
-
(2008)
Science
, vol.319
, Issue.5868
, pp. 1352-1355
-
-
Halazonetis, T.D.1
Gorgoulis, V.G.2
Bartek, J.3
-
21
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun, T. S., Pacek, M., Yee, M. C., Walter, J. C. and Cimprich, K. A. (2005) Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052
-
(2005)
Genes Dev.
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
22
-
-
77449086623
-
DNA resection in eukaryotes: Deciding how to fix the break
-
Huertas, P. (2010) DNA resection in eukaryotes: deciding how to fix the break. Nat. Struct. Mol. Biol. 17, 11-16
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 11-16
-
-
Huertas, P.1
-
23
-
-
0034663809
-
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast
-
Paciotti, V., Clerici, M., Lucchini, G. and Longhese, M. P. (2000) The checkpoint protein Ddc2, functionally related to S. pombeRad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast. Genes Dev. 14, 2046-2059 (Pubitemid 30637354)
-
(2000)
Genes and Development
, vol.14
, Issue.16
, pp. 2046-2059
-
-
Paciotti, V.1
Clerici, M.2
Lucchini, G.3
Longhese, M.P.4
-
24
-
-
0034329474
-
LCD1: An essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
-
Rouse, J. and Jackson, S. P. (2000) LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. EMBO J. 19, 5801-5812
-
(2000)
EMBO J.
, vol.19
, pp. 5801-5812
-
-
Rouse, J.1
Jackson, S.P.2
-
25
-
-
0033224201
-
A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
-
Edwards, R. J., Bentley, N. J. and Carr, A. M. (1999) A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Nat. Cell Biol. 1, 393-398
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 393-398
-
-
Edwards, R.J.1
Bentley, N.J.2
Carr, A.M.3
-
26
-
-
18244385718
-
ATRIP binding to RPA-ssDNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
-
Ball, H. L., Myers, J. S. and Cortez, D. (2005) ATRIP binding to RPA-ssDNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 16, 2372-2381
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2372-2381
-
-
Ball, H.L.1
Myers, J.S.2
Cortez, D.3
-
27
-
-
1642499359
-
Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities
-
Unsal-Kacmaz, K. and Sancar, A. (2004) Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol. Cell. Biol. 24, 1292-1300
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 1292-1300
-
-
Unsal-Kacmaz, K.1
Sancar, A.2
-
28
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
DOI 10.1126/science.1083430
-
Zou, L. and Elledge, S. J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548 (Pubitemid 36682880)
-
(2003)
Science
, vol.300
, Issue.5625
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
29
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai, A., Lee, J., Yoo, H. Y. and Dunphy, W. G. (2006) TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
30
-
-
44849093460
-
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
-
DOI 10.1101/gad.1666208
-
Mordes, D. A., Glick, G. G., Zhao, R. and Cortez, D. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 22, 1478-1489 (Pubitemid 351793082)
-
(2008)
Genes and Development
, vol.22
, Issue.11
, pp. 1478-1489
-
-
Mordes, D.A.1
Glick, G.G.2
Zhao, R.3
Cortez, D.4
-
31
-
-
37349014081
-
Tel2 Regulates the Stability of PI3K-Related Protein Kinases
-
DOI 10.1016/j.cell.2007.10.052, PII S0092867407014158
-
Takai, H., Wang, R. C., Takai, K. K., Yang, H. and de Lange, T. (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131, 1248-1259 (Pubitemid 350297416)
-
(2007)
Cell
, vol.131
, Issue.7
, pp. 1248-1259
-
-
Takai, H.1
Wang, R.C.2
Takai, K.K.3
Yang, H.4
De Lange, T.5
-
32
-
-
77956935673
-
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
-
Horejsi, Z., Takai, H., Adelman, C. A., Collis, S. J., Flynn, H., Maslen, S., Skehel, J. M., de Lange, T. and Boulton, S. J. (2010) CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol. Cell 39, 839-850
-
(2010)
Mol. Cell
, vol.39
, pp. 839-850
-
-
Horejsi, Z.1
Takai, H.2
Adelman, C.A.3
Collis, S.J.4
Flynn, H.5
Maslen, S.6
Skehel, J.M.7
De Lange, T.8
Boulton, S.J.9
-
33
-
-
77956283656
-
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
-
Hurov, K. E., Cotta-Ramusino, C. and Elledge, S. J. (2010) A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 24, 1939-1950
-
(2010)
Genes Dev.
, vol.24
, pp. 1939-1950
-
-
Hurov, K.E.1
Cotta-Ramusino, C.2
Elledge, S.J.3
-
34
-
-
77956856907
-
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
-
Takai, H., Xie, Y., de Lange, T. and Pavletich, N. P. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24, 2019-2030
-
(2010)
Genes Dev.
, vol.24
, pp. 2019-2030
-
-
Takai, H.1
Xie, Y.2
De Lange, T.3
Pavletich, N.P.4
-
35
-
-
77953800576
-
Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly
-
Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S., Natsume, T. and Mizushima, N. (2010) Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J. Biol. Chem. 285, 20109-20116
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 20109-20116
-
-
Kaizuka, T.1
Hara, T.2
Oshiro, N.3
Kikkawa, U.4
Yonezawa, K.5
Takehana, K.6
Iemura, S.7
Natsume, T.8
Mizushima, N.9
-
36
-
-
24744448894
-
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
-
Ball, H. L. and Cortez, D. (2005) ATRIP oligomerization is required for ATR-dependent checkpoint signaling. J. Biol. Chem. 280, 31390-31396
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31390-31396
-
-
Ball, H.L.1
Cortez, D.2
-
37
-
-
28644439565
-
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks
-
Itakura, E., Sawada, I. and Matsuura, A. (2005) Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks. Mol. Biol. Cell 16, 5551-5562
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5551-5562
-
-
Itakura, E.1
Sawada, I.2
Matsuura, A.3
-
38
-
-
73349088472
-
Functional genomic screens identify CINP as a genome maintenance protein
-
Lovejoy, C. A., Xu, X., Bansbach, C. E., Glick, G. G., Zhao, R., Ye, F., Sirbu, B. M., Titus, L. C., Shyr, Y. and Cortez, D. (2009) Functional genomic screens identify CINP as a genome maintenance protein. Proc. Natl. Acad. Sci. U.S.A. 106, 19304-19309
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 19304-19309
-
-
Lovejoy, C.A.1
Xu, X.2
Bansbach, C.E.3
Glick, G.G.4
Zhao, R.5
Ye, F.6
Sirbu, B.M.7
Titus, L.C.8
Shyr, Y.9
Cortez, D.10
-
39
-
-
34547129599
-
2-M checkpoint response to DNA damage
-
DOI 10.1158/0008-5472.CAN-07-0495
-
Myers, J. S., Zhao, R., Xu, X., Ham, A. J. and Cortez, D. (2007) Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res. 67, 6685-6690 (Pubitemid 47105514)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6685-6690
-
-
Myers, J.S.1
Zhao, R.2
Xu, X.3
Ham, A.-J.L.4
Cortez, D.5
-
40
-
-
78651248502
-
CEP152 is a genome maintenance protein disrupted in Seckel syndrome
-
Kalay, E., Yigit, G., Aslan, Y., Brown, K. E., Pohl, E., Bicknell, L. S., Kayserili, H., Li, Y., Tuysuz, B., Nurnberg, G. et al. (2011) CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat. Genet. 43, 23-26
-
(2011)
Nat. Genet.
, vol.43
, pp. 23-26
-
-
Kalay, E.1
Yigit, G.2
Aslan, Y.3
Brown, K.E.4
Pohl, E.5
Bicknell, L.S.6
Kayserili, H.7
Li, Y.8
Tuysuz, B.9
Nurnberg, G.10
-
41
-
-
38649092988
-
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
-
Griffith, E., Walker, S., Martin, C. A., Vagnarelli, P., Stiff, T., Vernay, B., Al Sanna, N., Saggar, A., Hamel, B., Earnshaw, W. C. et al. (2008) Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat. Genet. 40, 232-236
-
(2008)
Nat. Genet.
, vol.40
, pp. 232-236
-
-
Griffith, E.1
Walker, S.2
Martin, C.A.3
Vagnarelli, P.4
Stiff, T.5
Vernay, B.6
Al Sanna, N.7
Saggar, A.8
Hamel, B.9
Earnshaw, W.C.10
-
42
-
-
77953704592
-
Novel CENPJ mutation causes Seckel syndrome
-
Al-Dosari, M. S., Shaheen, R., Colak, D. and Alkuraya, F. S. (2010) Novel CENPJ mutation causes Seckel syndrome. J. Med. Genet. 47, 411-414
-
(2010)
J. Med. Genet.
, vol.47
, pp. 411-414
-
-
Al-Dosari, M.S.1
Shaheen, R.2
Colak, D.3
Alkuraya, F.S.4
-
43
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
DOI 10.1126/science.1140321
-
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, 3rd, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166 (Pubitemid 46877472)
-
(2007)
Science
, vol.316
, Issue.5828
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
44
-
-
40349087260
-
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1
-
DOI 10.1101/gad.1627708
-
Sivasubramaniam, S., Sun, X., Pan, Y. R., Wang, S. and Lee, E. Y. (2008) Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 22, 587-600 (Pubitemid 351342432)
-
(2008)
Genes and Development
, vol.22
, Issue.5
, pp. 587-600
-
-
Sivasubramaniam, S.1
Sun, X.2
Pan, Y.-R.3
Wang, S.4
Lee, E.Y.-H.P.5
-
45
-
-
35548974826
-
Cep164, a novel centriole appendage protein required for primary cilium formation
-
Graser, S., Stierhof, Y. D., Lavoie, S. B., Gassner, O. S., Lamla, S., Le Clech, M. and Nigg, E. A. (2007) Cep164, a novel centriole appendage protein required for primary cilium formation. J. Cell Biol. 179, 321-330
-
(2007)
J. Cell Biol.
, vol.179
, pp. 321-330
-
-
Graser, S.1
Stierhof, Y.D.2
Lavoie, S.B.3
Gassner, O.S.4
Lamla, S.5
Le Clech, M.6
Nigg, E.A.7
-
46
-
-
61449223621
-
UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity
-
Pan, Y. R. and Lee, E. Y. (2009) UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. Cell Cycle 8, 655-664
-
(2009)
Cell Cycle
, vol.8
, pp. 655-664
-
-
Pan, Y.R.1
Lee, E.Y.2
-
47
-
-
34447103672
-
Bid Plays a Role in the DNA Damage Response
-
DOI 10.1016/j.cell.2007.06.035, PII S0092867407008409
-
Zinkel, S. S., Hurov, K. E. and Gross, A. (2007) Bid plays a role in the DNA damage response. Cell 130, 9-10 (Pubitemid 47031328)
-
(2007)
Cell
, vol.130
, Issue.1
, pp. 9-10
-
-
Zinkel, S.S.1
Hurov, K.E.2
Gross, A.3
-
48
-
-
23944498161
-
Proapoptotic BID is an ATM effector in the DNA-damage response
-
DOI 10.1016/j.cell.2005.06.014, PII S0092867405005970
-
Kamer, I., Sarig, R., Zaltsman, Y., Niv, H., Oberkovitz, G., Regev, L., Haimovich, G., Lerenthal, Y., Marcellus, R. C. and Gross, A. (2005) Proapoptotic BID is an ATM effector in the DNA-damage response. Cell 122, 593-603 (Pubitemid 41191157)
-
(2005)
Cell
, vol.122
, Issue.4
, pp. 593-603
-
-
Kamer, I.1
Sarig, R.2
Zaltsman, Y.3
Niv, H.4
Oberkovitz, G.5
Regev, L.6
Haimovich, G.7
Lerenthal, Y.8
Marcellus, R.C.9
Gross, A.10
-
49
-
-
79954422730
-
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress
-
Liu, Y., Bertram, C. C., Shi, Q. and Zinkel, S. S. (2010) Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress. Cell Death Differ. 18, 841-852
-
(2010)
Cell Death Differ.
, vol.18
, pp. 841-852
-
-
Liu, Y.1
Bertram, C.C.2
Shi, Q.3
Zinkel, S.S.4
-
50
-
-
34247877694
-
Function of a conserved checkpoint recruitment domain in ATRIP proteins
-
Ball, H. L., Ehrhardt, M. R., Mordes, D. A., Glick, G. G., Chazin, W. J. and Cortez, D. (2007) Function of a conserved checkpoint recruitment domain in ATRIP proteins. Mol. Cell. Biol. 27, 3367-3377
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3367-3377
-
-
Ball, H.L.1
Ehrhardt, M.R.2
Mordes, D.A.3
Glick, G.G.4
Chazin, W.J.5
Cortez, D.6
-
51
-
-
78049517168
-
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled
-
Mohni, K. N., Livingston, C. M., Cortez, D. and Weller, S. K. (2010) ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. J. Virol. 84, 12152-12164
-
(2010)
J. Virol.
, vol.84
, pp. 12152-12164
-
-
Mohni, K.N.1
Livingston, C.M.2
Cortez, D.3
Weller, S.K.4
-
52
-
-
0031960691
-
Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism
-
Umezu, K., Sugawara, N., Chen, C., Haber, J. E. and Kolodner, R. D. (1998) Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics 148, 989-1005
-
(1998)
Genetics
, vol.148
, pp. 989-1005
-
-
Umezu, K.1
Sugawara, N.2
Chen, C.3
Haber, J.E.4
Kolodner, R.D.5
-
53
-
-
57349143725
-
The basic cleft of RPA70N binds multiple checkpoint proteins including RAD9 to regulate ATR signaling
-
Xu, X., Vaithiyalingam, S., Glick, G. G., Mordes, D. A., Chazin, W. J. and Cortez, D. (2008) The basic cleft of RPA70N binds multiple checkpoint proteins including RAD9 to regulate ATR signaling. Mol. Cell. Biol. 28, 7345-7353
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 7345-7353
-
-
Xu, X.1
Vaithiyalingam, S.2
Glick, G.G.3
Mordes, D.A.4
Chazin, W.J.5
Cortez, D.6
-
54
-
-
70549085855
-
Eukaryotic DNA replication control: Lock and load, then fire
-
Remus, D. and Diffley, J. F. (2009) Eukaryotic DNA replication control: lock and load, then fire. Curr. Opin. Cell Biol. 21, 771-777
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 771-777
-
-
Remus, D.1
Diffley, J.F.2
-
55
-
-
0036091885
-
Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p
-
Murakami, H., Yanow, S. K., Griffiths, D., Nakanishi, M. and Nurse, P. (2002) Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nat. Cell Biol. 4, 384-388
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 384-388
-
-
Murakami, H.1
Yanow, S.K.2
Griffiths, D.3
Nakanishi, M.4
Nurse, P.5
-
56
-
-
2142808749
-
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation
-
DOI 10.1083/jcb.200311044
-
Oehlmann, M., Score, A. J. and Blow, J. J. (2004) The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J. Cell Biol. 165, 181-190 (Pubitemid 38544521)
-
(2004)
Journal of Cell Biology
, vol.165
, Issue.2
, pp. 181-190
-
-
Oehlmann, M.1
Score, A.J.2
Blow, J.J.3
-
57
-
-
0037415724
-
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
-
Clay-Farrace, L., Pelizon, C., Santamaria, D., Pines, J. and Laskey, R. A. (2003) Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J. 22, 704-712
-
(2003)
EMBO J.
, vol.22
, pp. 704-712
-
-
Clay-Farrace, L.1
Pelizon, C.2
Santamaria, D.3
Pines, J.4
Laskey, R.A.5
-
58
-
-
33645505026
-
The functional role of Cdc6 in S-G2/M in mammalian cells
-
Lau, E., Zhu, C., Abraham, R. T. and Jiang, W. (2006) The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep. 7, 425-430
-
(2006)
EMBO Rep.
, vol.7
, pp. 425-430
-
-
Lau, E.1
Zhu, C.2
Abraham, R.T.3
Jiang, W.4
-
59
-
-
34248594803
-
Cdc18 Enforces Long-Term Maintenance of the S Phase Checkpoint by Anchoring the Rad3-Rad26 Complex to Chromatin
-
DOI 10.1016/j.molcel.2007.04.014, PII S109727650700250X
-
Hermand, D. and Nurse, P. (2007) Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin. Mol. Cell 26, 553-563 (Pubitemid 46765182)
-
(2007)
Molecular Cell
, vol.26
, Issue.4
, pp. 553-563
-
-
Hermand, D.1
Nurse, P.2
-
60
-
-
73849132639
-
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells
-
Yoshida, K., Sugimoto, N., Iwahori, S., Yugawa, T., Narisawa-Saito, M., Kiyono, T. and Fujita, M. (2010) CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J. Cell Sci. 123, 225-235
-
(2010)
J. Cell Sci.
, vol.123
, pp. 225-235
-
-
Yoshida, K.1
Sugimoto, N.2
Iwahori, S.3
Yugawa, T.4
Narisawa-Saito, M.5
Kiyono, T.6
Fujita, M.7
-
61
-
-
25144449181
-
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
-
Meetei, A. R., Medhurst, A. L., Ling, C., Xue, Y., Singh, T. R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C. G. et al. (2005) A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat. Genet. 37, 958-963
-
(2005)
Nat. Genet.
, vol.37
, pp. 958-963
-
-
Meetei, A.R.1
Medhurst, A.L.2
Ling, C.3
Xue, Y.4
Singh, T.R.5
Bier, P.6
Steltenpool, J.7
Stone, S.8
Dokal, I.9
Mathew, C.G.10
-
62
-
-
26944499485
-
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
-
Mosedale, G., Niedzwiedz, W., Alpi, A., Perrina, F., Pereira-Leal, J. B., Johnson, M., Langevin, F., Pace, P. and Patel, K. J. (2005) The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat. Struct. Mol. Biol. 12, 763-771
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 763-771
-
-
Mosedale, G.1
Niedzwiedz, W.2
Alpi, A.3
Perrina, F.4
Pereira-Leal, J.B.5
Johnson, M.6
Langevin, F.7
Pace, P.8
Patel, K.J.9
-
63
-
-
55049111236
-
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex
-
Collis, S. J., Ciccia, A., Deans, A. J., Horejsi, Z., Martin, J. S., Maslen, S. L., Skehel, J. M., Elledge, S. J., West, S. C. and Boulton, S. J. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol. Cell 32, 313-324
-
(2008)
Mol. Cell
, vol.32
, pp. 313-324
-
-
Collis, S.J.1
Ciccia, A.2
Deans, A.J.3
Horejsi, Z.4
Martin, J.S.5
Maslen, S.L.6
Skehel, J.M.7
Elledge, S.J.8
West, S.C.9
Boulton, S.J.10
-
64
-
-
33846799430
-
Identification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM
-
DOI 10.1016/j.molcel.2007.01.003, PII S109727650700007X
-
Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N., de Winter, J. P. et al. (2007) Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol. Cell 25, 331-343 (Pubitemid 46206138)
-
(2007)
Molecular Cell
, vol.25
, Issue.3
, pp. 331-343
-
-
Ciccia, A.1
Ling, C.2
Coulthard, R.3
Yan, Z.4
Xue, Y.5
Meetei, A.R.6
Laghmani, E.H.7
Joenje, H.8
McDonald, N.9
De Winter, J.P.10
Wang, W.11
West, S.C.12
-
65
-
-
46749106037
-
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
-
Kim, J. M., Kee, Y., Gurtan, A. and D'Andrea, A. D. (2008) Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood 111, 5215-5222
-
(2008)
Blood
, vol.111
, pp. 5215-5222
-
-
Kim, J.M.1
Kee, Y.2
Gurtan, A.3
D'Andrea, A.D.4
-
66
-
-
77149135723
-
ATR activation and replication fork restart are defective in FANCM-deficient cells
-
Schwab, R. A., Blackford, A. N. and Niedzwiedz, W. (2010) ATR activation and replication fork restart are defective in FANCM-deficient cells. EMBO J. 29, 806-818
-
(2010)
EMBO J.
, vol.29
, pp. 806-818
-
-
Schwab, R.A.1
Blackford, A.N.2
Niedzwiedz, W.3
-
67
-
-
77149123028
-
FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
-
Luke-Glaser, S., Luke, B., Grossi, S. and Constantinou, A. (2010) FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J. 29, 795-805
-
(2010)
EMBO J.
, vol.29
, pp. 795-805
-
-
Luke-Glaser, S.1
Luke, B.2
Grossi, S.3
Constantinou, A.4
-
68
-
-
77949563363
-
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM
-
Singh, T. R., Saro, D., Ali, A. M., Zheng, X. F., Du, C. H., Killen, M. W., Sachpatzidis, A., Wahengbam, K., Pierce, A. J., Xiong, Y. et al. (2010) MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol. Cell 37, 879-886
-
(2010)
Mol. Cell
, vol.37
, pp. 879-886
-
-
Singh, T.R.1
Saro, D.2
Ali, A.M.3
Zheng, X.F.4
Du, C.H.5
Killen, M.W.6
Sachpatzidis, A.7
Wahengbam, K.8
Pierce, A.J.9
Xiong, Y.10
-
69
-
-
77949701960
-
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
-
Yan, Z., Delannoy, M., Ling, C., Daee, D., Osman, F., Muniandy, P. A., Shen, X., Oostra, A. B., Du, H., Steltenpool, J. et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol. Cell 37, 865-878
-
(2010)
Mol. Cell
, vol.37
, pp. 865-878
-
-
Yan, Z.1
Delannoy, M.2
Ling, C.3
Daee, D.4
Osman, F.5
Muniandy, P.A.6
Shen, X.7
Oostra, A.B.8
Du, H.9
Steltenpool, J.10
-
70
-
-
77955505023
-
The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response
-
Huang, M., Kim, J. M., Shiotani, B., Yang, K., Zou, L. and D'Andrea, A. D. (2010) The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol. Cell 39, 259-268
-
(2010)
Mol. Cell
, vol.39
, pp. 259-268
-
-
Huang, M.1
Kim, J.M.2
Shiotani, B.3
Yang, K.4
Zou, L.5
D'Andrea, A.D.6
-
71
-
-
2442670292
-
N1 type methylating agents requires the ATR kinase
-
DOI 10.1101/gad.294404
-
Stojic, L., Mojas, N., Cejka, P., Di Pietro, M., Ferrari, S., Marra, G. and Jiricny, J. (2004) Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev. 18, 1331-1344 (Pubitemid 38720600)
-
(2004)
Genes and Development
, vol.18
, Issue.11
, pp. 1331-1344
-
-
Stojic, L.1
Mojas, N.2
Cejka, P.3
Di, P.M.4
Ferrari, S.5
Marra, G.6
Jiricny, J.7
-
73
-
-
0347364654
-
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
-
Wang, Y. and Qin, J. (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100, 15387-15392
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 15387-15392
-
-
Wang, Y.1
Qin, J.2
-
74
-
-
77949329988
-
Interactions of human mismatch repair proteins MutSα and MutLα with proteins of the ATR-Chk1 pathway
-
Liu, Y., Fang, Y., Shao, H., Lindsey-Boltz, L., Sancar, A. and Modrich, P. (2010) Interactions of human mismatch repair proteins MutSα and MutLα with proteins of the ATR-Chk1 pathway. J. Biol. Chem. 285, 5974-5982
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 5974-5982
-
-
Liu, Y.1
Fang, Y.2
Shao, H.3
Lindsey-Boltz, L.4
Sancar, A.5
Modrich, P.6
-
75
-
-
79953186673
-
HMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis
-
Pabla, N., Ma, Z., McIlhatton, M. A., Fishel, R. and Dong, Z. (2011) hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J. Biol. Chem. 286, 10411-10418
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 10411-10418
-
-
Pabla, N.1
Ma, Z.2
McIlhatton, M.A.3
Fishel, R.4
Dong, Z.5
-
76
-
-
0037076402
-
Preferential binding of ATR protein to UV-damaged DNA
-
Unsal-Kacmaz, K., Makhov, A. M., Griffith, J. D. and Sancar, A. (2002) Preferential binding of ATR protein to UV-damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 99, 6673-6678
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 6673-6678
-
-
Unsal-Kacmaz, K.1
Makhov, A.M.2
Griffith, J.D.3
Sancar, A.4
-
77
-
-
63249115140
-
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
-
Choi, J. H., Lindsey-Boltz, L. A. and Sancar, A. (2009) Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA. Nucleic Acids Res. 37, 1501-1509
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 1501-1509
-
-
Choi, J.H.1
Lindsey-Boltz, L.A.2
Sancar, A.3
-
78
-
-
78549243696
-
An unprecedented nucleic acid capture mechanism for excision of DNA damage
-
Rubinson, E. H., Gowda, A. S., Spratt, T. E., Gold, B. and Eichman, B. F. (2010) An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature 468, 406-411
-
(2010)
Nature
, vol.468
, pp. 406-411
-
-
Rubinson, E.H.1
Gowda, A.S.2
Spratt, T.E.3
Gold, B.4
Eichman, B.F.5
-
79
-
-
40049096125
-
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals α-helices and insight into DNA binding
-
Williams, D. R., Lee, K. J., Shi, J., Chen, D. J. and Stewart, P. L. (2008) Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals α-helices and insight into DNA binding. Structure 16, 468-477
-
(2008)
Structure
, vol.16
, pp. 468-477
-
-
Williams, D.R.1
Lee, K.J.2
Shi, J.3
Chen, D.J.4
Stewart, P.L.5
-
80
-
-
73849140503
-
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
-
Sibanda, B. L., Chirgadze, D. Y. and Blundell, T. L. (2010) Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 463, 118-121
-
(2010)
Nature
, vol.463
, pp. 118-121
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Blundell, T.L.3
-
81
-
-
37549028411
-
DNA damage induced acetylation of lysine 3016 of ATM activates ATM kinase activity
-
Sun, Y., Xu, Y., Roy, K. and Price, B. D. (2007) DNA damage induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol. Cell. Biol. 24, 8502-8509
-
(2007)
Mol. Cell. Biol.
, vol.24
, pp. 8502-8509
-
-
Sun, Y.1
Xu, Y.2
Roy, K.3
Price, B.D.4
-
82
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D. and Paull, T. T. (2010) ATM activation by oxidative stress. Science 330, 517-521
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
83
-
-
57749099248
-
Dpb11 activates the Mec1-Ddc2 complex
-
Mordes, D. A., Nam, E. A. and Cortez, D. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc. Natl. Acad. Sci. U.S.A. 105, 18730-18734
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 18730-18734
-
-
Mordes, D.A.1
Nam, E.A.2
Cortez, D.3
-
84
-
-
58149102035
-
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
-
Navadgi-Patil, V. M. and Burgers, P. M. (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J. Biol. Chem. 283, 35853-35859
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35853-35859
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
85
-
-
71149093704
-
The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms
-
Navadgi-Patil, V. M. and Burgers, P. M. (2009) The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol. Cell 36, 743-753
-
(2009)
Mol. Cell
, vol.36
, pp. 743-753
-
-
Navadgi-Patil, V.M.1
Burgers, P.M.2
-
86
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka, J., Niedziela-Majka, A. and Burgers, P. M. (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell 24, 891-901
-
(2006)
Mol. Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
87
-
-
77956375008
-
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
-
Choi, J. H., Lindsey-Boltz, L. A., Kemp, M., Mason, A. C., Wold, M. S. and Sancar, A. (2010) Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling. Proc. Natl. Acad. Sci. U.S.A. 107, 13660-13665
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 13660-13665
-
-
Choi, J.H.1
Lindsey-Boltz, L.A.2
Kemp, M.3
Mason, A.C.4
Wold, M.S.5
Sancar, A.6
-
88
-
-
4243156107
-
Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5′ recessed DNA
-
Ellison, V. and Stillman, B. (2003) Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol. 1, e33
-
(2003)
PLoS Biol.
, vol.1
-
-
Ellison, V.1
Stillman, B.2
-
89
-
-
0037452605
-
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
-
Bermudez, V. P., Lindsey-Boltz, L. A., Cesare, A. J., Maniwa, Y., Griffith, J. D., Hurwitz, J. and Sancar, A. (2003) Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc. Natl. Acad. Sci. U.S.A. 100, 1633-1638
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 1633-1638
-
-
Bermudez, V.P.1
Lindsey-Boltz, L.A.2
Cesare, A.J.3
Maniwa, Y.4
Griffith, J.D.5
Hurwitz, J.6
Sancar, A.7
-
90
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
DOI 10.1101/gad.950302
-
Zou, L., Cortez, D. and Elledge, S. J. (2002) Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16, 198-208 (Pubitemid 34075812)
-
(2002)
Genes and Development
, vol.16
, Issue.2
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
91
-
-
2442646547
-
Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
-
Furuya, K., Poitelea, M., Guo, L., Caspari, T. and Carr, A. M. (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 18, 1154-1164
-
(2004)
Genes Dev.
, vol.18
, pp. 1154-1164
-
-
Furuya, K.1
Poitelea, M.2
Guo, L.3
Caspari, T.4
Carr, A.M.5
-
92
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. and Karnitz, L. M. (2007) The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 21, 1472-1477
-
(2007)
Genes Dev.
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
93
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee, J., Kumagai, A. and Dunphy, W. G. (2007) The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 282, 28036-28044
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
94
-
-
0035955398
-
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
-
DOI 10.1126/science.1063827
-
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K. and Sugimoto, K. (2001) Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294, 867-870 (Pubitemid 33032107)
-
(2001)
Science
, vol.294
, Issue.5543
, pp. 867-870
-
-
Kondo, T.1
Wakayama, T.2
Naiki, T.3
Matsumoto, K.4
Sugimoto, K.5
-
95
-
-
0035498938
-
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
-
Melo, J. A., Cohen, J. and Toczyski, D. P. (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15, 2809-2821 (Pubitemid 33042052)
-
(2001)
Genes and Development
, vol.15
, Issue.21
, pp. 2809-2821
-
-
Melo, J.A.1
Cohen, J.2
Toczyski, D.P.3
-
96
-
-
64049105391
-
TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
-
Yan, S. and Michael, W. M. (2009) TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks. J. Cell Biol. 184, 793-804
-
(2009)
J. Cell Biol.
, vol.184
, pp. 793-804
-
-
Yan, S.1
Michael, W.M.2
-
97
-
-
78149284014
-
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint
-
Cescutti, R., Negrini, S., Kohzaki, M. and Halazonetis, T. D. (2010) TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J. 29, 3723-3732
-
(2010)
EMBO J.
, vol.29
, pp. 3723-3732
-
-
Cescutti, R.1
Negrini, S.2
Kohzaki, M.3
Halazonetis, T.D.4
-
98
-
-
0036134979
-
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival
-
Yamane, K., Wu, X. and Chen, J. (2002) A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol. Cell. Biol. 22, 555-566
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 555-566
-
-
Yamane, K.1
Wu, X.2
Chen, J.3
-
99
-
-
65649085176
-
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM
-
Yoo, H. Y., Kumagai, A., Shevchenko, A. and Dunphy, W. G. (2009) The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol. Biol. Cell 20, 2351-2360
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 2351-2360
-
-
Yoo, H.Y.1
Kumagai, A.2
Shevchenko, A.3
Dunphy, W.G.4
-
100
-
-
75749103708
-
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication
-
Kumagai, A., Shevchenko, A. and Dunphy, W. G. (2010) Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 140, 349-359
-
(2010)
Cell
, vol.140
, pp. 349-359
-
-
Kumagai, A.1
Shevchenko, A.2
Dunphy, W.G.3
-
101
-
-
79851488587
-
CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts
-
Ramirez-Lugo, J. S., Yoo, H. Y., Yoon, S. J. and Dunphy, W. G. (2011) CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. Cell Cycle 10, 469-480
-
(2011)
Cell Cycle
, vol.10
, pp. 469-480
-
-
Ramirez-Lugo, J.S.1
Yoo, H.Y.2
Yoon, S.J.3
Dunphy, W.G.4
-
102
-
-
79953020734
-
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control
-
Leung, C. C., Gong, Z., Chen, J. and Glover, J. N. (2011) Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J. Biol. Chem. 286, 4292-4301
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4292-4301
-
-
Leung, C.C.1
Gong, Z.2
Chen, J.3
Glover, J.N.4
-
103
-
-
75949092280
-
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control
-
Gong, Z., Kim, J. E., Leung, C. C., Glover, J. N. and Chen, J. (2010) BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol. Cell 37, 438-446
-
(2010)
Mol. Cell
, vol.37
, pp. 438-446
-
-
Gong, Z.1
Kim, J.E.2
Leung, C.C.3
Glover, J.N.4
Chen, J.5
-
104
-
-
17644432403
-
2/M DNA damage checkpoint
-
Liu, Q., Guntuku, S., Cui, X. S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A. et al. (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev. 14, 1448-1459 (Pubitemid 30421838)
-
(2000)
Genes and Development
, vol.14
, Issue.12
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.-S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
Donehower, L.A.11
Elledge, S.J.12
-
105
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao, H. and Piwnica-Worms, H. (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129-4139
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
106
-
-
9644275421
-
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
-
Kumagai, A., Kim, S. M. and Dunphy, W. G. (2004) Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J. Biol. Chem. 279, 49599-49608
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49599-49608
-
-
Kumagai, A.1
Kim, S.M.2
Dunphy, W.G.3
-
107
-
-
68249126215
-
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
-
Stracker, T. H., Usui, T. and Petrini, J. H. (2009) Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair 8, 1047-1054
-
(2009)
DNA Repair
, vol.8
, pp. 1047-1054
-
-
Stracker, T.H.1
Usui, T.2
Petrini, J.H.3
-
108
-
-
0035797444
-
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
-
Tercero, J. A. and Diffley, J. F. (2001) Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412, 553-557
-
(2001)
Nature
, vol.412
, pp. 553-557
-
-
Tercero, J.A.1
Diffley, J.F.2
-
109
-
-
33747432986
-
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
-
DOI 10.1083/jcb.200602108
-
Woodward, A. M., Gohler, T., Luciani, M. G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D. A. and Blow, J. J. (2006) Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. J. Cell Biol. 173, 673-683 (Pubitemid 46165576)
-
(2006)
Journal of Cell Biology
, vol.173
, Issue.5
, pp. 673-683
-
-
Woodward, A.M.1
Gohler, T.2
Luciani, M.G.3
Oehlmann, M.4
Ge, X.5
Gartner, A.6
Jackson, D.A.7
Blow, J.J.8
-
110
-
-
37249025795
-
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
-
DOI 10.1101/gad.457807
-
Ge, X. Q., Jackson, D. A. and Blow, J. J. (2007) Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev. 21, 3331-3341 (Pubitemid 350277759)
-
(2007)
Genes and Development
, vol.21
, Issue.24
, pp. 3331-3341
-
-
Ge, X.Q.1
Jackson, D.A.2
Blow, J.J.3
-
111
-
-
48249084972
-
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
-
Ibarra, A., Schwob, E. and Mendez, J. (2008) Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc. Natl. Acad. Sci. U.S.A. 105, 8956-8961
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 8956-8961
-
-
Ibarra, A.1
Schwob, E.2
Mendez, J.3
-
112
-
-
78149462002
-
Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7
-
Randell, J. C., Fan, A., Chan, C., Francis, L. I., Heller, R. C., Galani, K. and Bell, S. P. (2010) Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol. Cell 40, 353-363
-
(2010)
Mol. Cell
, vol.40
, pp. 353-363
-
-
Randell, J.C.1
Fan, A.2
Chan, C.3
Francis, L.I.4
Heller, R.C.5
Galani, K.6
Bell, S.P.7
-
113
-
-
77956944025
-
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
-
Liu, H., Takeda, S., Kumar, R., Westergard, T. D., Brown, E. J., Pandita, T. K., Cheng, E. H. and Hsieh, J. J. (2010) Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 467, 343-346
-
(2010)
Nature
, vol.467
, pp. 343-346
-
-
Liu, H.1
Takeda, S.2
Kumar, R.3
Westergard, T.D.4
Brown, E.J.5
Pandita, T.K.6
Cheng, E.H.7
Hsieh, J.J.8
-
114
-
-
40549093949
-
Biphasic MLL takes helm at cell cycle control: Implications in human mixed lineage leukemia
-
Liu, H., Takeda, S., Cheng, E. H. and Hsieh, J. J. (2008) Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia. Cell Cycle 7, 428-435 (Pubitemid 351366467)
-
(2008)
Cell Cycle
, vol.7
, Issue.4
, pp. 428-435
-
-
Liu, H.1
Takeda, S.2
Cheng, E.H.Y.3
Hsieh, J.J.D.4
-
115
-
-
34948839290
-
Cdc20 assures cell cycle execution: A critical regulatory circuit lost in leukemogenic MLL fusions
-
DOI 10.1101/gad.1574507
-
Liu, H., Cheng, E. H. and Hsieh, J. J. (2007) Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. Genes Dev. 21, 2385-2398 (Pubitemid 47529369)
-
(2007)
Genes and Development
, vol.21
, Issue.19
, pp. 2385-2398
-
-
Liu, H.1
Cheng, E.H.-Y.2
Hsieh, J.J.-D.3
-
116
-
-
11144227916
-
Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
-
Yoo, H. Y., Shevchenko, A. and Dunphy, W. G. (2004) Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J. Biol. Chem. 279, 53353-53364
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53353-53364
-
-
Yoo, H.Y.1
Shevchenko, A.2
Dunphy, W.G.3
-
117
-
-
3042798440
-
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
-
Cortez, D., Glick, G. and Elledge, S. J. (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc. Natl. Acad. Sci. U.S.A. 101, 10078-10083
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 10078-10083
-
-
Cortez, D.1
Glick, G.2
Elledge, S.J.3
-
118
-
-
40949133430
-
Plx1 is required for chromosomal DNA replication under stressful conditions
-
DOI 10.1038/emboj.2008.29, PII EMBOJ200829
-
Trenz, K., Errico, A. and Costanzo, V. (2008) Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J. 27, 876-885 (Pubitemid 351417175)
-
(2008)
EMBO Journal
, vol.27
, Issue.6
, pp. 876-885
-
-
Trenz, K.1
Errico, A.2
Costanzo, V.3
-
119
-
-
78650724206
-
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
-
Ge, X. Q. and Blow, J. J. (2010) Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J. Cell Biol. 191, 1285-1297
-
(2010)
J. Cell Biol.
, vol.191
, pp. 1285-1297
-
-
Ge, X.Q.1
Blow, J.J.2
-
120
-
-
77953954908
-
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
-
Labib, K. (2010) How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev. 24, 1208-1219
-
(2010)
Genes Dev.
, vol.24
, pp. 1208-1219
-
-
Labib, K.1
-
121
-
-
67651119997
-
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability
-
Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M. C., Guan, A., Hesley, J. A., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E. et al. (2009) A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol. Cell 35, 228-239
-
(2009)
Mol. Cell
, vol.35
, pp. 228-239
-
-
Paulsen, R.D.1
Soni, D.V.2
Wollman, R.3
Hahn, A.T.4
Yee, M.C.5
Guan, A.6
Hesley, J.A.7
Miller, S.C.8
Cromwell, E.F.9
Solow-Cordero, D.E.10
-
122
-
-
34047094441
-
Replication fork barriers: Pausing for a break or stalling for time?
-
Labib, K. and Hodgson, B. (2007) Replication fork barriers: pausing for a break or stalling for time? EMBO Rep. 8, 346-353
-
(2007)
EMBO Rep.
, vol.8
, pp. 346-353
-
-
Labib, K.1
Hodgson, B.2
-
123
-
-
57349170148
-
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
-
Romano, G. and Giordano, A. (2008) Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. Cell Cycle 7, 3664-3668
-
(2008)
Cell Cycle
, vol.7
, pp. 3664-3668
-
-
Romano, G.1
Giordano, A.2
-
124
-
-
70449915963
-
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing
-
Pirngruber, J., Shchebet, A. and Johnsen, S. A. (2009) Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing. Cell Cycle 8, 3636-3642
-
(2009)
Cell Cycle
, vol.8
, pp. 3636-3642
-
-
Pirngruber, J.1
Shchebet, A.2
Johnsen, S.A.3
-
125
-
-
78049339644
-
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response
-
Yu, D. S., Zhao, R., Hsu, E. L., Cayer, J., Ye, F., Guo, Y., Shyr, Y. and Cortez, D. (2010) Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep. 11, 876-882
-
(2010)
EMBO Rep.
, vol.11
, pp. 876-882
-
-
Yu, D.S.1
Zhao, R.2
Hsu, E.L.3
Cayer, J.4
Ye, F.5
Guo, Y.6
Shyr, Y.7
Cortez, D.8
-
126
-
-
78650675596
-
The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress
-
Clausing, E., Mayer, A., Chanarat, S., Muller, B., Germann, S. M., Cramer, P., Lisby, M. and Strasser, K. (2010) The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress. J. Biol. Chem. 285, 41665-41674
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 41665-41674
-
-
Clausing, E.1
Mayer, A.2
Chanarat, S.3
Muller, B.4
Germann, S.M.5
Cramer, P.6
Lisby, M.7
Strasser, K.8
-
127
-
-
77950643890
-
Molecular architecture of the human Prp19/CDC5L complex
-
Grote, M., Wolf, E., Will, C. L., Lemm, I., Agafonov, D. E., Schomburg, A., Fischle, W., Urlaub, H. and Luhrmann, R. (2010) Molecular architecture of the human Prp19/CDC5L complex. Mol. Cell. Biol. 30, 2105-2119
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 2105-2119
-
-
Grote, M.1
Wolf, E.2
Will, C.L.3
Lemm, I.4
Agafonov, D.E.5
Schomburg, A.6
Fischle, W.7
Urlaub, H.8
Luhrmann, R.9
-
128
-
-
69949120911
-
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint
-
Zhang, N., Kaur, R., Akhter, S. and Legerski, R. J. (2009) Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint. EMBO Rep. 10, 1029-1035
-
(2009)
EMBO Rep.
, vol.10
, pp. 1029-1035
-
-
Zhang, N.1
Kaur, R.2
Akhter, S.3
Legerski, R.J.4
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