A novel protein modification pathway related to the ubiquitin system

EMBO Journal

Volumn 17, Issue 8, 1998, Pages 2208-2214

  Liakopoulos, Dimitris ^a   Doenges, Georg ^a   Matuschewski, Kai ^a   Jentsch, Stefan ^a  

^a Zentrum fur Molec Biologie   (Germany)

Author keywords

CDC53; Cullin; NEDD8; RUB1; Ubiquitin

Indexed keywords

PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SEQUENCE; ARTICLE; CONJUGATION; CONTROLLED STUDY; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; YEAST;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL CYCLE PROTEINS; CULLIN PROTEINS; DNA, COMPLEMENTARY; FUNGAL PROTEINS; LIGASES; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 0032522382     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.8.2208     Document Type: Article

References (49)

1. Ausubel,F.M., Brent,R., Kingston,R.E., Moore,D.D., Seidman,J.G., Smith,J.A. and Struhl,K. (1994) Current Protocols in Molecular Biology. Green and Wiley, New York.
2. 1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev., 9, 399-409.
3. Biggins,S., Ivanovska,T. and Rose,M.D. (1996) Yeast ubiquitin-like genes are involved in duplication of the microtuble organizing center. J. Cell Biol., 133,1331-1346.
4. Ciechanover,A. (1994) The ubiquitin-proteasome system. Cell, 79,13-21.
5. Dohmen,R.J., Stappen,R., McGrath,J.P., Forrová,H., Kolarov,J., Goffeau,A. and Varshavsky,A. (1995) An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J. Biol. Chem., 270,18099-18109.
6. Feldman,R.M.R., Corell,C.C., Kaplan,K.B. and Deshaies,R.J. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell, 91,221-230.
7. Finley,D., Özkaynak,E. and Varshavsky,A. (1985) The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell, 48,1035-1046.
8. Galan,J.-M. and Haguenauer-Tsapis,R. (1997) Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J., 16,5847-5854.
9. Galan,J.-M., Moreau,V., Andre,B., Volland,C. and Haguenauer-Tsapis,R. (1996) Ubiquitination mediated by the Npi1p/Rasp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J. Biol. Chem., 271,10946-10952.
10. Gietz,D.R. and Sugino,A. (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene. 74,527-534.
11. Haas,A.L., Ahrens,P., Bright,P.M. and Ankel,H. (1987) Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin. J. Biol. Chem., 262,11315-11323.
12. Hochstrasser,M. (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet, 30,405-439.
13. Höhfeld,J. and Jentsch,S. (1997) GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J., 16,6209-6216.
14. Hicke,L. and Riezman,H. (1996) Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell, 84,277-287.
15. Hurt,E.C., McDowall,A. and Schlimmang,T.N. (1988) Nucleolar and nuclear envelope proteins of the yeast Saccharomyces cerevisiae. Eur. J. Cell Biol., 46,554-563.
16. Jentsch,S. (1992) The ubiquitin-conjugation system. Annu. Rev. Genet., 26,179-207.
17. Jentsch,S. and Schlenker,S. (1995) Selective protein degradation: a journey's end within the proteasome. Cell, 82,881-884.
18. Jentsch,S., Seufert,W., Sommer,T. and Reins,H.-A. (1990) Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells. Trends Biochem. Sci., 15,195-198.
19. Johnson,E.S and Blobel,G. (1997) Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J. Biol., Chem., 272,6799-26802.
20. Johnson,E.S., Schwienhorst,I., Dohmen,R.J. and Blobel,G. (1997) The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J., 16,5509-5519.
21. Johnson,P.R. and Hochstrasser,M. (1997) SUMO-1: ubiquitin gains weight. Trends Cell Biol., 7,408-413.
22. Kamitani,T., Kito,K., Nguyen,H.P. and Yeh,E.T.H. (1997) Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J. Biol. Chem., 272,28557-28562.
23. Kipreos,E.T., Lander,L.E., Wing,J.P., He,W.W. and Hedgecock,E.M. (1996) cul-1 is required for cell cycle exit in C.elegans and identifies a novel gene family. Cell,85,829-839.
24. Kölling,R. and Hollenberg,C.P. (1994) The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J., 13,3261-3271.
25. Kumar,S., Tomooka,Y. and Noda,M. (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem. Biophys. Res. Commun., 185,1155-1161.
26. Li,F.N. and Johnston,M. (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J., 16,5629-5638.
27. Loeb,K.R. and Haas,A.L. (1992) The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins. J. Biol. Chem., 267,7806-7813.
28. Loeb,K.R. and Haas,A.L. (1994) Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern. Mol. Cell. Biol., 145 8408-8419.
29. Mahajan,R., Delphin,C., Guan,T., Gerace,L. and Melchior,F. (1997) A small ubiquitin-related polypeptide involved in targeting RanGAP1 to the nuclear pore complex protein RanBP2. Cell, 88,97-107.
30. Mathias,N., Johnson,S.L., Winey,M., Adams,A.E.M., Goetsch,L., Pringle,J.R., Byers,B. and Goebl,M. (1996) Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mol. Cell. Biol., 16,6634-6643.
31. Matunis,M.J., Coutavas,E. and Blobel,G. (1996) A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell. Biol., 135,1457-1470.
32. McGrath,J.P., Jentsch,S. and Varshavsky,A. (1991) UBA1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J., 10,227-236.
33. Mortz,E., Vorm,O., Mann,M. and Roepstorff,P. (1994) Identification of proteins in polyacrylamide gels by mass spectrometric peptide mapping combined with database search. Biol. Mass Spectrom., 23,249-261.
34. Özkaynak,E., Finley,D., Solomon,M.J. and Varshavsky,A. (1987) The yeast ubiquitin genes: a family of natural gene fusions. EMBO J., 6,1429-1439.
35. Saitoh,H., Pu,R.T. and Dasso,M. (1997) SUMO-1: wrestling with a new ubiquitin-related modifier. Trends Biochem. Sci., 22,374-376.
36. Saitoh,H., Sparrow,D.B., Shiomi,T., Pu,R.T., Nishimoto,T., Mohun,T.J. and Dasso,M. (1998) Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2. Curr. Biol., 8,121-124.
37. Scheffner,M., Huibregtse,J.M., Vierstra,R.D. and Howley,P. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell, 75,495-505.
38. Scheffner,M., Nuber,U. and Huibregtse,J.M. (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature, 373,81-83.
39. Schwarz,S.E., Matuschewski,K., Liakopoulos,D., Scheffner,M and Jentsch,S. (1998) The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzymes. Proc. Natl Acad. Sci. USA, 95,560-564.
40. sIc1 controls the G1 to S transition in S.cerevisiae. Cell, 79, 233-244.
41. Seufert,W. and Jentsch,S. (1990) Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J., 9,543-550.
42. Skowyra,D., Craig,K.L., Tyers,M., Elledge,S.J. and Harper,J.W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell, 91,209-219.
43. Takayama,S., Sato,T., Krajewski,S., Kochel,K., Irie,S., Millan,J.A. and Reed,J.C. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 80,279-284.
44. Takayama,S., Bimston,D.N., Matsuzawa,S., Freeman,B.C., Aime-Sempe,C., Xie,Z., Morimoto,R.I. and Reed,J.C. (1997) BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO 7., 16,4887-4896.
45. Varshavsky,A. (1997) The ubiquitin system. Trends Biochem. Sci., 22,383-387.
46. Vijay-Kumar,S., Bugg,C.E. and Cook,W.J. (1987) Structure of ubiquitin refined at 1.8 Å resolution. J. Mol. Biol., 194,531-544.
47. Watkins,J.F., Sung,P. Prakash,L. and Prakash,S. (1993) The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function. Mol. Cell. Biol., 13,7757-7765.
48. Willems,A.R., Lanker,S., Patton,E.E., Craig,K.L., Nason,T.F., Mathias,N., Kobayashi,R., Wittenberg,C. and Tyers,M. (1996) Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell, 86,453-463.
49. Zeiner,M., Gebauer,M. and Gehring,U. (1997) Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock protein. EMBO J., 16,5483-5490.