NEDD8 Pathways in Cancer, Sine Quibus Non

Cancer Cell

Volumn 19, Issue 2, 2011, Pages 168-176

  Watson, Ian R ^a,b   Irwin, Meredith S ^a,b   Ohh, Michael ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; ENZYME INHIBITOR; MLN 4924; NEDD8 PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CARCINOGENESIS; CONJUGATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENETIC MODEL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 79751469547     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2011.01.002     Document Type: Review

References (120)

1. Abida W.M., Nikolaev A., Zhao W., Zhang W., Gu W. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J. Biol. Chem. 2007, 282:1797-1804.
2. Andrews P., He Y.J., Xiong Y. Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene 2006, 25:4534-4548.
3. Angers S., Thorpe C.J., Biechele T.L., Goldenberg S.J., Zheng N., MacCoss M.J., Moon R.T. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 2006, 8:348-357.
4. Bennett E.J., Rush J., Gygi S.P., Harper J.W. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 2010, 143:951-965.
5. Brownell J.E., Sintchak M.D., Gavin J.M., Liao H., Bruzzese F.J., Bump N.J., Soucy T.A., Milhollen M.A., Yang X., Burkhardt A.L., et al. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol. Cell. 2010, 37:102-111.
6. Cai Q.L., Knight J.S., Verma S.C., Zald P., Robertson E.S. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog. 2006, 2:e116.
7. Carter S., Vousden K.H. p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53. Cell Cycle 2008, 7:2519-2528.
8. Chairatvit K., Ngamkitidechakul C. Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma. Mol. Cell. Biochem. 2007, 306:163-169.
9. Chan Y., Yoon J., Wu J.T., Kim H.J., Pan K.T., Yim J., Chien C.T. DEN1 deneddylates non-cullin proteins in vivo. J. Cell Sci. 2008, 121:3218-3223.
10. Chen L.C., Manjeshwar S., Lu Y., Moore D., Ljung B.M., Kuo W.L., Dairkee S.H., Wernick M., Collins C., Smith H.S. The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res. 1998, 58:3677-3683.
11. Chen X., Zhang Y., Douglas L., Zhou P. UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. J. Biol. Chem. 2001, 276:48175-48182.
12. Chu G., Chang E. Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Science 1988, 242:564-567.
13. Ciechanover A., Heller H., Katz-Etzion R., Hershko A. Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc. Natl. Acad. Sci. USA 1981, 78:761-765.
14. Ciechanover A., Elias S., Heller H., Hershko A. "Covalent affinity" purification of ubiquitin-activating enzyme. J. Biol. Chem. 1982, 257:2537-2542.
15. Collier-Hyams L.S., Sloane V., Batten B.C., Neish A.S. Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1. J. Immunol. 2005, 175:4194-4198.
16. Cui J., Yao Q., Li S., Ding X., Lu Q., Mao H., Liu L., Zheng N., Chen S., Shao F. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 2010, 329:1215-1218.
17. Dehan E., Bassermann F., Guardavaccaro D., Vasiliver-Shamis G., Cohen M., Lowes K.N., Dustin M., Huang D.C., Taunton J., Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol. Cell 2009, 33:109-116.
18. Dharmasiri S., Dharmasiri N., Hellmann H., Estelle M. The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. EMBO J. 2003, 22:1762-1770.
19. Dohmesen C., Koeppel M., Dobbelstein M. Specific inhibition of Mdm2-mediated neddylation by Tip60. Cell Cycle 2008, 7:222-231.
20. Duda D.M., Borg L.A., Scott D.C., Hunt H.W., Hammel M., Schulman B.A. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 2008, 134:995-1006.
21. Eletr Z.M., Huang D.T., Duda D.M., Schulman B.A., Kuhlman B. E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer. Nat. Struct. Mol. Biol. 2005, 12:933-934.
22. Frantsve J., Schwaller J., Sternberg D.W., Kutok J., Gilliland D.G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 2001, 21:3547-3557.
23. Furukawa M., He Y.J., Borchers C., Xiong Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 2003, 5:1001-1007.
24. Gao F., Cheng J., Shi T., Yeh E.T. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat. Cell Biol. 2006, 8:1171-1177.
25. Gao M.X., Liao E.H., Yu B., Wang Y., Zhen M., Derry W.B. The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Cell Death Differ. 2008, 15:1054-1062.
26. Geyer R., Wee S., Anderson S., Yates J., Wolf D.A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 2003, 12:783-790.
27. Guardavaccaro D., Pagano M. Oncogenic aberrations of cullin-dependent ubiquitin ligases. Oncogene 2004, 23:2037-2049.
28. Haas A.L., Rose I.A. The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. J. Biol. Chem. 1982, 257:10329-10337.
29. Haas A.L., Warms J.V., Hershko A., Rose I.A. Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J. Biol. Chem. 1982, 257:2543-2548.
30. Handeli S., Weintraub H. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell 1992, 71:599-611.
31. He B., You L., Uematsu K., Zang K., Xu Z., Lee A.Y., Costello J.F., McCormick F., Jablons D.M. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc. Natl. Acad. Sci. USA 2003, 100:14133-14138.
32. Hilton D.J. Negative regulators of cytokine signal transduction. Cell. Mol. Life Sci. 1999, 55:1568-1577.
33. Hiramatsu Y., Kitagawa K., Suzuki T., Uchida C., Hattori T., Kikuchi H., Oda T., Hatakeyama S., Nakayama K.I., Yamamoto T., et al. Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 2006, 66:8477-8483.
34. Hirschberg J., Marcus M. Isolation by a replica-plating technique of Chinese hamster temperature-sensitive cell cycle mutants. J. Cell Physiol. 1982, 113:159-166.
35. Huang D.T., Paydar A., Zhuang M., Waddell M.B., Holton J.M., Schulman B.A. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol. Cell 2005, 17:341-350.
36. Huang H., Regan K.M., Wang F., Wang D., Smith D.I., van Deursen J.M., Tindall D.J. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl. Acad. Sci. USA 2005, 102:1649-1654.
37. Huang D.T., Hunt H.W., Zhuang M., Ohi M.D., Holton J.M., Schulman B.A. Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature 2007, 445:394-398.
38. Huang D.T., Ayrault O., Hunt H.W., Taherbhoy A.M., Duda D.M., Scott D.C., Borg L.A., Neale G., Murray P.J., Roussel M.F., Schulman B.A. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol. Cell 2009, 33:483-495.
39. Inuzuka H., Tseng A., Gao D., Zhai B., Zhang Q., Shaik S., Wan L., Ang X.L., Mock C., Yin H., et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell 2010, 18:147-159.
40. Jackson S., Xiong Y. CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem. Sci. 2009, 34:562-570.
41. Jones D., Candido E.P. The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis. Dev. Biol. 2000, 226:152-165.
42. Jones J., Wu K., Yang Y., Guerrero C., Nillegoda N., Pan Z.Q., Huang L. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. J. Proteome Res. 2008, 7:1274-1287.
43. Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
44. Kamitani T., Kito K., Nguyen H.P., Yeh E.T. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J. Biol. Chem. 1997, 272:28557-28562.
45. Kamizono S., Hanada T., Yasukawa H., Minoguchi S., Kato R., Minoguchi M., Hattori K., Hatakeyama S., Yada M., Morita S., et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 2001, 276:12530-12538.
46. Kamura T., Conrad M., Yan Q., Conaway R., Conaway J. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev. 1999, 13:2928-2933.
47. Kapetanaki M.G., Guerrero-Santoro J., Bisi D.C., Hsieh C.L., Rapic-Otrin V., Levine A.S. The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc. Natl. Acad. Sci. USA 2006, 103:2588-2593.
48. Kim S.S., Shago M., Kaustov L., Boutros P.C., Clendening J.W., Sheng Y., Trentin G.A., Barsyte-Lovejoy D., Mao D.Y., Kay R., et al. CUL7 is a novel antiapoptotic oncogene. Cancer Res. 2007, 67:9616-9622.
49. Kudo Y., Guardavaccaro D., Santamaria P.G., Koyama-Nasu R., Latres E., Bronson R., Yamasaki L., Pagano M. Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis. Mol. Cell. Biol. 2004, 24:8184-8194.
50. Kumar S., Tomooka Y., Noda M. Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem. Biophys. Res. Commun. 1992, 185:1155-1161.
51. Kumar A., Wu H., Collier-Hyams L.S., Hansen J.M., Li T., Yamoah K., Pan Z.Q., Jones D.P., Neish A.S. Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J. 2007, 26:4457-4466.
52. Kurz T., Pintard L., Willis J.H., Hamill D.R., Gonczy P., Peter M., Bowerman B. Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 2002, 295:1294-1298.
53. Kurz T., Ozlu N., Rudolf F., O'Rourke S.M., Luke B., Hofmann K., Hyman A.A., Bowerman B., Peter M. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature 2005, 435:1257-1261.
54. Kurz T., Chou Y.C., Willems A.R., Meyer-Schaller N., Hecht M.L., Tyers M., Peter M., Sicheri F. Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol. Cell 2008, 29:23-35.
55. Liakopoulos D., Doenges G., Matuschewski K., Jentsch S. A novel protein modification pathway related to the ubiquitin system. EMBO J. 1998, 17:2208-2214.
56. Liu G., Xirodimas D.P. NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways. Oncogene 2010, 29:2252-2261.
57. Liu J., Furukawa M., Matsumoto T., Xiong Y. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol. Cell 2002, 10:1511-1518.
58. Liu L., Lee S., Zhang J., Peters S.B., Hannah J., Zhang Y., Yin Y., Koff A., Ma L., Zhou P. CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol. Cell 2009, 34:451-460.
59. Lyapina S., Cope G., Shevchenko A., Serino G., Tsuge T., Zhou C., Wolf D.A., Wei N., Deshaies R.J. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 2001, 292:1382-1385.
60. Matsuoka S., Oike Y., Onoyama I., Iwama A., Arai F., Takubo K., Mashimo Y., Oguro H., Nitta E., Ito K., et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 2008, 22:986-991.
61. Melchor L., Saucedo-Cuevas L.P., Munoz-Repeto I., Rodriguez-Pinilla S.M., Honrado E., Campoverde A., Palacios J., Nathanson K.L., Garcia M.J., Benitez J. Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes. Breast Cancer Res. 2009, 11:R86.
62. Melzner I., Bucur A.J., Bruderlein S., Dorsch K., Hasel C., Barth T.F., Leithauser F., Moller P. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood 2005, 105:2535-2542.
63. Meyer-Schaller N., Chou Y.C., Sumara I., Martin D.D., Kurz T., Katheder N., Hofmann K., Berthiaume L.G., Sicheri F., Peter M. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc. Natl. Acad. Sci. USA 2009, 106:12365-12370.
64. Moberg K.H., Bell D.W., Wahrer D.C., Haber D.A., Hariharan I.K. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 2001, 413:311-316.
65. Moro L., Arbini A.A., Marra E., Greco M. Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation. J. Biol. Chem. 2006, 281:22100-22107.
66. Nag A., Bondar T., Shiv S., Raychaudhuri P. The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells. Mol. Cell Biol. 2001, 21:6738-6747.
67. Nikolaev A.Y., Li M., Puskas N., Qin J., Gu W. Parc: a cytoplasmic anchor for p53. Cell 2003, 112:29-40.
68. Niture S.K., Kaspar J.W., Shen J., Jaiswal A.K. Nrf2 signaling and cell survival. Toxicol. Appl. Pharmacol. 2010, 244:37-42.
69. Ohh M., Kim W.Y., Moslehi J.J., Chen Y., Chau V., Read M.A., Kaelin W.G. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 2002, 3:177-182.
70. Ohki Y., Funatsu N., Konishi N., Chiba T. The mechanism of poly-NEDD8 chain formation in vitro. Biochem. Biophys. Res. Commun. 2009, 381:443-447.
71. Okabe H., Lee S.H., Phuchareon J., Albertson D.G., McCormick F., Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One 2006, 1:e128.
72. Osaka F., Kawasaki H., Aida N., Saeki M., Chiba T., Kawashima S., Tanaka K., Kato S. A new NEDD8-ligating system for cullin-4A. Genes Dev. 1998, 12:2263-2268.
73. Ou C.Y., Lin Y.F., Chen Y.J., Chien C.T. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 2002, 16:2403-2414.
74. Oved S., Mosesson Y., Zwang Y., Santonico E., Shtiegman K., Marmor M.D., Kochupurakkal B.S., Katz M., Lavi S., Cesareni G., Yarden Y. Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J. Biol. Chem. 2006, 281:21640-21651.
75. Pan Z.Q., Kentsis A., Dias D.C., Yamoah K., Wu K. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 2004, 23:1985-1997.
76. Peschiaroli A., Scialpi F., Bernassola F., Pagano M., Melino G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene 2009, 28:3157-3166.
77. Petroski M.D., Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 2005, 6:9-20.
78. Pickart C.M., Kasperek E.M., Beal R., Kim A. Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1). J. Biol. Chem. 1994, 269:7115-7123.
79. Pintard L., Willis J.H., Willems A., Johnson J.L., Srayko M., Kurz T., Glaser S., Mains P.E., Tyers M., Bowerman B., Peter M. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 2003, 425:311-316.
80. Querido E., Morisson M.R., Chu-Pham-Dang H., Thirlwell S.W., Boivin D., Branton P.E. Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex. J. Virol. 2001, 75:699-709.
81. Rabut G., Peter M. Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008, 9:969-976.
82. Russell R.C., Ohh M. NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. EMBO Rep. 2008, 9:486-491.
83. Saha A., Deshaies R.J. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol. Cell 2008, 32:21-31.
84. Schmidt M.W., McQuary P.R., Wee S., Hofmann K., Wolf D.A. F-box-directed CRL complex assembly and regulation by the CSN and CAND1. Mol. Cell 2009, 35:586-597.
85. Schulman B.A., Harper J.W. Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat. Rev. Mol. Cell Biol. 2009, 10:319-331.
86. Schwechheimer C., Serino G., Callis J., Crosby W.L., Lyapina S., Deshaies R.J., Gray W.M., Estelle M., Deng X.W. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 2001, 292:1379-1382.
87. Scott D.C., Monda J.K., Grace C.R., Duda D.M., Kriwacki R.W., Kurz T., Schulman B.A. A dual E3 mechanism for Rub1 ligation to Cdc53. Mol. Cell 2010, 39:784-796.
88. Shibata T., Ohta T., Tong K.I., Kokubu A., Odogawa R., Tsuta K., Asamura H., Yamamoto M., Hirohashi S. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc. Natl. Acad. Sci. USA 2008, 105:13568-13573.
89. Singer J.D., Gurian-West M., Clurman B., Roberts J.M. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev. 1999, 13:2375-2387.
90. Skaar J.R., Florens L., Tsutsumi T., Arai T., Tron A., Swanson S.K., Washburn M.P., DeCaprio J.A. PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007, 67:2006-2014.
91. Song M.S., Song S.J., Kim S.Y., Oh H.J., Lim D.S. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008, 27:1863-1874.
92. Soucy T.A., Smith P.G., Milhollen M.A., Berger A.J., Gavin J.M., Adhikari S., Brownell J.E., Burke K.E., Cardin D.P., Critchley S., et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 2009, 458:732-736.
93. Stickle N.H., Chung J., Klco J.M., Hill R.P., Kaelin W.G., Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol. Cell Biol. 2004, 24:3251-3261.
94. Sugasawa K., Okuda Y., Saijo M., Nishi R., Matsuda N., Chu G., Mori T., Iwai S., Tanaka K., Hanaoka F. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 2005, 121:387-400.
95. Sumara I., Quadroni M., Frei C., Olma M.H., Sumara G., Ricci R., Peter M. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev. Cell 2007, 12:887-900.
96. Sun L., Shi L., Li W., Yu W., Liang J., Zhang H., Yang X., Wang Y., Li R., Yao X., et al. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc. Natl. Acad. Sci. USA 2009, 106:10195-10200.
97. Sun X.X., Wang Y.G., Xirodimas D.P., Dai M.S. Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. J. Biol. Chem. 2010, 285:25812-25821.
98. Sundqvist A., Liu G., Mirsaliotis A., Xirodimas D.P. Regulation of nucleolar signalling to p53 through NEDDylation of L11. EMBO Rep. 2009, 10:1132-1139.
99. Swords R.T., Kelly K.R., Smith P.G., Garnsey J.J., Mahalingam D., Medina E., Oberheu K., Padmanabhan S., O'Dwyer M., Nawrocki S.T., et al. Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. Blood 2010, 115:3796-3800.
100. Tetzlaff M.T., Yu W., Li M., Zhang P., Finegold M., Mahon K., Harper J.W., Schwartz R.J., Elledge S.J. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc. Natl. Acad. Sci. USA 2004, 101:3338-3345.
101. Uematsu K., He B., You L., Xu Z., McCormick F., Jablons D.M. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene 2003, 22:7218-7221.
102. Walden H., Podgorski M.S., Huang D.T., Miller D.W., Howard R.J., Minor D.L., Holton J.M., Schulman B.A. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol. Cell 2003, 12:1427-1437.
103. Wang D., Li Z., Messing E.M., Wu G. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. J. Biol. Chem. 2005, 280:16393-16401.
104. Watson I.R., Blanch A., Lin D.C., Ohh M., Irwin M.S. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J. Biol. Chem. 2006, 281:4096-4103.
105. Watson I.R., Li B.K., Roche O., Blanch A., Ohh M., Irwin M.S. Chemotherapy induces NEDP1-mediated destabilization of MDM2. Oncogene 2010, 29:297-304.
106. Welcker M., Clurman B.E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 2008, 8:83-93.
107. Whitby F.G., Xia G., Pickart C.M., Hill C.P. Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J. Biol. Chem. 1998, 273:34983-34991.
108. Xirodimas D.P. Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem. Soc. Trans. 2008, 36:802-806.
109. Xirodimas D.P., Saville M.K., Bourdon J.C., Hay R.T., Lane D.P. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004, 118:83-97.
110. Xirodimas D.P., Sundqvist A., Nakamura A., Shen L., Botting C., Hay R.T. Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 2008, 9:280-286.
111. Xu L., Wei Y., Reboul J., Vaglio P., Shin T.H., Vidal M., Elledge S.J., Harper J.W. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 2003, 425:316-321.
112. Xu X., Sarikas A., Dias-Santagata D.C., Dolios G., Lafontant P.J., Tsai S.C., Zhu W., Nakajima H., Nakajima H.O., Field L.J., et al. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol. Cell 2008, 30:403-414.
113. Yamoah K., Wu K., Pan Z.Q. In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1. Methods Enzymol. 2005, 398:509-522.
114. Yamoah K., Oashi T., Sarikas A., Gazdoiu S., Osman R., Pan Z.Q. Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc. Natl. Acad. Sci. USA 2008, 105:12230-12235.
115. Yen H.C., Elledge S.J. Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science 2008, 322:923-929.
116. Zhang Y., Lu H. Signaling to p53: ribosomal proteins find their way. Cancer Cell 2009, 16:369-377.
117. Zheng J., Yang X., Harrell J.M., Ryzhikov S., Shim E.H., Lykke-Andersen K., Wei N., Sun H., Kobayashi R., Zhang H. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol. Cell 2002, 10:1519-1526.
118. Zhong W., Feng H., Santiago F.E., Kipreos E.T. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 2003, 423:885-889.
119. Zhou L., Watts F.Z. Nep1, a Schizosaccharomyces pombe deneddylating enzyme. Biochem. J. 2005, 389:307-314.
120. Zhou C., Wee S., Rhee E., Naumann M., Dubiel W., Wolf D.A. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol. Cell 2003, 11:927-938.