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Volumn 8, Issue 9, 2009, Pages 1047-1054

Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

Author keywords

Apoptosis; ATM; ATR; Cell cycle; Checkpoint; Chk1; Chk2; DNA repair; Mre11; Nbs1; Rad50; Rad53; Rad9; Recombination; Tel1; Transcription

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA;

EID: 68249126215     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.04.012     Document Type: Article
Times cited : (196)

References (135)
  • 2
    • 35649021338 scopus 로고    scopus 로고
    • Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456
    • Kass E.M., Ahn J., Tanaka T., Freed-Pastor W.A., Keezer S., and Prives C. Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456. J. Biol. Chem. 282 (2007) 30311-30321
    • (2007) J. Biol. Chem. , vol.282 , pp. 30311-30321
    • Kass, E.M.1    Ahn, J.2    Tanaka, T.3    Freed-Pastor, W.A.4    Keezer, S.5    Prives, C.6
  • 4
    • 52649098505 scopus 로고    scopus 로고
    • Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379
    • Lovly C.M., Yan L., Ryan C.E., Takada S., and Piwnica-Worms H. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol. Cell. Biol. (2008)
    • (2008) Mol. Cell. Biol.
    • Lovly, C.M.1    Yan, L.2    Ryan, C.E.3    Takada, S.4    Piwnica-Worms, H.5
  • 5
    • 47749148089 scopus 로고    scopus 로고
    • A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function
    • Scorah J., Dong M.Q., Yates J.R., 3rd M., Scott D., Gillespie C.H., and McGowan. A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function. J. Biol. Chem. 283 (2008) 17250-17259
    • (2008) J. Biol. Chem. , vol.283 , pp. 17250-17259
    • Scorah, J.1    Dong, M.Q.2    Yates, J.R.3    3rd, M.4    Scott, D.5    Gillespie, C.H.6    McGowan7
  • 6
    • 1642546298 scopus 로고    scopus 로고
    • Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
    • Katsuragi Y., and Sagata N. Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation. Mol. Biol. Cell. 15 (2004) 1680-1689
    • (2004) Mol. Biol. Cell. , vol.15 , pp. 1680-1689
    • Katsuragi, Y.1    Sagata, N.2
  • 7
  • 8
    • 36949026694 scopus 로고    scopus 로고
    • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • Lee J.H., and Paull T.T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 26 (2007) 7741-7748
    • (2007) Oncogene , vol.26 , pp. 7741-7748
    • Lee, J.H.1    Paull, T.T.2
  • 9
    • 3242887431 scopus 로고    scopus 로고
    • Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex
    • Parrilla-Castellar E.R., Arlander S.J., and Karnitz L. Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex. DNA Repair (Amst) 3 (2004) 1009-1014
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1009-1014
    • Parrilla-Castellar, E.R.1    Arlander, S.J.2    Karnitz, L.3
  • 10
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich K.A., and Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell. Biol. 9 (2008) 616-627
    • (2008) Nat. Rev. Mol. Cell. Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 11
    • 51849114713 scopus 로고    scopus 로고
    • Activation of ATR and related PIKKs
    • Mordes D.A., and Cortez D. Activation of ATR and related PIKKs. Cell Cycle. (2008) 7
    • (2008) Cell Cycle. , pp. 7
    • Mordes, D.A.1    Cortez, D.2
  • 12
    • 34547154729 scopus 로고    scopus 로고
    • Activation segment exchange: a common mechanism of kinase autophosphorylation?
    • Oliver A.W., Knapp S., and Pearl L.H. Activation segment exchange: a common mechanism of kinase autophosphorylation?. Trends Biochem. Sci. 32 (2007) 351-356
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 351-356
    • Oliver, A.W.1    Knapp, S.2    Pearl, L.H.3
  • 13
    • 33645846943 scopus 로고    scopus 로고
    • Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast
    • Xu Y.J., Davenport M., and Kelly T.J. Two-stage mechanism for activation of the DNA replication checkpoint kinase Cds1 in fission yeast. Genes Dev. 20 (2006) 990-1003
    • (2006) Genes Dev. , vol.20 , pp. 990-1003
    • Xu, Y.J.1    Davenport, M.2    Kelly, T.J.3
  • 15
    • 29244440434 scopus 로고    scopus 로고
    • Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans
    • Garcia-Muse T., and Boulton S.J. Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J. 24 (2005) 4345-4355
    • (2005) EMBO J. , vol.24 , pp. 4345-4355
    • Garcia-Muse, T.1    Boulton, S.J.2
  • 19
    • 0042030879 scopus 로고    scopus 로고
    • Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex
    • Goudelock D.M., Jiang K., Pereira E., Russell B., and Sanchez Y. Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. J. Biol. Chem. 278 (2003) 29940-29947
    • (2003) J. Biol. Chem. , vol.278 , pp. 29940-29947
    • Goudelock, D.M.1    Jiang, K.2    Pereira, E.3    Russell, B.4    Sanchez, Y.5
  • 20
    • 7644236288 scopus 로고    scopus 로고
    • Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends
    • McSherry T.D., and Mueller P.R. Xenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends. Mol. Cell. Biol. 24 (2004) 9968-9985
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9968-9985
    • McSherry, T.D.1    Mueller, P.R.2
  • 21
    • 15744386741 scopus 로고    scopus 로고
    • Regulation of CHK2 by DNA-dependent protein kinase
    • Li J., and Stern D.F. Regulation of CHK2 by DNA-dependent protein kinase. J. Biol. Chem. 280 (2005) 12041-12050
    • (2005) J. Biol. Chem. , vol.280 , pp. 12041-12050
    • Li, J.1    Stern, D.F.2
  • 22
    • 46149124528 scopus 로고    scopus 로고
    • Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
    • Stracker T.H., Couto S.S., Cordon-Cardo C., Matos T., and Petrini J.H. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol. Cell. 31 (2008) 21-32
    • (2008) Mol. Cell. , vol.31 , pp. 21-32
    • Stracker, T.H.1    Couto, S.S.2    Cordon-Cardo, C.3    Matos, T.4    Petrini, J.H.5
  • 23
    • 24944575222 scopus 로고    scopus 로고
    • Signal transduction: how rad53 kinase is activated
    • Pellicioli A., and Foiani M. Signal transduction: how rad53 kinase is activated. Curr. Biol. 15 (2005) R769-R771
    • (2005) Curr. Biol. , vol.15
    • Pellicioli, A.1    Foiani, M.2
  • 24
    • 33847767159 scopus 로고    scopus 로고
    • Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae
    • Chen S.H., Smolka M.B., and Zhou H. Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. J. Biol. Chem. 282 (2007) 986-995
    • (2007) J. Biol. Chem. , vol.282 , pp. 986-995
    • Chen, S.H.1    Smolka, M.B.2    Zhou, H.3
  • 25
    • 33847296214 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53
    • Usui T., and Petrini J.H. The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 2797-2802
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 2797-2802
    • Usui, T.1    Petrini, J.H.2
  • 26
    • 40549112308 scopus 로고    scopus 로고
    • Characterization of the activation domain of the Rad53 checkpoint kinase
    • Fiorani S., Mimun G., Caleca L., Piccini D., and Pellicioli A. Characterization of the activation domain of the Rad53 checkpoint kinase. Cell Cycle 7 (2008) 493-499
    • (2008) Cell Cycle , vol.7 , pp. 493-499
    • Fiorani, S.1    Mimun, G.2    Caleca, L.3    Piccini, D.4    Pellicioli, A.5
  • 27
    • 58649097740 scopus 로고    scopus 로고
    • Maintenance of the DNA damage checkpoint requires mediator protein oligomerization
    • Usui T., Foster S., and Petrini J.H. Maintenance of the DNA damage checkpoint requires mediator protein oligomerization. Mol Cell. 33 (2009) 147-159
    • (2009) Mol Cell. , vol.33 , pp. 147-159
    • Usui, T.1    Foster, S.2    Petrini, J.H.3
  • 28
    • 0037112212 scopus 로고    scopus 로고
    • 53BP1, a mediator of the DNA damage checkpoint
    • Wang B., Matsuoka S., Carpenter P.B., and Elledge S.J. 53BP1, a mediator of the DNA damage checkpoint. Science 298 (2002) 1435-1438
    • (2002) Science , vol.298 , pp. 1435-1438
    • Wang, B.1    Matsuoka, S.2    Carpenter, P.B.3    Elledge, S.J.4
  • 30
    • 0346059615 scopus 로고    scopus 로고
    • 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
    • Mochan T.A., Venere M., DiTullio Jr. R.A., and Halazonetis T.D. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 63 (2003) 8586-8591
    • (2003) Cancer Res. , vol.63 , pp. 8586-8591
    • Mochan, T.A.1    Venere, M.2    DiTullio Jr., R.A.3    Halazonetis, T.D.4
  • 31
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • Lou Z., Minter-Dykhouse K., Wu X., and Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421 (2003) 957-961
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 33
    • 44649164582 scopus 로고    scopus 로고
    • Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
    • Minter-Dykhouse K., Ward I., Huen M.S., Chen J., and Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J. Cell. Biol. 181 (2008) 727-735
    • (2008) J. Cell. Biol. , vol.181 , pp. 727-735
    • Minter-Dykhouse, K.1    Ward, I.2    Huen, M.S.3    Chen, J.4    Lou, Z.5
  • 34
    • 0033634679 scopus 로고    scopus 로고
    • a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • Kumagai A., Dunphy W.G., and Claspin. a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell. 6 (2000) 839-849
    • (2000) Mol. Cell. , vol.6 , pp. 839-849
    • Kumagai, A.1    Dunphy, W.G.2    Claspin3
  • 35
    • 33746408535 scopus 로고    scopus 로고
    • Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
    • Wang X., Zou L., Lu T., Bao S., Hurov K.E., Hittelman W.N., Elledge S.J., and Li L. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell. 23 (2006) 331-341
    • (2006) Mol. Cell. , vol.23 , pp. 331-341
    • Wang, X.1    Zou, L.2    Lu, T.3    Bao, S.4    Hurov, K.E.5    Hittelman, W.N.6    Elledge, S.J.7    Li, L.8
  • 36
    • 0037289840 scopus 로고    scopus 로고
    • Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
    • Kumagai A., and Dunphy W.G. Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat. Cell. Biol. 5 (2003) 161-165
    • (2003) Nat. Cell. Biol. , vol.5 , pp. 161-165
    • Kumagai, A.1    Dunphy, W.G.2
  • 37
    • 33845625801 scopus 로고    scopus 로고
    • Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function
    • Chini C.C., and Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J. Biol. Chem. 281 (2006) 33276-33282
    • (2006) J. Biol. Chem. , vol.281 , pp. 33276-33282
    • Chini, C.C.1    Chen, J.2
  • 38
    • 33746047485 scopus 로고    scopus 로고
    • Chk1 is required to maintain claspin stability
    • Chini C.C., Wood J., and Chen J. Chk1 is required to maintain claspin stability. Oncogene 25 (2006) 4165-4171
    • (2006) Oncogene , vol.25 , pp. 4165-4171
    • Chini, C.C.1    Wood, J.2    Chen, J.3
  • 39
    • 30944435598 scopus 로고    scopus 로고
    • Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
    • Smits V.A., Reaper P.M., and Jackson S.P. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr. Biol. 16 (2006) 150-159
    • (2006) Curr. Biol. , vol.16 , pp. 150-159
    • Smits, V.A.1    Reaper, P.M.2    Jackson, S.P.3
  • 41
    • 34147206546 scopus 로고    scopus 로고
    • Specific role of Chk1 phosphorylations in cell survival and checkpoint activation
    • Niida H., Katsuno Y., Banerjee B., Hande M.P., and Nakanishi M. Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol. Cell. Biol. 27 (2007) 2572-2581
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 2572-2581
    • Niida, H.1    Katsuno, Y.2    Banerjee, B.3    Hande, M.P.4    Nakanishi, M.5
  • 45
    • 27144444111 scopus 로고    scopus 로고
    • ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    • Chen L., Gilkes D.M., Pan Y., Lane W.S., and Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 24 (2005) 3411-3422
    • (2005) EMBO J. , vol.24 , pp. 3411-3422
    • Chen, L.1    Gilkes, D.M.2    Pan, Y.3    Lane, W.S.4    Chen, J.5
  • 46
    • 33645290219 scopus 로고    scopus 로고
    • Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    • LeBron C., Chen L., Gilkes D.M., and Chen J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J. 25 (2006) 1196-1206
    • (2006) EMBO J. , vol.25 , pp. 1196-1206
    • LeBron, C.1    Chen, L.2    Gilkes, D.M.3    Chen, J.4
  • 47
    • 33645293151 scopus 로고    scopus 로고
    • 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
    • Jin Y., Dai M.S., Lu S.Z., Xu Y., Luo Z., Zhao Y., and Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 25 (2006) 1207-1218
    • (2006) EMBO J. , vol.25 , pp. 1207-1218
    • Jin, Y.1    Dai, M.S.2    Lu, S.Z.3    Xu, Y.4    Luo, Z.5    Zhao, Y.6    Lu, H.7
  • 48
    • 33746766974 scopus 로고    scopus 로고
    • A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
    • Zhang D., Zaugg K., Mak T.W., and Elledge S.J. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126 (2006) 529-542
    • (2006) Cell , vol.126 , pp. 529-542
    • Zhang, D.1    Zaugg, K.2    Mak, T.W.3    Elledge, S.J.4
  • 49
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J., and Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3 (2003) 421-429
    • (2003) Cancer Cell. , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 50
    • 33745001764 scopus 로고    scopus 로고
    • Cdc25: mechanisms of checkpoint inhibition and recovery
    • Karlsson-Rosenthal C., and Millar J.B. Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell. Biol. 16 (2006) 285-292
    • (2006) Trends Cell. Biol. , vol.16 , pp. 285-292
    • Karlsson-Rosenthal, C.1    Millar, J.B.2
  • 53
    • 0347361537 scopus 로고    scopus 로고
    • SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
    • Jin J., Shirogane T., Xu L., Nalepa G., Qin J., Elledge S.J., and Harper J.W. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 17 (2003) 3062-3074
    • (2003) Genes Dev. , vol.17 , pp. 3062-3074
    • Jin, J.1    Shirogane, T.2    Xu, L.3    Nalepa, G.4    Qin, J.5    Elledge, S.J.6    Harper, J.W.7
  • 54
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng C.Y., Graves P.R., Thoma R.S., Wu Z., Shaw A.S., and Piwnica-Worms H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277 (1997) 1501-1505
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1    Graves, P.R.2    Thoma, R.S.3    Wu, Z.4    Shaw, A.S.5    Piwnica-Worms, H.6
  • 55
    • 18144413891 scopus 로고    scopus 로고
    • Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases
    • Kanemori Y., Uto K., and Sagata N. Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 6279-6284
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 6279-6284
    • Kanemori, Y.1    Uto, K.2    Sagata, N.3
  • 57
    • 33746429958 scopus 로고    scopus 로고
    • Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    • Mailand N., Bekker-Jensen S., Bartek J., and Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23 (2006) 307-318
    • (2006) Mol. Cell , vol.23 , pp. 307-318
    • Mailand, N.1    Bekker-Jensen, S.2    Bartek, J.3    Lukas, J.4
  • 60
  • 62
    • 37349014081 scopus 로고    scopus 로고
    • Tel2 regulates the stability of PI3K-related protein kinases
    • Takai H., Wang R.C., Takai K.K., Yang H., and de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell 131 (2007) 1248-1259
    • (2007) Cell , vol.131 , pp. 1248-1259
    • Takai, H.1    Wang, R.C.2    Takai, K.K.3    Yang, H.4    de Lange, T.5
  • 63
    • 46249091563 scopus 로고    scopus 로고
    • The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage
    • Bahassi E.M., Ovesen J.L., Riesenberg A.L., Bernstein W.Z., Hasty P.E., and Stambrook P.J. The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene 27 (2008) 3977-3985
    • (2008) Oncogene , vol.27 , pp. 3977-3985
    • Bahassi, E.M.1    Ovesen, J.L.2    Riesenberg, A.L.3    Bernstein, W.Z.4    Hasty, P.E.5    Stambrook, P.J.6
  • 64
    • 1642307235 scopus 로고    scopus 로고
    • Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets
    • Pasero P., Shimada K., and Duncker B.P. Multiple roles of replication forks in S phase checkpoints: sensors, effectors and targets. Cell Cycle 2 (2003) 568-572
    • (2003) Cell Cycle , vol.2 , pp. 568-572
    • Pasero, P.1    Shimada, K.2    Duncker, B.P.3
  • 65
    • 33746816108 scopus 로고    scopus 로고
    • The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation
    • Branzei D., and Foiani M. The Rad53 signal transduction pathway: replication fork stabilization, DNA repair, and adaptation. Exp. Cell. Res. 312 (2006) 2654-2659
    • (2006) Exp. Cell. Res. , vol.312 , pp. 2654-2659
    • Branzei, D.1    Foiani, M.2
  • 66
    • 46249122812 scopus 로고    scopus 로고
    • Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks
    • Segurado M., and Diffley J.F. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev. 22 (2008) 1816-1827
    • (2008) Genes Dev. , vol.22 , pp. 1816-1827
    • Segurado, M.1    Diffley, J.F.2
  • 67
    • 51949118680 scopus 로고    scopus 로고
    • Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
    • Morin I., Ngo H.P., Greenall A., Zubko M.K., Morrice N., and Lydall D. Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J. 27 (2008) 2400-2410
    • (2008) EMBO J. , vol.27 , pp. 2400-2410
    • Morin, I.1    Ngo, H.P.2    Greenall, A.3    Zubko, M.K.4    Morrice, N.5    Lydall, D.6
  • 68
    • 43249094413 scopus 로고    scopus 로고
    • Chk1 and Claspin potentiate PCNA ubiquitination
    • Yang X.H., Shiotani B., Classon M., and Zou L. Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 22 (2008) 1147-1152
    • (2008) Genes Dev. , vol.22 , pp. 1147-1152
    • Yang, X.H.1    Shiotani, B.2    Classon, M.3    Zou, L.4
  • 69
    • 35448949105 scopus 로고    scopus 로고
    • Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
    • Errico A., Costanzo V., and Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 14929-14934
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 14929-14934
    • Errico, A.1    Costanzo, V.2    Hunt, T.3
  • 70
    • 34047261441 scopus 로고    scopus 로고
    • Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint
    • Yoshizawa-Sugata N., and Masai H. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J. Biol. Chem. 282 (2007) 2729-2740
    • (2007) J. Biol. Chem. , vol.282 , pp. 2729-2740
    • Yoshizawa-Sugata, N.1    Masai, H.2
  • 71
    • 33746495515 scopus 로고    scopus 로고
    • Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
    • Durkin S.G., Arlt M.F., Howlett N.G., and Glover T.W. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 25 (2006) 4381-4388
    • (2006) Oncogene , vol.25 , pp. 4381-4388
    • Durkin, S.G.1    Arlt, M.F.2    Howlett, N.G.3    Glover, T.W.4
  • 72
    • 18344386042 scopus 로고    scopus 로고
    • Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes
    • Wittenberg C., and Reed S.I. Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Oncogene 24 (2005) 2746-2755
    • (2005) Oncogene , vol.24 , pp. 2746-2755
    • Wittenberg, C.1    Reed, S.I.2
  • 75
    • 44949170836 scopus 로고    scopus 로고
    • Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade
    • Lee H., Yuan C., Hammet A., Mahajan A., Chen E.S., Wu M.R., Su M.I., Heierhorst J., and Tsai M.D. Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol. Cell. 30 (2008) 767-778
    • (2008) Mol. Cell. , vol.30 , pp. 767-778
    • Lee, H.1    Yuan, C.2    Hammet, A.3    Mahajan, A.4    Chen, E.S.5    Wu, M.R.6    Su, M.I.7    Heierhorst, J.8    Tsai, M.D.9
  • 76
    • 0032483576 scopus 로고    scopus 로고
    • The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
    • Huang M., Zhou Z., and Elledge S.J. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94 (1998) 595-605
    • (1998) Cell , vol.94 , pp. 595-605
    • Huang, M.1    Zhou, Z.2    Elledge, S.J.3
  • 77
    • 0038752083 scopus 로고    scopus 로고
    • Chk2 activates E2F-1 in response to DNA damage
    • Stevens C., Smith L., and La Thangue N.B. Chk2 activates E2F-1 in response to DNA damage. Nat. Cell. Biol. 5 (2003) 401-409
    • (2003) Nat. Cell. Biol. , vol.5 , pp. 401-409
    • Stevens, C.1    Smith, L.2    La Thangue, N.B.3
  • 78
    • 10644270921 scopus 로고    scopus 로고
    • p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
    • Urist M., Tanaka T., Poyurovsky M.V., and Prives C. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev. 18 (2004) 3041-3054
    • (2004) Genes Dev. , vol.18 , pp. 3041-3054
    • Urist, M.1    Tanaka, T.2    Poyurovsky, M.V.3    Prives, C.4
  • 79
    • 34247199852 scopus 로고    scopus 로고
    • Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
    • Inoue Y., Kitagawa M., and Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 26 (2007) 2083-2093
    • (2007) EMBO J. , vol.26 , pp. 2083-2093
    • Inoue, Y.1    Kitagawa, M.2    Taya, Y.3
  • 80
    • 3242880237 scopus 로고    scopus 로고
    • The emerging role of E2F-1 in the DNA damage response and checkpoint control
    • Stevens C., and La Thangue N.B. The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst) 3 (2004) 1071-1079
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1071-1079
    • Stevens, C.1    La Thangue, N.B.2
  • 87
    • 0036847998 scopus 로고    scopus 로고
    • PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
    • Yang S., Kuo C., Bisi J.E., and Kim M.K. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat. Cell. Biol. 4 (2002) 865-870
    • (2002) Nat. Cell. Biol. , vol.4 , pp. 865-870
    • Yang, S.1    Kuo, C.2    Bisi, J.E.3    Kim, M.K.4
  • 88
    • 33749547681 scopus 로고    scopus 로고
    • Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR
    • Dellaire G., Ching R.W., Ahmed K., Jalali F., Tse K.C., Bristow R.G., and Bazett-Jones D.P. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J. Cell. Biol. 175 (2006) 55-66
    • (2006) J. Cell. Biol. , vol.175 , pp. 55-66
    • Dellaire, G.1    Ching, R.W.2    Ahmed, K.3    Jalali, F.4    Tse, K.C.5    Bristow, R.G.6    Bazett-Jones, D.P.7
  • 90
    • 33750032892 scopus 로고    scopus 로고
    • CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
    • Huang H., Regan K.M., Lou Z., Chen J., and Tindall D.J. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314 (2006) 294-297
    • (2006) Science , vol.314 , pp. 294-297
    • Huang, H.1    Regan, K.M.2    Lou, Z.3    Chen, J.4    Tindall, D.J.5
  • 92
    • 38649118240 scopus 로고    scopus 로고
    • Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
    • Shimada M., Niida H., Zineldeen D.H., Tagami H., Tanaka M., Saito H., and Nakanishi M. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132 (2008) 221-232
    • (2008) Cell , vol.132 , pp. 221-232
    • Shimada, M.1    Niida, H.2    Zineldeen, D.H.3    Tagami, H.4    Tanaka, M.5    Saito, H.6    Nakanishi, M.7
  • 93
    • 0035336971 scopus 로고    scopus 로고
    • Asf1 links Rad53 to control of chromatin assembly
    • Hu F., Alcasabas A.A., and Elledge S.J. Asf1 links Rad53 to control of chromatin assembly. Genes Dev. 15 (2001) 1061-1066
    • (2001) Genes Dev. , vol.15 , pp. 1061-1066
    • Hu, F.1    Alcasabas, A.A.2    Elledge, S.J.3
  • 95
    • 0042470439 scopus 로고    scopus 로고
    • Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling
    • Lee S.J., Schwartz M.F., Duong J.K., and Stern D.F. Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol. Cell. Biol. 23 (2003) 6300-6314
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6300-6314
    • Lee, S.J.1    Schwartz, M.F.2    Duong, J.K.3    Stern, D.F.4
  • 96
    • 0033570172 scopus 로고    scopus 로고
    • Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication
    • Sillje H.H., Takahashi K., Tanaka K., Van Houwe G., and Nigg E.A. Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J. 18 (1999) 5691-5702
    • (1999) EMBO J. , vol.18 , pp. 5691-5702
    • Sillje, H.H.1    Takahashi, K.2    Tanaka, K.3    Van Houwe, G.4    Nigg, E.A.5
  • 97
    • 0037386947 scopus 로고    scopus 로고
    • Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
    • Groth A., Lukas J., Nigg E.A., Sillje H.H., Wernstedt C., Bartek J., and Hansen K. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 22 (2003) 1676-1687
    • (2003) EMBO J. , vol.22 , pp. 1676-1687
    • Groth, A.1    Lukas, J.2    Nigg, E.A.3    Sillje, H.H.4    Wernstedt, C.5    Bartek, J.6    Hansen, K.7
  • 98
    • 0141730324 scopus 로고    scopus 로고
    • Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
    • Krause D.R., Jonnalagadda J.C., Gatei M.H., Sillje H.H., Zhou B.B., Nigg E.A., and Khanna K. Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene 22 (2003) 5927-5937
    • (2003) Oncogene , vol.22 , pp. 5927-5937
    • Krause, D.R.1    Jonnalagadda, J.C.2    Gatei, M.H.3    Sillje, H.H.4    Zhou, B.B.5    Nigg, E.A.6    Khanna, K.7
  • 99
    • 0035838432 scopus 로고    scopus 로고
    • Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases
    • Sillje H.H., and Nigg E.A. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Curr. Biol. 11 (2001) 1068-1073
    • (2001) Curr. Biol. , vol.11 , pp. 1068-1073
    • Sillje, H.H.1    Nigg, E.A.2
  • 100
    • 47549105301 scopus 로고    scopus 로고
    • Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair
    • Chen C.C., Carson J.J., Feser J., Tamburini B., Zabaronick S., Linger J., and Tyler J.K. Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134 (2008) 231-243
    • (2008) Cell , vol.134 , pp. 231-243
    • Chen, C.C.1    Carson, J.J.2    Feser, J.3    Tamburini, B.4    Zabaronick, S.5    Linger, J.6    Tyler, J.K.7
  • 101
    • 0035105240 scopus 로고    scopus 로고
    • Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest
    • Pellicioli A., Lee S.E., Lucca C., Foiani M., and Haber J.E. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol. Cell. 7 (2001) 293-300
    • (2001) Mol. Cell. , vol.7 , pp. 293-300
    • Pellicioli, A.1    Lee, S.E.2    Lucca, C.3    Foiani, M.4    Haber, J.E.5
  • 102
  • 103
    • 0034117149 scopus 로고    scopus 로고
    • Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae
    • Marsolier M.C., Roussel P., Leroy C., and Mann C. Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae. Genetics 154 (2000) 1523-1532
    • (2000) Genetics , vol.154 , pp. 1523-1532
    • Marsolier, M.C.1    Roussel, P.2    Leroy, C.3    Mann, C.4
  • 104
    • 34547196917 scopus 로고    scopus 로고
    • Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage
    • O'Neill B.M., Szyjka S.J., Lis E.T., Bailey A.O., Yates J.R., 3rd O.M., Aparicio F.E., and Romesberg. Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 9290-9295
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 9290-9295
    • O'Neill, B.M.1    Szyjka, S.J.2    Lis, E.T.3    Bailey, A.O.4    Yates, J.R.5    3rd, O.M.6    Aparicio, F.E.7    Romesberg8
  • 106
    • 1842614272 scopus 로고    scopus 로고
    • Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
    • den Elzen N.R., and O'Connell M.J. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J. 23 (2004) 908-918
    • (2004) EMBO J. , vol.23 , pp. 908-918
    • den Elzen, N.R.1    O'Connell, M.J.2
  • 108
    • 18844405191 scopus 로고    scopus 로고
    • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
    • Lu X., Nannenga B., and Donehower L.A. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev. 19 (2005) 1162-1174
    • (2005) Genes Dev. , vol.19 , pp. 1162-1174
    • Lu, X.1    Nannenga, B.2    Donehower, L.A.3
  • 113
    • 21644447887 scopus 로고    scopus 로고
    • Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit
    • Dozier C., Bonyadi M., Baricault L., Tonasso L., and Darbon J.M. Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. Biol. Cell. 96 (2004) 509-517
    • (2004) Biol. Cell. , vol.96 , pp. 509-517
    • Dozier, C.1    Bonyadi, M.2    Baricault, L.3    Tonasso, L.4    Darbon, J.M.5
  • 115
    • 33644549654 scopus 로고    scopus 로고
    • Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint
    • Petersen P., Chou D.M., You Z., Hunter T., Walter J.C., and Walter G. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol. Cell. Biol. 26 (2006) 1997-2011
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 1997-2011
    • Petersen, P.1    Chou, D.M.2    You, Z.3    Hunter, T.4    Walter, J.C.5    Walter, G.6
  • 119
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
    • Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., Appella E., and Fornace Jr. A.J. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 36 (2004) 343-350
    • (2004) Nat. Genet. , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3    Timofeev, O.4    Donehower, L.A.5    Anderson, C.W.6    Appella, E.7    Fornace Jr., A.J.8
  • 120
    • 33749039966 scopus 로고    scopus 로고
    • The CHEK2 gene and inherited breast cancer susceptibility
    • Nevanlinna H., and Bartek J. The CHEK2 gene and inherited breast cancer susceptibility. Oncogene 25 (2006) 5912-5919
    • (2006) Oncogene , vol.25 , pp. 5912-5919
    • Nevanlinna, H.1    Bartek, J.2
  • 122
    • 33644510424 scopus 로고    scopus 로고
    • Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant
    • Kwak E.L., Kim S., Zhang J., Cardiff R.D., Schmidt E.V., and Haber D.A. Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant. Cancer Res. 66 (2006) 1923-1928
    • (2006) Cancer Res. , vol.66 , pp. 1923-1928
    • Kwak, E.L.1    Kim, S.2    Zhang, J.3    Cardiff, R.D.4    Schmidt, E.V.5    Haber, D.A.6
  • 125
    • 6344247481 scopus 로고    scopus 로고
    • Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1
    • Kim S.S., Cao L., Li C., Xu X., Huber L.J., Chodosh L.A., and Deng C.X. Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol. Cell. Biol. 24 (2004) 9498-9507
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9498-9507
    • Kim, S.S.1    Cao, L.2    Li, C.3    Xu, X.4    Huber, L.J.5    Chodosh, L.A.6    Deng, C.X.7
  • 126
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • Lam M.H., Liu Q., Elledge S.J., and Rosen J.M. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 6 (2004) 45-59
    • (2004) Cancer Cell. , vol.6 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 129
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • O'Driscoll M., Ruiz-Perez V.L., Woods C.G., Jeggo P.A., and Goodship J.A. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33 (2003) 497-501
    • (2003) Nat. Genet. , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 130
    • 4544269236 scopus 로고    scopus 로고
    • Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
    • Xu X., Lee J., and Stern D.F. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J. Biol. Chem. 279 (2004) 34091-34094
    • (2004) J. Biol. Chem. , vol.279 , pp. 34091-34094
    • Xu, X.1    Lee, J.2    Stern, D.F.3
  • 131
    • 27244445051 scopus 로고    scopus 로고
    • BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
    • Lin S.Y., Rai R., Li K., Xu Z.X., and Elledge S.J. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 15105-15109
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 15105-15109
    • Lin, S.Y.1    Rai, R.2    Li, K.3    Xu, Z.X.4    Elledge, S.J.5
  • 133
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: chemosensitization versus chemoprotection
    • Zhou B.B., and Bartek J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat. Rev. Cancer 4 (2004) 216-225
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 134
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?
    • Antoni L., Sodha N., Collins I., and Garrett M.D. CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?. Nat. Rev. Cancer 7 (2007) 925-936
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 135
    • 36949012288 scopus 로고    scopus 로고
    • Targeted cancer therapies based on the inhibition of DNA strand break repair
    • O'Connor M.J., Martin N.M., and Smith G.C. Targeted cancer therapies based on the inhibition of DNA strand break repair. Oncogene 26 (2007) 7816-7824
    • (2007) Oncogene , vol.26 , pp. 7816-7824
    • O'Connor, M.J.1    Martin, N.M.2    Smith, G.C.3


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