Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Nature

Volumn 434, Issue 7035, 2005, Pages 913-917

  Bryant, Helen E ^a   Schultz, Niklas ^b   Thomas, Huw D ^c   Parker, Kayan M ^a   Flower, Dan ^a   Lopez, Elena ^a   Kyle, Suzanne ^c   Meuth, Mark ^a   Curtin, Nicola J ^c   Helleday, Thomas ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIAGNOSIS; DNA; ENZYME INHIBITION; ENZYMES; ONCOLOGY; PROTEINS;

DNA DAMAGE; DNA REPAIR; HOMOLOGUS RECOMBINATION; POLYMERASE;

TUMORS;

1 (4 DIMETHYLAMINOMETHYLPHENYL) 8,9 DIHYDRO 7H 2,7,9A BENZO[CD]AZULEN 6 ONE; 3 AMINOBENZAMIDE; 8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; AG 14361; ANTINEOPLASTIC AGENT; AZULENE DERIVATIVE; GAMMA HISTONE H2AX; HISTONE H2A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD51 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; 1 (4 DIMETHYLAMINOMETHYLPHENYL) 8,9 DIHYDRO 7H 2,7,9A BENZO(CD)AZULEN 6 ONE; 1-(4-DIMETHYLAMINOMETHYLPHENYL)-8,9-DIHYDRO-7H-2,7,9A-BENZO(CD)AZULEN-6-ONE; BENZODIAZEPINE DERIVATIVE; BRCA2 PROTEIN;

BIOCHEMISTRY; BIOLOGY; MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER MODEL; CELL MUTANT; CELL STRAIN MCF 7; CELL STRAIN V 79; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; ENZYME ACTIVITY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TUMOR; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; ANIMAL; DNA DAMAGE; DNA REPLICATION; DRUG ANTAGONISM; DRUG SCREENING; ENZYMOLOGY; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; AZULENES; BENZODIAZEPINES; BRCA2 PROTEIN; CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENES, BRCA2; MICE; MICE, NUDE; NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 17244375049     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03443     Document Type: Article

References (26)

1. Lindahl, T., Satoh, M. S., Poirier, G. G. & Klungland, A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci. 20, 405-411 (1995).
2. D'Amours, D., Desnoyers, S., D'Silva, I. & Poirier, G. G. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J. 342, 249-268 (1999).
3. El-Khamisy, S. F., Masutani, M., Suzuki, H. & Caldecott, K. W. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 31, 5526-5533 (2003).
4. Conde, C. et al. Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. EMBO J. 20, 3535-3543 (2001).
5. de Murcia, J. M. et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl Acad. Sci. USA 94, 7303-7307 (1997).
6. Wang, Z. Q. et al. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11, 2347-2358 (1997).
7. Molinete, M. et al. Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J. 12, 2109-2117 (1993).
8. Schultz, N., Lopez, E., Saleh-Gohari, N. & Helleday, T. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res. 31, 4959-4964 (2003).
9. Yang, Y. G., Cortes, U., Patnaik, S., Jasin, M. & Wang, Z. Q. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene 23, 3872-3882 (2004).
10. Griffin, C. S., Simpson, P. J., Wilson, C. R. & Thacker, J. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nature Cell Biol. 2, 757-761 (2000).
11. Tebbs, R. S. et al. Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc. Natl Acad. Sci. USA 92, 6354-6358 (1995).
12. Bowman, K. J., Newell, D. R., Calvert, A. H. & Curtin, N. J. Differential effects of the poly(ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br. J. Cancer 84, 106-112 (2001).
13. Skalitzky, D. J. et al. Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J. Med. Chem. 46, 210-213 (2003).
14. Kraakman-van der Zwet, M. et al. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol. Cell. Biol. 22, 669-679 (2002).
15. Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature doi:10.1038/nature03445 (this issue).
16. Venkitaraman, A. R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
17. Menissier de Murcia, J. et al. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J. 22, 2255-2263 (2003).
18. Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709-715 (1993).
19. Paull, T. T. et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895 (2000).
20. Arnaudeau, C., Lundin, C. & Helleday, T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J. Mol. Biol. 307, 1235-1245 (2001).
21. Caldecott, K. W., Tucker, J. D. & Thompson, L. H. Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9. Nucleic Acids Res. 20, 4575-4579 (1992).
22. Calabrese, C. R. et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AGI4361. J. Natl Cancer Inst. 96, 56-67 (2004).
23. Mohindra, A. et al. Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. Hum. Mol. Genet. 11, 2189-2200 (2002).
24. Halldorsson, H., Gray, D. A. & Shall, S. Poly(ADP-ribose) polymerase activity in nucleotide permeable cells. FEBS Lett. 85, 349-352 (1978).
25. Grube, K., Kupper, J. H. & Burkle, A. Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers. Anal. Biochem. 193, 236-239 (1991).
26. Lundin, C. et al. RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J. Mol. Biol. 328, 521-535 (2003).