Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

EMBO Journal

Volumn 21, Issue 19, 2002, Pages 5195-5205

  Takai, Hiroyuki ^a   Naka, Kazuhito ^a   Okada, Yuki ^a   Watanabe, Miho ^a   Harada, Naoki ^a   Saito, Shin'ichi ^a   Anderson, Carl W ^a   Appella, Ettore ^a   Nakanishi, Makoto ^a   Suzuki, Hiroshi ^a   Nagashima, Kazuo ^a   Sawa, Hirofumi ^a   Ikeda, Kyoji ^a   Motoyama, Noboru ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Ataxia telangiectasia mutated (ATM); Cell cycle checkpoint; DNA damage; Phosphorylation; Transcriptional activation

Indexed keywords

ATM PROTEIN; CAFFEINE; CHECKPOINT KINASE 2; PROTEIN; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; BRAIN DEVELOPMENT; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO DEVELOPMENT; ENZYME DEFICIENCY; FIBROBLAST; GENE TARGETING; GENETIC DISORDER; GENETIC TRANSCRIPTION; IONIZING RADIATION; LYMPHOCYTE; MAMMAL; NERVE CELL; NEWBORN; NONHUMAN; ORGAN PRESERVATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; RADIATION INJURY; RADIATION RESPONSE; RADIOSENSITIVITY; SPLEEN CELL; THYMOCYTE; WILD TYPE;

ANIMALS; APOPTOSIS; BRAIN; CELL CYCLE; CELL DEATH; GENES, P53; MICE; MICE, KNOCKOUT; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; THYMUS GLAND; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 18644375649     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf506     Document Type: Article

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