메뉴 건너뛰기




Volumn 46, Issue 3, 2012, Pages 351-361

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; MRE11 PROTEIN; MULTIPROTEIN COMPLEX; NIBRIN; RAD50 PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN PROTEIN LIGASE E3;

EID: 84860740820     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.02.018     Document Type: Article
Times cited : (110)

References (38)
  • 1
    • 63649116570 scopus 로고    scopus 로고
    • Ubiquitylation in innate and adaptive immunity
    • Bhoj V.G., Chen Z.J. Ubiquitylation in innate and adaptive immunity. Nature 2009, 458:430-437.
    • (2009) Nature , vol.458 , pp. 430-437
    • Bhoj, V.G.1    Chen, Z.J.2
  • 3
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
    • Carney J.P., Maser R.S., Olivares H., Davis E.M., Le Beau M., Yates J.R., Hays L., Morgan W.F., Petrini J.H. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 1998, 93:477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 4
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano A.C., Eytan E., Hershko A., Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1999, 1:193-199.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 6
    • 77955883766 scopus 로고    scopus 로고
    • Regulation of Skp2 expression and activity and its role in cancer progression
    • Chan C.H., Lee S.W., Wang J., Lin H.K. Regulation of Skp2 expression and activity and its role in cancer progression. ScientificWorldJournal 2011, 10:1001-1015.
    • (2011) ScientificWorldJournal , vol.10 , pp. 1001-1015
    • Chan, C.H.1    Lee, S.W.2    Wang, J.3    Lin, H.K.4
  • 7
    • 59649086030 scopus 로고    scopus 로고
    • Nonproteolytic functions of ubiquitin in cell signaling
    • Chen Z.J., Sun L.J. Nonproteolytic functions of ubiquitin in cell signaling. Mol. Cell 2009, 33:275-286.
    • (2009) Mol. Cell , vol.33 , pp. 275-286
    • Chen, Z.J.1    Sun, L.J.2
  • 8
    • 3242892589 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks
    • Digweed M., Sperling K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst.) 2004, 3:1207-1217.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1207-1217
    • Digweed, M.1    Sperling, K.2
  • 9
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 10
    • 44349122993 scopus 로고    scopus 로고
    • Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
    • Frescas D., Pagano M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat. Rev. Cancer 2008, 8:438-449.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 438-449
    • Frescas, D.1    Pagano, M.2
  • 11
    • 22944478030 scopus 로고    scopus 로고
    • High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation
    • Harada K., Supriatno, Kawaguchi S., Kawashima Y., Itashiki Y., Yoshida H., Sato M. High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation. Anticancer Res. 2005, 25:2471-2475.
    • (2005) Anticancer Res. , vol.25 , pp. 2471-2475
    • Harada, K.1    Supriatno Kawaguchi, S.2    Kawashima, Y.3    Itashiki, Y.4    Yoshida, H.5    Sato, M.6
  • 12
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D., Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009, 458:438-444.
    • (2009) Nature , vol.458 , pp. 438-444
    • Hoeller, D.1    Dikic, I.2
  • 13
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan M.B., Lim D.S. The many substrates and functions of ATM. Nat. Rev. Mol. Cell Biol. 2000, 1:179-186.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 14
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim S.T., Xu B., Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 2002, 16:560-570.
    • (2002) Genes Dev. , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 16
    • 36949013395 scopus 로고    scopus 로고
    • ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
    • Lavin M.F. ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene 2007, 26:7749-7758.
    • (2007) Oncogene , vol.26 , pp. 7749-7758
    • Lavin, M.F.1
  • 17
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • Lavin M.F. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 2008, 9:759-769.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 18
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin M.F., Kozlov S. ATM activation and DNA damage response. Cell Cycle 2007, 6:931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 19
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • Lee J.H., Paull T.T. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004, 304:93-96.
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 20
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee J.H., Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005, 308:551-554.
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 21
    • 36949026694 scopus 로고    scopus 로고
    • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • Lee J.H., Paull T.T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 2007, 26:7741-7748.
    • (2007) Oncogene , vol.26 , pp. 7741-7748
    • Lee, J.H.1    Paull, T.T.2
  • 26
    • 36248966246 scopus 로고    scopus 로고
    • RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    • Mailand N., Bekker-Jensen S., Faustrup H., Melander F., Bartek J., Lukas C., Lukas J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007, 131:887-900.
    • (2007) Cell , vol.131 , pp. 887-900
    • Mailand, N.1    Bekker-Jensen, S.2    Faustrup, H.3    Melander, F.4    Bartek, J.5    Lukas, C.6    Lukas, J.7
  • 28
    • 17044370346 scopus 로고    scopus 로고
    • Regulation of the cell cycle by SCF-type ubiquitin ligases
    • Nakayama K.I., Nakayama K. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin. Cell Dev. Biol. 2005, 16:323-333.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 323-333
    • Nakayama, K.I.1    Nakayama, K.2
  • 32
    • 3242889151 scopus 로고    scopus 로고
    • Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
    • Taylor A.M., Groom A., Byrd P.J. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair (Amst.) 2004, 3:1219-1225.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1219-1225
    • Taylor, A.M.1    Groom, A.2    Byrd, P.J.3
  • 33
    • 36749025467 scopus 로고    scopus 로고
    • Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
    • Wang B., Elledge S.J. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. USA 2007, 104:20759-20763.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 20759-20763
    • Wang, B.1    Elledge, S.J.2
  • 34
    • 34948899943 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
    • Williams R.S., Williams J.S., Tainer J.A. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 2007, 85:509-520.
    • (2007) Biochem. Cell Biol. , vol.85 , pp. 509-520
    • Williams, R.S.1    Williams, J.S.2    Tainer, J.A.3
  • 36
    • 77951917753 scopus 로고    scopus 로고
    • Regulation of Akt signaling activation by ubiquitination
    • Yang W.L., Wu C.Y., Wu J., Lin H.K. Regulation of Akt signaling activation by ubiquitination. Cell Cycle 2010, 9:486-497.
    • (2010) Cell Cycle , vol.9 , pp. 486-497
    • Yang, W.L.1    Wu, C.Y.2    Wu, J.3    Lin, H.K.4
  • 37
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi P.T., Wang Y., Zhao S., Patel N., Lee E.Y., Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002, 16:571-582.
    • (2002) Genes Dev. , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 38
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z., Chahwan C., Bailis J., Hunter T., Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 2005, 25:5363-5379.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.