RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 10, 2010, Pages 4579-4584

  Fu, Xiaoyong ^a   Yucer, Nur ^a   Liu, Shangfeng ^a   Li, Muyang ^b   Yi, Ping ^a   Mu, Jung Jung ^a,c   Yang, Tao ^a   Chu, Jessica ^a   Jung, Sung Yun ^a   O'Malley, Bert W ^a   Gu, Wei ^b   Qin, Jun ^a   Wang, Yi ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c CENTER FOR DISEASE CONTROL   (Taiwan)

Author keywords

ATM ATR kinase; Degradation; E3 ubiquitin ligase; G1 cell cycle checkpoint; RING finger domain

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DNA; PROTEIN MDM2; PROTEIN P53; RFWD3 PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

AMINO ACID SEQUENCE; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; DNA DAMAGE; HCT116 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION, IONIZING; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77949522982     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912094107     Document Type: Article

References (24)

1. Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307-310.
2. Prives C, Hall PA (1999) The P53 pathway. J Pathol 187:112-126.
3. Vousden KH, Lane DP (2007) p53 in health and disease. Nat Rev Mol Cell Biol 8:275-283.
4. Elledge SJ (1996) Cell cycle checkpoints: Preventing an identity crisis. Science 274:1664-1672.
5. Bartek J, Lukas J (2001) Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 13:738-747.
6. Toledo F, Wahl GM (2006) Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 6:909-923.
7. Brooks CL, Gu W (2006) p53 ubiquitination: Mdm2 and beyond. Mol Cell 21:307-315.
8. De Oca Luna RM, Wagner DS, Lozano G (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
9. Jones SN, et al. (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378:206-208.
10. Barak Y, et al. (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12:461-468.
11. Stommel JM, Wahl GM (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23:1547-1556.
12. Kruse JP, Gu W (2008) SnapShot: p53 posttranslational modifications. Cell 133:930.
13. Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-1166.
14. Mu JJ, et al. (2007) A proteomic analysis of ataxia telangiectasia- mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem 282:17330-17334.
15. Chehab NH, et al. (1999) Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 96:13777-13782.
16. Shimizu H, et al. (2002) The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem 277:28446-28458.
17. Wallace M, et al. (2006) Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell 23:251-263.
18. Yu GW, et al. (2006) The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci USA 103:1227-1232.
19. Canman CE, et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679.
20. Maya R, et al. (2001) ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage. Gene Dev 15:1067-1077.
21. Li M, et al. (2003) Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2. Science 302:1972-1975.
22. Wang Y, et al. (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Gene Dev 14:927-939.
23. Jung SY, et al. (2005) Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol 19:2451-2465.
24. Wang Y, Qin J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci USA 100:15387-15392.